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160, 184], 'eishmania': [71, 82, 114, 130, 161, 185], ',': [72], 'which': [73], 'vector‐borne': [75], 'protozoan': [76], 'parasites': [77, 131], 'responsible': [78], 'for': [79, 128], 'leishmaniasis.': [80], 'large,': [86], 'cytoplasmic': [87], 'capable': [89], 'phosphorylating': [91], 'both': [92, 105], 'dihydrosphingosine.': [95], 'Remarkably,': [96], 'deletion': [97], 'leads': [100], 'to': [101, 132, 136, 141, 182], 'catastrophic': [102], 'defects': [103], 'insect': [107], 'stage': [108, 111], 'mammalian': [110, 172], 'parasites.': [115], 'Genetic': [116], 'biochemical': [118], 'analyses': [119], 'demonstrate': [120], 'that': [121, 175], 'proper': [122], 'expression': [123], 'essential': [127], 'remove': [133], 'toxic': [134], 'metabolites,': [135], 'survive': [137], 'stressful': [138], 'conditions,': [139], 'cause': [142], 'disease': [143], 'mice.': [145], 'Therefore,': [146], 'pleiotropic': [150], 'with': [152], 'vital': [153], 'roles': [154], 'throughout': [155], 'life': [157], 'cycle': [158], '.': [162], 'The': [163], 'essentiality': [164], 'its': [168], 'apparent': [169], 'divergence': [170], 'from': [171], 'counterparts': [173], 'suggests': [174], 'this': [176], 'selectively': [180], 'targeted': [181], 'reduce': [183], 'infection.': [186]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1946325796', 'counts_by_year': [{'year': 2022, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-09-23T23:37:22.061657', 'created_date': '2016-06-24'}