Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1909984798', 'doi': 'https://doi.org/10.4049/jimmunol.0902005', 'title': 'Critical Role of the IFN-Stimulated Gene Factor 3 Complex in TLR-Mediated IL-27p28 Gene Expression Revealing a Two-Step Activation Process', 'display_name': 'Critical Role of the IFN-Stimulated Gene Factor 3 Complex in TLR-Mediated IL-27p28 Gene Expression Revealing a Two-Step Activation Process', 'publication_year': 2010, 'publication_date': '2010-01-18', 'ids': {'openalex': 'https://openalex.org/W1909984798', 'doi': 'https://doi.org/10.4049/jimmunol.0902005', 'mag': '1909984798', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20083668'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0902005', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/184/4/1784/1318728/ji_0902005.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.aai.org/jimmunol/article-pdf/184/4/1784/1318728/ji_0902005.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5074820743', 'display_name': 'Céline Molle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Céline Molle', 'raw_affiliation_strings': ['Institute for Medical Immunology, Université Libre de Bruxelles, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Institute for Medical Immunology, Université Libre de Bruxelles, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I132053463']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016249576', 'display_name': 'Michel Goldman', 'orcid': 'https://orcid.org/0000-0003-0222-7287'}, 'institutions': [{'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Michel Goldman', 'raw_affiliation_strings': ['Institute for Medical Immunology, Université Libre de Bruxelles, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Institute for Medical Immunology, Université Libre de Bruxelles, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I132053463']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048936767', 'display_name': 'Stanislas Goriely', 'orcid': 'https://orcid.org/0000-0002-7005-6195'}, 'institutions': [{'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}], 'countries': ['BE'], 'is_corresponding': True, 'raw_author_name': 'Stanislas Goriely', 'raw_affiliation_strings': ['Institute for Medical Immunology, Université Libre de Bruxelles, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Institute for Medical Immunology, Université Libre de Bruxelles, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I132053463']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5048936767'], 'corresponding_institution_ids': ['https://openalex.org/I132053463'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.961, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 73, 'citation_normalized_percentile': {'value': 0.999917, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '184', 'issue': '4', 'first_page': '1784', 'last_page': '1792'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11668', 'display_name': 'Innate Immunity to Viral Infection', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11668', 'display_name': 'Innate Immunity to Viral Infection', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Innate Immune Recognition and Signaling Pathways', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11503', 'display_name': 'Role of STAT3 in Cancer Inflammation and Immunity', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adaptive-immunity-regulation', 'display_name': 'Adaptive Immunity Regulation', 'score': 0.47217}], 'concepts': [{'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.57648003}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5666643}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.42691576}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35325694}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.34300596}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15078449}], 'mesh': [{'descriptor_ui': 'D050838', 'descriptor_name': 'Interferon Regulatory Factor-3', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D051193', 'descriptor_name': 'Toll-Like Receptors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050856', 'descriptor_name': 'Interferon Regulatory Factor-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050856', 'descriptor_name': 'Interferon Regulatory Factor-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050856', 'descriptor_name': 'Interferon Regulatory Factor-1', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D050856', 'descriptor_name': 'Interferon Regulatory Factor-1', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D050838', 'descriptor_name': 'Interferon Regulatory Factor-3', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D050838', 'descriptor_name': 'Interferon Regulatory Factor-3', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050838', 'descriptor_name': 'Interferon Regulatory Factor-3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007370', 'descriptor_name': 'Interferon Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007370', 'descriptor_name': 'Interferon Type I', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D050834', 'descriptor_name': 'Interferon-Stimulated Gene Factor 3, gamma Subunit', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D050834', 'descriptor_name': 'Interferon-Stimulated Gene Factor 3, gamma Subunit', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050834', 'descriptor_name': 'Interferon-Stimulated Gene Factor 3, gamma Subunit', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D050834', 'descriptor_name': 'Interferon-Stimulated Gene Factor 3, gamma Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020239', 'descriptor_name': 'Receptor Cross-Talk', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D020239', 'descriptor_name': 'Receptor Cross-Talk', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051193', 'descriptor_name': 'Toll-Like Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0902005', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/184/4/1784/1318728/ji_0902005.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20083668', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0902005', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/184/4/1784/1318728/ji_0902005.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1583708762', 'https://openalex.org/W1749291720', 'https://openalex.org/W1814395405', 'https://openalex.org/W1929549821', 'https://openalex.org/W1931329582', 'https://openalex.org/W1963632824', 'https://openalex.org/W1966209864', 'https://openalex.org/W1969446328', 'https://openalex.org/W1986148978', 'https://openalex.org/W1994158191', 'https://openalex.org/W1999561404', 'https://openalex.org/W2004660702', 'https://openalex.org/W2009219530', 'https://openalex.org/W2014444689', 'https://openalex.org/W2032064870', 'https://openalex.org/W2042436346', 'https://openalex.org/W2044580027', 'https://openalex.org/W2047180710', 'https://openalex.org/W2049874360', 'https://openalex.org/W2053236313', 'https://openalex.org/W2063273780', 'https://openalex.org/W2065554630', 'https://openalex.org/W2067640086', 'https://openalex.org/W2067678108', 'https://openalex.org/W2068577743', 'https://openalex.org/W2073242835', 'https://openalex.org/W2084880831', 'https://openalex.org/W2088901705', 'https://openalex.org/W2089077517', 'https://openalex.org/W2097679528', 'https://openalex.org/W2104546854', 'https://openalex.org/W2111922856', 'https://openalex.org/W2123076394', 'https://openalex.org/W2126197815', 'https://openalex.org/W2130776189', 'https://openalex.org/W2136850954', 'https://openalex.org/W2141753982', 'https://openalex.org/W2144206734', 'https://openalex.org/W2144787399', 'https://openalex.org/W2147640266', 'https://openalex.org/W2151109138', 'https://openalex.org/W2159546356', 'https://openalex.org/W2165323521', 'https://openalex.org/W2167192576', 'https://openalex.org/W4249383371'], 'related_works': ['https://openalex.org/W3032874291', 'https://openalex.org/W2415025170', 'https://openalex.org/W2363156284', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2082860237', 'https://openalex.org/W2046158694', 'https://openalex.org/W2005057264', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418'], 'abstract_inverted_index': {'Abstract': [0], 'In': [1, 31], 'myeloid': [2], 'dendritic': [3], 'cells,': [4], 'activation': [5, 56], 'of': [6, 15, 59, 87, 94, 119, 127, 136, 159], 'the': [7, 22, 60, 80, 92, 116, 120, 125, 137, 146, 157], 'IL-27p28': [8, 45, 81, 95, 121], 'gene': [9, 63, 122, 139], 'is': [10], 'selectively': [11], 'induced': [12], 'by': [13], 'ligands': [14], 'TLR4': [16, 112], 'or': [17, 113], 'TLR3,': [18], 'both': [19, 34], 'coupled': [20], 'to': [21, 33, 79, 105, 111], 'Toll/IL-1R–related': [23], 'domain-containing': [24], 'adaptor-inducing': [25], 'IFN/IFN': [26], 'regulatory': [27, 83], 'factor': [28, 64, 140], '(IRF)3': [29], 'pathway.': [30], 'response': [32, 110], 'ligands,': [35], 'autocrine': [36], 'type': [37, 153], '1': [38], 'IFN': [39, 49], 'production': [40], 'was': [41, 51, 96], 'required': [42], 'for': [43, 53, 156], 'optimal': [44], 'expression.': [46], 'Type': [47], 'I': [48, 154], 'signaling': [50], 'necessary': [52], 'sustained': [54], 'IRF1': [55, 71, 88, 128], 'and': [57, 72, 77, 89, 100, 129, 152], 'formation': [58], 'IRF9-containing': [61], 'IFN-stimulated': [62, 82, 138], '3': [65, 141], 'complex.': [66, 142], 'Indeed,': [67], 'we': [68], 'demonstrated': [69], 'that': [70], 'IRF9': [73, 90], 'are': [74], 'sequentially': [75], 'activated': [76], 'recruited': [78], 'element': [84], 'site.': [85], 'Involvement': [86], 'in': [91, 98, 102, 109], 'induction': [93, 118], 'confirmed': [97], 'vitro': [99], 'upon': [101], 'vivo': [103], 'exposure': [104], 'TLR': [106], 'ligands.': [107], 'Thus,': [108], 'TLR3': [114], 'ligation,': [115], 'initial': [117], 'depends': [123], 'on': [124], 'recruitment': [126, 135], 'IRF3,': [130], 'whereas': [131], 'transcriptional': [132], 'amplification': [133], 'requires': [134], 'These': [143], 'results': [144], 'highlight': [145], 'complex': [147], 'molecular': [148], 'interplay': [149], 'between': [150], 'TLRs': [151], 'IFNs': [155], 'control': [158], 'IL-27': [160], 'synthesis.': [161]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1909984798', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-09-19T23:52:39.404853', 'created_date': '2016-06-24'}