Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1945665742', 'doi': 'https://doi.org/10.18632/oncotarget.5861', 'title': '(E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol inhibits growth of colon tumors in mice', 'display_name': '(E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol inhibits growth of colon tumors in mice', 'publication_year': 2015, 'publication_date': '2015-10-14', 'ids': {'openalex': 'https://openalex.org/W1945665742', 'doi': 'https://doi.org/10.18632/oncotarget.5861', 'mag': '1945665742', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26474284', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4747199'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5861', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5861&path%5B%5D=13988', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5861&path%5B%5D=13988', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028470655', 'display_name': 'Jie Zheng', 'orcid': 'https://orcid.org/0000-0002-6446-2250'}, 'institutions': [{'id': 'https://openalex.org/I163753206', 'display_name': 'Chungbuk National University', 'ror': 'https://ror.org/02wnxgj78', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I163753206']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jie Zheng', 'raw_affiliation_strings': ['College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea', 'institution_ids': ['https://openalex.org/I163753206']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069231922', 'display_name': 'Mi Hee Park', 'orcid': 'https://orcid.org/0000-0002-5579-2696'}, 'institutions': [{'id': 'https://openalex.org/I163753206', 'display_name': 'Chungbuk National University', 'ror': 'https://ror.org/02wnxgj78', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I163753206']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Mi Hee Park', 'raw_affiliation_strings': ['College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea', 'institution_ids': ['https://openalex.org/I163753206']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020709597', 'display_name': 'Dong Ju Son', 'orcid': 'https://orcid.org/0000-0001-7520-6909'}, 'institutions': [{'id': 'https://openalex.org/I163753206', 'display_name': 'Chungbuk National University', 'ror': 'https://ror.org/02wnxgj78', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I163753206']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Dong Ju Son', 'raw_affiliation_strings': ['College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea', 'institution_ids': ['https://openalex.org/I163753206']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009876042', 'display_name': 'Min Gi Choi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I163753206', 'display_name': 'Chungbuk National University', 'ror': 'https://ror.org/02wnxgj78', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I163753206']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Min Gi Choi', 'raw_affiliation_strings': ['College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea', 'institution_ids': ['https://openalex.org/I163753206']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006447610', 'display_name': 'Jeong Soon Choi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I163753206', 'display_name': 'Chungbuk National University', 'ror': 'https://ror.org/02wnxgj78', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I163753206']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jeong Soon Choi', 'raw_affiliation_strings': ['College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea', 'institution_ids': ['https://openalex.org/I163753206']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012153489', 'display_name': 'Kyung Tak Nam', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I163753206', 'display_name': 'Chungbuk National University', 'ror': 'https://ror.org/02wnxgj78', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I163753206']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kyung Tak Nam', 'raw_affiliation_strings': ['College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea', 'institution_ids': ['https://openalex.org/I163753206']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059295023', 'display_name': 'Hae Deun Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I163753206', 'display_name': 'Chungbuk National University', 'ror': 'https://ror.org/02wnxgj78', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I163753206']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hae Deun Kim', 'raw_affiliation_strings': ['College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea', 'institution_ids': ['https://openalex.org/I163753206']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060906856', 'display_name': 'Kevin Rodriguez', 'orcid': 'https://orcid.org/0000-0002-5229-4106'}, 'institutions': [{'id': 'https://openalex.org/I197572798', 'display_name': 'Utah Valley University', 'ror': 'https://ror.org/02rxpxc98', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I197572798']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kevin Rodriguez', 'raw_affiliation_strings': ['Department of Chemistry, Utah Valley University, Orem, UT, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Utah Valley University, Orem, UT, USA', 'institution_ids': ['https://openalex.org/I197572798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072688632', 'display_name': 'Benjamin Gann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197572798', 'display_name': 'Utah Valley University', 'ror': 'https://ror.org/02rxpxc98', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I197572798']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Benjamin Gann', 'raw_affiliation_strings': ['Department of Chemistry, Utah Valley University, Orem, UT, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Utah Valley University, Orem, UT, USA', 'institution_ids': ['https://openalex.org/I197572798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027339900', 'display_name': 'Young Wan Ham', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197572798', 'display_name': 'Utah Valley University', 'ror': 'https://ror.org/02rxpxc98', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I197572798']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Young Wan Ham', 'raw_affiliation_strings': ['Department of Chemistry, Utah Valley University, Orem, UT, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Utah Valley University, Orem, UT, USA', 'institution_ids': ['https://openalex.org/I197572798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037204409', 'display_name': 'Sang‐Bae Han', 'orcid': 'https://orcid.org/0000-0001-6656-6523'}, 'institutions': [{'id': 'https://openalex.org/I163753206', 'display_name': 'Chungbuk National University', 'ror': 'https://ror.org/02wnxgj78', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I163753206']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sang Bae Han', 'raw_affiliation_strings': ['College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea', 'institution_ids': ['https://openalex.org/I163753206']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007610160', 'display_name': 'Jin Tae Hong', 'orcid': 'https://orcid.org/0000-0002-6534-9575'}, 'institutions': [{'id': 'https://openalex.org/I163753206', 'display_name': 'Chungbuk National University', 'ror': 'https://ror.org/02wnxgj78', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I163753206']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Jin Tae Hong', 'raw_affiliation_strings': ['College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic of Korea', 'institution_ids': ['https://openalex.org/I163753206']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5007610160'], 'corresponding_institution_ids': ['https://openalex.org/I163753206'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.391, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.612786, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 84}, 'biblio': {'volume': '6', 'issue': '39', 'first_page': '41929', 'last_page': '41943'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12356', 'display_name': 'Role of Quinones in Toxicology and Pharmacology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12356', 'display_name': 'Role of Quinones in Toxicology and Pharmacology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Cyclooxygenase-2 Inhibitors in Inflammation and Cancer', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11385', 'display_name': 'Biological Activities of Triterpenoids and Saponins', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/anticancer-agents', 'display_name': 'Anticancer Agents', 'score': 0.488973}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.77067554}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.57687235}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.5394358}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5033297}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.49641043}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.47264498}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.44387043}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33962077}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26418668}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.21055222}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15659359}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000498', 'descriptor_name': 'Allyl Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010636', 'descriptor_name': 'Phenols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000498', 'descriptor_name': 'Allyl Compounds', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000498', 'descriptor_name': 'Allyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001152', 'descriptor_name': 'Arsenicals', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001152', 'descriptor_name': 'Arsenicals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003499', 'descriptor_name': 'Cyclic S-Oxides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003499', 'descriptor_name': 'Cyclic S-Oxides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045325', 'descriptor_name': 'HCT116 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062105', 'descriptor_name': 'Molecular Docking Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052002', 'descriptor_name': 'NF-kappa B p50 Subunit', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D052002', 'descriptor_name': 'NF-kappa B p50 Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D052002', 'descriptor_name': 'NF-kappa B p50 Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052002', 'descriptor_name': 'NF-kappa B p50 Subunit', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010636', 'descriptor_name': 'Phenols', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010636', 'descriptor_name': 'Phenols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053219', 'descriptor_name': 'Receptors, Tumor Necrosis Factor, Member 25', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053219', 'descriptor_name': 'Receptors, Tumor Necrosis Factor, Member 25', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047368', 'descriptor_name': 'Tumor Burden', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D047368', 'descriptor_name': 'Tumor Burden', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019014', 'descriptor_name': 'fas Receptor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019014', 'descriptor_name': 'fas Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5861', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5861&path%5B%5D=13988', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4747199', 'pdf_url': 'https://europepmc.org/articles/pmc4747199?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747199', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26474284', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5861', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5861&path%5B%5D=13988', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1971284419', 'https://openalex.org/W1973705667', 'https://openalex.org/W1978297711', 'https://openalex.org/W1981118144', 'https://openalex.org/W1994323817', 'https://openalex.org/W1998422493', 'https://openalex.org/W2004349741', 'https://openalex.org/W2006514214', 'https://openalex.org/W2007456673', 'https://openalex.org/W2016869568', 'https://openalex.org/W2018324712', 'https://openalex.org/W2022897778', 'https://openalex.org/W2024282024', 'https://openalex.org/W2038890616', 'https://openalex.org/W2042905349', 'https://openalex.org/W2053932848', 'https://openalex.org/W2054078002', 'https://openalex.org/W2065349428', 'https://openalex.org/W2065676042', 'https://openalex.org/W2079680569', 'https://openalex.org/W2081107312', 'https://openalex.org/W2082736271', 'https://openalex.org/W2083802827', 'https://openalex.org/W2088645803', 'https://openalex.org/W2102912734', 'https://openalex.org/W2105971712', 'https://openalex.org/W2124076790', 'https://openalex.org/W2126767360', 'https://openalex.org/W2134064455', 'https://openalex.org/W2134967712', 'https://openalex.org/W2137113418', 'https://openalex.org/W2137648328', 'https://openalex.org/W2138640102', 'https://openalex.org/W2140770071', 'https://openalex.org/W2140963203', 'https://openalex.org/W2148719225', 'https://openalex.org/W2152585148', 'https://openalex.org/W2161070956', 'https://openalex.org/W2161817637', 'https://openalex.org/W2183890269', 'https://openalex.org/W2315613727', 'https://openalex.org/W2404515494', 'https://openalex.org/W284554531', 'https://openalex.org/W4238843411', 'https://openalex.org/W4297820769', 'https://openalex.org/W89255747'], 'related_works': ['https://openalex.org/W4390709402', 'https://openalex.org/W3148810057', 'https://openalex.org/W303802408', 'https://openalex.org/W2418264232', 'https://openalex.org/W2350538445', 'https://openalex.org/W2345263070', 'https://openalex.org/W2157355069', 'https://openalex.org/W2021792849', 'https://openalex.org/W2017920131', 'https://openalex.org/W1968701816'], 'abstract_inverted_index': {'//': [0, 99, 104], 'Jie': [1], 'Zheng': [2], '1,*': [3, 8], ',': [4, 9, 14, 19, 24, 29, 34, 38, 42, 47], 'Mi': [5], 'Hee': [6], 'Park': [7], 'Dong': [10], 'Ju': [11], 'Son': [12], '1': [13, 18, 23, 28, 33, 51, 56, 57], 'Min': [15], 'Gi': [16], 'Choi': [17, 22], 'Jeong': [20], 'Soon': [21], 'Kyung': [25], 'Tak': [26], 'Nam': [27], 'Hae': [30], 'Deun': [31], 'Kim': [32], 'Kevin': [35], 'Rodriguez': [36], '2': [37, 41, 46, 74], 'Benjamin': [39], 'Gann': [40], 'Young': [43], 'Wan': [44], 'Ham': [45], 'Sang': [48, 100], 'Bae': [49, 101], 'Han': [50], 'and': [52, 61, 147, 179, 188, 214, 221, 233, 246, 261, 276, 309, 324, 334], 'Jin': [53, 95], 'Tae': [54, 96], 'Hong': [55], 'College': [58], 'of': [59, 72, 76, 145, 168, 182, 212, 248, 259, 273, 280, 307], 'Pharmacy': [60], 'Medical': [62], 'Research': [63], 'Center,': [64], 'Chungbuk': [65], 'National': [66], 'University,': [67, 80], 'Heungduk-gu,': [68], 'Cheongju,': [69], 'Chungbuk,': [70], 'Republic': [71], 'Korea': [73], 'Department': [75], 'Chemistry,': [77], 'Utah': [78], 'Valley': [79], 'Orem,': [81], 'UT,': [82], 'USA': [83], '*': [84], 'These': [85], 'authors': [86], 'have': [87, 151], 'contributed': [88], 'equally': [89], 'to': [90, 332], 'this': [91, 193], 'work': [92], 'Correspondence': [93], 'to:': [94], 'Hong,': [97], 'email:': [98, 103], 'Han,': [102], 'Keywords': [105], ':': [106, 115, 120, 125], 'colon': [107, 169, 223, 300, 341, 367], 'cancer,': [108], 'apoptosis,': [109], 'STAT3,': [110], 'NF-κB,': [111], 'death': [112, 202, 215], 'receptor': [113, 216], 'Received': [114], 'June': [116], '08,': [117], '2015': [118, 123, 128], 'Accepted': [119], 'August': [121], '31,': [122], 'Published': [124], 'October': [126], '14,': [127], 'Abstract': [129], 'In': [130, 192, 265], 'our': [131], 'previous': [132], 'study,': [133, 194], 'we': [134, 174, 195], 'found': [135, 196], 'that': [136, 197, 328, 358], '(E)-2,4-bis(p-hydroxyphenyl)-2-butenal': [137, 154], 'showed': [138, 143, 164, 327], 'anti-cancer': [139, 177, 364], 'effect,': [140], 'but': [141], 'it': [142], 'lack': [144], 'stability': [146], 'drug': [148], 'likeness.': [149], 'We': [150, 159], 'prepared': [152], 'several': [153], 'analogues': [155], 'by': [156, 286], 'Heck': [157], 'reaction.': [158], 'selected': [160], 'two': [161], 'compounds': [162], 'which': [163], 'significant': [165], 'inhibitory': [166, 297], 'effect': [167, 298], 'cancer': [170, 224, 301, 368], 'cell': [171, 201, 225, 302], 'growth.': [172, 303], 'Thus,': [173], 'evaluated': [175], 'the': [176, 228, 257, 269, 305], 'effects': [178], 'possible': [180], 'mechanisms': [181], 'one': [183], 'compound': [184], '(E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol': [185, 198, 232, 267, 329, 339, 359], 'in': [186, 189, 203, 219, 313, 344, 352], 'vitro': [187], 'vivo': [190], '.': [191], 'induced': [199], 'apoptotic': [200], 'a': [204, 345, 362], 'dose': [205, 346], 'dependent': [206, 347], 'manner': [207, 348], '(0-15': [208], 'μg/ml)': [209], 'through': [210], 'activation': [211], 'Fas': [213, 260, 308], '(DR)': [217], '3': [218, 250], 'HCT116': [220], 'SW480': [222], 'lines.': [226], 'Moreover,': [227, 321], 'combination': [229], 'treatment': [230], 'with': [231, 369], 'nuclear': [234], 'factor': [235], 'κB': [236], '(NF-κB)': [237], 'inhibitor,': [238, 252], 'phenylarsine': [239], 'oxide': [240], '(0.1': [241], 'μM)': [242, 255], 'or': [243, 282, 292, 316], 'signal': [244], 'transducer': [245], 'activator': [247], 'transcription': [249], '(STAT3)': [251], 'Stattic': [253], '(50': [254], 'increased': [256, 312], 'expression': [258, 306], 'DR3': [262, 310], 'more': [263, 370], 'significantly.': [264], 'addition,': [266], 'suppressed': [268], 'DNA': [270], 'binding': [271], 'activity': [272], 'both': [274], 'STAT3': [275, 281, 287, 314, 333], 'NF-κB.': [277], 'Knock': [278], 'down': [279], 'NF-κB': [283, 335], 'p50': [284, 293, 317, 336], 'subunit': [285], 'small': [288], 'interfering': [289], 'RNA': [290], '(siRNA)': [291], 'siRNA': [294, 315, 318], 'magnified': [295], '(E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol-induced': [296], 'on': [299], 'Besides,': [304], 'was': [311], 'transfected': [319], 'cells.': [320], 'docking': [322], 'model': [323], 'pull-down': [325], 'assay': [326], 'directly': [330], 'bound': [331], 'subunit.': [337], 'Furthermore,': [338], 'inhibited': [340], 'tumor': [342], 'growth': [343], '(2.5': [349], 'mg/kg-5': [350], 'mg/kg)': [351], 'mice.': [353], 'Therefore,': [354], 'these': [355], 'findings': [356], 'indicated': [357], 'may': [360], 'be': [361], 'promising': [363], 'agent': [365], 'for': [366], 'advanced': [371], 'research.': [372]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1945665742', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-20T01:28:34.227952', 'created_date': '2016-06-24'}