A proposal for dose‐adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time

Name: Work Video:
Duration: 3 min 30 s
Paul K. L. Chin; Daniel F. B. Wright; David Patterson; Matthew Doogue; Evan J. Begg
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'abstract_inverted_index': {'Dabigatran': [0], 'is': [1, 6, 24], 'an': [2], 'oral': [3], 'anticoagulant': [4], 'that': [5, 19, 34, 84], 'increasingly': [7], 'used': [8, 98], 'for': [9, 63], 'atrial': [10], 'fibrillation': [11], '(': [12, 93], 'AF': [13, 58], ').': [14, 80], 'Presently,': [15], 'many': [16], 'authorities': [17], 'state': [18], 'routine': [20], 'laboratory': [21], 'coagulation': [22, 88], 'monitoring': [23], 'not': [25, 103], 'required.': [26], 'However,': [27], 'data': [28], 'have': [29], 'recently': [30], 'been': [31], 'published': [32], 'demonstrating': [33], 'higher': [35, 46], 'trough': [36, 72], 'plasma': [37, 73], 'dabigatran': [38, 74, 110], 'concentrations': [39, 75], 'are': [40, 105], 'associated': [41], 'with': [42, 60], 'lower': [43], 'thromboembolic': [44], 'and': [45, 66], 'haemorrhagic': [47], 'event': [48], 'rates.': [49], 'Using': [50], 'these': [51, 64], 'data,': [52], 'we': [53, 82], 'simulate': [54], 'a': [55, 68, 85], 'range': [56, 70, 108], 'of': [57, 71, 109], 'patients': [59, 104], 'varying': [61], 'risks': [62], 'events': [65], 'derive': [67], 'target': [69], '(30–130': [76], 'μg': [77], 'l': [78], '−1': [79], 'Finally,': [81], 'propose': [83], 'conventional': [86], 'screening': [87], 'assay,': [89], 'the': [90], 'thrombin': [91], 'time': [92], 'TT': [94], '),': [95], 'can': [96], 'be': [97], 'to': [99], 'discern': [100], 'whether': [101], 'or': [102], 'within': [106], 'this': [107], 'concentrations.': [111]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1926627776', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}], 'updated_date': '2024-12-14T08:44:29.957603', 'created_date': '2016-06-24'}
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