Title: Patterning the Zebrafish Central Nervous System
Abstract: One of the hallmarks of the vertebrate nervous system is the enormous diversity of neurons of which it is composed. The ability of an animal to carry out its normal behavioral repertoire requires that all of these neurons develop in the appropriate numbers and at the appropriate times and positions and that they elaborate the appropriate differentiated characteristics. This process begins with patterning of the nascent nervous system, the neural plate, along the dorsoventral (DV) and anteroposterior (AP) axes of the body. In this chapter we consider what is currently known about the mechanisms involved in patterning the zebrafish neural plate. Although we discuss many of the similarities and differences between zebrafish and other vertebrates, we limit our primary focus to zebrafish, as including an exhaustive description of neural patterning in other model vertebrates would exceed the space limitations of this chapter. We apologize for any work we have overlooked and for discussion of work on other model vertebrates we direct the reader to several excellent reviews (Goulding and Lamar 2000; Jessel1 2000; Patten and Placzek 2000; Wilson and Rubenstein 2000; Altmann and Brivanlou 2001; Briscoe and Ericson 2001).
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 63
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