Title: Miscarriage risk from amniocentesis performed for abnormal maternal serum screening
Abstract: Objective The purpose of this study was to evaluate miscarriage after mid-trimester amniocentesis for abnormal maternal serum screening. Study Design An analysis of summary data from the California State maternal serum screening program on 32,050 women with an abnormal serum screen, a singleton fetus, and normal ultrasound was performed. Miscarriage before 24 weeks, days until miscarriage, gestational age at miscarriage, and maternal factors were compared. The power of this study could detect a 50% increase in miscarriage. Results The miscarriage rate with amniocentesis, 0.46% (69/15,005), was no different than without, 0.53% (90/17,045), P= .38. There was no difference in maternal age, serum biochemical factors, gestational age at miscarriage (21.1 weeks for both groups), or days until miscarriage (23 after amniocentesis and 20.4 without). Log-rank test revealed no difference for gestational age at miscarriage (P= .61) or number of days until miscarriage (P= .40). Conclusion The rate and timing of miscarriage was similar with or without amniocentesis in California women with abnormal maternal serum screening. The purpose of this study was to evaluate miscarriage after mid-trimester amniocentesis for abnormal maternal serum screening. An analysis of summary data from the California State maternal serum screening program on 32,050 women with an abnormal serum screen, a singleton fetus, and normal ultrasound was performed. Miscarriage before 24 weeks, days until miscarriage, gestational age at miscarriage, and maternal factors were compared. The power of this study could detect a 50% increase in miscarriage. The miscarriage rate with amniocentesis, 0.46% (69/15,005), was no different than without, 0.53% (90/17,045), P= .38. There was no difference in maternal age, serum biochemical factors, gestational age at miscarriage (21.1 weeks for both groups), or days until miscarriage (23 after amniocentesis and 20.4 without). Log-rank test revealed no difference for gestational age at miscarriage (P= .61) or number of days until miscarriage (P= .40). The rate and timing of miscarriage was similar with or without amniocentesis in California women with abnormal maternal serum screening.
Publication Year: 2007
Publication Date: 2007-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 31
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