Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1940692058', 'doi': None, 'title': 'Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate.', 'display_name': 'Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate.', 'publication_year': 1988, 'publication_date': '1988-11-01', 'ids': {'openalex': 'https://openalex.org/W1940692058', 'mag': '1940692058', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3139287'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3139287', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113638716', 'display_name': 'Mou‐Tuan Huang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M T Huang', 'raw_affiliation_strings': ['Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers, State University of New Jersey, Piscataway 08855-0789.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers, State University of New Jersey, Piscataway 08855-0789.', 'institution_ids': ['https://openalex.org/I102322142']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087238768', 'display_name': 'Robert C. Smart', 'orcid': 'https://orcid.org/0000-0002-6767-6756'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R C Smart', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042065563', 'display_name': 'Ching-Quo Wong', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C Q Wong', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010768963', 'display_name': 'Allan H. Conney', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A H Conney', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.538, 'has_fulltext': False, 'cited_by_count': 735, 'citation_normalized_percentile': {'value': 0.989657, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '48', 'issue': '21', 'first_page': '5941', 'last_page': '6'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11924', 'display_name': 'Polyamine Metabolism and Applications', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11924', 'display_name': 'Polyamine Metabolism and Applications', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11332', 'display_name': 'Genomics, phytochemicals, and oxidative stress', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11319', 'display_name': "Curcumin's Biomedical Applications", 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chlorogenic-acid', 'display_name': 'Chlorogenic Acid', 'score': 0.8313876}, {'id': 'https://openalex.org/keywords/12-o-tetradecanoylphorbol-13-acetate', 'display_name': '12-O-Tetradecanoylphorbol-13-acetate', 'score': 0.64732677}, {'id': 'https://openalex.org/keywords/tumor-promotion', 'display_name': 'Tumor promotion', 'score': 0.6158724}], 'concepts': [{'id': 'https://openalex.org/C2778224086', 'wikidata': 'https://www.wikidata.org/wiki/Q414116', 'display_name': 'Caffeic acid', 'level': 3, 'score': 0.9075452}, {'id': 'https://openalex.org/C2780117898', 'wikidata': 'https://www.wikidata.org/wiki/Q421964', 'display_name': 'Chlorogenic acid', 'level': 2, 'score': 0.8313876}, {'id': 'https://openalex.org/C121289238', 'wikidata': 'https://www.wikidata.org/wiki/Q931579', 'display_name': 'Ornithine decarboxylase', 'level': 3, 'score': 0.81439817}, {'id': 'https://openalex.org/C2780213334', 'wikidata': 'https://www.wikidata.org/wiki/Q417362', 'display_name': 'Ferulic acid', 'level': 2, 'score': 0.7661346}, {'id': 'https://openalex.org/C2778250585', 'wikidata': 'https://www.wikidata.org/wiki/Q312266', 'display_name': 'Curcumin', 'level': 2, 'score': 0.766049}, {'id': 'https://openalex.org/C2777168633', 'wikidata': 'https://www.wikidata.org/wiki/Q416716', 'display_name': '12-O-Tetradecanoylphorbol-13-acetate', 'level': 5, 'score': 0.64732677}, {'id': 'https://openalex.org/C2780122803', 'wikidata': 'https://www.wikidata.org/wiki/Q7852681', 'display_name': 'Tumor promotion', 'level': 4, 'score': 0.6158724}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.60024947}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.53979665}, {'id': 'https://openalex.org/C2777497464', 'wikidata': 'https://www.wikidata.org/wiki/Q418834', 'display_name': 'Spermidine', 'level': 3, 'score': 0.4721539}, {'id': 'https://openalex.org/C2778362808', 'wikidata': 'https://www.wikidata.org/wiki/Q375837', 'display_name': 'Gallic acid', 'level': 3, 'score': 0.41333354}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.390758}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20495397}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.20464069}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.17598364}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.089116514}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.073761284}, {'id': 'https://openalex.org/C3017695315', 'wikidata': 'https://www.wikidata.org/wiki/Q37713691', 'display_name': 'Phorbol ester', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002109', 'descriptor_name': 'Caffeic Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002396', 'descriptor_name': 'Catechols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002726', 'descriptor_name': 'Chlorogenic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002934', 'descriptor_name': 'Cinnamates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003373', 'descriptor_name': 'Coumaric Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D015127', 'descriptor_name': '9,10-Dimethyl-1,2-benzanthracene', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001095', 'descriptor_name': 'Arachidonic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001095', 'descriptor_name': 'Arachidonic Acids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002109', 'descriptor_name': 'Caffeic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002396', 'descriptor_name': 'Catechols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002726', 'descriptor_name': 'Chlorogenic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002934', 'descriptor_name': 'Cinnamates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003373', 'descriptor_name': 'Coumaric Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D004487', 'descriptor_name': 'Edema', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004487', 'descriptor_name': 'Edema', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009955', 'descriptor_name': 'Ornithine Decarboxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009955', 'descriptor_name': 'Ornithine Decarboxylase', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3139287', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.6, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W132956966', 'https://openalex.org/W1483821950', 'https://openalex.org/W1526424654', 'https://openalex.org/W1563668204', 'https://openalex.org/W1969265519', 'https://openalex.org/W1970441944', 'https://openalex.org/W1973830862', 'https://openalex.org/W1978472337', 'https://openalex.org/W1984373476', 'https://openalex.org/W1986735216', 'https://openalex.org/W1988497727', 'https://openalex.org/W1993523815', 'https://openalex.org/W1993580791', 'https://openalex.org/W1998789277', 'https://openalex.org/W1999811430', 'https://openalex.org/W2004576295', 'https://openalex.org/W2006136207', 'https://openalex.org/W2008652381', 'https://openalex.org/W2021002396', 'https://openalex.org/W2021085921', 'https://openalex.org/W2023150880', 'https://openalex.org/W2023540150', 'https://openalex.org/W2027799502', 'https://openalex.org/W2043486125', 'https://openalex.org/W2047069988', 'https://openalex.org/W2063233877', 'https://openalex.org/W2075238780', 'https://openalex.org/W2079908353', 'https://openalex.org/W2080745163', 'https://openalex.org/W2082084880', 'https://openalex.org/W2086605115', 'https://openalex.org/W2086790670', 'https://openalex.org/W2088039859', 'https://openalex.org/W2093344987', 'https://openalex.org/W2100614587', 'https://openalex.org/W2123324044', 'https://openalex.org/W2128690353', 'https://openalex.org/W2141180018', 'https://openalex.org/W2277196563', 'https://openalex.org/W227923971', 'https://openalex.org/W2397373187', 'https://openalex.org/W2414413802', 'https://openalex.org/W2426661946', 'https://openalex.org/W309402855'], 'related_works': ['https://openalex.org/W4225139588', 'https://openalex.org/W3025670507', 'https://openalex.org/W296673108', 'https://openalex.org/W2756226447', 'https://openalex.org/W2184874448', 'https://openalex.org/W2058577077', 'https://openalex.org/W2056944100', 'https://openalex.org/W1940692058', 'https://openalex.org/W1567806963', 'https://openalex.org/W1029716245'], 'abstract_inverted_index': {'The': [0, 104, 259, 285], 'effects': [1], 'of': [2, 26, 37, 44, 56, 64, 73, 76, 95, 102, 107, 110, 118, 124, 127, 140, 161, 165, 170, 176, 182, 198, 211, 216, 228, 233, 247, 256, 267, 276, 282, 288, 293, 300, 303], 'topically': [3], 'applied': [4], 'curcumin,': [5, 77], 'chlorogenic': [6, 78, 217], 'acid,': [7, 9, 79, 81, 148, 150, 218, 220], 'caffeic': [8, 80, 149, 219], 'and': [10, 23, 151, 244], 'ferulic': [11, 83, 152, 222], 'acid': [12, 84, 153, 223, 269, 305], 'on': [13, 278], '12-O-tetradecanoylphorbol-13-acetate': [14], '(TPA)-induced': [15], 'epidermal': [16, 20, 57, 130], 'ornithine': [17, 58, 96], 'decarboxylase': [18, 59, 97], 'activity,': [19], 'DNA': [21, 131, 166], 'synthesis,': [22], 'the': [24, 54, 70, 93, 121, 125, 162, 196, 231, 248, 265, 274, 298], 'promotion': [25], 'skin': [27], 'tumors': [28, 200, 235], 'were': [29, 154], 'evaluated': [30, 271], 'in': [31], 'female': [32], 'CD-1': [33], 'mice.': [34], 'Topical': [35, 168], 'application': [36, 72, 106, 169, 287, 299], '0.5,': [38], '1,': [39, 171], '3,': [40, 172], 'or': [41, 51, 82, 90, 115, 134, 144, 173, 206, 221, 241, 290, 312], '10': [42, 74, 108, 174, 214, 291], 'mumol': [43, 75, 109, 175, 215, 292, 302], 'curcumin': [45, 111, 141, 158, 177, 262, 277, 294], 'inhibited': [46, 85, 120, 195, 230, 306], 'by': [47, 61, 86, 99, 132, 203, 238, 272, 310], '31,': [48], '46,': [49], '84,': [50], '98%,': [52, 207], 'respectively,': [53, 92, 136, 243], 'induction': [55, 94], 'activity': [60, 98], '5': [62, 100, 116, 180, 226], 'nmol': [63, 101, 117, 181, 227], 'TPA.': [65, 103], 'In': [66], 'an': [67], 'additional': [68], 'study,': [69], 'topical': [71, 105, 286], '91,': [87], '25,': [88], '42,': [89], '46%,': [91], 'together': [112, 178, 224], 'with': [113, 179, 193, 213, 225], '2': [114], 'TPA': [119, 183, 229], 'TPA-dependent': [122, 163], 'stimulation': [123, 164], 'incorporation': [126], '[3H]-thymidine': [128], 'into': [129], '49': [133], '29%,': [135], 'whereas': [137], 'lower': [138], 'doses': [139, 246], 'had': [142], 'little': [143], 'no': [145], 'effect.': [146], 'Chlorogenic': [147], 'less': [155], 'effective': [156], 'than': [157], 'as': [159], 'inhibitors': [160], 'synthesis.': [167], 'twice': [184], 'weekly': [185], 'for': [186], '20': [187], 'weeks': [188], 'to': [189], 'mice': [190, 212], 'previously': [191], 'initiated': [192], '7,12-dimethylbenz[a]anthracene': [194], 'number': [197, 232], 'TPA-induced': [199, 234], 'per': [201, 236], 'mouse': [202, 237, 283], '39,': [204], '77,': [205], 'respectively.': [208, 314], 'Similar': [209], 'treatment': [210], '60,': [239], '28,': [240], '35%,': [242], 'higher': [245], 'phenolic': [249], 'acids': [250], 'caused': [251], 'a': [252], 'more': [253], 'pronounced': [254], 'inhibition': [255], 'tumor': [257], 'promotion.': [258], 'possibility': [260], 'that': [261], 'could': [263], 'inhibit': [264], 'action': [266], 'arachidonic': [268, 279, 304, 307], 'was': [270], 'studying': [273], 'effect': [275], 'acid-induced': [280, 308], 'edema': [281, 309], 'ears.': [284], '3': [289], '30': [295], 'min': [296], 'before': [297], '1': [301], '33': [311], '80%,': [313]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1940692058', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 34}, {'year': 2016, 'cited_by_count': 28}, {'year': 2015, 'cited_by_count': 25}, {'year': 2014, 'cited_by_count': 29}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 28}], 'updated_date': '2024-12-14T08:38:47.222592', 'created_date': '2016-06-24'}