Publication Information

{'id': 'https://openalex.org/W1922867421', 'doi': 'https://doi.org/10.1523/jneurosci.22-07-02977.2002', 'title': 'Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists', 'display_name': 'Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists', 'publication_year': 2002, 'publication_date': '2002-04-01', 'ids': {'openalex': 'https://openalex.org/W1922867421', 'doi': 'https://doi.org/10.1523/jneurosci.22-07-02977.2002', 'mag': '1922867421', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11923462', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6758322'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.22-07-02977.2002', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/22/7/2977.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.jneurosci.org/content/jneuro/22/7/2977.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005389722', 'display_name': 'S. Barak Caine', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I2801148111', 'display_name': 'McLean Hospital', 'ror': 'https://ror.org/01kta7d96', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801148111']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S. Barak Caine', 'raw_affiliation_strings': ['Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478,'], 'affiliations': [{'raw_affiliation_string': 'Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478,', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I2801148111']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020814543', 'display_name': 'S. Stevens Negus', 'orcid': 'https://orcid.org/0000-0001-8471-645X'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I2801148111', 'display_name': 'McLean Hospital', 'ror': 'https://ror.org/01kta7d96', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801148111']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S. Stevens Negus', 'raw_affiliation_strings': ['Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478,'], 'affiliations': [{'raw_affiliation_string': 'Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478,', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I2801148111']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111605325', 'display_name': 'Nancy K. Mello', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801148111', 'display_name': 'McLean Hospital', 'ror': 'https://ror.org/01kta7d96', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801148111']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nancy K. Mello', 'raw_affiliation_strings': ['Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478,'], 'affiliations': [{'raw_affiliation_string': 'Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478,', 'institution_ids': ['https://openalex.org/I2801148111', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034388856', 'display_name': 'Smita S. Patel', 'orcid': 'https://orcid.org/0000-0002-2523-4933'}, 'institutions': [{'id': 'https://openalex.org/I4210087189', 'display_name': 'MSD (UK) Limited (United Kingdom)', 'ror': 'https://ror.org/004nn4n27', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155', 'https://openalex.org/I4210087189']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Smita Patel', 'raw_affiliation_strings': ['Merck, Sharp and Dohme Neuroscience Research Laboratories, Harlow, Essex CM20 2QR, United Kingdom, and'], 'affiliations': [{'raw_affiliation_string': 'Merck, Sharp and Dohme Neuroscience Research Laboratories, Harlow, Essex CM20 2QR, United Kingdom, and', 'institution_ids': ['https://openalex.org/I4210087189']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030640333', 'display_name': 'Linda J. Bristow', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087189', 'display_name': 'MSD (UK) Limited (United Kingdom)', 'ror': 'https://ror.org/004nn4n27', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155', 'https://openalex.org/I4210087189']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Linda Bristow', 'raw_affiliation_strings': ['Merck, Sharp and Dohme Neuroscience Research Laboratories, Harlow, Essex CM20 2QR, United Kingdom, and'], 'affiliations': [{'raw_affiliation_string': 'Merck, Sharp and Dohme Neuroscience Research Laboratories, Harlow, Essex CM20 2QR, United Kingdom, and', 'institution_ids': ['https://openalex.org/I4210087189']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071924682', 'display_name': 'Janusz J. Kulagowski', 'orcid': 'https://orcid.org/0000-0002-8155-9919'}, 'institutions': [{'id': 'https://openalex.org/I4210087189', 'display_name': 'MSD (UK) Limited (United Kingdom)', 'ror': 'https://ror.org/004nn4n27', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155', 'https://openalex.org/I4210087189']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Janusz Kulagowski', 'raw_affiliation_strings': ['Merck, Sharp and Dohme Neuroscience Research Laboratories, Harlow, Essex CM20 2QR, United Kingdom, and'], 'affiliations': [{'raw_affiliation_string': 'Merck, Sharp and Dohme Neuroscience Research Laboratories, Harlow, Essex CM20 2QR, United Kingdom, and', 'institution_ids': ['https://openalex.org/I4210087189']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076305462', 'display_name': 'Daniela Vallone', 'orcid': 'https://orcid.org/0000-0002-4492-7751'}, 'institutions': [{'id': 'https://openalex.org/I4210086872', 'display_name': 'Institut de génétique et de biologie moléculaire et cellulaire', 'ror': 'https://ror.org/0015ws592', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I4210086872', 'https://openalex.org/I4210096427', 'https://openalex.org/I68947357']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Daniela Vallone', 'raw_affiliation_strings': ['Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch Cedex, Strasbourg, France'], 'affiliations': [{'raw_affiliation_string': 'Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch Cedex, Strasbourg, France', 'institution_ids': ['https://openalex.org/I4210086872']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084161610', 'display_name': 'Adolfo Saiardi', 'orcid': 'https://orcid.org/0000-0002-4351-0081'}, 'institutions': [{'id': 'https://openalex.org/I4210086872', 'display_name': 'Institut de génétique et de biologie moléculaire et cellulaire', 'ror': 'https://ror.org/0015ws592', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I4210086872', 'https://openalex.org/I4210096427', 'https://openalex.org/I68947357']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Adolfo Saiardi', 'raw_affiliation_strings': ['Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch Cedex, Strasbourg, France'], 'affiliations': [{'raw_affiliation_string': 'Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch Cedex, Strasbourg, France', 'institution_ids': ['https://openalex.org/I4210086872']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080427251', 'display_name': 'Emiliana Borrelli', 'orcid': 'https://orcid.org/0000-0002-1813-2541'}, 'institutions': [{'id': 'https://openalex.org/I4210086872', 'display_name': 'Institut de génétique et de biologie moléculaire et cellulaire', 'ror': 'https://ror.org/0015ws592', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I4210086872', 'https://openalex.org/I4210096427', 'https://openalex.org/I68947357']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Emiliana Borrelli', 'raw_affiliation_strings': ['Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch Cedex, Strasbourg, France'], 'affiliations': [{'raw_affiliation_string': 'Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch Cedex, Strasbourg, France', 'institution_ids': ['https://openalex.org/I4210086872']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.796, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 231, 'citation_normalized_percentile': {'value': 0.999838, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '22', 'issue': '7', 'first_page': '2977', 'last_page': '2988'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/eticlopride', 'display_name': 'Eticlopride', 'score': 0.806299}], 'concepts': [{'id': 'https://openalex.org/C44208683', 'wikidata': 'https://www.wikidata.org/wiki/Q15335165', 'display_name': 'Dopamine receptor D2', 'level': 3, 'score': 0.8917595}, {'id': 'https://openalex.org/C2778125517', 'wikidata': 'https://www.wikidata.org/wiki/Q12745201', 'display_name': 'Eticlopride', 'level': 5, 'score': 0.806299}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.6869805}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.59775716}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.49989104}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.4675414}, {'id': 'https://openalex.org/C199596767', 'wikidata': 'https://www.wikidata.org/wiki/Q21110872', 'display_name': 'Dopamine receptor D3', 'level': 4, 'score': 0.4598542}, {'id': 'https://openalex.org/C120069818', 'wikidata': 'https://www.wikidata.org/wiki/Q415496', 'display_name': 'Dopamine receptor', 'level': 3, 'score': 0.45949557}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.37543362}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3650322}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34634072}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30930296}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.29202318}, {'id': 'https://openalex.org/C2779917531', 'wikidata': 'https://www.wikidata.org/wiki/Q7389148', 'display_name': 'SCH-23390', 'level': 4, 'score': 0.12195957}], 'mesh': [{'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D019970', 'descriptor_name': 'Cocaine-Related Disorders', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D018492', 'descriptor_name': 'Dopamine Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017448', 'descriptor_name': 'Receptors, Dopamine D2', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003216', 'descriptor_name': 'Conditioning, Operant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018491', 'descriptor_name': 'Dopamine Agonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D065127', 'descriptor_name': 'Dopamine D2 Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006579', 'descriptor_name': 'Heterozygote', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006720', 'descriptor_name': 'Homozygote', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008817', 'descriptor_name': 'Mice, Mutant Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011804', 'descriptor_name': 'Quinolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011869', 'descriptor_name': 'Radioligand Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050637', 'descriptor_name': 'Receptors, Dopamine D3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050638', 'descriptor_name': 'Receptors, Dopamine D4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012054', 'descriptor_name': 'Reinforcement, Psychology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012457', 'descriptor_name': 'Salicylamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012646', 'descriptor_name': 'Self Administration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.22-07-02977.2002', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/22/7/2977.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6758322', 'pdf_url': 'https://europepmc.org/articles/pmc6758322?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758322', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11923462', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.22-07-02977.2002', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/22/7/2977.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.76}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 99, 'referenced_works': ['https://openalex.org/W1506870724', 'https://openalex.org/W1618289512', 'https://openalex.org/W1671798294', 'https://openalex.org/W17879022', 'https://openalex.org/W1819218275', 'https://openalex.org/W1832727056', 'https://openalex.org/W1915122765', 'https://openalex.org/W1916318562', 'https://openalex.org/W1916785887', 'https://openalex.org/W1943544645', 'https://openalex.org/W1959543927', 'https://openalex.org/W1964909230', 'https://openalex.org/W1969748095', 'https://openalex.org/W1972024955', 'https://openalex.org/W1974387854', 'https://openalex.org/W1975977959', 'https://openalex.org/W1977966461', 'https://openalex.org/W1979466068', 'https://openalex.org/W1981275799', 'https://openalex.org/W1981800062', 'https://openalex.org/W1986322740', 'https://openalex.org/W1989416066', 'https://openalex.org/W1990599317', 'https://openalex.org/W1997829966', 'https://openalex.org/W2002418297', 'https://openalex.org/W2002988343', 'https://openalex.org/W2003165750', 'https://openalex.org/W2005897842', 'https://openalex.org/W2005997674', 'https://openalex.org/W2007689138', 'https://openalex.org/W2017989900', 'https://openalex.org/W2018079054', 'https://openalex.org/W2018089787', 'https://openalex.org/W2018330782', 'https://openalex.org/W2019069783', 'https://openalex.org/W2019417698', 'https://openalex.org/W2021524503', 'https://openalex.org/W2023042672', 'https://openalex.org/W2025495736', 'https://openalex.org/W2025951831', 'https://openalex.org/W2034811328', 'https://openalex.org/W2038370141', 'https://openalex.org/W2038505533', 'https://openalex.org/W2040147686', 'https://openalex.org/W2041080698', 'https://openalex.org/W2043600875', 'https://openalex.org/W2045231609', 'https://openalex.org/W2056162837', 'https://openalex.org/W2056467138', 'https://openalex.org/W2060509660', 'https://openalex.org/W2061418383', 'https://openalex.org/W2068236127', 'https://openalex.org/W2069309932', 'https://openalex.org/W2072123096', 'https://openalex.org/W2074631079', 'https://openalex.org/W2076271072', 'https://openalex.org/W2077194388', 'https://openalex.org/W2077707065', 'https://openalex.org/W2081420373', 'https://openalex.org/W2085038977', 'https://openalex.org/W2085627491', 'https://openalex.org/W2086981544', 'https://openalex.org/W2087657646', 'https://openalex.org/W2089486589', 'https://openalex.org/W2090658360', 'https://openalex.org/W2094309508', 'https://openalex.org/W2094554392', 'https://openalex.org/W2095217951', 'https://openalex.org/W2097300084', 'https://openalex.org/W2100216270', 'https://openalex.org/W2102642731', 'https://openalex.org/W2118774378', 'https://openalex.org/W2122620193', 'https://openalex.org/W2123268199', 'https://openalex.org/W2134340301', 'https://openalex.org/W2134366865', 'https://openalex.org/W2137493690', 'https://openalex.org/W2139547655', 'https://openalex.org/W2139591064', 'https://openalex.org/W2141225680', 'https://openalex.org/W2143212013', 'https://openalex.org/W2149928224', 'https://openalex.org/W2155207556', 'https://openalex.org/W2155941702', 'https://openalex.org/W2169093280', 'https://openalex.org/W2171141130', 'https://openalex.org/W2172219495', 'https://openalex.org/W2240581719', 'https://openalex.org/W2248197263', 'https://openalex.org/W2261629206', 'https://openalex.org/W2268781774', 'https://openalex.org/W2269687382', 'https://openalex.org/W2279012500', 'https://openalex.org/W2338649220', 'https://openalex.org/W2395697241', 'https://openalex.org/W2414854770', 'https://openalex.org/W2626068026', 'https://openalex.org/W4254260364', 'https://openalex.org/W48980239'], 'related_works': ['https://openalex.org/W318371905', 'https://openalex.org/W2328497721', 'https://openalex.org/W2319429007', 'https://openalex.org/W2095357032', 'https://openalex.org/W2089695550', 'https://openalex.org/W2016349928', 'https://openalex.org/W2003790404', 'https://openalex.org/W1987843978', 'https://openalex.org/W1977676214', 'https://openalex.org/W1901192990'], 'abstract_inverted_index': {'Dopamine': [0], 'receptor': [1, 47, 87, 121, 269, 315, 324], 'subtypes': [2, 48, 88, 270], 'have': [3], 'been': [4, 38], 'classified': [5], 'generally': [6], 'as': [7, 232], 'D1-like': [8], '(e.g.,': [9], 'D1,': [10], 'D5)': [11], 'or': [12, 154], 'D2-like': [13, 22, 46, 86, 112, 214, 228, 300, 358], '(D2,': [14], 'D3,': [15, 65], 'D4),': [16], 'and': [17, 66, 98, 107, 125, 226, 245, 293, 298, 343], 'converging': [18], 'evidence': [19], 'suggests': [20], 'that': [21, 117, 252, 312, 330, 341], 'receptors': [23, 68, 345], 'may': [24], 'be': [25], 'especially': [26], 'important': [27], 'in': [28, 49, 69, 89, 114, 182, 200, 205, 250, 275, 328, 351], 'mediating': [29], 'the': [30, 42, 45, 50, 57, 75, 83, 90, 119, 134, 138, 158, 162, 213, 227, 254, 260, 299, 313, 352], 'abuse-related': [31], 'effects': [32, 52, 92, 109, 242, 261], 'of': [33, 44, 53, 56, 61, 74, 78, 85, 93, 110, 131, 137, 161, 173, 191, 194, 219, 221, 224, 243, 262, 286, 288, 291, 296, 333, 354], 'cocaine.': [34, 239], 'However,': [35, 240], 'it': [36], 'has': [37], 'difficult': [39], 'to': [40, 81, 179], 'differentiate': [41], 'roles': [43, 350], 'behavioral': [51], 'cocaine': [54, 94, 104, 132, 139, 163, 272, 292, 297, 320, 335, 355], 'because': [55, 185], 'relatively': [58], 'low': [59], 'selectivity': [60], 'drugs': [62], 'for': [63, 238, 266, 319], 'D2,': [64], 'D4': [67, 126, 344], 'vivo': [70], '.': [71], 'The': [72], 'goal': [73], 'present': [76], 'series': [77], 'studies': [79], 'was': [80], 'investigate': [82], 'contributions': [84], 'reinforcing': [91], 'using': [95], 'new': [96], 'genetic': [97], 'pharmacological': [99], 'tools.': [100], 'First,': [101], 'we': [102, 258], 'evaluated': [103], 'self-administration': [105, 220, 273, 287, 356], 'behavior,': [106], 'related': [108], 'nonselective': [111], 'drugs,': [113], 'mutant': [115, 145, 202], 'mice': [116, 146, 203, 251], 'lack': [118], 'D2': [120, 144, 201, 255, 268, 281, 314], 'but': [122, 157, 322], 'express': [123], 'D3': [124, 342], 'receptors.': [127], 'When': [128], 'high': [129, 222, 289], 'doses': [130, 223, 290], 'on': [133, 271], 'descending': [135], 'limb': [136, 160], 'dose–effect': [140, 164], 'function': [141, 165], 'were': [142, 176, 197, 247, 306], 'available,': [143], 'self-administered': [147], 'at': [148], 'higher': [149], 'rates': [150, 172, 187, 218, 285, 332], 'than': [151, 204], 'their': [152], 'heterozygous': [153], 'wild-type': [155, 206, 209], 'littermates,': [156], 'ascending': [159], 'did': [166], 'not': [167, 177, 248, 317, 347], 'differ': [168], 'between': [169], 'genotypes.': [170], 'Elevated': [171], 'drug': [174], 'intake': [175], 'attributable': [178], 'nonspecific': [180], 'increases': [181], 'response': [183, 186], 'rate,': [184], 'maintained': [188], 'by': [189, 357], 'presentation': [190], 'a': [192, 233, 280], 'range': [193], 'food': [195], 'concentrations': [196], 'significantly': [198], 'lower': [199], 'mice.': [207], 'In': [208, 278], 'mice,': [210], 'pretreatment': [211], 'with': [212], 'antagonist': [215, 283], 'eticlopride': [216, 244], 'increased': [217, 284], 'cocaine,': [225], 'agonist': [229, 301], 'quinelorane': [230, 246], 'served': [231], 'positive': [234], 'reinforcer': [235], 'when': [236], 'substituted': [237], 'these': [241, 309], 'observed': [249], 'lacked': [253], 'receptor.': [256], 'Next,': [257], 'compared': [259], 'novel': [263], 'antagonists': [264, 305], 'selective': [265, 282], 'different': [267], 'behavior': [274], 'outbred': [276], 'rats.': [277], 'rats,': [279], 'also': [294, 339], 'combinations': [295], 'quinelorane,': [302], 'whereas': [303], 'D3/D4': [304], 'ineffective.': [307], 'Collectively,': [308], 'findings': [310], 'suggest': [311, 340], 'is': [316, 326], 'necessary': [318], 'self-administration,': [321], 'this': [323], 'subtype': [325], 'involved': [327], 'mechanisms': [329], 'limit': [331], 'high-dose': [334], 'self-administration.': [336], 'Our': [337], 'results': [338], 'do': [346], 'play': [348], 'major': [349], 'modulation': [353], 'drugs.': [359]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1922867421', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-14T08:46:33.757074', 'created_date': '2016-06-24'}