Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1908186060', 'doi': 'https://doi.org/10.1096/fasebj.9.11.7649405', 'title': 'Structural and functional relationships of heterotrimeric G‐proteins', 'display_name': 'Structural and functional relationships of heterotrimeric G‐proteins', 'publication_year': 1995, 'publication_date': '1995-08-01', 'ids': {'openalex': 'https://openalex.org/W1908186060', 'doi': 'https://doi.org/10.1096/fasebj.9.11.7649405', 'mag': '1908186060', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7649405'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fasebj.9.11.7649405', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fasebj.9.11.7649405', 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fasebj.9.11.7649405', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033527900', 'display_name': 'Stephanie Rens‐Domiano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephanie Rens‐Domiano', 'raw_affiliation_strings': ['Department of Physiology and BiophysicsUniversity of Illinois at ChicagoCollege of MedicineChicagoIllinois60612USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and BiophysicsUniversity of Illinois at ChicagoCollege of MedicineChicagoIllinois60612USA', 'institution_ids': ['https://openalex.org/I39422238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5023618339', 'display_name': 'Heidi E. Hamm', 'orcid': 'https://orcid.org/0000-0001-5437-5287'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Heidi E. Hamm', 'raw_affiliation_strings': ['Department of Physiology and BiophysicsUniversity of Illinois at ChicagoCollege of MedicineChicagoIllinois60612USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and BiophysicsUniversity of Illinois at ChicagoCollege of MedicineChicagoIllinois60612USA', 'institution_ids': ['https://openalex.org/I39422238']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.644, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 160, 'citation_normalized_percentile': {'value': 0.586667, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '9', 'issue': '11', 'first_page': '1059', 'last_page': '1066'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/g-beta-gamma-complex', 'display_name': 'G beta-gamma complex', 'score': 0.69226444}, {'id': 'https://openalex.org/keywords/gtp-binding-protein-regulators', 'display_name': 'GTP-binding protein regulators', 'score': 0.502414}], 'concepts': [{'id': 'https://openalex.org/C139407321', 'wikidata': 'https://www.wikidata.org/wiki/Q408561', 'display_name': 'Heterotrimeric G protein', 'level': 4, 'score': 0.9955528}, {'id': 'https://openalex.org/C80631254', 'wikidata': 'https://www.wikidata.org/wiki/Q407438', 'display_name': 'G protein', 'level': 3, 'score': 0.8136566}, {'id': 'https://openalex.org/C163181125', 'wikidata': 'https://www.wikidata.org/wiki/Q408592', 'display_name': 'GTPase-activating protein', 'level': 4, 'score': 0.7429788}, {'id': 'https://openalex.org/C78254988', 'wikidata': 'https://www.wikidata.org/wiki/Q22328498', 'display_name': 'G beta-gamma complex', 'level': 5, 'score': 0.69226444}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.65945226}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6556371}, {'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.5876584}, {'id': 'https://openalex.org/C207332259', 'wikidata': 'https://www.wikidata.org/wiki/Q769143', 'display_name': 'GTPase', 'level': 2, 'score': 0.5287024}, {'id': 'https://openalex.org/C85771745', 'wikidata': 'https://www.wikidata.org/wiki/Q5514732', 'display_name': 'GTP-binding protein regulators', 'level': 4, 'score': 0.502414}, {'id': 'https://openalex.org/C126619667', 'wikidata': 'https://www.wikidata.org/wiki/Q901088', 'display_name': 'Guanine nucleotide exchange factor', 'level': 3, 'score': 0.4873422}, {'id': 'https://openalex.org/C83730767', 'wikidata': 'https://www.wikidata.org/wiki/Q24778884', 'display_name': 'G alpha subunit', 'level': 4, 'score': 0.4773105}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.46710244}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.46267837}, {'id': 'https://openalex.org/C33235085', 'wikidata': 'https://www.wikidata.org/wiki/Q4355943', 'display_name': 'G protein-coupled receptor kinase', 'level': 4, 'score': 0.45941505}, {'id': 'https://openalex.org/C135285700', 'wikidata': 'https://www.wikidata.org/wiki/Q38173', 'display_name': 'G protein-coupled receptor', 'level': 3, 'score': 0.4536691}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33176768}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2963145}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006160', 'descriptor_name': 'Guanosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006160', 'descriptor_name': 'Guanosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fasebj.9.11.7649405', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fasebj.9.11.7649405', 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7649405', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fasebj.9.11.7649405', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fasebj.9.11.7649405', 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1482828226', 'https://openalex.org/W1490670694', 'https://openalex.org/W1492894785', 'https://openalex.org/W1503310668', 'https://openalex.org/W1512107284', 'https://openalex.org/W1512691892', 'https://openalex.org/W1517746500', 'https://openalex.org/W1520928812', 'https://openalex.org/W1528051864', 'https://openalex.org/W1531303582', 'https://openalex.org/W1546091073', 'https://openalex.org/W1547693430', 'https://openalex.org/W1566533641', 'https://openalex.org/W1567065545', 'https://openalex.org/W1573946811', 'https://openalex.org/W1577226222', 'https://openalex.org/W1579000749', 'https://openalex.org/W1681309649', 'https://openalex.org/W1848020035', 'https://openalex.org/W1942777601', 'https://openalex.org/W1969814518', 'https://openalex.org/W1972760976', 'https://openalex.org/W1980105614', 'https://openalex.org/W1982849102', 'https://openalex.org/W1988803183', 'https://openalex.org/W1990033844', 'https://openalex.org/W1994090158', 'https://openalex.org/W1998889596', 'https://openalex.org/W2001013796', 'https://openalex.org/W2022754746', 'https://openalex.org/W2023038974', 'https://openalex.org/W2027234006', 'https://openalex.org/W2029896705', 'https://openalex.org/W2031351133', 'https://openalex.org/W2037629081', 'https://openalex.org/W2042352993', 'https://openalex.org/W2050662518', 'https://openalex.org/W2060871246', 'https://openalex.org/W2075758658', 'https://openalex.org/W2124136616', 'https://openalex.org/W2140686653', 'https://openalex.org/W2210204186', 'https://openalex.org/W2400385201', 'https://openalex.org/W316299713'], 'related_works': ['https://openalex.org/W2329936852', 'https://openalex.org/W2114446441', 'https://openalex.org/W2095013577', 'https://openalex.org/W2083195970', 'https://openalex.org/W2062336089', 'https://openalex.org/W2029445497', 'https://openalex.org/W2020066265', 'https://openalex.org/W2011014082', 'https://openalex.org/W1953109900', 'https://openalex.org/W1599069035'], 'abstract_inverted_index': {'Heterotrimeric': [0, 32], 'GTP-binding': [1], 'proteins': [2], '(G-proteins)': [3], 'are': [4], 'a': [5, 28, 62, 65], 'critical': [6], 'component': [7], 'of': [8, 35, 77, 83, 105, 129], 'signal': [9, 91], 'transduction': [10, 92], 'pathways': [11], 'that': [12], 'carry': [13], 'information': [14], 'received': [15], 'at': [16], 'the': [17, 21, 40, 58, 75, 78, 102, 111], 'cell': [18], 'surface': [19], 'to': [20, 56, 73], 'appropriate': [22], 'cellular': [23, 30], 'effector': [24], 'system,': [25, 69], 'ultimately': [26], 'achieving': [27], 'specific': [29], 'response.': [31], 'G-proteins': [33, 54, 115], 'consist': [34], 'an': [36, 50], 'a-subunit,': [37], 'which': [38, 61, 114], 'contains': [39], 'guanine': [41], 'nucleotide': [42], 'binding': [43], 'site': [44], 'and': [45, 49, 85, 119, 126], 'intrinsic': [46], 'GTPase': [47], 'activity,': [48], 'inseparable': [51], 'βγ-subunit': [52], 'complex.': [53], 'act': [55], 'define': [57], 'specificity': [59], 'by': [60, 113], 'receptor': [63], 'regulates': [64], 'particular': [66], 'intracellular': [67], 'signaling': [68], 'as': [70, 72, 107, 109], 'well': [71, 108], 'regulate': [74], 'duration': [76], 'signal.': [79], 'A': [80], 'great': [81], 'deal': [82], 'structural': [84, 103], 'functional': [86, 127], 'insight': [87], 'into': [88], 'how': [89], 'G-protein-mediated': [90], 'occurs': [93], 'has': [94], 'recently': [95], 'been': [96], 'achieved.': [97], 'This': [98], 'review': [99], 'will': [100], 'discuss': [101], 'features': [104], 'G-proteins,': [106], 'detail': [110], 'mechanism': [112], 'interact': [116], 'with': [117], 'receptors': [118], 'effectors.—Rens-Domiano,': [120], 'S.,': [121], 'Hamm,': [122], 'H.': [123], 'E.': [124], 'Structure': [125], 'relationships': [128], 'heterotrimeric': [130], 'G-proteins.': [131], 'FASEBJ.': [132], '9,': [133], '1059-1066': [134], '(1995)': [135]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1908186060', 'counts_by_year': [{'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-10T08:17:11.209338', 'created_date': '2016-06-24'}