Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1930737326', 'doi': 'https://doi.org/10.18632/oncotarget.4249', 'title': 'Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001', 'display_name': 'Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001', 'publication_year': 2015, 'publication_date': '2015-06-04', 'ids': {'openalex': 'https://openalex.org/W1930737326', 'doi': 'https://doi.org/10.18632/oncotarget.4249', 'mag': '1930737326', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26280276', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4673285'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4249', 'pdf_url': 'https://www.oncotarget.com/article/4249/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/4249/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110461189', 'display_name': 'Shoucheng Ning', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}, {'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shoucheng Ning', 'raw_affiliation_strings': ['Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305 USA', 'institution_ids': ['https://openalex.org/I97018004', 'https://openalex.org/I4210137306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108210164', 'display_name': 'Thillai Veerapazham Sekar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thillai Veerapazham Sekar', 'raw_affiliation_strings': ['Department of Radiology, Stanford University Medical Center, Stanford, CA 94304, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiology, Stanford University Medical Center, Stanford, CA 94304, USA.', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018521707', 'display_name': 'Jan Scicinski', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jan Scicinski', 'raw_affiliation_strings': ['EpicentRx, Inc., Mountain View, CA 94041, USA.'], 'affiliations': [{'raw_affiliation_string': 'EpicentRx, Inc., Mountain View, CA 94041, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016532174', 'display_name': 'Bryan Oronsky', 'orcid': 'https://orcid.org/0000-0002-3940-6329'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bryan Oronsky', 'raw_affiliation_strings': ['EpicentRx, Inc., Mountain View, CA 94041, USA.'], 'affiliations': [{'raw_affiliation_string': 'EpicentRx, Inc., Mountain View, CA 94041, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109552590', 'display_name': 'Donna M. Peehl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}, {'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Donna M. Peehl', 'raw_affiliation_strings': ['Department of Urology Stanford University Medical Center Stanford, CA 94305, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology Stanford University Medical Center Stanford, CA 94305, USA.', 'institution_ids': ['https://openalex.org/I97018004', 'https://openalex.org/I4210137306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090898520', 'display_name': 'Susan J. Knox', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}, {'id': 'https://openalex.org/I4210137306', 'display_name': 'Stanford Medicine', 'ror': 'https://ror.org/03mtd9a03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137306', 'https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Susan J. Knox', 'raw_affiliation_strings': ['Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305 USA', 'institution_ids': ['https://openalex.org/I97018004', 'https://openalex.org/I4210137306']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018880989', 'display_name': 'Ramasamy Paulmurugan', 'orcid': 'https://orcid.org/0000-0001-7155-4738'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ramasamy Paulmurugan', 'raw_affiliation_strings': ['Department of Radiology, Stanford University Medical Center, Stanford, CA 94304, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiology, Stanford University Medical Center, Stanford, CA 94304, USA.', 'institution_ids': ['https://openalex.org/I97018004']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.528, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.856575, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '6', 'issue': '25', 'first_page': '21547', 'last_page': '21556'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11332', 'display_name': 'Genomics, phytochemicals, and oxidative stress', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11332', 'display_name': 'Genomics, phytochemicals, and oxidative stress', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12187', 'display_name': 'Glutathione Transferases and Polymorphisms', 'score': 0.9861, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13574', 'display_name': 'Family Support in Illness', 'score': 0.9568, 'subfield': {'id': 'https://openalex.org/subfields/3312', 'display_name': 'Sociology and Political Science'}, 'field': {'id': 'https://openalex.org/fields/33', 'display_name': 'Social Sciences'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.73126346}, {'id': 'https://openalex.org/C2781197716', 'wikidata': 'https://www.wikidata.org/wiki/Q864574', 'display_name': 'Biomarker', 'level': 2, 'score': 0.7052693}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.60133046}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.42311418}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3889591}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.37448347}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.32588708}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2668322}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1584174}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12150809}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D001384', 'descriptor_name': 'Azetidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051267', 'descriptor_name': 'NF-E2-Related Factor 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009574', 'descriptor_name': 'Nitro Compounds', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001384', 'descriptor_name': 'Azetidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051547', 'descriptor_name': 'Heme Oxygenase-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051547', 'descriptor_name': 'Heme Oxygenase-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D049449', 'descriptor_name': 'Luminescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008164', 'descriptor_name': 'Luminescent Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008164', 'descriptor_name': 'Luminescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016660', 'descriptor_name': 'NAD(P)H Dehydrogenase (Quinone)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016660', 'descriptor_name': 'NAD(P)H Dehydrogenase (Quinone)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051267', 'descriptor_name': 'NF-E2-Related Factor 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009368', 'descriptor_name': 'Neoplasm Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009574', 'descriptor_name': 'Nitro Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000097573', 'descriptor_name': 'Red Fluorescent Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4249', 'pdf_url': 'https://www.oncotarget.com/article/4249/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4673285', 'pdf_url': 'https://europepmc.org/articles/pmc4673285?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673285', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26280276', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4249', 'pdf_url': 'https://www.oncotarget.com/article/4249/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/16', 'display_name': 'Peace, justice, and strong institutions', 'score': 0.41}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1675907706', 'https://openalex.org/W1767659454', 'https://openalex.org/W1971864849', 'https://openalex.org/W1974843588', 'https://openalex.org/W1980030522', 'https://openalex.org/W1980947120', 'https://openalex.org/W1990141059', 'https://openalex.org/W1996521867', 'https://openalex.org/W2033633352', 'https://openalex.org/W2035676834', 'https://openalex.org/W2052548231', 'https://openalex.org/W2058316486', 'https://openalex.org/W2059378857', 'https://openalex.org/W2064327102', 'https://openalex.org/W2080155284', 'https://openalex.org/W2083466407', 'https://openalex.org/W2089813815', 'https://openalex.org/W2100850228', 'https://openalex.org/W2102348938', 'https://openalex.org/W2103802402', 'https://openalex.org/W2104718696', 'https://openalex.org/W2111772495', 'https://openalex.org/W2111774458', 'https://openalex.org/W2117959909', 'https://openalex.org/W2128039856', 'https://openalex.org/W2137836635', 'https://openalex.org/W2146883699', 'https://openalex.org/W2150140277', 'https://openalex.org/W2155324869', 'https://openalex.org/W2165167356', 'https://openalex.org/W2165500341', 'https://openalex.org/W2325933305'], 'related_works': ['https://openalex.org/W4387875454', 'https://openalex.org/W4386476622', 'https://openalex.org/W4366603091', 'https://openalex.org/W3000356375', 'https://openalex.org/W2979314934', 'https://openalex.org/W2949100461', 'https://openalex.org/W2789983651', 'https://openalex.org/W2770084104', 'https://openalex.org/W2146527561', 'https://openalex.org/W2059272320'], 'abstract_inverted_index': {'//': [0], 'Shoucheng': [1], 'Ning': [2], '1': [3, 26, 31], ',': [4, 9, 13, 17, 22, 27], 'Thillai': [5], 'Veerapazham': [6], 'Sekar': [7], '2': [8, 30, 44, 107], 'Jan': [10], 'Scicinski': [11], '4': [12, 16, 68], 'Bryan': [14], 'Oronsky': [15], 'Donna': [18], 'M.': [19], 'Peehl': [20], '3': [21, 56], 'Susan': [23], 'J.': [24], 'Knox': [25], 'Ramasamy': [28, 78], 'Paulmurugan': [29], 'Department': [32, 45, 57], 'of': [33, 46, 58, 159, 164, 166, 177, 191, 229, 237, 245, 272, 275, 292], 'Radiation': [34], 'Oncology': [35], 'Stanford': [36, 48, 60], 'University': [37, 49, 61], 'Medical': [38, 50, 62], 'Center': [39, 51, 63], 'Stanford,': [40, 52, 64], 'CA': [41, 53, 65, 73], '94305,': [42, 66], 'USA': [43, 55, 67, 75], 'Radiology': [47], '94304,': [54], 'Urology': [59], 'EpicentRx,': [69], 'Inc.,': [70], 'Mountain': [71], 'View,': [72], '94041,': [74], 'Correspondence': [76], 'to:': [77], 'Paulmurugan,': [79], 'e-mail:': [80], '[email protected]': [81], 'Keywords:': [82], 'Nrf2,': [83, 246], 'ARE,': [84], 'biomarker,': [85], 'oxidative': [86], 'stress,': [87], 'cancer': [88, 149], 'Received:': [89], 'March': [90], '23,': [91], '2015 ': [92, 96], 'Accepted:': [93], 'May': [94], '21,': [95], 'Published:': [97], 'June': [98], '04,': [99], '2015': [100], 'ABSTRACT': [101], 'Nuclear': [102], 'factor': [103, 106, 114], 'erythroid': [104], '2-related': [105], '(Nrf2)': [108], 'is': [109, 131, 225], 'a': [110, 132, 217, 284], 'master': [111], 'regulatory': [112], 'transcription': [113], 'that': [115, 136, 208, 223, 260], 'plays': [116], 'an': [117, 226], 'important': [118], 'role': [119], 'in': [120, 148, 173, 200, 203, 205, 214, 216, 240, 267], 'the': [121, 154, 162, 230, 250, 258, 289], 'antioxidant': [122, 264], 'response': [123, 252, 293], 'pathway': [124], 'against': [125], 'anticancer': [126, 134], 'drug-induced': [127], 'cytotoxic': [128], 'effects.': [129], 'RRx-001': [130, 155, 209, 224, 261, 295], 'new': [133], 'agent': [135], 'generates': [137], 'reactive': [138], 'oxygen': [139], 'and': [140, 143, 161, 171, 197, 202, 219, 297], 'nitrogen': [141], 'species,': [142], 'leads': [144], 'to': [145, 187, 253, 294], 'epigenetic': [146], 'alterations': [147], 'cells.': [150, 175, 269], 'Here': [151], 'we': [152], 'report': [153], 'mediated': [156], 'nuclear': [157], 'translocation': [158], 'Nrf2': [160, 179], 'activation': [163, 274], 'expression': [165, 180], 'its': [167], 'downstream': [168, 276], 'enzymes': [169], 'HO-1': [170], 'NQO1': [172], 'tumor': [174, 192, 251, 268], 'Inhibition': [176], 'intrinsic': [178], 'by': [181], 'Nrf2-specific': [182], 'siRNA': [183], 'increased': [184, 211], 'cell': [185], 'sensitivity': [186], 'RRx-001.': [188, 254], 'Molecular': [189], 'imaging': [190], 'cells': [193, 215], 'co-expressing': [194], 'pARE-Firefly': [195], 'luciferase': [196], 'pCMV-Renilla': [198], 'luciferase-mRFP': [199], 'vitro': [201], 'vivo': [204], 'mice': [206], 'revealed': [207], 'significantly': [210], 'ARE-FLUC': [212, 238], 'signal': [213, 239], 'dose-': [218], 'time-dependent': [220], 'manner,': [221], 'suggesting': [222], 'effective': [227], 'activator': [228], 'Nrf2-ARE': [231, 263], 'signaling': [232, 265, 281], 'pathway.': [233], 'The': [234, 255], 'pre-treatment': [235], 'level': [236], 'cells,': [241], 'reflecting': [242], 'basal': [243], 'activity': [244], 'negatively': [247], 'correlated': [248], 'with': [249], 'results': [256], 'support': [257], 'concept': [259], 'activates': [262], 'pathways': [266], 'Hence': [270], 'measurement': [271], 'Nrf2-mediated': [273], 'target': [277], 'genes': [278], 'through': [279], 'ARE': [280], 'may': [282], 'constitute': [283], 'useful': [285], 'molecular': [286], 'biomarker': [287], 'for': [288], 'early': [290], 'prediction': [291], 'treatment,': [296], 'thereby': [298], 'guide': [299], 'therapeutic': [300], 'decision-making.': [301]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1930737326', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-15T17:27:56.241615', 'created_date': '2016-06-24'}