Publication Information

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3126, 3156, 3194, 3327, 3333, 3394, 3424, 3430, 3436, 3450, 3457, 3472, 3516, 3521, 3524, 3546, 3560, 3567, 3575, 3585, 3592, 3600, 3605, 3618, 3665, 3706, 3735, 3742, 3745, 3751, 3769, 3807, 3848, 3881, 3890, 3954, 3964, 3972, 3989, 4004, 4016, 4022, 4030, 4047, 4073, 4097, 4289, 4318, 4322, 4339, 4415, 4431, 4463, 4472, 4545, 4548, 4556, 4567, 4584, 4615, 4622, 4636, 4640, 4647, 4710, 4953, 5006, 5009, 5029, 5040, 5077, 5141, 5289, 5327, 5380, 5424, 5480, 5496, 5542, 5547, 5554, 5626, 5629, 5657, 5686, 5698, 5717, 5723, 5742, 5918, 5939, 5959, 5967, 5970, 5976, 5979, 5992, 6084, 6089, 6102, 6114, 6142, 6182, 6193, 6217, 6223, 6231, 6255, 6264, 6301, 6329, 6340], 'Smad2': [5, 33, 165, 179, 191, 219, 351, 365, 727, 1665, 1688, 1852, 1884, 1955, 1993, 2014, 2037, 2097, 2109, 2990, 3185, 3364, 3695, 3752, 3850, 3859, 4076, 4326, 4497, 4549, 5235, 5258, 5329, 5396, 5411, 5482, 5523, 5550, 5571, 5630, 6090, 6119, 6265, 6319, 6330, 6341], 'with': [6, 29, 102, 146, 167, 192, 215, 288, 332, 353, 786, 903, 1226, 1297, 1340, 1441, 1997, 2105, 2141, 2179, 2502, 2547, 2640, 2737, 2759, 2776, 2829, 2908, 3073, 3105, 3281, 3409, 3415, 3439, 3455, 3766, 3773, 3816, 3830, 3844, 3938, 4038, 4041, 4056, 4259, 4264, 4307, 4310, 4328, 4398, 4487, 4496, 4553, 4628, 4714, 4723, 4728, 4906, 5597, 5643, 5740, 6124, 6262, 6344], 'a': [7, 193, 475, 545, 603, 753, 1134, 1148, 1298, 1841, 1995, 2036, 2459, 2464, 2470, 2641, 2648, 2919, 3106, 3177, 3187, 3379, 3527, 3998, 4057, 4688, 4914, 4923, 5004, 5280, 5417, 5672, 5691, 5949, 5998, 6129, 6307, 6333], 'deletion': [8, 194, 4072, 5625], 'exon': [10, 35, 162, 196, 221, 348, 2030, 2041, 2062, 2099, 3366, 4074, 4546, 5470, 5485, 5525, 5627, 5647, 6313], '3': [11, 36, 163, 197, 222, 349, 2042, 2063, 2100, 2788, 3092, 4547, 5471, 5486, 5526, 5628, 5648, 6314, 6328], '(Smad2Δexon3)': [12, 198, 2101], 'is': [13, 199, 484, 752, 1147, 1845, 1943, 2003, 2016, 2027, 2043, 2056, 3202, 3426, 4878, 5472, 5506, 5649, 5662, 5690, 5905, 6240, 6315], 'found': [14, 200, 2005, 2034, 3204, 3867], 'in': [15, 108, 125, 130, 134, 180, 201, 294, 311, 316, 320, 366, 502, 551, 560, 572, 711, 767, 1224, 1485, 1496, 1671, 1679, 1891, 2006, 2011, 2045, 2497, 2520, 2592, 2613, 2620, 2634, 2790, 2918, 3158, 3191, 3205, 3208, 3257, 3319, 3347, 3406, 3530, 3543, 3554, 3587, 3610, 3621, 3660, 3702, 3740, 3793, 3809, 3834, 3857, 3870, 3961, 3986, 4001, 4010, 4013, 4027, 4082, 4286, 4385, 4404, 4410, 4427, 4447, 4581, 4612, 4653, 4707, 4881, 4918, 4926, 5247, 5271, 5374, 5393, 5403, 5415, 5421, 5431, 5463, 5474, 5549, 5552, 5636, 5653, 5694, 5711, 5972, 6080, 6099, 6229, 6318, 6322, 6325, 6336], 'various': [16, 202, 536, 893, 2360, 2596, 3216, 3767, 4708, 5475], 'cell': [17, 203, 2361, 2525, 2636, 2755, 2809, 2899, 3039, 3087, 3218, 3224, 3229, 3235, 3241, 3243, 3351, 3930, 4261, 5322, 5382, 5491, 5704, 6295], 'types.': [18, 204, 5492], 'Here,': [19, 205], 'we': [20, 206, 2033, 2092, 3315, 3356, 3377, 3445, 3747, 3866, 5519], 'studied': [21, 207, 2093, 3446, 3820, 3878], 'the': [22, 46, 64, 91, 117, 168, 176, 208, 232, 250, 277, 303, 354, 362, 374, 460, 467, 488, 495, 503, 561, 565, 573, 613, 712, 722, 735, 794, 886, 890, 1158, 1442, 1448, 1451, 1478, 1503, 1892, 1899, 1936, 1951, 2051, 2054, 2094, 2114, 2119, 2160, 2175, 2185, 2266, 2323, 2330, 2351, 2427, 2537, 2593, 2614, 2635, 2659, 2689, 2749, 2754, 2760, 2791, 2808, 2830, 2858, 2865, 2904, 3037, 3057, 3071, 3120, 3159, 3192, 3195, 3221, 3255, 3263, 3348, 3359, 3370, 3392, 3447, 3462, 3469, 3513, 3519, 3531, 3544, 3588, 3611, 3616, 3661, 3666, 3690, 3736, 3749, 3805, 3845, 3849, 3879, 3887, 3939, 3955, 3962, 3970, 3987, 3990, 4002, 4014, 4028, 4042, 4062, 4078, 4094, 4101, 4256, 4276, 4287, 4294, 4311, 4319, 4323, 4411, 4428, 4432, 4473, 4477, 4499, 4543, 4554, 4565, 4578, 4582, 4590, 4599, 4613, 4623, 4629, 4637, 4641, 4875, 4882, 4911, 4919, 4954, 4963, 5007, 5010, 5015, 5037, 5074, 5248, 5267, 5287, 5319, 5375, 5391, 5422, 5425, 5432, 5464, 5481, 5502, 5516, 5540, 5543, 5555, 5569, 5621, 5654, 5658, 5669, 5683, 5695, 5699, 5713, 5891, 5896, 5902, 5955, 5964, 5973, 6002, 6075, 6087, 6095, 6100, 6103, 6112, 6115, 6179, 6183, 6196, 6215, 6299, 6338, 6345], 'function': [23, 177, 209, 363, 1484, 2095, 5008, 5541, 6305, 6339], 'Smad2Δexon3': [25, 49, 73, 126, 211, 235, 259, 312, 2122, 2147, 2172, 2261, 2274, 3402, 3425, 3451, 3578, 3606, 3715, 3743, 3785, 3835, 3885, 4017, 4269, 4459, 5505, 5661, 5726, 5908, 6303], 'and': [26, 38, 55, 81, 99, 111, 140, 148, 174, 212, 224, 241, 267, 285, 297, 326, 334, 360, 440, 491, 577, 691, 699, 714, 718, 728, 741, 770, 783, 888, 911, 914, 982, 1114, 1126, 1140, 1251, 1338, 1445, 1529, 1666, 1686, 1885, 1896, 1933, 1956, 2021, 2048, 2102, 2111, 2128, 2138, 2148, 2171, 2181, 2183, 2199, 2319, 2363, 2381, 2442, 2463, 2510, 2602, 2631, 2667, 2693, 2743, 2753, 2799, 2827, 2845, 2911, 2942, 3060, 3062, 3116, 3168, 3181, 3237, 3251, 3260, 3262, 3274, 3285, 3321, 3330, 3391, 3417, 3432, 3452, 3459, 3477, 3722, 3753, 3771, 3786, 3812, 3824, 3836, 3841, 3860, 3865, 3874, 3898, 3943, 3945, 3975, 4050, 4240, 4266, 4270, 4299, 4330, 4408, 4413, 4442, 4489, 4596, 4644, 4664, 4681, 4719, 4726, 4884, 4910, 5032, 5063, 5123, 5134, 5154, 5236, 5242, 5250, 5259, 5330, 5369, 5378, 5386, 5397, 5462, 5477, 5512, 5559, 5562, 5715, 5725, 6064, 6126, 6171, 6210, 6251, 6364, 6371, 6373, 6376, 6395], 'compared': [27, 213, 2103, 3453, 4037, 4306, 6261], 'it': [28, 214, 1473, 2104, 3454, 3570, 4007, 6239], 'those': [30, 216, 709, 719, 2106, 3414, 3456, 4039, 4455, 5741], 'wild-type': [32, 218, 2108, 5570], 'containing': [34, 220, 2061, 2795, 2922, 3047, 3064, 3091, 3111, 3615, 4435, 4439, 4456, 4560, 4577, 5138, 5668], '(Smad2(wt))': [37, 223, 2110], 'Smad3.': [39, 60, 112, 225, 246, 298, 2112, 2134, 3558, 3576, 3813, 3875], 'When': [40, 226], 'transcriptional': [41, 227, 1341, 1842, 2115, 3448, 3514, 3532, 3555, 3565, 3580, 3603, 3738, 3795, 4387, 4729, 5281, 5529, 5696, 5911, 5924, 5937, 5974, 6082], 'activity': [42, 57, 228, 243, 571, 1154, 1449, 2130, 2633, 3125, 3449, 3515, 3533, 3566, 3581, 3604, 3705, 3739, 3796, 4388, 5288, 5530, 5656, 5912, 5925], 'was': [43, 50, 74, 123, 229, 236, 260, 309, 1498, 2123, 2155, 2262, 2345, 2456, 2467, 2618, 2638, 2683, 2871, 3052, 3066, 3161, 3246, 3396, 3403, 3536, 3551, 3571, 3595, 3607, 3696, 3716, 3800, 3818, 3832, 3842, 3855, 3893, 4104, 4381, 4401, 4492, 4625, 5565, 5709, 5727, 6078], 'measured': [44, 230, 2671, 2684], 'using': [45, 231, 2118, 2372, 2430, 2469, 2530, 2647, 2847, 3248, 3271, 3461, 3693, 3779, 3821], 'p3TP-lux': [47, 122, 233, 308, 2120, 2548, 2666, 3058, 3463, 3535, 3741, 3908, 5078, 5532, 5700, 5927], 'construct,': [48, 234, 2121, 3466], 'more': [51, 237, 1945, 2124, 3596, 3698, 3789, 4383, 4626], 'potent': [52, 84, 238, 270, 1946, 2125, 3597, 3699, 3790, 4384], 'than': [53, 85, 239, 271, 1947, 2126, 3428, 3434, 3557, 3573, 3598, 3700, 3726, 3744, 3791, 4391, 5533, 5568, 5913], 'Smad2(wt),': [54, 110, 138, 240, 296, 324, 2127, 2154, 2198, 3431, 3568, 3746, 3811, 3823, 3873, 3979, 4406, 4440, 4668, 5914, 6069], 'had': [56, 242, 2129, 3579], 'similar': [58, 76, 106, 244, 262, 292, 2132, 3412, 3582, 3717, 4453, 6000], 'to': [59, 77, 105, 116, 156, 245, 263, 291, 302, 342, 466, 555, 601, 901, 984, 987, 1157, 1438, 1491, 1500, 1502, 1535, 1537, 1684, 1693, 1840, 2133, 2157, 2159, 2279, 2426, 2658, 2801, 2814, 2819, 3036, 3082, 3123, 3163, 3254, 3268, 3277, 3363, 3413, 3511, 3563, 3583, 3689, 3718, 3732, 3904, 3947, 4054, 4080, 4093, 4107, 4110, 4255, 4274, 4332, 4337, 4449, 4454, 4470, 4494, 4572, 4575, 4587, 4589, 4655, 4658, 4671, 4674, 4961, 4966, 5022, 5036, 5071, 5073, 5128, 5130, 5149, 5266, 5279, 5488, 5499, 5634, 5664, 5666, 5688, 5933, 5963, 5983, 6001, 6061, 6072, 6091, 6134, 6178, 6258, 6349, 6355], 'Transcriptional': [61, 247], 'activation': [62, 248, 504, 534, 563, 2116, 3556, 5697, 5938, 5975, 6083], 'activin-responsive': [65, 251, 403, 420, 2176], 'element': [66, 252, 6004], '(ARE)': [67, 253], 'Mix.2': [69, 255, 2187, 3619, 5995, 6076, 6116, 6250], 'gene': [70, 256, 1508, 2015, 2188, 2612, 3613, 4341, 5042, 5981], 'promoter': [71, 257, 3464, 3470, 3620, 4342, 5996, 6122, 6144], 'by': [72, 79, 87, 90, 258, 265, 273, 276, 533, 721, 746, 779, 1133, 1253, 2029, 2136, 2264, 2328, 2342, 2370, 2490, 2552, 2687, 2774, 2785, 2997, 3054, 3068, 3166, 3183, 3398, 3714, 3720, 3728, 3755, 3777, 3863, 3884, 4071, 4687, 5152, 5638, 5901, 5988, 6342], 'also': [75, 261, 983, 1220, 1532, 1888, 3608, 3819, 6383], 'that': [78, 86, 161, 264, 272, 347, 607, 1477, 2035, 2060, 3063, 3358, 3429, 3435, 3574, 3584, 3599, 3719, 3727, 3896, 4061, 4070, 4308, 4476, 4542, 4652, 5467, 5522, 5646, 5682, 5890, 6189, 6263, 6297], 'Smad3,': [80, 131, 266, 317, 1957, 3437, 3721, 4019, 4483, 5274, 5331, 6063, 6302], 'slightly': [82, 268, 3697, 3723, 4382], 'less': [83, 269, 3552, 3572, 3724, 5566, 5985, 6108, 6241], 'Smad2(wt).': [88, 135, 274, 321, 2149, 2276, 3601, 4023, 5535, 5677], 'Phosphorylation': [89, 275, 788, 2135], 'activated': [92, 278, 720, 745, 5151, 6120], 'transforming': [93, 279, 375, 384], 'growth': [94, 280, 376, 385, 1937, 5376], 'factor-β': [95, 281, 377], 'type': [96, 282, 438, 441, 469, 480, 1227, 4715, 4907], 'I': [97, 283, 442, 481, 1228, 3075, 4716, 4908], 'receptor': [98, 284, 462, 471, 482, 4451], 'heteromer': [100, 286, 2139, 3853, 5641], 'formation': [101, 287, 2140, 3815, 3854, 3880, 4397, 4555, 5642, 5708], 'Smad4': [103, 147, 289, 333, 751, 1530, 2142, 3561, 3817, 3831, 3993, 4329, 4488, 5124, 5155, 5596, 6125], 'occurred': [104, 290], 'extents': [107, 293], 'Smad2Δexon3,': [109, 139, 295, 325, 2151, 3810, 3822, 3872, 3976, 4407, 4485, 4665, 6066], 'However,': [113, 299, 1472, 2150, 5254, 5929], 'DNA': [114, 170, 300, 356, 989, 1493, 1539, 1694, 3354, 3909, 4111, 4576, 4659, 5024, 5132, 5144, 5667, 5689, 5721, 5916, 5957, 5968, 5990, 6191, 6221, 6347], 'binding': [115, 171, 301, 357, 1160, 1490, 4588, 4657, 4964, 5021, 5685, 5722, 5917, 5958, 5969, 5991, 6088, 6192, 6203, 6222, 6348], 'activating': [118, 304, 400, 2161], 'protein-1': [119, 305], 'sites': [120, 306, 2164, 3049, 3482, 3889, 4096, 4592, 5076], 'observed': [124, 310, 1846, 3316, 3833, 4402, 5675, 5710, 6316], 'as': [127, 129, 313, 315, 437, 544, 731, 907, 1118, 2392, 2672, 2873, 2952, 4660, 4970, 5003, 5244, 6199, 6201, 6236, 6306], 'well': [128, 314, 6200], 'but': [132, 318, 1849, 1941, 2152, 3900, 3977, 4006, 4020, 4279, 4602, 4666, 4696, 5065, 5275, 6173, 6320], 'not': [133, 153, 319, 339, 1690, 1850, 2004, 2144, 2153, 3203, 3420, 3901, 3967, 3978, 3996, 4021, 4551, 4605, 4667, 5066, 5276, 5632, 5650, 5674, 5953, 6174, 6321], 'In': [136, 322, 459, 1682, 2113, 2167, 2277, 3518, 3687, 3730, 3969, 4949, 5013, 5264, 5318, 5515, 5620, 5702, 5961, 6293], 'contrast,': [137, 323, 2168], 'Smad3': [141, 327, 729, 1528, 1667, 1685, 1848, 1886, 1963, 2007, 2200, 2992, 3418, 3460, 3538, 3586, 3701, 3754, 3787, 3825, 3861, 3897, 3974, 4099, 4271, 4392, 4409, 4457, 4663, 5062, 5122, 5153, 5237, 5260, 5290, 5337, 5398, 5414, 5724, 6138, 6170, 6256], 'efficiently': [142, 328, 3404, 3539, 4444], 'formed': [143, 329, 3958, 3980], 'ARE-binding': [144, 330], 'complexes': [145, 331, 3883, 3960, 3984, 4012, 4064, 4434, 4480], 'FAST1,': [149, 335, 6136], 'although': [150, 336, 2050, 3569, 4033, 4293], 'Smad2(wt)': [151, 337, 2170, 3374, 3416, 3458, 3550, 3792, 3837, 4280, 4380, 5931], 'did': [152, 338, 2143, 3995, 4008, 4281, 4604, 5631], 'directly': [154, 340, 985, 1691, 2812, 4091, 4108, 4573, 4672, 5034, 5651, 6073, 6176], 'bind': [155, 341, 986, 1501, 1536, 1692, 2158, 3903, 4092, 4109, 4275, 4574, 4673, 5072, 5129, 5665, 6074], 'ARE.': [157, 343], 'These': [158, 344, 4067, 4539, 4649, 5678, 5737, 6186], 'results': [159, 345, 501, 559, 3279, 3691, 4068, 4257, 5592], 'suggest': [160, 346, 5681, 5889, 6188], 'interferes': [166, 352], 'direct': [169, 355, 1489, 5684, 5915, 5956, 5989, 6190, 6346], 'Smad2,': [173, 359, 3902, 4482, 4872, 5067, 5277, 6175], 'modifies': [175, 361], 'transcription': [181, 367, 891, 909, 1299, 3541, 5978, 6113, 6131, 6216, 6230], 'certain': [183, 369, 1677, 2046, 5510, 6232, 6294], 'target': [184, 370, 894, 4886, 5946, 6218, 6233, 6350], 'genes.': [185, 371, 895, 6219, 6351], 'Members': [372], '(TGF-β)': [378], '1The': [379], 'abbreviations': [380], 'used': [381, 3510, 4246], 'are:': [382], 'TGF-β,': [383], 'factor-β;': [386], 'TβR,': [387], 'TGF-β': [388, 461, 468, 479, 576, 614, 713, 1895, 1932, 1942, 1949, 4450, 5249, 5324, 5368], 'receptor;': [389], 'Mad,': [390, 5026], 'Mothers': [391, 1119], 'against': [392, 1120, 2989], 'decapentaplegic;': [393], 'MH,': [394], 'Mad': [395, 1495], 'homology;': [396], 'wt,': [397], 'wild-type;': [398], 'AP,': [399], 'protein;': [401], 'ARF,': [402, 4334], 'factor;': [404], 'PCR,': [405], 'polymerase': [406, 2268], 'chain': [407, 2269], 'reaction;': [408], 'PAGE,': [409], 'polyacrylamide': [410, 3179], 'gel': [411, 2803, 3180, 4248], 'electrophoresis;': [412], 'PAI,': [413], 'plasminogen': [414, 3473], 'activator': [415, 3474], 'inhibitor;': [416], 'GST,': [417], 'glutathioneS-transferase;': [418], 'ARE,': [419], 'element;': [421], 'bp,': [422], 'base': [423], 'pair(s).': [424], 'superfamily': [425, 615], 'transduce': [426], 'signals': [427, 532, 609], 'through': [428, 679, 1541, 4498, 5895, 5948, 6094], 'two': [429, 3317, 3350], 'different': [430, 4436, 4568, 5372], 'types': [431, 6296], 'serine/threonine': [433, 780], 'kinase': [434, 507, 529, 781], 'receptors,': [435, 782, 4717, 4909], 'known': [436, 1117], 'II': [439, 470], 'receptors': [443, 1229], '(1Derynck': [444], 'R.': [445, 513, 580, 805, 1263, 1280, 1351, 1363, 4791, 4803], 'Feng': [446, 1260], 'X.-H.': [447, 1261, 1345, 4785], 'Biochim.': [448], 'Biophys.': [449], 'Acta.': [450], '1997;': [451, 624, 641, 840, 868, 1002, 1025, 1209, 1267, 1283, 1315, 1330, 1464, 1520, 1556, 1579, 1731, 1754, 2230, 2253, 2579, 2724, 2891, 3026, 3647, 3921, 4152, 4356, 4372, 4515, 4531, 4740, 4757, 5054, 5094, 5583, 5612, 5781, 5804], '1333:': [452], 'F105-F150Crossref': [453], 'PubMed': [454, 522, 590, 627, 647, 663, 819, 848, 876, 927, 952, 977, 1005, 1028, 1055, 1078, 1105, 1180, 1212, 1245, 1270, 1291, 1318, 1333, 1357, 1373, 1403, 1427, 1467, 1523, 1559, 1582, 1609, 1632, 1659, 1715, 1734, 1757, 1784, 1807, 1834, 1875, 1927, 1988, 2086, 2233, 2256, 2309, 2416, 2587, 2727, 2894, 2972, 3029, 3148, 3310, 3495, 3655, 3682, 3924, 4132, 4155, 4182, 4205, 4232, 4359, 4375, 4518, 4534, 4743, 4763, 4779, 4797, 4813, 4843, 4867, 4897, 4944, 4991, 5057, 5097, 5115, 5180, 5203, 5230, 5313, 5362, 5457, 5586, 5615, 5765, 5784, 5807, 5834, 5857, 5884, 6029, 6056, 6165, 6288], 'Scopus': [455, 523, 591, 628, 648, 664, 820, 849, 877, 928, 953, 978, 1006, 1056, 1079, 1106, 1181, 1213, 1246, 1271, 1292, 1319, 1334, 1358, 1374, 1404, 1428, 1468, 1524, 1560, 1610, 1633, 1660, 1716, 1735, 1785, 1808, 1835, 1876, 1928, 1989, 2087, 2234, 2257, 2310, 2417, 2588, 2728, 2973, 3030, 3149, 3311, 3656, 3683, 3925, 4133, 4183, 4206, 4233, 4360, 4376, 4519, 4535, 4744, 4764, 4780, 4798, 4814, 4844, 4868, 4898, 4945, 4992, 5058, 5116, 5181, 5204, 5231, 5314, 5363, 5458, 5587, 5616, 5766, 5785, 5835, 5858, 5885, 6030, 6057, 6166, 6289], '(508)': [456], 'Google': [457, 525, 593, 630, 650, 666, 822, 851, 879, 930, 955, 980, 1008, 1029, 1058, 1081, 1108, 1183, 1215, 1248, 1273, 1294, 1321, 1336, 1360, 1376, 1406, 1430, 1470, 1526, 1562, 1583, 1612, 1635, 1662, 1718, 1737, 1758, 1787, 1810, 1837, 1878, 1930, 1991, 2089, 2236, 2259, 2312, 2419, 2590, 2730, 2895, 2975, 3032, 3151, 3313, 3496, 3658, 3685, 3927, 4135, 4156, 4185, 4208, 4235, 4362, 4378, 4521, 4537, 4746, 4766, 4782, 4800, 4816, 4846, 4870, 4900, 4947, 4994, 5060, 5098, 5118, 5183, 5206, 5233, 5316, 5365, 5460, 5589, 5618, 5768, 5787, 5808, 5837, 5860, 5887, 6032, 6059, 6168, 6291], 'Scholar).': [458, 526, 594, 667, 880, 1109, 1216, 1431, 1471, 1527, 1663, 1838, 1879, 1931, 1992, 2090, 2260, 2313, 2420, 2731, 2896, 2976, 3152, 3686, 3928, 4236, 4379, 4538, 4871, 4901, 4948, 4995, 5061, 5119, 5234, 5317, 5366, 5590, 5619, 6169, 6292], 'system,': [463], 'ligand': [464], 'binds': [465, 4336, 5035, 5278], '(TβR-II),': [472], 'which': [473, 500, 568, 1130, 1151, 2002, 2039, 3201, 3467, 3505, 3594, 4335, 4684, 4873, 5284, 5951, 6062, 6070], 'has': [474, 569, 764, 1152, 1435, 1474, 1481, 1887, 1994, 3186, 4957, 5018, 5527, 5909], 'constitutively': [476, 4879], 'active': [477, 5567], 'kinase.': [478], '(TβR-I)': [483], 'then': [485, 883, 2783, 3080, 3174, 3877], 'recruited': [486], 'into': [487, 684, 708, 885, 2275, 2290, 2333, 2347, 3373, 3388, 3762], 'TGF-β·TβR-II': [489], 'complex,': [490], 'phosphorylated': [492, 778], 'mainly': [493], 'at': [494, 793, 3886, 5401, 5599], 'glycine/serine-rich': [496], 'domain': [497, 1146, 1161, 1219, 1434, 1480, 3197, 4103, 4501, 4703, 4904, 4956, 4998, 5017, 5538, 5904, 6105, 6198], '(GS': [498], 'domain),': [499], 'TβR-I': [506, 528, 541, 554, 566, 2137], '(2Wrana': [508], 'J.L.': [509, 582, 655, 809, 864, 964, 1034, 1588, 1702, 1763, 2553, 2575, 3643, 4119, 4161, 4771, 5159, 5752, 5813, 6008, 6152], 'Attisano': [510, 806, 861, 965, 1703, 4120, 5753, 6153], 'L.': [511, 653, 807, 862, 935, 966, 1032, 1190, 1586, 1704, 1761, 4121, 4159, 4769, 5157, 5754, 5811, 6006, 6154, 6391], 'Wieser': [512], 'Ventura': [514], 'F.': [515, 637, 1163, 1323, 4365, 4524, 4753], 'Massagué': [516, 583, 1174, 1238, 1326, 1461, 3487, 4368, 4527, 4937, 4984, 5580, 5609], 'J.': [517, 584, 586, 633, 837, 865, 992, 1074, 1094, 1169, 1171, 1175, 1198, 1239, 1241, 1327, 1411, 1415, 1462, 1510, 1546, 1628, 1648, 1721, 1803, 1823, 2220, 2229, 2247, 2491, 2562, 2714, 2723, 2968, 3016, 3025, 3137, 3484, 3488, 3630, 3911, 4201, 4221, 4369, 4528, 4749, 4851, 4855, 4938, 4940, 4985, 5044, 5111, 5199, 5219, 5581, 5610, 5771, 5853, 5873, 6045, 6385, 6390], 'Nature.': [518, 623, 923, 1001, 1176, 1314, 1463, 1519, 1555, 1730, 1871, 2252, 3678, 3920, 4355, 4514, 4739, 5053, 5309, 5582, 5611, 5780], '1994;': [519], '370:': [520], '341-347Crossref': [521], '(2114)': [524], 'The': [527, 881, 1144, 1217, 1432, 2013, 2190, 2365, 2421, 2453, 2493, 2662, 2780, 3045, 3077, 3153, 3339, 3383, 3422, 3500, 3602, 3711, 3983, 4024, 4283, 4609, 4701, 4902, 4996, 5536, 5994, 6310], 'transduces': [530], 'intracellular': [531], 'proteins,': [537, 905, 2285, 4725], 'including': [538], 'Smad': [539, 595, 672, 763, 896, 1254, 2599, 3043, 3384, 3758, 3941, 3956, 4291, 4324, 4570, 4616, 4677, 5941], 'proteins.': [540, 3044, 3851], 'thus': [542, 757], 'acts': [543, 6244], 'downstream': [546], 'component': [547], 'TβR-II.': [549], 'Mutation': [550, 5546], 'Thr-204': [552], 'aspartic': [556], 'acid': [557, 1142, 1673, 2000, 2025, 3189, 3199, 4916, 5419], '(TβR-I(TD))': [558], 'constitutive': [562], 'kinase,': [567], 'signaling': [570, 716, 737, 5252], 'absence': [574, 3545, 3589, 3664, 3963, 4414, 4583, 5716], 'TβR-II': [578], '(3Wieser': [579], 'Wrana': [581, 654, 808, 863, 963, 1701, 2574, 3642, 4118, 4770, 5751, 6151, 6392], 'EMBO': [585, 1073, 1240, 1627, 1802, 2228, 2722, 2967, 3024, 4200, 4939, 5110, 5198, 5852], '1995;': [587, 3140, 3492], '14:': [588], '2199-2208Crossref': [589], '(597)': [592], 'proteins': [596, 606, 673, 897, 1255, 2949, 3099, 3395, 3957, 4571, 4678, 4968, 5731, 5942], 'have': [597, 674, 898, 1111, 1531, 1676, 2201, 2695, 4669, 4679, 4693, 4697, 5068, 5125, 5146, 5261, 5371, 5429, 5520, 6107], 'recently': [598, 4958], 'been': [599, 675, 765, 899, 1436, 1475, 1533, 1889, 2202, 2696, 4959, 5069, 5126, 5147, 5262], 'shown': [600, 900, 1437, 1476, 1499, 1534, 3895, 4106, 4493, 4960, 5070, 5127, 5148, 5430, 5521], 'comprise': [602], 'family': [604], 'mediate': [608], 'for': [610, 734, 1847, 1851, 2315, 2628, 2740, 2787, 3381, 4247, 5406, 5595, 5676, 6246, 6368, 6379, 6388, 6393, 6398], 'members': [611], '(4Heldin': [616, 4732], 'C.-H.': [617, 836, 1088, 1642, 1817, 1915, 1976, 2222, 2716, 3018, 4215, 4733, 5213, 5350, 5867, 6039, 6362], 'Miyazono': [618, 1418, 1920, 1981, 2078, 2223, 2250, 2408, 2717, 3019, 3302, 4734, 4858, 5108, 5355, 5449, 6280], 'K.': [619, 827, 994, 1188, 1419, 1512, 1548, 1723, 1856, 1858, 1868, 1921, 1982, 2071, 2073, 2079, 2081, 2218, 2224, 2251, 2401, 2403, 2409, 2411, 2712, 2718, 3014, 3020, 3295, 3297, 3303, 3305, 3913, 4735, 4859, 5046, 5109, 5294, 5296, 5306, 5356, 5442, 5444, 5450, 5452, 5773, 6273, 6275, 6281, 6283], 'ten': [620, 832, 1066, 1089, 1620, 1643, 1795, 1818, 1911, 1972, 2225, 2719, 2960, 2999, 3021, 4193, 4216, 4736, 5191, 5214, 5346, 5845, 5868, 6040, 6366], 'Dijke': [621, 833, 1067, 1090, 1621, 1644, 1796, 1819, 1912, 1973, 2226, 2720, 2961, 3022, 4194, 4217, 4737, 5192, 5215, 5347, 5846, 5869, 6041, 6367], 'P.': [622, 834, 1036, 1068, 1091, 1202, 1590, 1622, 1645, 1765, 1797, 1820, 1913, 1974, 2227, 2721, 2962, 2998, 3023, 4163, 4195, 4218, 4738, 5161, 5193, 5216, 5348, 5815, 5847, 5870, 6010, 6042, 6365], '390:': [625, 4741], '465-471Crossref': [626, 4742], '(3348)': [629, 4745], 'Scholar,': [631, 651, 823, 852, 931, 956, 1009, 1030, 1059, 1082, 1184, 1274, 1361, 1377, 1407, 1563, 1584, 1613, 1636, 1719, 1738, 1759, 1788, 1811, 2237, 4136, 4157, 4186, 4209, 4363, 4522, 4747, 4767, 4783, 4801, 4817, 4847, 5099, 5184, 5207, 5769, 5788, 5809, 5838, 5861, 6033], '5Massagué': [632, 4748], 'Hata': [634, 1164, 4750, 4974], 'A.': [635, 1000, 1165, 1399, 1409, 1454, 1518, 1554, 1729, 1904, 1908, 1965, 1969, 2067, 2075, 2206, 2214, 2243, 2397, 2405, 2700, 2708, 3002, 3010, 3291, 3299, 3486, 3919, 4751, 4839, 4849, 4975, 5052, 5105, 5339, 5343, 5438, 5446, 5573, 5602, 5779, 6269, 6277, 6374, 6386], 'Liu': [636, 4752], 'Trends': [638, 4754], 'Cell': [639, 658, 4755, 4774], 'Biol.': [640, 659, 838, 866, 1024, 1095, 1266, 1282, 1578, 1649, 1753, 1824, 2890, 3138, 3491, 4151, 4222, 4756, 4775, 5093, 5220, 5803, 5874, 6046], '7:': [642, 1284, 4758], '187-192Abstract': [643, 4759], 'Full': [644, 814, 816, 843, 845, 871, 873, 947, 949, 972, 974, 1050, 1052, 1100, 1102, 1286, 1288, 1604, 1606, 1654, 1656, 1710, 1712, 1779, 1781, 1829, 1831, 2582, 2584, 3143, 3145, 3650, 3652, 4127, 4129, 4177, 4179, 4227, 4229, 4760, 5175, 5177, 5225, 5227, 5760, 5762, 5829, 5831, 5879, 5881, 6024, 6026, 6051, 6053, 6160, 6162], 'Text': [645, 815, 817, 844, 846, 872, 874, 948, 950, 973, 975, 1051, 1053, 1101, 1103, 1287, 1289, 1605, 1607, 1655, 1657, 1711, 1713, 1780, 1782, 1830, 1832, 2583, 2585, 3144, 3146, 3651, 3653, 4128, 4130, 4178, 4180, 4228, 4230, 4761, 5176, 5178, 5226, 5228, 5761, 5763, 5830, 5832, 5880, 5882, 6025, 6027, 6052, 6054, 6161, 6163], 'PDF': [646, 818, 847, 875, 951, 976, 1054, 1104, 1290, 1608, 1658, 1714, 1783, 1833, 2586, 3147, 3654, 4131, 4181, 4231, 4762, 5179, 5229, 5764, 5833, 5883, 6028, 6055, 6164], '(271)': [649, 4765], '6Attisano': [652, 4768], 'Curr.': [656, 1281, 4772], 'Opin.': [657, 4773], '1998;': [660, 944, 969, 1047, 1075, 1097, 1242, 1354, 1370, 1400, 1424, 1601, 1629, 1651, 1707, 1776, 1804, 1826, 1872, 1924, 1985, 2083, 2413, 2969, 3307, 4124, 4174, 4202, 4224, 4776, 4794, 4810, 4840, 4864, 4941, 4988, 5112, 5172, 5200, 5222, 5310, 5359, 5454, 5757, 5826, 5854, 5876, 6021, 6048, 6157, 6285], '10:': [661, 4777, 4895], '188-194Crossref': [662, 4778], '(178)': [665, 4781], 'Thus': [668], 'far,': [669], 'eight': [670], 'mammalian': [671, 5030], 'identified,': [676], 'termed': [677], 'Smad1': [678, 5031], 'Smad8.': [680], 'Smads': [681, 703, 733, 776, 791, 1110, 2010, 3207, 4265, 4692, 5246, 5919, 6194, 6224, 6324], 'are': [682, 744, 772, 777, 1131, 1668, 4424, 4685, 5238, 6353], 'classified': [683], 'three': [685, 3478], 'subgroups': [686], 'based': [687], 'on': [688, 1898, 2458, 3176, 3534, 3797, 4389, 5531, 5926, 6111], 'their': [689, 1542, 3440, 5407, 5923], 'structure': [690, 6101], 'function,': [692], 'i.e.': [693, 1488, 3220, 3324, 4712, 6249], 'pathway-restricted': [694, 732, 790, 5245], 'Smads,': [695, 698, 2741, 4711], 'common': [696, 754, 761], 'mediator': [697, 755, 762], 'inhibitory': [700, 773], 'Smads.': [701, 774, 3517, 4437, 5960], 'Pathway-restricted': [702, 775], 'can': [704, 4090, 5943], 'be': [705, 5150, 5495, 5984, 6259], 'further': [706, 4563], 'subdivided': [707], 'involved': [710, 5652], 'activin': [715, 1897, 1934, 1959, 5251, 5333, 5370], 'pathways,': [717], 'bone': [723, 747], 'morphogenetic': [724, 748], 'protein': [725, 749, 2162, 2777, 3410], 'pathway.': [726], 'serve': [730, 5243], 'TGF-β/activin': [736], 'pathways.': [738, 5253], 'Smad1,': [739], 'Smad5,': [740], 'possibly': [742, 6065], 'Smad8/MADH6': [743], 'receptors.': [750], 'Smad;': [756], 'far': [758], 'only': [759, 3343, 6317], 'one': [760], 'identified': [766], 'mammals.': [768, 2012, 6326], 'Smad6': [769], 'Smad7': [771], 'form': [784, 2174, 3997, 4333], 'hetero-oligomers': [785], 'Smad4.': [787, 4066, 5719], 'occurs': [792, 6093], 'C-terminal': [795, 1115], 'Ser-Ser-X-Ser': [796], 'motif': [797], '(7Macı́as-Silva': [798], 'M.': [799, 856, 922, 1309, 1313, 1421, 1854, 1906, 1917, 1967, 1978, 2069, 2212, 2241, 2249, 2343, 2399, 2706, 3008, 3293, 3677, 4350, 4354, 4509, 4513, 4861, 5101, 5292, 5341, 5352, 5387, 5440, 6271, 6360, 6396], 'Abdollah': [800, 2557, 3625], 'S.': [801, 825, 854, 933, 998, 1038, 1061, 1063, 1070, 1086, 1398, 1417, 1516, 1552, 1592, 1615, 1617, 1624, 1640, 1727, 1767, 1790, 1792, 1799, 1815, 1864, 1919, 1980, 2065, 2210, 2395, 2558, 2704, 2955, 2957, 2964, 3006, 3289, 3626, 3917, 4165, 4188, 4190, 4197, 4213, 4838, 4857, 5050, 5163, 5186, 5188, 5195, 5211, 5302, 5354, 5436, 5777, 5817, 5840, 5842, 5849, 5865, 6012, 6037, 6267], 'Hoodless': [802, 961, 1699, 4116, 5749, 6149], 'P.A.': [803, 962, 1700, 4117, 5750, 6150], 'Pirone': [804], 'Cell.': [810, 943, 968, 1023, 1046, 1265, 1577, 1600, 1706, 1752, 1775, 2578, 2889, 3490, 3646, 4123, 4150, 4173, 5092, 5171, 5756, 5802, 5825, 6020, 6156], '1996;': [811, 924, 1177, 2306, 3679, 4894], '87:': [812], '1215-1224Abstract': [813], '(651)': [821], '8Souchelnytskyi': [824], 'Tamaki': [826, 2217, 2711, 3013], 'Engström': [828], 'U.': [829, 1397, 4837], 'Wernstedt': [830], 'C.': [831, 937, 960, 1015, 1192, 1204, 1325, 1569, 1698, 1744, 2881, 4115, 4142, 4367, 4526, 5084, 5748, 5794, 6148], 'Heldin': [835, 1087, 1641, 1816, 1914, 1975, 2221, 2715, 3017, 4214, 5212, 5349, 5866, 6038], 'Chem.': [839, 867, 1096, 1650, 1825, 3139, 4223, 5221, 5875, 6047], '272:': [841, 869], '28107-28115Abstract': [842], '(339)': [850], '9Abdollah': [853], 'Macı́as-Silva': [855], 'Tsukazaki': [857], 'T.': [858, 1278, 1367, 1389, 1860, 1862, 1910, 1971, 2208, 2239, 2702, 3004, 4807, 4829, 5107, 5298, 5300, 5345], 'Hayashi': [859], 'H.': [860, 1194, 1870, 2556, 3624, 5103, 5308, 6356, 6358], '27678-27685Abstract': [870], '(414)': [878], 'heteromers': [882], 'translocate': [884], 'nucleus': [887, 4883], 'activate': [889, 5945], 'interact': [902, 1440, 4495], 'DNA-binding': [904, 3668, 3882, 3959, 3981, 3999, 4011, 4063, 4083, 4429, 4478, 4557, 4724, 4967, 5272, 5706, 6206], 'such': [906, 4969, 6235], 'winged-helix': [908, 6130], 'factors,Xenopus,': [910], 'human': [912, 3217, 3227, 3232, 3239], 'FAST1': [913, 1301, 2180, 2339, 2912, 3671, 4331, 4400, 4443, 4491, 4971, 6092, 6209], 'mouse': [915, 6127], 'FAST2': [916], '(10Chen': [917, 3672], 'X.': [918, 1303, 3673, 4344, 4503], 'Rubock': [919, 3674], 'M.J.': [920, 3675], 'Whitman': [921, 1312, 3676, 4353, 4512, 6397], '383:': [925, 3680], '691-696Crossref': [926, 3681], '(632)': [929, 3684], '11Zhou': [932], 'Zawel': [934], 'Lengauer': [936], 'Kinzler': [938, 1039, 1593, 1768, 4166, 5164, 5818, 6013], 'K.W.': [939, 1040, 1594, 1769, 4167, 5165, 5819, 6014], 'Vogelstein': [940, 1041, 1595, 1770, 4168, 5166, 5820, 6015], 'B.': [941, 1042, 1596, 1771, 4169, 5167, 5821, 6016], 'Mol.': [942, 967, 1022, 1045, 1264, 1576, 1599, 1705, 1751, 1774, 2888, 3489, 4122, 4149, 4172, 5091, 5170, 5755, 5801, 5824, 6019, 6155], '2:': [945, 970, 1708, 4125, 5758, 6158], '121-127Abstract': [946], '(212)': [954], '12Labbé': [957], 'E.': [958, 1305, 1696, 2216, 2245, 2710, 3012, 4113, 4346, 4505, 5746, 6146], 'Silvestri': [959, 1697, 4114, 5747, 6147], '109-120Abstract': [971, 1709, 4126, 5759, 6159], '(464)': [979, 1717, 4134, 5767, 6167], 'Scholar),': [981, 1249, 1295, 1337, 3314, 6060], 'specific': [988, 1492, 1538, 3667, 5023, 5131, 5143], 'sequences': [990, 1540, 3256, 5145, 6181], '(13Kim': [991, 1509, 1545, 3910, 5043], 'Johnson': [993, 1511, 1547, 1722, 3912, 5045, 5772], 'Chen': [995, 1232, 1513, 1549, 1724, 3914, 4931, 5047, 5774], 'H.J.': [996, 1514, 1550, 1725, 3915, 5048, 5775], 'Carroll': [997, 1515, 1551, 1726, 3916, 5049, 5776], 'Laughon': [999, 1517, 1553, 1728, 3918, 5051, 5778], '388:': [1003, 1465, 1521, 1557, 1732, 3922, 5055, 5584, 5613, 5782], '304-308Crossref': [1004, 1522, 1558, 1733, 3923, 5056, 5783], '(449)': [1007, 1525, 1561, 1736, 3926, 5059, 5786], '14Yingling': [1010, 1564, 1739, 4137, 5789], 'J.M.': [1011, 1565, 1740, 2877, 4138, 5080, 5790], 'Datto': [1012, 1566, 1741, 2878, 4139, 5081, 5791], 'M.B.': [1013, 1567, 1742, 2879, 3132, 4140, 5082, 5792], 'Wong': [1014, 1568, 1743, 2880, 4141, 5083, 5793], 'Frederick': [1016, 1570, 1745, 2882, 4143, 5085, 5795], 'J.P.': [1017, 1571, 1746, 2883, 4144, 5086, 5796], 'Liberati': [1018, 1572, 1747, 2884, 4145, 5087, 5797], 'N.T.': [1019, 1573, 1748, 2885, 4146, 5088, 5798], 'Wang': [1020, 1574, 1749, 2886, 3135, 4147, 5089, 5799], 'X.-F.': [1021, 1575, 1750, 2887, 3136, 4148, 5090, 5800], '17:': [1026, 1076, 1243, 1268, 1580, 1630, 1755, 1805, 2892, 2970, 4153, 4203, 4942, 5095, 5113, 5201, 5805, 5855], '7019-7028Crossref': [1027, 1581, 1756, 2893, 4154, 5096, 5806], '15Zawel': [1031, 1585, 1760, 4158, 5810], 'Dai': [1033, 1587, 1762, 4160, 5158, 5812, 6007], 'Buckhaults': [1035, 1589, 1764, 4162, 5160, 5814, 6009], 'Zhou': [1037, 1591, 1766, 4164, 5162, 5816, 6011], 'Kern': [1043, 1597, 1772, 4170, 5168, 5822, 6017], 'S.E.': [1044, 1598, 1773, 4171, 5169, 5823, 6018], '1:': [1048, 1602, 1777, 4175, 5173, 5827, 6022], '611-617Abstract': [1049, 1603, 1778, 4176, 5174, 5828, 6023], '(890)': [1057, 1611, 1786, 4184, 5182, 5836, 6031], '16Dennler': [1060, 1614, 1789, 4187, 5185, 5839], 'Itoh': [1062, 1085, 1616, 1639, 1791, 1814, 2956, 4189, 4212, 5187, 5210, 5841, 5864, 6036], 'Vivien': [1064, 1618, 1793, 2958, 4191, 5189, 5843], 'D.': [1065, 1206, 1387, 1458, 1619, 1794, 2577, 2959, 3645, 4192, 4827, 4979, 5190, 5577, 5606, 5844], 'Huet': [1069, 1623, 1798, 2963, 4196, 5194, 5848], 'Gauthier': [1071, 1625, 1800, 2965, 4198, 5196, 5850], 'J.-M.': [1072, 1626, 1801, 2966, 4199, 5197, 5851], '3091-3100Crossref': [1077, 1631, 1806, 2971, 4204, 5202, 5856], '(1581)': [1080, 1634, 1809, 2974, 4207, 5205, 5859], '17Jonk': [1083, 1637, 1812, 4210, 5208, 5862, 6034], 'L.J.C.': [1084, 1638, 1813, 4211, 5209, 5863, 6035], 'Kruijer': [1092, 1646, 1821, 4219, 5217, 5871, 6043], 'W.': [1093, 1647, 1822, 4220, 5218, 5872, 6044], '273:': [1098, 1652, 1827, 4225, 5223, 5877, 6049], '21145-21152Abstract': [1099, 1653, 1828, 4226, 5224, 5878, 6050], '(511)': [1107, 1661, 1836, 4234, 5232, 5886, 6058], 'conserved': [1112], 'N-': [1113], 'regions': [1116], 'decapentaplegic': [1121], '(Mad)': [1122], 'homology': [1123], 'domain-1': [1124], '(MH1)': [1125], '-2': [1127], '(MH2),': [1128], 'respectively,': [1129], 'linked': [1132, 3480, 4686], 'linker': [1135, 4689], 'region': [1136, 1996, 2026, 3190, 3471, 4917, 5420, 6311], 'variable': [1138], 'length': [1139], 'amino': [1141, 1672, 1999], 'sequence.': [1143], 'MH2': [1145, 1218, 1443, 2324, 4102, 4243, 4500, 4682, 4694, 4702, 4903, 4920, 4955, 5011, 5544, 5560, 5733, 5903, 6096], 'functional': [1149, 1881, 3507, 5255], 'domain,': [1150, 1444, 4877, 4921, 5898, 6097], 'transactivation': [1153, 6141], 'when': [1155, 5729, 5899], 'fused': [1156], 'Gal4-DNA': [1159], '(18Liu': [1162], 'Baker': [1166], 'J.C.': [1167, 4889], 'Doody': [1168], 'Cárcamo': [1170], 'Harland': [1172, 4890], 'R.M.': [1173, 4891], '381:': [1178], '620-623Crossref': [1179], '(592)': [1182], '19Meersseman': [1185], 'G.': [1186, 1196, 1311, 1460, 4352, 4511, 5579, 5608], 'Verschueren': [1187], 'Nelles': [1189], 'Blumenstock': [1191], 'Kraft': [1193], 'Wuytens': [1195], 'Remacle': [1197], 'Kozak': [1199], 'C.A.': [1200], 'Tylzanowski': [1201], 'Niehrs': [1203], 'Huylebroeck': [1205], 'Mech.': [1207], 'Dev.': [1208, 1329, 1353, 1369, 4371, 4530, 4793, 4809, 4893, 4987], '61:': [1210], '127-140Crossref': [1211], '(63)': [1214], 'plays': [1221, 4704, 4922, 4999], 'important': [1222, 4705, 5001, 6109, 6227], 'roles': [1223, 4706, 6228], 'interaction': [1225, 1296, 3829, 4713, 4727, 4928, 5892], '(20Lo': [1230, 4929], 'R.S.': [1231, 1456, 4930, 4977, 5575, 5604], 'Y.-G.': [1233, 4932], 'Shi': [1234, 4933, 4980], 'Y.': [1235, 1259, 1276, 1347, 1866, 2077, 2407, 2560, 3134, 3301, 3628, 4787, 4934, 4981, 5304, 5448, 6279, 6377], 'Pavletich': [1236, 4935, 4982], 'N.P.': [1237, 4936], '996-1005Crossref': [1244, 4943], '(208)': [1247, 4946], 'homo-': [1250, 4718], 'hetero-oligomerization': [1252], '(21Wu': [1256], 'R.-Y.': [1257], 'Zhang': [1258, 1346, 4786], 'Derynck': [1262, 1279, 1350, 4790], '2521-2528Crossref': [1269], '(186)': [1272], '22Zhang': [1275], 'Musci': [1277], '270-276Abstract': [1285], '(276)': [1293], 'factor,': [1300], '(23Chen': [1302, 4343, 4502], 'Weisberg': [1304, 4345, 4504], 'Fridmacher': [1306, 4347, 4506], 'V.': [1307, 4348, 4507], 'Watanabe': [1308, 4349, 4508], 'Naco': [1310, 4351, 4510], '389:': [1316, 2254, 4357, 4516], '85-89Crossref': [1317, 4358, 4517], '(494)': [1320, 4361, 4520], 'Scholar,24Liu': [1322], 'Pouponnot': [1324, 4366, 4525], 'Genes': [1328, 1352, 1368, 1922, 1983, 4370, 4529, 4792, 4808, 4892, 4986, 5357], '11:': [1331, 4373, 4532], '3157-3167Crossref': [1332, 4374, 4533], '(399)': [1335, 4377, 4536], 'association': [1339, 4722], 'co-activators,': [1342], 'p300/CBP': [1343, 4731], '(25Feng': [1344], 'Wu': [1348, 4788], 'R.Y.': [1349, 4789], '12:': [1355, 1371, 4795, 4811, 4989], '2153-2163Crossref': [1356, 4796], '(450)': [1359, 4799], '26Janknecht': [1362, 4802], 'Wells': [1364, 4804], 'N.J.': [1365, 4805], 'Hunter': [1366, 4806], '2114-2119Crossref': [1372, 4812], '(437)': [1375, 4815], '27Topper': [1378, 4818], 'J.N.': [1379, 2570, 3638, 4819], 'DiChiara': [1380, 4820], 'M.R.': [1381, 4821], 'Brown': [1382, 4822], 'J.D.': [1383, 4823], 'Williams': [1384, 4824], 'A.J.': [1385, 4825], 'Falb': [1386, 2576, 3644, 4826], 'Collins': [1388, 4828], 'Gimbrone': [1390, 2571, 3639, 4830], 'Jr.,': [1391, 2572, 3640, 4831], 'M.A.': [1392, 2568, 2573, 3636, 3641, 4832], 'Proc.': [1393, 4833], 'Natl.': [1394, 4834], 'Acad.': [1395, 4835], 'Sci.': [1396, 4836], '95:': [1401, 4841], '9506-9511Crossref': [1402, 4842], '(154)': [1405, 4845], '28Nishihara': [1408, 4848], 'Hanai': [1410, 2219, 2246, 2713, 3015, 4850], 'Okamoto': [1412, 4852], 'N.': [1413, 4853, 4983], 'Yanagisawa': [1414, 4854], 'Kato': [1416, 1905, 1966, 4856, 5340], 'Kawabata': [1420, 1916, 1977, 2211, 2248, 2705, 3007, 4860, 5351], 'Gene': [1422, 4862], 'Cells.': [1423, 1923, 1984, 4863, 5358], '3:': [1425, 1925, 1986, 4865, 5360], '613-623Crossref': [1426, 4866], '(130)': [1429, 4869], 'MH1': [1433, 1479, 1543, 3196, 4680, 4876, 4997, 5016, 5426, 5537, 5558, 5659, 5897, 6104, 6197], 'physically': [1439], 'thereby': [1446], 'inhibits': [1447], 'latter': [1452], '(29Hata': [1453, 5572, 5601], 'Lo': [1455, 4976, 5574, 5603], 'Wotton': [1457, 4978, 5576, 5605], 'Lagna': [1459, 5578, 5607], '82-87Crossref': [1466, 5585, 5614], '(295)': [1469, 5588, 5617], 'an': [1482, 2678, 2848, 3124, 5000, 5027], 'intrinsic': [1483, 5019], 'signal': [1486], 'transduction,': [1487], 'sequences.': [1494], 'Drosophila': [1497], 'quadrant': [1504, 5038], 'enhancer': [1505, 5039], 'vestigial': [1507, 5041], 'domains': [1544, 2325, 4244, 5734], 'Although': [1664, 3784], '91%': [1669], 'identical': [1670], 'sequence,': [1674, 4601], 'they': [1675, 4034], 'differences': [1678, 3869, 4426, 5256, 6098], 'biological': [1680, 5409], 'activity.': [1681], 'contrast': [1683, 3688, 5962], 'Smad4,': [1687, 2182, 3548, 3593, 3899, 4441, 5064, 5644, 6172], 'does': [1689, 4550, 5534, 5952], '(12Labbé': [1695, 4112, 5745, 6145], '13Kim': [1720, 5770], 'Binding': [1839], 'regulator,': [1843], 'Evi-1,': [1844, 5283], '(30Kurokawa': [1853, 5291], 'Mitani': [1855, 5293], 'Irie': [1857, 5295], 'Matsuyama': [1859, 5297], 'Takahashi': [1861, 5299], 'Chiba': [1863, 5301], 'Yazaki': [1865, 5303], 'Matsumoto': [1867, 5305], 'Hirai': [1869, 5307], '394:': [1873, 5311], '92-96Crossref': [1874, 5312], '(301)': [1877, 5315], 'A': [1880, 1960, 5334], 'difference': [1882, 3803, 5268, 5392], 'between': [1883, 2146, 3804, 3871, 4405, 5257, 5269, 5395, 5490, 5557], 'suggested': [1890], 'effects': [1893, 6110], 'HaCaT': [1900, 1939, 3222, 3286, 3320, 5320], 'keratinocyte': [1901, 3223, 5321], 'cells': [1902, 2476, 2487, 2494, 2519, 2543, 2625, 2734, 2750, 2906, 3764, 3936], '(31Shimizu': [1903, 1964, 5338], 'Nakao': [1907, 1968, 5342], 'Imamura': [1909, 1970, 2207, 2701, 3003, 5106, 5344], 'Shimada': [1918, 1979, 5353], '125-134Crossref': [1926, 1987, 5361], '(64)': [1929, 1990, 5364], 'inhibit': [1935], 'cells,': [1940, 2049, 3323, 3390, 3408, 3504], 'much': [1944], 'activin.': [1948], 'induces': [1950, 5325], 'phosphorylation': [1952, 3750, 3808, 3847, 5326, 5394, 5637], 'both': [1954, 2169, 4048, 4268, 5328, 5712], 'whereas': [1958, 6137], 'preferentially': [1961, 5335, 5507], 'activates': [1962, 4885, 5336], '30': [1998], 'residues,': [2001], 'or': [2008, 2523, 2549, 2766, 2839, 2987, 2991, 3041, 3096, 3590, 3663, 4018, 4393, 4458, 4466, 4484, 5640, 6243], 'other': [2009, 3206, 3349, 6205, 6247, 6323], 'composed': [2017], '11': [2019], 'exons,': [2020], 'this': [2022, 4927, 5381, 5563, 6143], 'short': [2023], '30-amino': [2024, 3188, 5418], 'translated': [2028], '3.': [2031, 3367], 'Recently,': [2032], 'transcript': [2038, 2055, 5483], 'lacks': [2040, 4874], 'present': [2044, 5465, 5473, 5517, 5622], 'tissues': [2047, 5476], 'amount': [2052], 'about': [2057], '1/10': [2058], '(32Takenoshita': [2064, 2394, 3288, 5435, 6266], 'Mogi': [2066, 2396, 3290, 5437, 6268], 'Nagashima': [2068, 2398, 3292, 5439, 6270], 'Yang': [2070, 2400, 3294, 5441, 6272], 'Yagi': [2072, 2402, 3296, 5443, 6274], 'Hanyu': [2074, 2404, 3298, 5104, 5445, 6276, 6375], 'Nagamachi': [2076, 2406, 3300, 5447, 6278], 'Hagiwara': [2080, 2410, 3304, 5451, 6282], 'Genomics.': [2082, 2412, 3306, 5453, 6284], '48:': [2084, 2414, 3308, 5455, 6286], '1-11Crossref': [2085, 2415, 3309, 5456, 6287], '(46)': [2088, 2418, 3312, 5459, 6290], 'Here': [2091], 'without': [2098, 3839], 'assay': [2117, 2644, 2870], 'almost': [2131], 'differ': [2145, 5489], 'able': [2156, 4273, 5663], '(AP)-1': [2163], 'from': [2165, 2359, 2479, 2903, 3215, 3283, 3907, 3934, 5413], 'p3TP-lux.': [2166, 3891, 4098], 'could': [2173], 'factor': [2177, 6132], '(ARF)': [2178], 'transactivate': [2184], 'Xenopus': [2186, 2338, 3622, 3670, 4399, 6135, 6399], 'promoter.': [2189, 5928, 6185], 'original': [2191], 'constructions': [2192], 'Flag-pcDNA3,': [2194], 'Myc-pcDNA3,': [2195], 'HA-pcDNA3,': [2196], 'TβR-I(TD)-HA,': [2197], 'described': [2203, 2393, 2697, 2874, 2953], 'previously': [2204, 2698, 2875, 3894, 4105], '(33Nakao': [2205, 2699, 3001], 'Souchelnytskyi': [2209, 2703, 3005], 'Ishisaki': [2213, 2707, 3009], 'Oeda': [2215, 2244, 2709, 3011], '16:': [2231, 2725, 3027], '5353-5362Crossref': [2232, 2726, 3028], '(916)': [2235, 2729, 3031], '34Imamura': [2238], 'Takase': [2240], 'Nishihara': [2242], '622-626Crossref': [2255], '(871)': [2258], 'prepared': [2263, 2358, 2902, 2951, 3067, 3214, 3378, 3906, 3933], 'inserting': [2265, 3369], '330-bp': [2267, 2465, 3340, 3360, 3371], 'reaction': [2270], '(PCR)': [2271], 'product': [2272, 2466, 3372], 'order': [2278, 3731], 'obtain': [2280], 'efficient': [2281, 3553, 6079], 'expression': [2282, 2292, 2738, 2913, 3393, 6300], 'levels': [2283, 3411, 3806], 'some': [2286, 5934], 'constructs': [2287, 2669, 2739, 3385, 3759, 3862, 3942, 5137], 'were': [2288, 2326, 2354, 2357, 2368, 2424, 2477, 2488, 2495, 2528, 2544, 2626, 2670, 2735, 2751, 2757, 2782, 2811, 2817, 2862, 2901, 2916, 2950, 3034, 3079, 3103, 3173, 3213, 3266, 3342, 3386, 3509, 3760, 3788, 3932, 4035, 4245, 4272, 4304, 5593, 5735], 'subcloned': [2289, 2346], 'another': [2291], 'vector,': [2293], 'pcDEF3': [2294], '(35Goldman': [2295], 'L.A.': [2296], 'Cutrone': [2297], 'E.C.': [2298], 'Kotenko': [2299], 'S.V.': [2300], 'Krause': [2301], 'C.D.': [2302], 'Langer': [2303, 6387], 'J.A.': [2304], 'BioTechniques.': [2305], '21:': [2307], '1013-1015Crossref': [2308], '(151)': [2311], 'Constructs': [2314], 'GST-fused': [2316, 3042, 4237, 4569], 'Smad2(wt)ΔMH2,': [2317, 4238], 'Smad3ΔMH2,': [2318, 4239], 'Flag-tagged': [2320, 3401, 3757], 'Smad2Δexon3ΔMH2': [2321, 4089, 4241, 4597], 'lacking': [2322, 3365, 4100, 4242, 5469, 5484, 5524, 5732], 'obtained': [2327, 2478, 3280, 3692, 4040, 4258, 4309], 'subcloning': [2329], 'corresponding': [2331, 3253, 4290], 'cDNAs': [2332, 2367], 'pGEX-4T-1': [2334], '(Amersham': [2335, 2853], 'Pharmacia': [2336, 2854], 'Biotech).': [2337, 2855], 'cDNA': [2340], '(provided': [2341, 2551], 'Whitman)': [2344], 'HA-pcDEF3.': [2348], 'All': [2349], 'PCR': [2352, 2371, 2422, 2429, 2454, 3245, 3264, 3270], 'products': [2353, 2423, 3265, 3361], 'sequenced.': [2355], 'Poly(A)+RNAs': [2356], 'lines': [2362], 'reverse-transcribed.': [2364], 'resulting': [2366], 'amplified': [2369], 'primers': [2373, 2431, 3249, 3272], '2A': [2374], '(5′-TTT': [2375], 'TCC': [2376], 'TAG': [2377], 'CGT': [2378], 'GGC': [2379, 2445], 'TTG-3′)': [2380], '4A': [2382], '(5′-TCA': [2383], 'GAG': [2384, 2434], 'AGT': [2385], 'TGA': [2386, 2447], 'GAC': [2387], 'ACC': [2388], 'AG-3′)': [2389], 'under': [2390, 5509], 'conditions': [2391], 'subjected': [2425, 2800, 2813, 3081, 3267, 3946], 'second-round': [2428, 3269], '2B': [2432, 3273], '(5′-GAA': [2433], 'ACT': [2435], 'GCT': [2436], 'GGG': [2437], 'ATG': [2438], 'GAA': [2439, 2440], 'GT-3′)': [2441], '4B': [2443], '(5′-CAA': [2444], 'AAT': [2446], 'AAA': [2448], 'CTG': [2449], 'CGA': [2450], 'ATA': [2451], 'TGC-3′).': [2452], 'fragment': [2455], 'run': [2457], '2%': [2460], 'agarose': [2461], 'gel,': [2462], 'cloned': [2468], 'TA': [2471], 'cloning': [2472], 'kit': [2473], '(Promega).': [2474], 'COS7': [2475, 2733, 2905, 3389, 3407, 3763, 3935], 'American': [2480], 'Type': [2481], 'Culture': [2482], 'Collection.': [2483], 'R': [2484, 2540, 3501], 'mutant': [2485, 2541, 3502, 5564], 'Mv1Lu': [2486, 2542, 3503], 'provided': [2489, 2996], 'Massagué.': [2492], 'cultured': [2496], "Dulbecco's": [2498], 'modified': [2499], "Eagle's": [2500], 'medium': [2501], '10%': [2503], 'fetal': [2504], 'bovine': [2505], 'serum,': [2506], '100': [2507], 'units/ml': [2508], 'penicillin,': [2509], '10': [2511, 2796], 'μg/ml': [2512], 'gentamycin.': [2513], 'For': [2514, 2604, 2856, 2977], 'transient': [2515], 'transfection,': [2516, 2624, 2748], '60–80%': [2517], 'confluent': [2518], 'six-well': [2521], 'plates': [2522], '10-cm': [2524], 'culture': [2526], 'dishes': [2527], 'transfected': [2529, 2546, 2736, 2907, 3387, 3761, 3937, 4263, 5718], 'FuGENE6': [2531], 'transfection': [2532, 2607], 'reagent': [2533], '(Boehringer': [2534, 2837], 'Mannheim)': [2535], 'following': [2536, 2864], "manufacturer's": [2538, 2660, 2866], 'protocol.': [2539, 2867], 'transiently': [2545], 'pAR3-lux': [2550, 2668, 3072, 3614, 3707, 4390], 'Wrana)': [2554], '(36Hayashi': [2555, 3623], 'Qiu': [2559, 3627], 'Cai': [2561, 3629], 'Xu': [2563, 3631], 'Y.-Y.': [2564, 3632], 'Grinnell': [2565, 3633], 'B.W.': [2566, 3634], 'Richardson': [2567, 3635], 'Topper': [2569, 3637], '89:': [2580, 3648], '1165-1173Abstract': [2581, 3649], '(1164)': [2589, 3657], 'Scholar)': [2591, 3033, 3497, 3659, 5461, 5888], 'presence': [2594, 3520, 3591, 3662, 3971, 3988, 4003, 4015, 4029, 4288, 4412, 4544, 4614, 5714], 'combinations': [2597], 'constructs,': [2600], 'TβR-I(TD),': [2601, 2742, 2910, 3770, 3840, 3864, 3944, 3973, 4005, 4267], 'FAST1.': [2603, 2744, 4490, 4561, 4585, 6400], 'normalization': [2605], 'efficiency,': [2608], 'theRenilla': [2609], 'luciferase': [2610, 2632, 2643, 2663, 2682, 3704, 3712, 5135], 'reporter': [2611, 3465, 3612, 5136], 'pRL-CMV': [2615], 'vector': [2616], '(Promega)': [2617, 2646], 'co-transfected': [2619], 'each': [2621], 'transfection.': [2622], 'After': [2623], 'incubated': [2627, 2758], '36': [2629], 'h,': [2630], 'lysates': [2637, 2756, 2810, 3040, 3088], 'determined': [2639], 'dual': [2642], 'system': [2645, 2852], 'luminometer': [2649], '(Lumat': [2650], 'LB': [2651], '9501,': [2652], 'EG': [2653], '&': [2654], 'G': [2655], 'Berthold)': [2656], 'according': [2657], 'recommendations.': [2661], 'activities': [2664, 5373], 'luminescence': [2673], 'firefly': [2675, 2690], 'luciferase.': [2676], 'As': [2677], 'internal': [2679], 'control,': [2680], 'Renilla': [2681], 'immediately': [2685], 'afterward': [2686], 'quenching': [2688], 'luminescence.': [2691], 'Immunoprecipitation': [2692], 'immunoblotting': [2694, 3778], 'Briefly,': [2732, 2897], 'Forty-eight': [2745], 'hours': [2746], 'after': [2747], 'solubilized,': [2752], 'anti-Flag': [2761, 2831, 2980, 3774, 3991, 4043, 4051, 4312, 4630, 4642], 'M2': [2762], '(Eastman': [2763], 'Kodak': [2764], 'Co.)': [2765], 'anti-Myc': [2767, 2833, 2982, 4031, 4049], '9E10': [2768], 'antibodies': [2769, 2841, 2983, 3781, 4052, 4468], '(Santa': [2770], 'Cruz': [2771], 'Biotechnology),': [2772], 'followed': [2773, 3776], 'incubation': [2775], 'G-Sepharose': [2778], 'beads.': [2779], 'immunocomplexes': [2781], 'eluted': [2784], 'boiling': [2786], 'min': [2789], 'SDS': [2792], 'sample': [2793], 'buffer': [2794, 2921], 'mm': [2797, 2924, 2929, 2935, 2940, 3165], 'dithiothreitol': [2798], 'SDS-polyacrylamide': [2802], 'electrophoresis': [2804], '(PAGE).': [2805], 'Aliquots': [2806], 'SDS-PAGE.': [2815], 'Proteins': [2816], 'electrotransferred': [2818], 'polyvinylidene': [2820, 2859], 'difluoride': [2821, 2860], 'membrane': [2822], '(ProBlott': [2823], 'membranes,': [2824], 'Applied': [2825], 'Biosystems)': [2826], 'immunoblotted': [2828], 'M2,': [2832], '9E10,': [2834], 'anti-HA': [2835, 4467], '3F10': [2836], 'Mannheim),': [2838], 'anti-phosphoserine': [2840, 3780], '(Zymed': [2842], 'Laboratories': [2843], 'Inc.)': [2844], 'developed': [2846], 'enhanced': [2849], 'chemiluminescence': [2850], 'detection': [2851], 're-blotting,': [2857], 'membranes': [2861], 'stripped': [2863], 'Gel-mobility': [2868], 'shift': [2869, 3949, 4055, 4249, 4295], 'performed': [2872, 3247], '(14Yingling': [2876, 5079], 'whole': [2898, 3038, 4260, 5703], 'extracts': [2900, 3931, 4262], 'Smad,': [2909], 'constructs.': [2914], 'Cells': [2915], 'lysed': [2917], 'lysis': [2920, 3170], '50': [2923, 2934], 'Tris-HCl,': [2925], 'pH': [2926], '7.5,': [2927], '150': [2928], 'NaCl,': [2930], '0.5%': [2931], 'Nonidet': [2932], 'P-40,': [2933], 'NaF,': [2936], '1': [2937, 2939, 3112, 3117, 3337], 'mmNaPO4,': [2938], 'dithiothreitol,': [2941], 'protease': [2943], 'inhibitors.': [2944], 'Glutathione': [2945], 'S-transferase': [2946], '(GST)': [2947], 'fusion': [2948, 3098], '(16Dennler': [2954], 'supershift': [2978], 'analysis,': [2979], 'and/or': [2981], '(1–2': [2984], 'μl': [2985, 2994, 3118], 'each)': [2986, 3102], 'antisera': [2988, 4617], '(2': [2993], 'each,': [2995], 'Dijke)': [3000], 'added': [3035, 3104], 'probe': [3046, 3121, 3905], 'AP-1': [3048, 3481, 3888, 4095, 4277, 4591, 5075, 5670], '(77': [3050], 'bp)': [3051], 'created': [3053], 'digestion': [3055, 3069], 'withNdeI': [3059], 'SphI,': [3061], 'ARE': [3065, 3617, 4338, 4446, 4579, 4600, 4675], 'Acc': [3074], 'andBamHI.': [3076], 'probes': [3078], '[α-32P]dCTP': [3083], 'Klenow': [3084], 'labeling.': [3085], 'Whole': [3086, 3929], '(3': [3089], 'μl,': [3090], 'μg': [3093, 3113], 'protein)': [3095], 'GST': [3097], '(150': [3100], 'ng': [3101], 'premix': [3107], 'solution': [3108], '(13.4': [3109], 'μl)': [3110], 'poly(dI-dC)': [3115], 'labeled': [3122], '2.0': [3127], '×': [3128], '104': [3129], 'cpm/μl': [3130], '(37Datto': [3131], 'Yu': [3133], '270:': [3141], '28623-28628Abstract': [3142], '(400)': [3150], 'final': [3154], 'concentration': [3155], 'NaCl': [3157], 'samples': [3160], 'adjusted': [3162], '110': [3164], 'hypotonic': [3167], 'hypertonic': [3169], 'buffers.': [3171], 'Complexes': [3172], 'resolved': [3175], '4%': [3178], 'analyzed': [3182, 3397], 'autoradiography.': [3184], 'middle': [3193, 5423], '(amino': [3198], '79–108),': [3200], 'mammals': [3209], '(Fig.1': [3210], 'A).': [3211, 3499, 3783, 3952, 4418], 'mRNAs': [3212, 3282], 'lines,': [3219], 'line,': [3225, 3230, 3236, 5323], 'HEL': [3226], 'erythroleukemia': [3228], 'U937': [3231], 'monocytic': [3233], 'leukemia': [3234, 3242], 'Molt-4': [3238, 3322], 'T': [3240], 'line.': [3244], '(2A': [3250], '4A)': [3252], 'exons': [3258], '2': [3259, 3709, 4952], '4,': [3261], '4B.': [3275], 'Similar': [3276, 4254, 4586, 5591], 'previous': [3278, 5433, 5743], 'placenta': [3284], 'keratinocytes': [3287], 'bands': [3318, 3326, 3332, 3341, 4025, 4284, 4296, 4610, 4624], 'major': [3325], '420': [3328], 'bp': [3329, 3335], 'faint': [3331], '330': [3334], '(Fig.': [3336, 3708, 3826, 4251, 4606], 'B).': [3338, 3710, 4253, 4461], 'very': [3344, 5240], 'weakly': [3345], 'detected': [3346, 5728], 'lines.': [3352], 'By': [3353, 3368], 'sequencing,': [3355], 'confirmed': [3357], 'correspond': [3362], 'atPvuII-RcaI': [3375], 'sites,': [3376, 4278, 5671], 'construct': [3380], 'Smad2Δexon3.': [3382], 'immunoblotting.': [3399], 'N-terminally': [3400], 'expressed': [3405], '(data': [3419, 3966], 'shown).': [3421, 3968], 'size': [3423], 'smaller': [3427], 'larger': [3433], 'consistent': [3438], 'estimated': [3441], 'molecular': [3442], 'weights.': [3443], 'Next,': [3444], 'contains': [3468, 5997], 'inhibitor': [3475], '(PAI)-1': [3476], 'tandemly': [3479], '(38Cárcamo': [3483], 'Zentella': [3485], '15:': [3493], '1573-1581Crossref': [3494], '(Fig.2': [3498], 'lack': [3506, 6298], 'TβR-I,': [3508, 5639], 'determine': [3512, 4962, 5500], 'small': [3522], 'amounts': [3523, 3768], 'TβR-I(TD)': [3525, 3965, 4416], 'plasmid,': [3526], 'slight': [3528], 'increase': [3529, 5553, 5635], 'observed.': [3537], 'induced': [3540, 3856, 5508], 'even': [3542, 3838], 'exogenous': [3547], 'while': [3549, 5332, 6238], 'Co-expression': [3559], 'led': [3562, 4053, 4469], 'higher': [3564, 3737, 4638, 5528, 5910], 'Interestingly,': [3577, 6118], 'tested': [3609], 'protein,': [3669], 'p3TP-lux,': [3694, 3798, 5940], 'inducing': [3703, 3794, 4386, 6081], 'induction': [3713, 4646], 'effective': [3725], 'Smad2.': [3729], 'understand': [3733], 'mechanism': [3734, 5950], 'examined': [3748, 4087, 4421], 'TβR-I.': [3756], 'together': [3765, 4486, 5739, 6123], 'immunoprecipitated': [3772], 'antibody,': [3775, 4032], '(Fig.3': [3782], 'there': [3799, 4423], 'no': [3801, 3868], 'significant': [3802], 'Heteromer': [3814], '3B).': [3827], 'Weak': [3828], 'correlated': [3843], 'weak': [3846, 4036, 4305], 'Strong': [3852], 'all': [3858], 'We': [3876, 4085, 4562, 5428, 6352, 6382], 'It': [3892, 5493], 'indicated': [3940], 'gel-mobility': [3948], 'analysis': [3950, 4250], '(Fig.4': [3951, 4593], 'None': [3953], 'complexes.': [3982, 4084], 'supershifted': [3985], 'antibody.': [3992, 4044], 'alone': [3994], 'complex': [4000, 4396, 4559, 5707], 'participate': [4009, 4081], 'shifted': [4026, 4285, 4611], 'Moreover,': [4045], 'addition': [4046, 4654, 5265], 'slower': [4058], 'mobility,': [4059], 'indicating': [4060, 4475], 'contained': [4065, 4481], 'indicate': [4069, 4541, 4651], '3,': [4075], 'acquired': [4077], 'ability': [4079, 4566], 'next': [4086], 'whether': [4088, 4422, 5501], '4': [4252, 4302], 'not.': [4282], 'antisera,': [4292], '(lane': [4297, 4314, 4632], '15': [4298], '18,': [4300], 'Fig.': [4301], 'B)': [4303], 'antibody': [4313, 4631, 4643], '19),': [4315], 'probably': [4316, 4634], 'because': [4317, 4635], 'lower': [4320], 'affinities': [4321], 'antisera.': [4325], 'associates': [4327], 'theMix.2': [4340, 5980], '24Liu': [4364, 4523], 'Smad2Δexon3;': [4394], 'however,': [4395, 5624], 'similarly': [4403], '(Fig.5': [4417, 4460], 'We,': [4419], 'therefore,': [4420], 'any': [4425], 'abilities': [4430, 4670], 'ARF': [4433, 4438, 4479, 4558, 4661], 'bound': [4445, 6177], 'response': [4448], 'activation,': [4452], 'Addition': [4462], 'anti-Flag,': [4464], 'anti-Myc,': [4465], 'shifts': [4471], 'bands,': [4474], 'findings': [4540, 5679, 5738, 6187], 'interfere': [4552], 'investigated': [4564], 'sequence': [4580, 5999], 'A),': [4594], 'Smad3ΔMH2': [4595], 'recognized': [4598], 'Smad2(wt)ΔMH2': [4603], '5': [4607], 'C).': [4608], '(lanes': [4618], '6and': [4619], '8).': [4620], 'Shift': [4621], 'remarkable': [4627], '9),': [4633], 'affinity': [4639, 5556], 'possible': [4645, 5965], 'oligomerization.': [4648], 'data': [4650], 'indirectly': [4656], 'complexes,': [4662], '.': [4676], 'domains,': [4683, 4695, 5561], 'region.': [4690], 'Inhibitory': [4691], 'divergent': [4698], 'MH1-like': [4699], 'regions.': [4700], 'functions': [4709], 'hetero-oligomer': [4720], 'formation,': [4721], 'coactivators,e.g.': [4730], '25Feng': [4784], 'located': [4880], 'genes': [4887, 5947], '(39Baker': [4888], '1880-1889Crossref': [4896], '(307)': [4899], 'interacts': [4905], 'L3': [4912], 'loop,': [4913], '17-amino': [4915], 'critical': [4924, 6242], 'role': [4925, 5002, 5966, 6335], 'addition,': [4950, 5014], 'α-helix': [4951], 'specificity': [4965], '(40Chen': [4972], 'Y.G.': [4973], '2144-2152Crossref': [4990], '(305)': [4993], 'repressor': [5005, 5655], 'domain.': [5012, 5427, 5545, 5660], 'activity,i.e.': [5020], 'sequences.Drosophila': [5025], 'ortholog': [5028], '5,': [5033], '41Kawabata': [5100], 'Inoue': [5102], '4056-4065Crossref': [5114], '(248)': [5117], 'More': [5120], 'recently,': [5121], 'sequences,': [5133], 'multiple': [5139], 'copies': [5140], 'these': [5142], '(15Zawel': [5156, 6005], 'structurally': [5239], 'similar,': [5241], 'suggested.': [5263], 'them': [5270], 'ability,': [5273], 'regulator': [5282], 'consequently': [5285], 'suppresses': [5286], 'Since': [5367, 5907, 6086], 'inhibition': [5377], 'differentiation': [5379], 'type,': [5383], '2A.': [5384], 'Shimizu': [5385], 'Kato,': [5388], 'unpublished': [5389], 'data.': [5390], 'may': [5399, 5893, 5920, 6067, 6106, 6212, 6225, 6304, 6331], 'be,': [5400], 'least': [5402], 'part,': [5404], 'responsible': [5405], 'distinct': [5408], 'effects.': [5410], 'differs': [5412], 'having': [5416], 'report': [5434], 'study': [5466], 'mRNA': [5468, 5503], 'cells.': [5478], 'Amounts': [5479], 'appear': [5487], 'would': [5494], 'great': [5497], 'interest': [5498], 'encoding': [5504], 'physiological': [5511], 'pathological': [5513], 'conditions.': [5514], 'study,': [5518, 5623], 'represses': [5539], 'Arg-133': [5548], 'resulted': [5551], 'reported': [5594], 'mutation': [5598], 'Arg-100': [5600], 'lead': [5633], 'suggesting': [5645], 'finding': [5673], 'strongly': [5680, 5986, 6139], 'Smad2/3': [5687, 5971], 'crucial': [5692, 6334], 'step': [5693], 'reporter.': [5701], 'extracts,': [5705], 'Direct': [5720, 6220], 'GST-Smad': [5730], 'used.': [5736], 'reports': [5744], 'occur': [5894], 'repression': [5900], 'released.': [5906], 'positively': [5921], 'regulate': [5922, 6214], 'since': [5930], 'can,': [5932], 'extents,': [5935], 'induce': [5936], 'partially': [5944], 'require': [5954], 'p3TP,': [5977], 'appeared': [5982], 'affected': [5987], 'Smad2/3.': [5993], 'Smad-binding': [6003], 'bind.': [6068], 'failed': [6071], 'promoter,': [6077], 'pAR3-lux.': [6085], 'gene.': [6117], 'thegoosecoid': [6121], 'FAST2,': [6128, 6211], 'related': [6133], 'suppressed': [6140], 'GC-rich': [6180], 'goosecoid': [6184], 'thorough': [6195], 'indirect': [6202], 'via': [6204], 'factors,': [6207], 'e.g.': [6208], 'cooperatively': [6213], 'play': [6226, 6332], 'genes,': [6234, 6248], 'PAI-1,': [6237], 'negatively': [6245], 'goosecoid.': [6252], 'Expression': [6253], 'profile': [6254], 'appears': [6257], 'limited': [6260], 'Smad3-like': [6308], 'molecule.': [6309], 'like': [6312], 'Exon': [6327], 'modulating': [6337], 'interfering': [6343], 'grateful': [6354], 'Hoshikawa,': [6357], 'Inoue,': [6359], 'Kawabata,': [6361], 'Heldin,': [6363], 'valuable': [6369], 'discussion': [6370], 'comments,': [6372], 'Yuuki': [6378], 'technical': [6380], 'assistance.': [6381], 'thank': [6384], 'pcDEF3,': [6389], 'pAR3-lux,': [6394]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1964036489', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-14T08:26:12.610655', 'created_date': '2016-06-24'}