Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1931180781', 'doi': 'https://doi.org/10.4049/jimmunol.1202278', 'title': 'Enhancing T Lineage Production in Aged Mice: A Novel Function of Foxn1 in the Bone Marrow Niche', 'display_name': 'Enhancing T Lineage Production in Aged Mice: A Novel Function of Foxn1 in the Bone Marrow Niche', 'publication_year': 2013, 'publication_date': '2013-12-01', 'ids': {'openalex': 'https://openalex.org/W1931180781', 'doi': 'https://doi.org/10.4049/jimmunol.1202278', 'mag': '1931180781', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24184560', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4081451'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1202278', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/191/11/5583.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jimmunol.org/content/jimmunol/191/11/5583.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067457672', 'display_name': 'Erin C. Zook', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Erin C. Zook', 'raw_affiliation_strings': ['*Cell Biology, Neurobiology, and Anatomy Graduate Program, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', '†Program for Immunology and Aging, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;'], 'affiliations': [{'raw_affiliation_string': '†Program for Immunology and Aging, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', 'institution_ids': ['https://openalex.org/I1925986']}, {'raw_affiliation_string': '*Cell Biology, Neurobiology, and Anatomy Graduate Program, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023051373', 'display_name': 'Shubin Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shubin Zhang', 'raw_affiliation_strings': ['‡Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153; and'], 'affiliations': [{'raw_affiliation_string': '‡Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153; and', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057150258', 'display_name': 'Rachel M. Gerstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I166722992', 'display_name': 'University of Massachusetts Chan Medical School', 'ror': 'https://ror.org/0464eyp60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I166722992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rachel M. Gerstein', 'raw_affiliation_strings': ['§Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605'], 'affiliations': [{'raw_affiliation_string': '§Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605', 'institution_ids': ['https://openalex.org/I166722992']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024908764', 'display_name': 'Pamela L. Witte', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pamela L. Witte', 'raw_affiliation_strings': ['*Cell Biology, Neurobiology, and Anatomy Graduate Program, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', '†Program for Immunology and Aging, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', '‡Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153; and'], 'affiliations': [{'raw_affiliation_string': '‡Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153; and', 'institution_ids': ['https://openalex.org/I1925986']}, {'raw_affiliation_string': '†Program for Immunology and Aging, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', 'institution_ids': ['https://openalex.org/I1925986']}, {'raw_affiliation_string': '*Cell Biology, Neurobiology, and Anatomy Graduate Program, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038969236', 'display_name': 'Phong T. Le', 'orcid': 'https://orcid.org/0000-0001-5403-7261'}, 'institutions': [{'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Phong T. Le', 'raw_affiliation_strings': ['*Cell Biology, Neurobiology, and Anatomy Graduate Program, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', '†Program for Immunology and Aging, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', '‡Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153; and'], 'affiliations': [{'raw_affiliation_string': '‡Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153; and', 'institution_ids': ['https://openalex.org/I1925986']}, {'raw_affiliation_string': '†Program for Immunology and Aging, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', 'institution_ids': ['https://openalex.org/I1925986']}, {'raw_affiliation_string': '*Cell Biology, Neurobiology, and Anatomy Graduate Program, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153;', 'institution_ids': ['https://openalex.org/I1925986']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5038969236'], 'corresponding_institution_ids': ['https://openalex.org/I1925986'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.654, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.636501, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 78, 'max': 80}, 'biblio': {'volume': '191', 'issue': '11', 'first_page': '5583', 'last_page': '5593'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10345', 'display_name': 'Hematopoietic Stem Cell Biology', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10345', 'display_name': 'Hematopoietic Stem Cell Biology', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'Regulatory T Cell Development and Function', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Natural Killer Cells in Immunity', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lineage', 'display_name': 'Lineage (genetic)', 'score': 0.7730528}, {'id': 'https://openalex.org/keywords/thymic-selection', 'display_name': 'Thymic Selection', 'score': 0.50392}], 'concepts': [{'id': 'https://openalex.org/C2776817793', 'wikidata': 'https://www.wikidata.org/wiki/Q6553369', 'display_name': 'Lineage (genetic)', 'level': 3, 'score': 0.7730528}, {'id': 'https://openalex.org/C153991713', 'wikidata': 'https://www.wikidata.org/wiki/Q17142856', 'display_name': 'Niche', 'level': 2, 'score': 0.76684296}, {'id': 'https://openalex.org/C14036430', 'wikidata': 'https://www.wikidata.org/wiki/Q3736076', 'display_name': 'Function (biology)', 'level': 2, 'score': 0.62098324}, {'id': 'https://openalex.org/C2780007613', 'wikidata': 'https://www.wikidata.org/wiki/Q546523', 'display_name': 'Bone marrow', 'level': 2, 'score': 0.6150937}, {'id': 'https://openalex.org/C2778348673', 'wikidata': 'https://www.wikidata.org/wiki/Q739302', 'display_name': 'Production (economics)', 'level': 2, 'score': 0.49200723}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37958074}, {'id': 'https://openalex.org/C78458016', 'wikidata': 'https://www.wikidata.org/wiki/Q840400', 'display_name': 'Evolutionary biology', 'level': 1, 'score': 0.29634455}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.28402415}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.18481836}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.08899167}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.054086417}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.048781037}, {'id': 'https://openalex.org/C139719470', 'wikidata': 'https://www.wikidata.org/wiki/Q39680', 'display_name': 'Macroeconomics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D054503', 'descriptor_name': 'Lymphoid Progenitor Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015703', 'descriptor_name': 'Antigens, CD', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015703', 'descriptor_name': 'Antigens, CD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001853', 'descriptor_name': 'Bone Marrow', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D001853', 'descriptor_name': 'Bone Marrow', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016130', 'descriptor_name': 'Immunophenotyping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018655', 'descriptor_name': 'Lymphocyte Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054503', 'descriptor_name': 'Lymphoid Progenitor Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055153', 'descriptor_name': 'Stem Cell Niche', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D055153', 'descriptor_name': 'Stem Cell Niche', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019076', 'descriptor_name': 'Transgenes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019076', 'descriptor_name': 'Transgenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1202278', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/191/11/5583.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4081451', 'pdf_url': 'https://europepmc.org/articles/pmc4081451?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081451', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24184560', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1202278', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/191/11/5583.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1489320194', 'https://openalex.org/W1496114012', 'https://openalex.org/W1546422536', 'https://openalex.org/W1555798758', 'https://openalex.org/W1575237114', 'https://openalex.org/W1587921637', 'https://openalex.org/W1966534825', 'https://openalex.org/W1971833736', 'https://openalex.org/W1975025595', 'https://openalex.org/W1981611424', 'https://openalex.org/W1982130774', 'https://openalex.org/W1985801522', 'https://openalex.org/W1993405888', 'https://openalex.org/W2007335712', 'https://openalex.org/W2014924154', 'https://openalex.org/W2016774587', 'https://openalex.org/W2022070851', 'https://openalex.org/W2039006670', 'https://openalex.org/W2050700188', 'https://openalex.org/W2060253847', 'https://openalex.org/W2061307900', 'https://openalex.org/W2062036642', 'https://openalex.org/W2067821750', 'https://openalex.org/W2068767740', 'https://openalex.org/W2070154483', 'https://openalex.org/W2070793750', 'https://openalex.org/W2072910535', 'https://openalex.org/W2077330278', 'https://openalex.org/W2084289371', 'https://openalex.org/W2086737883', 'https://openalex.org/W2090034696', 'https://openalex.org/W2090168946', 'https://openalex.org/W2094457561', 'https://openalex.org/W2107543871', 'https://openalex.org/W2109553674', 'https://openalex.org/W2112045900', 'https://openalex.org/W2112721427', 'https://openalex.org/W2119709204', 'https://openalex.org/W2123410322', 'https://openalex.org/W2134924448', 'https://openalex.org/W2136510952', 'https://openalex.org/W2137896220', 'https://openalex.org/W2142284410', 'https://openalex.org/W2146812443', 'https://openalex.org/W2147195750', 'https://openalex.org/W2154124733', 'https://openalex.org/W56430987', 'https://openalex.org/W78744612'], 'related_works': ['https://openalex.org/W3151521698', 'https://openalex.org/W3123236151', 'https://openalex.org/W2992665962', 'https://openalex.org/W2506149209', 'https://openalex.org/W2393629471', 'https://openalex.org/W2365766658', 'https://openalex.org/W2362135624', 'https://openalex.org/W2352153050', 'https://openalex.org/W2095253586', 'https://openalex.org/W2035911516'], 'abstract_inverted_index': {'Abstract': [0], 'Foxn1': [1, 12, 23, 88, 110, 201, 210], 'is': [2, 68, 85, 94, 101, 111, 146], 'essential': [3], 'for': [4], 'thymic': [5], 'organogenesis': [6], 'and': [7, 63, 116, 131, 159, 170, 206, 208], 'T': [8, 19, 38, 40, 45, 74, 204, 220], 'lymphopoiesis.': [9, 39, 75], 'Whereas': [10], 'reduced': [11, 73, 80], 'expression': [13], 'results': [14], 'in': [15, 18, 24, 37, 54, 61, 87, 96, 113, 118, 126, 149, 167, 215], 'a': [16, 28, 135, 179], 'decline': [17, 36, 60], 'lymphopoiesis,': [20], 'overexpression': [21], 'of': [22, 27, 124, 138, 182], 'the': [25, 34, 55, 92, 97, 122, 143, 209], 'thymus': [26], 'transgenic': [29, 89], 'mouse': [30], 'model': [31], '(Foxn1Tg)': [32], 'attenuates': [33], 'age-associated': [35], 'lymphopoiesis': [41, 205], 'begins': [42], 'with': [43, 66, 83, 99, 174], 'early': [44], 'cell': [46, 162], 'progenitors': [47, 52, 158], '(ETP),': [48], 'derived': [49], 'from': [50], 'multipotent': [51], '(MPP)': [53], 'bone': [56], 'marrow': [57], '(BM).': [58], 'A': [59], 'MPP': [62, 100, 125, 217], 'ETP': [64, 81], 'numbers': [65, 163], 'age': [67, 84], 'thought': [69], 'to': [70, 72, 154], 'contribute': [71], 'Previously,': [76], 'we': [77, 107], 'showed': [78], 'that': [79, 109, 195], 'number': [82, 123], 'attenuated': [86], '(Tg);': [90], 'whether': [91], 'effect': [93], 'initiated': [95], 'BM': [98, 115, 145, 193, 211], 'not': [102, 129], 'known.': [103], 'In': [104, 152], 'this': [105], 'study,': [106], 'report': [108], 'expressed': [112], 'wild-type': [114], 'overexpressed': [117], 'Foxn1Tg.': [119], 'With': [120], 'age,': [121], 'Foxn1Tg': [127, 132, 144, 172], 'was': [128], 'reduced,': [130], 'also': [133, 196], 'have': [134], 'larger': [136], 'pool': [137], 'hematopoietic': [139], 'stem': [140], 'cells.': [141], 'Furthermore,': [142], 'more': [147], 'efficient': [148], 'generating': [150], 'MPP.': [151], 'contrast': [153], 'MPP,': [155], 'common': [156], 'lymphoid': [157], 'B': [160], 'lineage': [161, 221], 'were': [164], 'significantly': [165], 'lower': [166], 'both': [168, 203], 'young': [169], 'aged': [171], 'compared': [173], 'wild': [175], 'type.': [176], 'We': [177], 'identified': [178], 'novel': [180], 'population': [181], 'lineageneg/low,': [183], 'CD45pos': [184], 'EpCAMpos,': [185], 'SCA1pos,': [186], 'CD117neg,': [187], 'CD138neg,': [188], 'MHCIIneg': [189], 'cells': [190, 194], 'as': [191], 'Foxn1-expressing': [192], 'express': [197], 'Delta-like': [198], '4.': [199], 'Thus,': [200], 'affects': [202], 'hematopoiesis,': [207], 'niche': [212], 'may': [213], 'function': [214], 'skewing': [216], 'development': [218], 'toward': [219], 'progenitors.': [222]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1931180781', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-09-16T21:03:25.023474', 'created_date': '2016-06-24'}