Publication Information

{'id': 'https://openalex.org/W1919426430', 'doi': None, 'title': 'Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists.', 'display_name': 'Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists.', 'publication_year': 2000, 'publication_date': '2000-08-01', 'ids': {'openalex': 'https://openalex.org/W1919426430', 'mag': '1919426430', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10900248'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10900248', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083281465', 'display_name': 'Taline V. Khroyan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I115020962', 'display_name': 'New England Biolabs (United States)', 'ror': 'https://ror.org/04ywg3445', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I115020962']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'T V Khroyan', 'raw_affiliation_strings': ['Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772-9102, USA.'], 'affiliations': [{'raw_affiliation_string': 'Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772-9102, USA.', 'institution_ids': ['https://openalex.org/I115020962', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047031822', 'display_name': 'Rita L. Barrett-Larimore', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R L Barrett-Larimore', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044132616', 'display_name': 'James K. Rowlett', 'orcid': 'https://orcid.org/0000-0002-4077-5017'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J K Rowlett', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111515710', 'display_name': 'Roger D. Spealman', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R D Spealman', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.454, 'has_fulltext': False, 'cited_by_count': 198, 'citation_normalized_percentile': {'value': 0.903496, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '294', 'issue': '2', 'first_page': '680', 'last_page': '7'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10537', 'display_name': 'Attention Deficit Hyperactivity Disorder', 'score': 0.9878, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/quinpirole', 'display_name': 'Quinpirole', 'score': 0.846381}, {'id': 'https://openalex.org/keywords/self-administration', 'display_name': 'Self-administration', 'score': 0.41669023}], 'concepts': [{'id': 'https://openalex.org/C2778296116', 'wikidata': 'https://www.wikidata.org/wiki/Q253187', 'display_name': 'Quinpirole', 'level': 4, 'score': 0.846381}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.6803234}, {'id': 'https://openalex.org/C44208683', 'wikidata': 'https://www.wikidata.org/wiki/Q15335165', 'display_name': 'Dopamine receptor D2', 'level': 3, 'score': 0.65999603}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.6228093}, {'id': 'https://openalex.org/C199596767', 'wikidata': 'https://www.wikidata.org/wiki/Q21110872', 'display_name': 'Dopamine receptor D3', 'level': 4, 'score': 0.5353584}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.4929211}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.47695267}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.47310138}, {'id': 'https://openalex.org/C120069818', 'wikidata': 'https://www.wikidata.org/wiki/Q415496', 'display_name': 'Dopamine receptor', 'level': 3, 'score': 0.46985614}, {'id': 'https://openalex.org/C120750228', 'wikidata': 'https://www.wikidata.org/wiki/Q2035393', 'display_name': 'Dopamine receptor D1', 'level': 4, 'score': 0.42043552}, {'id': 'https://openalex.org/C2778555786', 'wikidata': 'https://www.wikidata.org/wiki/Q7448011', 'display_name': 'Self-administration', 'level': 2, 'score': 0.41669023}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.3626912}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29326552}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25224409}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.23756918}], 'mesh': [{'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D019970', 'descriptor_name': 'Cocaine-Related Disorders', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D018491', 'descriptor_name': 'Dopamine Agonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018492', 'descriptor_name': 'Dopamine Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017447', 'descriptor_name': 'Receptors, Dopamine D1', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D017448', 'descriptor_name': 'Receptors, Dopamine D2', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019970', 'descriptor_name': 'Cocaine-Related Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003214', 'descriptor_name': 'Conditioning, Classical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018491', 'descriptor_name': 'Dopamine Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018492', 'descriptor_name': 'Dopamine Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065127', 'descriptor_name': 'Dopamine D2 Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017447', 'descriptor_name': 'Receptors, Dopamine D1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017447', 'descriptor_name': 'Receptors, Dopamine D1', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D017447', 'descriptor_name': 'Receptors, Dopamine D1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D017448', 'descriptor_name': 'Receptors, Dopamine D2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017448', 'descriptor_name': 'Receptors, Dopamine D2', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D012453', 'descriptor_name': 'Saimiri', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012646', 'descriptor_name': 'Self Administration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10900248', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.84, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1518495152', 'https://openalex.org/W1597719689', 'https://openalex.org/W1895373152', 'https://openalex.org/W1906762169', 'https://openalex.org/W1926556416', 'https://openalex.org/W1964739293', 'https://openalex.org/W1981514537', 'https://openalex.org/W1984027349', 'https://openalex.org/W1996581174', 'https://openalex.org/W2005008592', 'https://openalex.org/W2009578696', 'https://openalex.org/W2012639577', 'https://openalex.org/W2019417698', 'https://openalex.org/W2020092365', 'https://openalex.org/W2021168935', 'https://openalex.org/W2022248874', 'https://openalex.org/W2023042672', 'https://openalex.org/W2028326172', 'https://openalex.org/W2036218676', 'https://openalex.org/W2060060999', 'https://openalex.org/W2060509660', 'https://openalex.org/W2076532525', 'https://openalex.org/W2077707065', 'https://openalex.org/W2084485648', 'https://openalex.org/W2090375124', 'https://openalex.org/W2093348357', 'https://openalex.org/W2093757762', 'https://openalex.org/W2094337655', 'https://openalex.org/W2101583045', 'https://openalex.org/W2130795067', 'https://openalex.org/W2156539550', 'https://openalex.org/W2160531011', 'https://openalex.org/W2170187491', 'https://openalex.org/W2259522204', 'https://openalex.org/W2261629206', 'https://openalex.org/W2267759826', 'https://openalex.org/W2269687382', 'https://openalex.org/W2284228974', 'https://openalex.org/W2308013795', 'https://openalex.org/W2316853317'], 'related_works': ['https://openalex.org/W2975198581', 'https://openalex.org/W2334283077', 'https://openalex.org/W2317263974', 'https://openalex.org/W2067787254', 'https://openalex.org/W2059485222', 'https://openalex.org/W2057788173', 'https://openalex.org/W2052497807', 'https://openalex.org/W2047619967', 'https://openalex.org/W1983491666', 'https://openalex.org/W1965261574'], 'abstract_inverted_index': {'Dopaminergic': [0], 'mechanisms': [1, 24], 'are': [2], 'thought': [3], 'to': [4, 10, 246, 251], 'be': [5, 247], 'critical': [6], 'in': [7, 25, 42, 219], 'mediating': [8], 'relapse': [9, 27, 221], 'cocaine-seeking': [11], 'behavior.': [12], 'This': [13], 'study': [14], 'examined': [15], 'the': [16, 26, 73, 86, 126, 141, 157, 164, 202, 220], 'different': [17, 217], 'roles': [18, 218], 'of': [19, 35, 72, 80, 85, 92, 108, 136, 183, 193, 205, 225, 236, 242], 'D1-': [20, 114, 211], 'and': [21, 52, 69, 115, 119, 131, 148, 154, 162, 177, 212], 'D2-like': [22, 116, 142, 213], 'receptor': [23, 117, 143, 159, 199], 'process.': [28, 222], 'Squirrel': [29], 'monkeys': [30], 'were': [31, 110, 138], 'given': [32], 'extended': [33], 'histories': [34], 'i.': [36], 'v.': [37], 'cocaine': [38, 50, 67, 81, 103, 109, 137], 'self-administration': [39], 'under': [40], 'conditions': [41], 'which': [43], 'responding': [44], 'was': [45, 60], 'maintained': [46, 100], 'jointly': [47], 'by': [48, 63, 101, 112, 125, 140, 152, 156, 187], 'response-contingent': [49], 'injections': [51, 68, 79], 'a': [53, 188], 'cocaine-paired': [54, 74, 87], 'visual': [55], 'stimulus': [56, 88], '(second-order': [57], 'schedule).': [58], 'Responding': [59], 'then': [61], 'extinguished': [62], 'substituting': [64], 'saline': [65], 'for': [66, 234], 'omitting': [70], 'presentations': [71], 'stimulus.': [75], 'Subsequently,': [76], 'noncontingent': [77], 'priming': [78, 106, 134, 191, 203], 'combined': [82], 'with': [83, 95, 174, 197, 249], 'restoration': [84], 'induced': [89, 186], 'dose-dependent': [90], 'reinstatement': [91, 182], 'drug-seeking': [93, 184], 'behavior,': [94], 'response': [96], 'rates': [97], 'approaching': [98], 'those': [99], 'active': [102], 'self-administration.': [104], 'The': [105, 133, 207], 'effects': [107, 135, 204], 'attenuated': [111, 201], 'several': [113], 'antagonists': [118, 128], 'low': [120, 170], 'efficacy': [121, 171], 'agonists': [122, 144, 160, 200], 'but': [123, 227], 'not': [124, 155, 180, 229], 'D3-preferring': [127, 165], 'UH': [129], '232': [130], 'AJ-76.': [132], 'mimicked': [139], 'R(-)-propylnorapomorphine': [145], 'hydrochloride': [146], '(NPA)': [147], 'quinpirole,': [149], 'less': [150], 'consistently': [151], '7-OH-DPAT,': [153], 'D1-like': [158, 198, 243], 'SKF-81297': [161], 'SKF-82958,': [163], 'agonist': [166], 'PD-128,907,': [167, 176], 'or': [168, 240], 'any': [169], 'agonist.': [172], 'Cotreatment': [173], 'NPA,': [175], '7-OH-DPAT': [178], 'did': [179], 'alter': [181], 'behavior': [185], 'maximally': [189], 'effective': [190], 'dose': [192], 'cocaine,': [194], 'whereas': [195], 'cotreatment': [196], 'cocaine.': [206], 'results': [208], 'suggest': [209], 'that': [210], 'receptors': [214, 231, 244], 'play': [215], 'fundamentally': [216], 'Although': [223], 'stimulation': [224, 239], 'D2-like,': [226], 'probably': [228], 'D3-like,': [230], 'appears': [232, 245], 'necessary': [233], 'induction': [235], 'relapse,': [237], 'either': [238], 'blockade': [241], 'inhibitory': [248], 'respect': [250], 'relapse.': [252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1919426430', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-14T08:47:48.549801', 'created_date': '2016-06-24'}