Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1954869870', 'doi': None, 'title': '[Pathophysiological aspects of K+: Cl- cotransporters].', 'display_name': '[Pathophysiological aspects of K+: Cl- cotransporters].', 'publication_year': 2014, 'publication_date': '2014-06-25', 'ids': {'openalex': 'https://openalex.org/W1954869870', 'mag': '1954869870', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24960328'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24960328', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037202169', 'display_name': 'Adriana Mercado', 'orcid': 'https://orcid.org/0000-0002-6881-0160'}, 'institutions': [{'id': 'https://openalex.org/I4210157394', 'display_name': 'Instituto Nacional de Cardiología', 'ror': 'https://ror.org/046e90j34', 'country_code': 'MX', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157394']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Adriana Mercado', 'raw_affiliation_strings': ['Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Nefrología, México, Distrito Federal, México'], 'affiliations': [{'raw_affiliation_string': 'Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Nefrología, México, Distrito Federal, México', 'institution_ids': ['https://openalex.org/I4210157394']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024458289', 'display_name': 'Zeresergio Melo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097900', 'display_name': 'Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán', 'ror': 'https://ror.org/00xgvev73', 'country_code': 'MX', 'type': 'facility', 'lineage': ['https://openalex.org/I4210095685', 'https://openalex.org/I4210097900', 'https://openalex.org/I4210128723']}, {'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Zeresergio Melo', 'raw_affiliation_strings': ['Unidad de Fisiología Molecular. Instituto de Investigaciones Biomédicas. Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.'], 'affiliations': [{'raw_affiliation_string': 'Unidad de Fisiología Molecular. Instituto de Investigaciones Biomédicas. Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.', 'institution_ids': ['https://openalex.org/I4210097900', 'https://openalex.org/I8961855']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '66', 'issue': '2', 'first_page': '173', 'last_page': '80'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.2202, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.2202, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.2005, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/solute-carrier-family', 'display_name': 'Solute carrier family', 'score': 0.6018847}], 'concepts': [{'id': 'https://openalex.org/C188053792', 'wikidata': 'https://www.wikidata.org/wiki/Q3640664', 'display_name': 'Cotransporter', 'level': 3, 'score': 0.95658183}, {'id': 'https://openalex.org/C120405084', 'wikidata': 'https://www.wikidata.org/wiki/Q285307', 'display_name': 'Symporter', 'level': 4, 'score': 0.70947164}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.6580081}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6255558}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.6079178}, {'id': 'https://openalex.org/C168785527', 'wikidata': 'https://www.wikidata.org/wiki/Q1401099', 'display_name': 'Solute carrier family', 'level': 4, 'score': 0.6018847}, {'id': 'https://openalex.org/C24530287', 'wikidata': 'https://www.wikidata.org/wiki/Q424204', 'display_name': 'Transmembrane protein', 'level': 3, 'score': 0.53246385}, {'id': 'https://openalex.org/C99975950', 'wikidata': 'https://www.wikidata.org/wiki/Q911011', 'display_name': 'Ion transporter', 'level': 3, 'score': 0.45496875}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.43042767}, {'id': 'https://openalex.org/C194583182', 'wikidata': 'https://www.wikidata.org/wiki/Q21114084', 'display_name': 'Alternative splicing', 'level': 4, 'score': 0.41366726}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3994236}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.33939153}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31165105}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.29844266}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.25733197}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.24787521}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.08899912}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D028021', 'descriptor_name': 'Sodium-Potassium-Chloride Symporters', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000141', 'descriptor_name': 'Acidosis, Renal Tubular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000141', 'descriptor_name': 'Acidosis, Renal Tubular', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000141', 'descriptor_name': 'Acidosis, Renal Tubular', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D061085', 'descriptor_name': 'Agenesis of Corpus Callosum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061085', 'descriptor_name': 'Agenesis of Corpus Callosum', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D061085', 'descriptor_name': 'Agenesis of Corpus Callosum', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D004827', 'descriptor_name': 'Epilepsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004827', 'descriptor_name': 'Epilepsy', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004827', 'descriptor_name': 'Epilepsy', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006453', 'descriptor_name': 'Hemoglobinopathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006453', 'descriptor_name': 'Hemoglobinopathies', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006453', 'descriptor_name': 'Hemoglobinopathies', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D010523', 'descriptor_name': 'Peripheral Nervous System Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010523', 'descriptor_name': 'Peripheral Nervous System Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010523', 'descriptor_name': 'Peripheral Nervous System Diseases', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D028021', 'descriptor_name': 'Sodium-Potassium-Chloride Symporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028021', 'descriptor_name': 'Sodium-Potassium-Chloride Symporters', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24960328', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.47}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W87609575', 'https://openalex.org/W4211235288', 'https://openalex.org/W3164432699', 'https://openalex.org/W3135039097', 'https://openalex.org/W3021224621', 'https://openalex.org/W3015866410', 'https://openalex.org/W2118162153', 'https://openalex.org/W1971456879', 'https://openalex.org/W1954869870', 'https://openalex.org/W1903117841'], 'abstract_inverted_index': {'The': [0], 'K+:Cl-': [1, 91], 'cotransporters': [2, 35, 92, 141], 'or': [3], 'KCCs': [4, 22, 186], 'are': [5, 39, 60, 77, 106, 122], 'membrane': [6, 16], 'proteins': [7], 'that': [8], 'move': [9], 'K+': [10], 'and': [11, 37, 88, 102, 119, 158, 182], 'Cl-': [12], 'ions': [13], 'across': [14], 'the': [15, 19, 25, 46, 50, 55, 83, 90, 134, 161, 168, 173, 179, 185], 'without': [17], 'changing': [18], 'transmembrane': [20], 'potential.': [21], 'belong': [23], 'to': [24, 110, 133, 170], 'SLC12': [26], '(Solute': [27], 'Carrier': [28], 'Family': [29], '12)': [30], 'family': [31], 'of': [32, 160, 184], 'electroneutral': [33], 'cation-chloride': [34], '(CCC),': [36], 'they': [38], 'secondary': [40], 'active': [41, 52], 'ion': [42], 'transporters': [43], 'because': [44], 'use': [45], 'established': [47], 'gradients': [48], 'from': [49, 103], 'primary': [51], 'transporter': [53], 'through': [54], 'Na+/K+-': [56], 'ATPase.': [57], 'Although': [58], 'there': [59, 105], 'nine': [61], 'members': [62], 'identify': [63], 'in': [64, 126, 146, 187], 'this': [65], 'family,': [66], 'up': [67], 'today': [68], 'only': [69], 'seven': [70], 'genes': [71, 100], 'had': [72], 'been': [73], 'characterized.': [74], 'Among': [75], 'them': [76], 'two': [78], 'loop': [79], 'diuretics-sensitive': [80], 'Na+:K+:2Clcotransporters': [81], '(NKCC1/NKCC2),': [82], 'thiazide-sensitive': [84], 'Na+:Cl-': [85], 'cotransporter': [86], '(NCC),': [87], 'finally': [89], '(KCC),': [93], 'encoded': [94], 'for': [95], 'at': [96], 'least': [97], 'four': [98], 'homologous': [99], '(KCC1-KCC4),': [101], 'which': [104], 'many': [107, 147], 'isoforms': [108, 121], 'due': [109], 'alternative': [111], 'splicing.': [112], 'KCC1': [113], 'is': [114, 131], 'a': [115], 'ubiquitous': [116], 'isoform,': [117], 'KCC3': [118], 'KCC4': [120], 'widely': [123], 'expressed,': [124], 'particularly': [125], 'epithelial': [127], 'cells,': [128], 'while': [129], 'KCC2': [130], 'restricted': [132], 'central': [135], 'nervous': [136], 'system': [137], '(CNS).': [138], 'All': [139], 'these': [140], 'play': [142], 'an': [143], 'essential': [144], 'role': [145], 'physiological': [148, 180], 'processes': [149], 'such': [150], 'as': [151, 176, 178], 'cell': [152], 'volume': [153], 'regulation,': [154], 'transepithelial': [155], 'salt': [156], 'transport': [157], 'regulation': [159], 'intraneuronal': [162], 'chloride': [163], 'concentration.': [164], 'This': [165], 'review': [166], 'has': [167], 'purpose': [169], 'show': [171], 'briefly': [172], 'molecular': [174], 'characteristics': [175], 'well': [177], 'importance': [181], 'roles': [183], 'several': [188], 'pathologies.': [189]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1954869870', 'counts_by_year': [], 'updated_date': '2024-12-16T05:39:56.177467', 'created_date': '2016-06-24'}