Title: Effect of Methanol Leaf Extract of Nauclea latifolia on Albino Mice Infected with Plasmodium berghei berghei
Abstract:Background: In Nigeria the leaf decoction of Nauclea latifolia is taken to treat malaria and sexually transmitted diseases. This study intends to generate a scientific data in support of the tradition...Background: In Nigeria the leaf decoction of Nauclea latifolia is taken to treat malaria and sexually transmitted diseases. This study intends to generate a scientific data in support of the traditional use of the leaves in malaria treatment. Objective: To investigate the antiplasmodial effect of the methanol extract of the leaves of Nauclea latifolia on chloroquine sensitive Plasmodium berghei berghei in experimentally infected albino mice. Materials and Methods: The fresh leaves of Nauclea latifolia were collected, dried under shade, ground into powder and macerated in methanol for 72 hrs. The dried extract was stored at -4 °C for use. Thirty (30) mice were divided into five groups (A,B,C,D,E). Group A received 10 ml/kg/day of distilled water (negative control). Groups B, C and D received 370, 740 and 1110 mg/kg/day of the extract respectively. Group E received 1.2 mg/kg/day of artesunate (positive control). This experiment was repeated for suppressive, prophylactic and curative tests. Results: The extract produced considerable antiplasmodial activity in all the three tests evaluated compared to the standard drug (artesunate). The extract reduced parasitaemia significantly (p<0.05) in a dose dependent manner. Bioactive constituents of the plant could be responsible for the antiplasmodial activity Conclusion: The result of the study supports the need for continued search for components of traditional medicine as potential antimalarial agents. Keywords: Malaria, Nauclea latifolia , mice , Plasmodium berghei bergheiRead More
Publication Year: 2013
Publication Date: 2013-01-10
Language: en
Type: article
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Cited By Count: 3
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