Abstract: Periodontology 2000Volume 57, Issue 1 p. 118-131 Oral cancers: supportive care issues Barbara A. Murphy, Barbara A. MurphySearch for more papers by this authorJill Gilbert, Jill GilbertSearch for more papers by this author Barbara A. Murphy, Barbara A. MurphySearch for more papers by this authorJill Gilbert, Jill GilbertSearch for more papers by this author First published: 22 July 2011 https://doi.org/10.1111/j.1600-0757.2011.00394.xCitations: 7Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Adelstein DJ, Adams GL, Wagner H Jr, Kish JA, Ensley JF, Schuller DE, Forastiere AA. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 2003: 21: 92–98. 2 Backstrom I, Funegård U, Andersson I, Franzén L, Johansson I. Dietary intake in head and neck irradiated patients with permanent dry mouth symptoms. Eur J Cancer B Oral Oncol 1995: 31B: 253–257. 3 Bardet E, Martin L, Calais G, Alfonsi M, Feham NE, Tuchais C, Boisselier P, Seng SH, Rhein B. Subcutaneous versus intravenous admnistration of amifostine for head and neck cancer patients receiving radiotherapy: preliminary results of the GORTEC 2000-02 randomized trial. Int J Radiat Oncol Biol Phys 2005: 63: S127. 4 Bentzen SM, Trotti A. Evaluation of early and late toxicities in chemoradiation trials. J Clin Oncol 2007: 25: 4096–4103. 5 Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefèbvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, Cognetti F, Bourhis J, Kirkpatrick A, van Glabbeke M; European Organization for Research and Treatment of Cancer Trial 22931. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 2004: 350: 1945–1952. 6 Blackburn GL, Bistrian B, Maini BS, Schlamm HT, Smith MF. Nutritional and metabolic assessment of the hospitalized patient. JPEN J Parenter Enteral Nutr 1977: 1: 11–22. 7 Bomeli SR, Desai SC, Johnson JT, Walvekar RR. Management of salivary flow in head and neck patients. Oral Oncol 2008: 44: 1000–1008. 8 Borggreven P, Verdonck-de Loeuw I, Rinkel R, Langendijk J, Roos J, David E, deBree R, Leemans R. Swallowing after major surgery of the oral cavity or oropharynx: a prospective and longitudinal assessment of patients treated by microvascular soft tissue reconstruction. Head Neck 2007: 29: 638–647. 9 Brizel DM, Murphy BA, Rosenthal D, Pandya K, Gluck S, Brizel HE, Meredith RF, Berger D, Chen MG, Mendenhall W. Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma. J Clin Oncol 2008: 26: 2489–2496. 10 Brosky M. The role of saliva in oral health: strategies for prevention and management of xerostomia. J Support Oncol 2007: 5: 215–225. 11 Cappiello J, Piazza C, Giudice M, De Maria G, Nicolai P. Shoulder disability after different selective neck dissections (level II–IV versus levels II–V): a comparative study. Laryngoscope 2005: 115: 259–263. 12 Cella D. Manual for the Functional Assessment of Therapy (FACT) Measurement System (Version 3). Chicago, IL: Rush Medical Center, 1994. 13 Chambers MS, Posner M, Jones CU, Biel MA, Hodge KM, Vitti R, Armstrong I, Yen C, Weber RS. Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer. Int J Radiat Oncol Biol Phys 2007: 68: 1102–1109. 14 Chao KS, Majhail N, Huang CJ, Simpson JR, Perez CA, Haughey B, Spector G. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. Radiother Oncol 2001: 61: 275–280. 15 Cheng PT, Hao SP, Lin YH, Yeh AR. Objective comparison of shoulder dysfunction after three neck dissection techniques. Ann Otol Rhinol Laryngol 2000: 109: 761–766. 16 Chua D, Lo C, Yuen J, Foo YC. A pilot study of pentoxifylline in the treatment of radiation-induced trismus. Am J Clin Oncol 2001: 24: 366–369. 17 Cmelak AJ, Li S, Sigui L, Goldwasser M, Murphy B, Cannon M, Pinto H, Rosenthal D, Gillison M, Forastiere A. Phase II trial of chemoradiation for organ preservation in resectable stage III or IV squamous cell carcinomas of the larynx or oropharynx: results of Eastern Cooperative Oncology Group Study E2399. J Clin Oncol 2007: 25: 3971–3977. 18 Daly ME, Lieskovsky Y, Pawlicki T, Yau J, Pinto H, Kaplan M, Fee WE, Koong A, Goffinet DR, Xing L, Le QT. Evaluation of patterns of failure and subjective salivary function in patients treated with intensity modulated radiotherapy for head and neck squamous cell carcinoma. Head Neck 2007: 29: 211–220. 19 Dijkstra PU, Kalk WW, Roodenberg JL. Trismus in head and neck oncology: a systematic review. Oral Oncol 2004: 40: 879–889. 20 Dijkstra PU, Sterken MW, Pater R, Spijkervet FK, Roodenburg JL. Exercise therapy for trismus in head and neck cancer. Oral Oncol 2007: 43: 389–394. 21 Duncan GG, Epstein JB, Tu D, El Sayed S, Bezjak A, Ottaway J, Pater J; National Cancer Institute of Canada Clinical Trials Group. Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis. Head Neck 2005: 27: 421–428. 22 Eisbruch A, Schwartz M, Rasch C, Vineberg K, Damen E, Van As CJ, Marsh R, Pameijer FA, Balm AJ. Dysphagia and aspiration after chemoradiotherapy for head and neck cancer: which anatomic structures are affected and can they be spared by IMRT? Int J Radiat Biol Phys 2004: 60: 1425–1439. 23 Eisbruch A, Ten Haken R, Kin HM, Marsh LH, Ship JA. Dose, volume, and function relationships in parotic salivary glands following conformal and intensity-modulated irradiation of the head and neck cancer. Int J Radiat Oncol Biol Phys 1999: 45: 577–587. 24 Feng FY, Kim HM, Lyden TH, Haxer MJ, Feng M, Worden FP, Chepeha DB, Eisbruch A. Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys 2007: 68: 1289–1298. 25 Finlay PM, Dawson F, Robertson AG, Soutar DS. An evaluation of functional outcome after surgery and radiotherapy for intraoral cancer. Br J Oral Maxillofac Surg 1992: 20: 14–17. 26 Finnerup NB, Jensen TS. Mechanisms of disease: mechanism-based classification of neuropathic pain – a critical analysis. Nat Clin Pract Neurol 2006: 2: 107–115. 27 Forastiere A, Arlene A, Trotti A, Pfister D, Grandis J. Head and neck cancer: recent advances and new standards of care. J Clin Oncol 2006: 24: 2603–2605. 28 Frazen L, Funegard U, Ericson T, Henriksson R. Parotid gland function during and following radiotherapy of malignancies in the head and neck. Br J Cancer 1992: 28: 457–462. 29 Gerlach NL, Barkhuysen R, Kaanders J, Janssens G, Sterk W, Merkx M. The effect of hyperbaric oxygen therapy on quality of life in oral and oropharyngeal cancer patients treated with radiotherapy. Int J Oral Maxillofac Surg 2008: 37: 255–259. 30 Goodrich SJ, Walker AI. Clinical swallow evaluation. In: R Leonard, K Kendall editors. Dysphagia assessment and treatment planning. San Diego: Plural Publishing, 2008: 103–114. 31 Guldiken Y, Orhan KS, Demirel T, Ural HI, Yücel EA, Değer K. Assessment of shoulder impairment after functional neck dissection: long term results. Auris Nasus Larynx 2005: 32: 387–391. 32 Hamlet S, Faull J, Klein B, Aref A, Fontanesi J, Stachler R, Shamsa F, Jones L, Simpson M. Mastication and swallowing in patients with postirradiation xerostomia. Int J Radiat Oncol Biol Phys 1997: 37: 789–796. 33 Hand A. Salivary glands. Oral histology. Cate T. St. Louis: Mosby Elsevier, 2008: 290–291. 34 Hartl DM, Cohen M, Juliéron M, Marandas P, Janot F, Bourhis J. Botulinum toxin for radiation-induced facial pain and trismus. Otolaryngol Head Neck Surg 2008: 138: 459–463. 35 Henson BS, Inglehart MR, Eisbruch A, Ship JA. Preserved salivary output and xerostomia-related quality-of-life in head and neck cancer patients receiving parotid-sparing radiotherapy. Oral Oncol 2001: 1: 84–93. 36 Hsiung C-Y, Huang E-Y, Ting H-M, Huang H-Y. Intensity-modulated radiotherapy for nasopharyngeal carcinoma: the reduction of radiation-induced trismus. Br J Radiol 2008: 81: 809–814. 37 Murphy BA BJ, Isitt J, Garden AS, Gwede CK, Trotti AM, Meredith RF, Epstein JB, Le QT, Brizel D, Bellm L, Wells N, Cella D. (2009). Prospective study of mucositis-related morbidity and resource utilization in patients receiving radiation therapy with or without chemotherapy for head and neck cancer. J Pain and Symptom Manage 38: 522–532. 38 Jager-Wittenaar H, Dijkstra PU, Vissink A, van Oort RP, Roodenburg JL. Variation in repeated mouth-opening measurements in head and neck cancer patients with and without trismus. Int J Oral Maxillofac Surg 2009: 38: 26–30. 39 Jellema AP SB, Doornaert P, Leemans CR, Langenduk JA. Impact of radiation–induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer. Int J Radiat Oncol Biol Phys, 2007: 69(3): 751–760. 40 Jha N, Seikaly H, Harris J, Williams D, Liu R, McGaw T, Hofmann H, Robinson D, Hanson J, Barnaby P. Prevention of radiation induced xerostomia by surgical transfer of submandibular salivary gland into the submental space. Radiother Oncol 2003: 66: 283–289. 41 Jha N, Seikaly H, Harris J, Williams D, Sultanem K, Hier M, Ghosh S, Black M, Butler J, Sutherland D, Kerr P, Barnaby P. Phase III randomized study: oral pilocarpine versus submandibular salivary gland transfer protocol for the management of radiation-induced xerostomia. Head Neck 2009: 31: 234–243. 42 Johnson JT, Ferretti GA, Nethery WJ, Valdez IH, Fox PC, Ng D, Muscoplat CC, Gallagher SC. Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer. N Engl J Med 1993: 329: 390–395. 43 Kam MK, Leung SF, Zee B, Chau RM, Suen JJ, Mo F, Lai M, Ho R, Cheung KY, Yu BK, Chiu SK, Teo PM, Kwan WH, Chan AT. Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J Clin Oncol 2007: 25: 4873–4879. 44 Keck T, Rozsasi A, Leiacker R, Scheithauer MO. Lower airway humidification in spontaneously breathing tracheostomized patients: comparative study of trachea spray versus heated humidifier. Head Neck 2008: 30: 582–588. 45 Kent ML, Brennan MT, Noll JL, Fox PC, Burri SH, Hunter JC, Lockhart PB. Radiation-induced trismus in head and neck cancer patients. Support Care Cancer 2008: 16: 305–309. 46 Koukourakis MI, Danielidis V. Preventing radiation induced xerostomia. Cancer Treat Rev 2005: 31: 546–554. 47 Laurell G, Kraepelien T, Mavroidis P, Lind BK, Fernberg J, Beckman M, Lind M. Stricture of the proximal esophagus in head and neck carcinoma patients after radiotherapy. Cancer 2003: 97: 1693–1700. 48 Lawson JD, Otto K, Grist W, Johnstone PA. Frequency of esophageal stenosis after simultaneous modulated accelerated radiation therapy and chemotherapy for head and neck cancer. Am J Otolaryngol 2008: 29: 13–19. 49 Lee JH, Machtay M, Unger LD, Weinstein GS, Weber RS, Chalian AA, Rosenthal DI. Prophylactic gastrostomy tubes in patients undergoing intensive irradiation for cancer of the head and neck. Arch Otolaryngol Head Neck Surg 1998: 124: 871–875. 50 Lin A, Kim HM, Terrell JE, Dawson LA, Ship JA, Eisbruch A. Quality of life after parotid-sparing IMRT for head and neck cancer: a prospective longitudinal study. Int J Radiat Oncol Biol Phys 2003: 57: 61–70. 51 Logemann JA, Bytell D. Swallowing disorders in three types of head and neck surgical patients. Cancer 1979: 44: 1095–1105. 52 Logemann JA, Smith CH, Pauloski BR, Rademaker AW, Lazarus CL, Colangelo LA, Mittal B, MacCracken E, Gaziano J, Stachowiak L, Newman LA. Effects of xerostomia on perception and performance of swallow function. Head Neck 2001: 23: 317–321. 53 Mandel ID. The role of saliva in maintaining oral homeostasis. J Am Dent Assoc 1989: 119: 298–304. 54 Martini DV, Har-El G, Lucente FE, Slavit DH. Swallowing and pharyngeal function in postoperative pharyngeal cancer patients. Ear Nose Throat J 1997: 76: 450–456. 55 Meirovitz A, Murdoch-Kinch CA, Schipper M, Pan C, Eisbruch A. Grading xerostomia by physicians or by patients after intensity-modulated radiotherapy of head-and-neck cancer. Int J Radiat Oncol Biol Phys 2006: 66: 445–453. 56 Murphy BA. Clinical and economic consequences of mucositis induced by chemotherapy and/or radiation therapy. J Support Oncol 2007: 5(Suppl. 4): 13–21. 57 Murphy BA, Chen A, Curran WJ Jr, Garden AS, Harari PM, Wong SJ, Ang KK. Longitudinal oncology resgistry of head and neck carcinoma (LORHAN): initial supportive care findings. Support Care Cancer 2009: 17: 1393–1401. 58 Murphy BA, Chen A, Harari P, Curran W, Wong S, Bellm L, Gamber D, Dawson D, Garden A, Ang K. Longitudinal Oncology Registry of Head and Neck Carcinoma: (LORHAN), A new national cancer registry. Presentation #7. Proceedings Multidisciplinary Head and Neck Cancer Symposium: January 18–20; Rancho Mirage, California, 2007. 59 Murphy BA, Gilbert J. Dysphagia in head and neck cancer patients treated with radiation: assessment, sequelae, and rehabilitation. Semin Radiat Oncol 2009: 19: 35–42. 60 Murphy BA, Gilbert J, Cmelak A, Ridner SH. Symptom control issues and supportive care of patients with head and neck cancers. Clin Adv Hematol Oncol 2007: 5: 807–822. 61 Murphy BA, Gilbert J, Ridner S. Systemic and global toxicities of head and neck treatment. Expert Rev Anticancer Ther 2007: 7: 1043–1053. 62 Murphy BA, Lewin JS, Ridner S, Trotti A (2006). Mechanisms of weight loss in patients with head and neck cancer who were treated with Chemoradiation. American Society of Clinical Oncology 2006 Educational Book. http://www.asco.org/ : American Society of Clinical Oncology. 63 Murphy BA, Ridner S, Wells N, Dietrich N. Quality of life research in head and neck cancer: a review of the current state of the science. Crit Rev Oncol Hematol 2007: 62: 251–267. 64 Murry T, Carrau CR. Anatomy and function of the swallowing mechanism. Clincal management of swallowing disorders. San Diego, CA: Plural Publishing, 2006: 15–33. 65 Nguyen NP, Smith HJ, Moltz CC, Frank C, Millar C, Dutta S, Lee H, North D, Karlsson U, Vos P, Nguyen LM, Sallah S. Prevalence of pharyngeal and esophageal stenosis following radiation for head and neck cancer. J Otolaryngol Head Neck Surg 2008: 37: 219–224. 66 Nowak P, Parzuchowski J, Jacobs JR. Effects of combined modality therapy of head and neck carcinoma on shoulder and mobility. J Surg Oncol 1989: 41: 143–147. 67 O'Leary M. Trismus: modern pathophysiological correlates. Am J Emerg Med 1990: 8: 220–227. 68 Palazzi M, Tomatis S, Orlandi E, Guzzo M, Sangalli C, Potepan P, Fantini S, Bergamini C, Gavazzi C, Licitra L, Scaramellini G, Cantu' G, Olmi P. Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system. Int J Radiat Oncol Biol Phys 2008: 70: 330–337. 69 Papas AS, Clark RE, Martuscelli G, O'Loughlin KT, Johansen E, Miller KB. A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant 2003: 31: 705–712. 70 Rho GJ, Balasubramanian S, Dong-Sik K, Woo-Jin S, Sang-Rae C, Jung-Gon K, Kumar B, Sang-Young C. Influence of in vitro oxygen concentrations on preimplantation embryo development, gene expression and production of Hanwoo calves following embryo transfer. Mol Reprod Dev 2007: 74: 486–496. 71 Rhodus NL, Moller K, Colby S, Bereuter J. Articulatory speech performance in patients with salivary galnd dysfunction: a pilot study. Quintessence Int 1995: 26: 805–810. 72 Ringdal GI, Ringdal K. Testing the EORTC Quality of Life Questionnaire on cancer patients with heterogeneous diagnoses. Qual Life Res 1993: 2: 129–140. 73 Rosenthal DI, Lewin JS, Eisbruch A. Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer. J Clin Oncol 2006: 24: 2636–2643. 74 Rudat V, Meyer J, Momm F, Bendel M, Henke M, Strnad V, Grötz K, Schulte A. Protective effect of amifostine on dental health after radiotherapy of the head and neck. Int J Radiat Oncol Biol Phys 2000: 48: 1339–1343. 75 Saarilahti K, Kouri M, Collan J, Kangasmäki A, Atula T, Joensuu H, Tenhunen M. Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head and neck cancer. Radiation Oncology 2006: 73: 320–325. 76 Sasse AD, Clark LG, Sasse EC, Clark OA. Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis. Int J Radiat Oncol Biol Phys 2005: 64: 784–791. 77 Scarantino C, LeVeque F, Swann RS, White R, Schulsinger A, Hodson DI, Meredith R, Foote R, Brachman D, Lee N. Effect of pilocarpine during radiation therapy: results of RTOG 97-09, a phase III randomized study in head and neck cancer patients. J Support Oncol 2006: 4: 252–258. 78 Scott B, Butterworth C, Lowe D, Rogers SN. Factors associated with restricted mouth opening and its relationship to health-related quality of life in patients attending a maxillofacial oncology clinic. Oral Oncol 2008: 44: 430–438. 79 Sherman AC, Simonton S. S., Adams DC, Emre V, Owens B, Hanna E. Assessing quality of life in patients with head and neck cancer: cross-validation of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Head and Neck Module (QLQ-H&N35). Arch Otolaryngol Head Neck Surg 2000: 126: 459–467. 80 Short SO, Kaplan JN, Laramore GE, Cummings CW. Shoulder pain and function after neck dissection with or without preservation of the spinal accessory nerve. Am J Surg 1984: 148: 478–482. 81 Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, Bekele BN, Raber-Durlacher J, Donnelly JP, Rubenstein EB; Mucositis Study Section of the Multinational Association for Supportive Care in Cancer; International Society for Oral Oncology. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 2004: 100(Suppl. 9): 1995–2025. 82 Sreebny LM, Valdini A. Xerostomia A neglected symptom. Arch Intern Med 1987: 147: 1333–13337. 83 Teguh DN, Levendag PC, Voet P, van der Est H, Noever I, de Kruijf W, van Rooij P, Schmitz PIM, Heijmen BJ. Trismus in patients with oropharyngeal cancer: relationship with dose in structures of mastication apparatus. Head Neck 2008: 30: 622–630. 84 Trotti A. Toxicity in head and neck cancer: a review of trends and issues. Int J Radiat Oncol Biol Phys 2000: 47: 1–12. 85 Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, Komaroff E, Nalysnyk L, Zilbergerg MD. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiother Oncol 2003: 66: 253–262. 86 Trotti A, Colevas AD, Setser A, Basch E. Patient-reported outcomes and the evolution of adverse event reporting in oncology. J Clin Oncol 2007: 25: 5121–5127. 87 Trotti A, Colevas AD, Setser A, Rusch V, Jaques D, Budach V, Langer C, Murphy B, Cumberlin R, Coleman CN, Rubin P. CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 2003: 13: 176–181. 88 Tyldesley S, Sheehan F, Munk P, Tsang V, Skarsgard D, Bowman C, Hobenshield SE. The use of radiologically placed gastrostomy tubes in head and neck cancer patients receiving radiotherapy. Int J Radiat Oncol Biol Phys 1996: 36: 1205–1209. 89 Vu KN, Day TA, Gillespie MB, Martin-Harris B, Sinha D, Stuart RK, Sharma AK. Proximal esophageal stenosis in head and neck cancer patients after total laryngectomy and radiation. ORL J Otorhinolaryngol Relat Spec 2005: 70: 229–235. 90 Wasserman T, Mackowiak JI, Brizel DM, Oster W, Zhang J, Peeples PJ, Sauer R. Effect of amifostine on patient assessed clinical benefit in irradiated head and neck cancer. Int J Radiat Oncol Biol Phys 2000: 48: 1035–1039. 91 van Wilgen CP, Dijkstra PU, van der Laan BF, Plukker JT, Roodenburg JL. Shoulder complaints after nerve sparing neck dissections. Int J Oral Maxillofac Surg 2004: 33: 253–257. 92 Worthington HV, Clarkson JE, Eden OB. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev 2006: CD000978. 93 Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008: 214: 199–210. Citing Literature Volume57, Issue1October 2011Pages 118-131 ReferencesRelatedInformation
Publication Year: 2011
Publication Date: 2011-07-22
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 16
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot