Title: Positional Correlations in Splicing Patterns-Its Application to Prediction of Splice Sites
Abstract: The recognition of splicing patterns is an important step in the initial stage of pre-mRNA splicing process. In accordance with the type of splice site, there are two types of splicing patterns, i.e., donor and acceptor patterns. The donor and acceptor patterns are a sequence of 12 bps (upstream 4 bps and downstream 8 bps) and a sequence of 31 bps (upstream 28 bps and downstream 3 bps), respectively. In a previous study [4], it was found that there are correlations among some positions in donor patterns. In this study, we analyze the positional correlations in the splicing patterns of human genes from the viewpoint of “the relative change of information contents (RC)” and propose a new model to describe the correlations. Moreover, a splice site prediction is performed based on the correlations and compared with other methods.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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