Abstract: Clinical and Experimental DermatologyVolume 35, Issue 1 p. 2-6 Opioid-induced pruritus: an update A. Reich, A. Reich Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland; and Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandSearch for more papers by this authorJ. C. Szepietowski, J. C. Szepietowski Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland; and Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandSearch for more papers by this author A. Reich, A. Reich Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland; and Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandSearch for more papers by this authorJ. C. Szepietowski, J. C. Szepietowski Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland; and Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandSearch for more papers by this author First published: 07 December 2009 https://doi.org/10.1111/j.1365-2230.2009.03463.xCitations: 66 Dr Adam Reich, Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Ul. T. Chalubinskiego 1, 50-368 Wroclaw, PolandE-mail: [email protected] Conflict of interest: none declared. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary Pruritus is an unpleasant sensation leading to scratching. It can be a feature of numerous skin or systemic diseases, and may also be a side-effect of various drugs. Opioids are one of the best-known medicines evoking pruritus. The pathogenesis of opioid-induced pruritus is still not fully known, but two different mechanisms have been proposed: peripheral and central. Several treatment options have been tested for opioid-induced pruritus, but none has been completely satisfactory. Opioid antagonists seem to be the most potent antipruritic drugs, but they also decrease analgesia, which limits their usage. Many other treatments have been tried, but to date, the data are conflicting or only limited studies have been performed to confirm their efficacy. Further studies are still needed to better elucidate the mechanism of opioid-induced pruritus and to develop more effective treatment options. Citing Literature Volume35, Issue1January 2010Pages 2-6 RelatedInformation
Publication Year: 2009
Publication Date: 2009-07-29
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 103
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