Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1932904334', 'doi': 'https://doi.org/10.1146/annurev.physiol.64.081501.155847', 'title': 'Human and Murine Phenotypes Associated with Defects in Cation-Chloride Cotransport', 'display_name': 'Human and Murine Phenotypes Associated with Defects in Cation-Chloride Cotransport', 'publication_year': 2002, 'publication_date': '2002-03-01', 'ids': {'openalex': 'https://openalex.org/W1932904334', 'doi': 'https://doi.org/10.1146/annurev.physiol.64.081501.155847', 'mag': '1932904334', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11826289'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev.physiol.64.081501.155847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196366644', 'display_name': 'Annual Review of Physiology', 'issn_l': '0066-4278', 'issn': ['0066-4278', '1545-1585'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088649225', 'display_name': 'Eric Delpire', 'orcid': 'https://orcid.org/0000-0002-3702-1599'}, 'institutions': [{'id': 'https://openalex.org/I4210103776', 'display_name': 'Nashville VA Medical Center', 'ror': 'https://ror.org/024xyyq03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210101790', 'https://openalex.org/I4210103776', 'https://openalex.org/I4210112672']}, {'id': 'https://openalex.org/I901861585', 'display_name': 'Vanderbilt University Medical Center', 'ror': 'https://ror.org/05dq2gs74', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210162197', 'https://openalex.org/I901861585']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric Delpire', 'raw_affiliation_strings': ['Center for Molecular Neuroscience; Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'Department of Medicine, Division of Nephrology, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'Departments of Anesthesiology, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'Molecular Physiology and Biophysics, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Neuroscience; Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'institution_ids': ['https://openalex.org/I4210103776', 'https://openalex.org/I901861585']}, {'raw_affiliation_string': 'Molecular Physiology and Biophysics, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'institution_ids': ['https://openalex.org/I4210103776', 'https://openalex.org/I901861585']}, {'raw_affiliation_string': 'Department of Medicine, Division of Nephrology, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'institution_ids': ['https://openalex.org/I4210103776', 'https://openalex.org/I901861585']}, {'raw_affiliation_string': 'Departments of Anesthesiology, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'institution_ids': ['https://openalex.org/I4210103776', 'https://openalex.org/I901861585']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074145664', 'display_name': 'David B. Mount', 'orcid': 'https://orcid.org/0000-0003-0310-2304'}, 'institutions': [{'id': 'https://openalex.org/I4210103776', 'display_name': 'Nashville VA Medical Center', 'ror': 'https://ror.org/024xyyq03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210101790', 'https://openalex.org/I4210103776', 'https://openalex.org/I4210112672']}, {'id': 'https://openalex.org/I901861585', 'display_name': 'Vanderbilt University Medical Center', 'ror': 'https://ror.org/05dq2gs74', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210162197', 'https://openalex.org/I901861585']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David B. Mount', 'raw_affiliation_strings': ['Center for Molecular Neuroscience; Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'Department of Medicine, Division of Nephrology, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'Departments of Anesthesiology, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'Molecular Physiology and Biophysics, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;'], 'affiliations': [{'raw_affiliation_string': 'Departments of Anesthesiology, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'institution_ids': ['https://openalex.org/I4210103776', 'https://openalex.org/I901861585']}, {'raw_affiliation_string': 'Molecular Physiology and Biophysics, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'institution_ids': ['https://openalex.org/I4210103776', 'https://openalex.org/I901861585']}, {'raw_affiliation_string': 'Center for Molecular Neuroscience; Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'institution_ids': ['https://openalex.org/I4210103776', 'https://openalex.org/I901861585']}, {'raw_affiliation_string': 'Department of Medicine, Division of Nephrology, Nashville VA Medical Center and Vanderbilt University Medical Center, Nashville, Tennessee 37232;', 'institution_ids': ['https://openalex.org/I4210103776', 'https://openalex.org/I901861585']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.598, 'has_fulltext': False, 'cited_by_count': 219, 'citation_normalized_percentile': {'value': 0.999631, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '64', 'issue': '1', 'first_page': '803', 'last_page': '843'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11204', 'display_name': 'Ion Channels and Receptors', 'score': 0.986, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/distal-convoluted-tubule', 'display_name': 'Distal convoluted tubule', 'score': 0.70361906}, {'id': 'https://openalex.org/keywords/solute-carrier-family', 'display_name': 'Solute carrier family', 'score': 0.5885067}, {'id': 'https://openalex.org/keywords/bartter-syndrome', 'display_name': 'Bartter syndrome', 'score': 0.48519352}, {'id': 'https://openalex.org/keywords/bumetanide', 'display_name': 'Bumetanide', 'score': 0.47741258}], 'concepts': [{'id': 'https://openalex.org/C188053792', 'wikidata': 'https://www.wikidata.org/wiki/Q3640664', 'display_name': 'Cotransporter', 'level': 3, 'score': 0.967543}, {'id': 'https://openalex.org/C2776777027', 'wikidata': 'https://www.wikidata.org/wiki/Q2914731', 'display_name': 'Distal convoluted tubule', 'level': 4, 'score': 0.70361906}, {'id': 'https://openalex.org/C168785527', 'wikidata': 'https://www.wikidata.org/wiki/Q1401099', 'display_name': 'Solute carrier family', 'level': 4, 'score': 0.5885067}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.55076194}, {'id': 'https://openalex.org/C2777616141', 'wikidata': 'https://www.wikidata.org/wiki/Q790971', 'display_name': 'Bartter syndrome', 'level': 3, 'score': 0.48519352}, {'id': 'https://openalex.org/C2778212192', 'wikidata': 'https://www.wikidata.org/wiki/Q275926', 'display_name': 'Bumetanide', 'level': 4, 'score': 0.47741258}, {'id': 'https://openalex.org/C120405084', 'wikidata': 'https://www.wikidata.org/wiki/Q285307', 'display_name': 'Symporter', 'level': 4, 'score': 0.46736667}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.41067368}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39843503}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38011384}, {'id': 'https://openalex.org/C56906281', 'wikidata': 'https://www.wikidata.org/wiki/Q4391435', 'display_name': 'Reabsorption', 'level': 3, 'score': 0.3548231}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35394812}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3497895}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3303037}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.28827825}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.15625018}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.122571915}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.08497509}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2778242168', 'wikidata': 'https://www.wikidata.org/wiki/Q794086', 'display_name': 'Hypokalemia', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D028021', 'descriptor_name': 'Sodium-Potassium-Chloride Symporters', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D028021', 'descriptor_name': 'Sodium-Potassium-Chloride Symporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001477', 'descriptor_name': 'Bartter Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001477', 'descriptor_name': 'Bartter Syndrome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001477', 'descriptor_name': 'Bartter Syndrome', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000096922', 'descriptor_name': 'K Cl- Cotransporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009422', 'descriptor_name': 'Nervous System Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009422', 'descriptor_name': 'Nervous System Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009422', 'descriptor_name': 'Nervous System Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049992', 'descriptor_name': 'Sodium Chloride Symporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028021', 'descriptor_name': 'Sodium-Potassium-Chloride Symporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev.physiol.64.081501.155847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196366644', 'display_name': 'Annual Review of Physiology', 'issn_l': '0066-4278', 'issn': ['0066-4278', '1545-1585'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11826289', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.54, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 233, 'referenced_works': ['https://openalex.org/W1499118957', 'https://openalex.org/W1507537143', 'https://openalex.org/W1521708710', 'https://openalex.org/W1534158089', 'https://openalex.org/W1546941284', 'https://openalex.org/W1559729412', 'https://openalex.org/W1563576581', 'https://openalex.org/W1567934730', 'https://openalex.org/W1580090335', 'https://openalex.org/W1585150602', 'https://openalex.org/W1588629441', 'https://openalex.org/W1589412808', 'https://openalex.org/W1592372503', 'https://openalex.org/W1596884260', 'https://openalex.org/W165429568', 'https://openalex.org/W1691998622', 'https://openalex.org/W1705218924', 'https://openalex.org/W1757204763', 'https://openalex.org/W1854895726', 'https://openalex.org/W1856380311', 'https://openalex.org/W1889684242', 'https://openalex.org/W1893611275', 'https://openalex.org/W1903117841', 'https://openalex.org/W1914869039', 'https://openalex.org/W1921602963', 'https://openalex.org/W1925649505', 'https://openalex.org/W192600439', 'https://openalex.org/W1930369674', 'https://openalex.org/W1938250799', 'https://openalex.org/W1957270349', 'https://openalex.org/W1962126956', 'https://openalex.org/W1964071799', 'https://openalex.org/W1964485689', 'https://openalex.org/W1965273192', 'https://openalex.org/W1966799178', 'https://openalex.org/W1969503127', 'https://openalex.org/W1969679239', 'https://openalex.org/W1971931358', 'https://openalex.org/W1972417122', 'https://openalex.org/W1972988611', 'https://openalex.org/W1973873939', 'https://openalex.org/W1977475418', 'https://openalex.org/W1979717718', 'https://openalex.org/W1980345371', 'https://openalex.org/W1980425497', 'https://openalex.org/W1983067137', 'https://openalex.org/W1983220103', 'https://openalex.org/W1983284668', 'https://openalex.org/W1983469458', 'https://openalex.org/W1985300178', 'https://openalex.org/W1985793100', 'https://openalex.org/W1986400814', 'https://openalex.org/W1988331277', 'https://openalex.org/W1989335464', 'https://openalex.org/W1990690213', 'https://openalex.org/W1990913409', 'https://openalex.org/W1993652234', 'https://openalex.org/W1993818398', 'https://openalex.org/W1995826486', 'https://openalex.org/W1995865634', 'https://openalex.org/W1996631946', 'https://openalex.org/W1996803267', 'https://openalex.org/W1996969679', 'https://openalex.org/W1996986731', 'https://openalex.org/W1997610195', 'https://openalex.org/W1998453182', 'https://openalex.org/W2000053828', 'https://openalex.org/W2000437112', 'https://openalex.org/W2001331690', 'https://openalex.org/W2003154897', 'https://openalex.org/W2003269536', 'https://openalex.org/W2004943605', 'https://openalex.org/W2006276593', 'https://openalex.org/W2006402903', 'https://openalex.org/W2007854066', 'https://openalex.org/W2008533018', 'https://openalex.org/W2011404836', 'https://openalex.org/W2012329129', 'https://openalex.org/W2013993451', 'https://openalex.org/W2014232729', 'https://openalex.org/W2015782074', 'https://openalex.org/W2019120014', 'https://openalex.org/W2019909157', 'https://openalex.org/W2021339638', 'https://openalex.org/W2021564100', 'https://openalex.org/W2022493904', 'https://openalex.org/W2022585333', 'https://openalex.org/W2023461134', 'https://openalex.org/W2023836847', 'https://openalex.org/W2023909857', 'https://openalex.org/W2024171202', 'https://openalex.org/W2024654563', 'https://openalex.org/W2026252777', 'https://openalex.org/W2027447434', 'https://openalex.org/W2027574921', 'https://openalex.org/W2028414806', 'https://openalex.org/W2030824596', 'https://openalex.org/W2033595361', 'https://openalex.org/W2035798516', 'https://openalex.org/W2036475318', 'https://openalex.org/W2038055445', 'https://openalex.org/W2038836296', 'https://openalex.org/W2039981172', 'https://openalex.org/W2042015732', 'https://openalex.org/W2042907302', 'https://openalex.org/W2043815378', 'https://openalex.org/W2044313153', 'https://openalex.org/W2045464295', 'https://openalex.org/W2045816070', 'https://openalex.org/W2046436667', 'https://openalex.org/W2046839160', 'https://openalex.org/W2047640546', 'https://openalex.org/W2047872096', 'https://openalex.org/W2049506864', 'https://openalex.org/W2049824487', 'https://openalex.org/W2052056209', 'https://openalex.org/W2052103988', 'https://openalex.org/W2052348332', 'https://openalex.org/W2052724934', 'https://openalex.org/W2053229854', 'https://openalex.org/W2055041944', 'https://openalex.org/W2055625933', 'https://openalex.org/W2056426987', 'https://openalex.org/W2058633925', 'https://openalex.org/W2059116113', 'https://openalex.org/W2059803012', 'https://openalex.org/W2064946020', 'https://openalex.org/W2065010622', 'https://openalex.org/W2066031126', 'https://openalex.org/W2066551294', 'https://openalex.org/W2069487926', 'https://openalex.org/W2070669658', 'https://openalex.org/W2071702312', 'https://openalex.org/W2073627392', 'https://openalex.org/W2073881942', 'https://openalex.org/W2076744665', 'https://openalex.org/W2079130054', 'https://openalex.org/W2079433948', 'https://openalex.org/W2080950035', 'https://openalex.org/W2081886348', 'https://openalex.org/W2083818654', 'https://openalex.org/W2084629278', 'https://openalex.org/W2084712021', 'https://openalex.org/W2085542086', 'https://openalex.org/W2088228189', 'https://openalex.org/W2089641235', 'https://openalex.org/W2090362914', 'https://openalex.org/W2090754553', 'https://openalex.org/W2091106745', 'https://openalex.org/W2092177657', 'https://openalex.org/W2093164617', 'https://openalex.org/W2094131991', 'https://openalex.org/W2096696183', 'https://openalex.org/W2099218390', 'https://openalex.org/W2101439149', 'https://openalex.org/W2102329408', 'https://openalex.org/W2113500592', 'https://openalex.org/W2113550436', 'https://openalex.org/W2117194128', 'https://openalex.org/W2118048861', 'https://openalex.org/W2118298733', 'https://openalex.org/W2121091466', 'https://openalex.org/W2123449311', 'https://openalex.org/W2126561023', 'https://openalex.org/W2126578880', 'https://openalex.org/W2128429545', 'https://openalex.org/W2128556903', 'https://openalex.org/W2128705422', 'https://openalex.org/W2130493951', 'https://openalex.org/W2131472638', 'https://openalex.org/W2133316521', 'https://openalex.org/W2133332709', 'https://openalex.org/W2134263027', 'https://openalex.org/W2143906670', 'https://openalex.org/W2145479235', 'https://openalex.org/W2149085480', 'https://openalex.org/W2151206192', 'https://openalex.org/W2154711050', 'https://openalex.org/W2156223714', 'https://openalex.org/W2157375458', 'https://openalex.org/W2158738489', 'https://openalex.org/W2160446373', 'https://openalex.org/W2171419480', 'https://openalex.org/W2176632303', 'https://openalex.org/W2182325886', 'https://openalex.org/W2184793333', 'https://openalex.org/W2185791982', 'https://openalex.org/W2188196872', 'https://openalex.org/W2210295583', 'https://openalex.org/W2223020656', 'https://openalex.org/W2230118829', 'https://openalex.org/W2236847225', 'https://openalex.org/W2240145697', 'https://openalex.org/W2243281268', 'https://openalex.org/W2249390418', 'https://openalex.org/W2255152718', 'https://openalex.org/W2256885068', 'https://openalex.org/W2257214194', 'https://openalex.org/W2263637300', 'https://openalex.org/W2265630203', 'https://openalex.org/W2267979056', 'https://openalex.org/W2275095892', 'https://openalex.org/W2287412339', 'https://openalex.org/W2287827025', 'https://openalex.org/W2303146437', 'https://openalex.org/W2305383475', 'https://openalex.org/W2312795520', 'https://openalex.org/W2327123852', 'https://openalex.org/W2336072428', 'https://openalex.org/W2336549233', 'https://openalex.org/W2338898030', 'https://openalex.org/W2404294586', 'https://openalex.org/W2404366936', 'https://openalex.org/W2409939180', 'https://openalex.org/W2412342807', 'https://openalex.org/W2412470031', 'https://openalex.org/W2413712718', 'https://openalex.org/W2414467915', 'https://openalex.org/W2417395629', 'https://openalex.org/W2418002802', 'https://openalex.org/W2430502463', 'https://openalex.org/W2435285487', 'https://openalex.org/W278313891', 'https://openalex.org/W4210981986', 'https://openalex.org/W4247458718', 'https://openalex.org/W4248035914', 'https://openalex.org/W4248282367', 'https://openalex.org/W4250481068', 'https://openalex.org/W4252346311', 'https://openalex.org/W4388311404', 'https://openalex.org/W54549707', 'https://openalex.org/W82418673', 'https://openalex.org/W90751401'], 'related_works': ['https://openalex.org/W4210371619', 'https://openalex.org/W3092153183', 'https://openalex.org/W2127361245', 'https://openalex.org/W2113788831', 'https://openalex.org/W2040760766', 'https://openalex.org/W2016528283', 'https://openalex.org/W1998325624', 'https://openalex.org/W1880094279', 'https://openalex.org/W1600374408', 'https://openalex.org/W136570053'], 'abstract_inverted_index': {'▪': [0], 'Abstract': [1], 'The': [2, 38, 59, 82, 139], 'diuretic-sensitive': [3], 'cotransport': [4], 'of': [5, 22, 35, 45, 53, 79, 141, 149, 164, 167, 187, 193, 211, 221, 238, 253], 'cations': [6], 'with': [7, 97, 143, 201, 227], 'chloride': [8], 'is': [9], 'mediated': [10], 'by': [11], 'the': [12, 102, 122, 159, 168, 174, 185, 194, 208, 219, 239, 254], 'cation-chloride': [13, 39, 112, 151, 231], 'cotransporters,': [14, 28], 'a': [15, 20, 42, 202], 'large': [16], 'gene': [17, 169], 'family': [18], 'encompassing': [19], 'total': [21], 'seven': [23], 'Na-Cl,': [24], 'Na-K-2Cl,': [25], 'and': [26, 48, 56, 64, 72, 91, 106, 121, 146, 161, 184, 206, 223, 242, 250], 'K-Cl': [27, 123, 196], 'in': [29, 51, 70, 89, 95, 101, 126, 131, 178, 214, 230, 236], 'addition': [30], 'to': [31, 86, 136], 'two': [32, 240], 'related': [33], 'transporters': [34], 'unknown': [36], 'function.': [37], 'cotransporters': [40, 113, 152, 232], 'perform': [41], 'wide': [43], 'variety': [44], 'physiological': [46, 160, 249], 'roles': [47, 100, 163], 'differ': [49], 'dramatically': [50], 'patterns': [52], 'tissue': [54], 'expression': [55], 'cellular': [57], 'localization.': [58], 'renal-specific': [60], 'Na-Cl': [61], 'cotransporter': [62, 66, 124, 176, 197], '(NCC)': [63], 'Na-K-2Cl': [65, 175], '(NKCC2)': [67], 'are': [68, 93, 114], 'involved': [69, 130], 'Gitelman': [71], 'Bartter': [73], 'syndrome,': [74], 'respectively,': [75], 'autosomal': [76], 'recessive': [77], 'forms': [78], 'metabolic': [80], 'alkalosis.': [81], 'associated': [83, 226], 'phenotypes': [84, 225], 'due': [85], 'loss-of-function': [87, 228], 'mutations': [88, 148, 229], 'NCC': [90], 'NKCC2': [92], 'consistent,': [94], 'part,': [96], 'their': [98], 'functional': [99], 'distal': [103], 'convoluted': [104], 'tubule': [105], 'thick': [107], 'ascending': [108], 'limb,': [109], 'respectively.': [110], 'Other': [111], 'positional': [115], 'candidates': [116], 'for': [117, 247], 'Mendelian': [118], 'human': [119, 222], 'disorders,': [120], 'KCC3,': [125], 'particular,': [127], 'may': [128], 'be': [129], 'degenerative': [132], 'peripheral': [133], 'neuropathies': [134], 'linked': [135], 'chromosome': [137], '15q14.': [138], 'characterization': [140], 'mice': [142, 200], 'both': [144], 'spontaneous': [145], 'targeted': [147], 'several': [150, 165], 'has': [153], 'also': [154], 'yielded': [155], 'significant': [156], 'insight': [157], 'into': [158], 'pathophysiological': [162], 'members': [166], 'family.': [170], 'These': [171], 'studies': [172], 'implicate': [173], 'NKCC1': [177], 'hearing,': [179], 'salivation,': [180], 'pain': [181], 'perception,': [182], 'spermatogenesis,': [183], 'control': [186], 'extracellular': [188], 'fluid': [189], 'volume.': [190], 'Targeted': [191], 'deletion': [192], 'neuronal-specific': [195], 'KCC2': [198], 'generates': [199], 'profound': [203], 'seizure': [204], 'disorder': [205], 'confirms': [207], 'central': [209], 'role': [210], 'this': [212], 'transporter': [213], 'modulating': [215], 'neuronal': [216], 'excitability.': [217], 'Finally,': [218], 'comparison': [220], 'murine': [224], 'indicates': [233], 'important': [234, 245], 'differences': [235], 'physiology': [237], 'species': [241], 'provides': [243], 'an': [244], 'opportunity': [246], 'detailed': [248], 'morphological': [251], 'analysis': [252], 'tissues': [255], 'involved.': [256]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1932904334', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-09T02:15:04.459010', 'created_date': '2016-06-24'}