Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1951511875', 'doi': 'https://doi.org/10.1093/nar/gkv700', 'title': 'Characterisation of aptamer–target interactions by branched selection and high-throughput sequencing of SELEX pools', 'display_name': 'Characterisation of aptamer–target interactions by branched selection and high-throughput sequencing of SELEX pools', 'publication_year': 2015, 'publication_date': '2015-07-10', 'ids': {'openalex': 'https://openalex.org/W1951511875', 'doi': 'https://doi.org/10.1093/nar/gkv700', 'mag': '1951511875', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26163061', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4666376'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkv700', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/43/21/e139/17434995/gkv700.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://academic.oup.com/nar/article-pdf/43/21/e139/17434995/gkv700.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011753158', 'display_name': 'Daniel M. Dupont', 'orcid': 'https://orcid.org/0000-0003-1378-1670'}, 'institutions': [{'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Daniel M Dupont', 'raw_affiliation_strings': ['Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 8000 Aarhus C, Denmark [email protected].'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 8000 Aarhus C, Denmark [email protected].', 'institution_ids': ['https://openalex.org/I204337017']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103538640', 'display_name': 'Niels Larsen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Niels Larsen', 'raw_affiliation_strings': ['iNANO Interdisciplinary Nanoscience Center, Aarhus University, 8000 Aarhus C, Denmark.'], 'affiliations': [{'raw_affiliation_string': 'iNANO Interdisciplinary Nanoscience Center, Aarhus University, 8000 Aarhus C, Denmark.', 'institution_ids': ['https://openalex.org/I204337017']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047355282', 'display_name': 'Jan K. Jensen', 'orcid': 'https://orcid.org/0000-0002-7131-1418'}, 'institutions': [{'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Jan K Jensen', 'raw_affiliation_strings': ['Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 8000 Aarhus C, Denmark.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 8000 Aarhus C, Denmark.', 'institution_ids': ['https://openalex.org/I204337017']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026143955', 'display_name': 'Peter A. Andreasen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Peter A Andreasen', 'raw_affiliation_strings': ['Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 8000 Aarhus C, Denmark.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 8000 Aarhus C, Denmark.', 'institution_ids': ['https://openalex.org/I204337017']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072940644', 'display_name': 'Jørgen Kjems', 'orcid': 'https://orcid.org/0000-0003-4128-9317'}, 'institutions': [{'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Jørgen Kjems', 'raw_affiliation_strings': ['Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark iNANO Interdisciplinary Nanoscience Center, Aarhus University, 8000 Aarhus C, Denmark.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark iNANO Interdisciplinary Nanoscience Center, Aarhus University, 8000 Aarhus C, Denmark.', 'institution_ids': ['https://openalex.org/I204337017']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'fwci': 2.359, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 48, 'citation_normalized_percentile': {'value': 0.865308, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': None, 'issue': None, 'first_page': 'gkv700', 'last_page': 'gkv700'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10207', 'display_name': 'DNA Nanotechnology and Bioanalytical Applications', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10207', 'display_name': 'DNA Nanotechnology and Bioanalytical Applications', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aptamer', 'display_name': 'Aptamer', 'score': 0.9827353}, {'id': 'https://openalex.org/keywords/selex-aptamer-technique', 'display_name': 'SELEX Aptamer Technique', 'score': 0.7417924}, {'id': 'https://openalex.org/keywords/aptamers', 'display_name': 'aptamers', 'score': 0.532816}], 'concepts': [{'id': 'https://openalex.org/C128972844', 'wikidata': 'https://www.wikidata.org/wiki/Q418722', 'display_name': 'Aptamer', 'level': 2, 'score': 0.9827353}, {'id': 'https://openalex.org/C122682173', 'wikidata': 'https://www.wikidata.org/wiki/Q907101', 'display_name': 'Systematic evolution of ligands by exponential enrichment', 'level': 4, 'score': 0.9683558}, {'id': 'https://openalex.org/C2911215874', 'wikidata': 'https://www.wikidata.org/wiki/Q418722', 'display_name': 'SELEX Aptamer Technique', 'level': 5, 'score': 0.7417924}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7139324}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.6505221}, {'id': 'https://openalex.org/C81917197', 'wikidata': 'https://www.wikidata.org/wiki/Q628760', 'display_name': 'Selection (genetic algorithm)', 'level': 2, 'score': 0.5860815}, {'id': 'https://openalex.org/C24107716', 'wikidata': 'https://www.wikidata.org/wiki/Q123619', 'display_name': 'Nucleic acid', 'level': 2, 'score': 0.4843091}, {'id': 'https://openalex.org/C51679486', 'wikidata': 'https://www.wikidata.org/wiki/Q380546', 'display_name': 'DNA sequencing', 'level': 3, 'score': 0.45122}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.44061288}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.35093236}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.266454}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.13549805}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11346403}, {'id': 'https://openalex.org/C154945302', 'wikidata': 'https://www.wikidata.org/wiki/Q11660', 'display_name': 'Artificial intelligence', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D052157', 'descriptor_name': 'Aptamers, Nucleotide', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D059014', 'descriptor_name': 'High-Throughput Nucleotide Sequencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D052156', 'descriptor_name': 'SELEX Aptamer Technique', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D052157', 'descriptor_name': 'Aptamers, Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009690', 'descriptor_name': 'Nucleic Acid Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017395', 'descriptor_name': 'Plasminogen Activator Inhibitor 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017395', 'descriptor_name': 'Plasminogen Activator Inhibitor 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017395', 'descriptor_name': 'Plasminogen Activator Inhibitor 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017423', 'descriptor_name': 'Sequence Analysis, RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkv700', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/43/21/e139/17434995/gkv700.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4666376', 'pdf_url': 'https://europepmc.org/articles/pmc4666376?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://pure.au.dk/ws/files/94987144/Nucl._Acids_Res._2015_Dupont_e139.pdf', 'pdf_url': 'https://pure.au.dk/ws/files/94987144/Nucl._Acids_Res._2015_Dupont_e139.pdf', 'source': {'id': 'https://openalex.org/S4306400063', 'display_name': 'Scopus (Elsevier)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://pure.au.dk/portal/en/publications/1527a361-f26c-4794-8fd6-14358518f5fc', 'pdf_url': 'https://pure.au.dk/portal/files/94987144/Nucl._Acids_Res._2015_Dupont_e139.pdf', 'source': {'id': 'https://openalex.org/S4306400063', 'display_name': 'Scopus (Elsevier)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666376', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26163061', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkv700', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/43/21/e139/17434995/gkv700.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1592870802', 'https://openalex.org/W1964591062', 'https://openalex.org/W1992323997', 'https://openalex.org/W2009301312', 'https://openalex.org/W2020628782', 'https://openalex.org/W2039092261', 'https://openalex.org/W2039628136', 'https://openalex.org/W2042532665', 'https://openalex.org/W2046143615', 'https://openalex.org/W2046319392', 'https://openalex.org/W2048907669', 'https://openalex.org/W2057382350', 'https://openalex.org/W2058263654', 'https://openalex.org/W2063454131', 'https://openalex.org/W2066074720', 'https://openalex.org/W2076215478', 'https://openalex.org/W2088628587', 'https://openalex.org/W2104702173', 'https://openalex.org/W2109169619', 'https://openalex.org/W2117904651', 'https://openalex.org/W2129099356', 'https://openalex.org/W2131462431', 'https://openalex.org/W2136735223', 'https://openalex.org/W2137918942', 'https://openalex.org/W2140089353', 'https://openalex.org/W2149005864', 'https://openalex.org/W2149981547', 'https://openalex.org/W2157009395', 'https://openalex.org/W2314611360'], 'related_works': ['https://openalex.org/W96566440', 'https://openalex.org/W4389028830', 'https://openalex.org/W4283324873', 'https://openalex.org/W4282964019', 'https://openalex.org/W3027502831', 'https://openalex.org/W2943446673', 'https://openalex.org/W2768740994', 'https://openalex.org/W2112239026', 'https://openalex.org/W1939162951', 'https://openalex.org/W1502158823'], 'abstract_inverted_index': {'Nucleic': [0], 'acid': [1], 'aptamer': [2, 73, 129, 184], 'selection': [3, 48, 74, 117, 194], 'by': [4, 9, 43, 75, 92], 'systematic': [5], 'evolution': [6], 'of': [7, 22, 46, 52, 62, 79, 106, 115, 140, 151, 168, 183], 'ligands': [8], 'exponential': [10], 'enrichment': [11], '(SELEX)': [12], 'has': [13], 'shown': [14], 'great': [15], 'promise': [16], 'for': [17, 118, 133, 155, 158], 'use': [18], 'in': [19, 59, 83, 187], 'the': [20, 80, 84, 88, 98, 141, 159, 188, 198], 'development': [21], 'research': [23], 'tools,': [24], 'therapeutics': [25], 'and': [26, 91, 110, 137], 'diagnostics.': [27], 'Typically,': [28], 'aptamers': [29, 156], 'are': [30], 'identified': [31], 'from': [32, 192], 'libraries': [33], 'containing': [34], 'up': [35], 'to': [36, 120, 178, 200], '1016': [37], 'different': [38, 121], 'RNA': [39, 153], 'or': [40], 'DNA': [41], 'sequences': [42, 185], '5–10': [44], 'rounds': [45, 167], 'affinity': [47], 'towards': [49], 'a': [50, 112, 148], 'target': [51, 122, 135], 'interest.': [53], 'Such': [54], 'library': [55, 193], 'screenings': [56], 'can': [57, 124], 'result': [58], 'complex': [60, 189], 'pools': [61, 190], 'many': [63], 'target-binding': [64], 'aptamers.': [65, 142, 203], 'New': [66], 'high-throughput': [67, 104], 'sequencing': [68, 105], 'techniques': [69], 'may': [70], 'potentially': [71], 'revolutionise': [72], 'allowing': [76], 'quantitative': [77], 'assessment': [78], 'dynamic': [81], 'changes': [82], 'pool': [85, 150], 'composition': [86], 'during': [87], 'SELEX': [89, 107], 'process': [90], 'facilitating': [93], 'large-scale': [94, 180], 'post-SELEX': [95], 'characterisation.': [96], 'In': [97], 'present': [99], 'study,': [100], 'we': [101], 'demonstrate': [102, 173], 'how': [103], 'pools,': [108], 'before': [109], 'after': [111], 'single': [113], 'round': [114], 'branched': [116], 'binding': [119, 130], 'variants,': [123], 'provide': [125], 'detailed': [126, 181], 'information': [127], 'about': [128], 'sites,': [131], 'preferences': [132], 'specific': [134, 157], 'conformations,': [136], 'functional': [138], 'effects': [139], 'The': [143, 171], 'procedure': [144], 'was': [145], 'applied': [146], 'on': [147], 'diverse': [149], '2′-fluoropyrimidine-modified': [152], 'enriched': [154], 'serpin': [160], 'plasminogen': [161], 'activator': [162], 'inhibitor-1': [163], '(PAI-1)': [164], 'through': [165], 'five': [166], 'standard': [169], 'selection.': [170], 'results': [172], 'that': [174], 'it': [175], 'is': [176], 'possible': [177], 'perform': [179], 'characterisation': [182], 'directly': [186], 'obtained': [191], 'methods,': [195], 'thus': [196], 'without': [197], 'need': [199], 'produce': [201], 'individual': [202]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1951511875', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 8}], 'updated_date': '2024-09-19T19:56:53.900031', 'created_date': '2016-06-24'}