Title: Enantioselective Total Synthesis of 1,3‐Disubstituted β‐Carboline Alkaloids, (–)‐Dichotomine A and (+)‐Dichotomide II
Abstract: Abstract ( S )‐(–)‐Dichotomine A and its enantiomer were synthesized from the key intermediate, methyl 1‐(1‐hydroxyethyl)‐β‐carboline‐3‐carboxylate, by enantioselective esterification with Lipase QLM. The first total synthesis of (+)‐dichotomide II and its enantiomer were also achieved from ( S )‐(–)‐dichotomine A methyl ester and its enantiomer. The absolute configuration of the stereogenic center of the reported (+)‐dichotomide II was determined to be R .
Publication Year: 2013
Publication Date: 2013-02-06
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 19
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