Title: p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.
Abstract: Research Article1 January 1993free access p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system. M. Hamaguchi M. Hamaguchi Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author N. Matsuyoshi N. Matsuyoshi Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author Y. Ohnishi Y. Ohnishi Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author B. Gotoh B. Gotoh Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author M. Takeichi M. Takeichi Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author Y. Nagai Y. Nagai Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author M. Hamaguchi M. Hamaguchi Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author N. Matsuyoshi N. Matsuyoshi Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author Y. Ohnishi Y. Ohnishi Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author B. Gotoh B. Gotoh Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author M. Takeichi M. Takeichi Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author Y. Nagai Y. Nagai Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. Search for more papers by this author Author Information M. Hamaguchi1, N. Matsuyoshi1, Y. Ohnishi1, B. Gotoh1, M. Takeichi1 and Y. Nagai1 1Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. The EMBO Journal (1993)12:307-314https://doi.org/10.1002/j.1460-2075.1993.tb05658.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Transformation of chick embryonic fibroblasts with Rous sarcoma virus strongly suppresses N-cadherin-mediated cell-cell adhesion, without inhibiting its expression. This suppression is correlated with tyrosine phosphorylation of N-cadherin and catenins, the cadherin-associated proteins, which are known to regulate cadherin function. Experiments with non-myristylation and temperature-sensitive mutants of RSV and with herbimycin A, a potent inhibitor of tyrosine kinases, suggest that both the suppression of cell adhesion and tyrosine phosphorylation of catenins are highly transformation-specific. Previous ArticleNext Article Volume 12Issue 11 January 1993In this issue RelatedDetailsLoading ...