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'(I3C),': [3], 'a': [4, 16], 'major': [5], 'indole': [6], 'compound': [7], 'found': [8], 'in': [9, 12, 106, 163], 'high': [10], 'levels': [11], 'cruciferous': [13], 'vegetables,': [14], 'shows': [15], 'broad': [17], 'spectrum': [18], 'of': [19, 29, 44, 80, 88, 109, 136, 147, 215, 243, 248, 253], 'biological': [20], 'activities.': [21], 'However,': [22], 'few': [23], 'studies': [24], 'have': [25], 'reported': [26], 'the': [27, 36, 41, 85, 134, 144, 160, 188, 213, 241], 'effect': [28, 43, 196], 'I3C': [30, 45, 81, 157, 167, 191, 210, 229], 'on': [31, 46], 'alcoholic': [32, 110, 233], 'liver': [33, 59, 91, 234], 'injury.': [34], 'In': [35, 138, 166], 'present': [37], 'study,': [38], 'we': [39], 'investigated': [40], 'protective': [42], 'acute': [47], 'ethanol‐induced': [48], 'hepatotoxicity': [49], 'and': [50, 75, 102, 125, 143, 200, 251], 'acetaldehyde‐stimulated': [51], 'hepatic': [52], 'stellate': [53], 'cells': [54], '(HSC)': [55], 'activation': [56, 135, 199], 'using': [57], 'precision‐cut': [58], 'slices': [60], '(PCLS).': [61], '2.': [62], 'Rat': [63], 'PCLS': [64, 231], 'were': [65, 82, 112, 128, 150, 174], 'incubated': [66, 208], 'with': [67, 187, 209, 240], '50': [68], 'mmol/L': [69], 'ethanol': [70, 244], 'or': [71], '350': [72], 'μmol/L': [73], 'acetaldehyde,': [74], 'different': [76], 'concentrations': [77], '(100–400': [78], 'μmol/L)': [79], 'added': [83], 'into': [84], 'culture': [86], 'system': [87], 'these': [89], 'two': [90], 'injury': [92, 250], 'models,': [93], 'respectively.': [94], 'Hepatotoxicity': [95], 'was': [96, 183, 217, 222], 'assessed': [97], 'by': [98, 176, 204], 'measuring': [99], 'enzyme': [100, 161], 'leakage': [101, 162], 'malondialdehyde': [103], '(MDA)': [104], 'content': [105], 'tissue.': [107], 'Activities': [108], 'enzymes': [111], 'also': [113, 192], 'determined.': [114], 'α‐Smooth': [115], 'muscle': [116], 'actin': [117], '(α‐SMA),': [118], 'transforming': [119], 'growth': [120], 'factor': [121], '(TGF‐β': [122], '1': [123], ')': [124], 'hydroxyproline': [126], '(HYP)': [127], 'used': [129], 'as': [130], 'indices': [131], 'to': [132, 152], 'evaluate': [133], 'HSC.': [137], 'addition,': [139], 'matrix': [140], 'metalloproteinase‐1': [141], '(MMP‐1)': [142], 'tissue': [145], 'inhibitor': [146], 'metalloproteinase': [148], '(TIMP‐1)': [149], 'observed': [151], 'estimate': [153], 'collagen': [154, 201, 254], 'degradation.': [155, 255], '3.': [156], 'significantly': [158], 'reduced': [159], 'ethanol‐treated': [164, 189], 'slices.': [165], 'groups,': [168], 'cytochrome': [169], 'P450': [170], '(CYP)': [171], '2E1': [172], 'activities': [173], 'inhibited': [175], '40.9–51.8%,': [177], 'whereas': [178, 220], 'alcohol': [179], 'dehydrogenase': [180], '(ADH)': [181], 'activity': [182], 'enhanced': [184], '1.6‐fold': [185], 'compared': [186], 'group.': [190], 'showed': [193, 227], 'an': [194], 'inhibitory': [195], 'against': [197, 232], 'HSC': [198], 'production': [202], 'stimulated': [203], 'acetaldehyde.': [205], 'After': [206], 'being': [207], '(400': [211], 'μmol/L),': [212], 'expression': [214], 'MMP‐1': [216], 'markedly': [218], 'enhanced,': [219], 'TIMP‐1': [221], 'decreased.': [223], '4.': [224], 'These': [225], 'results': [226], 'that': [228], 'protected': [230], 'injury,': [235], 'which': [236], 'might': [237], 'be': [238], 'associated': [239], 'regulation': [242], 'metabolic': [245], 'enzymes,': [246], 'attenuation': [247], 'oxidative': [249], 'acceleration': [252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1961748766', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-08-31T14:19:24.588367', 'created_date': '2016-06-24'}