Increased levels of 2‐hydroxyglutarate in AML patients with IDH1‐R132H and IDH2‐R140Q mutations

Name: Work Video:
Duration: 3 min 30 s
Leopold Sellner; David Capper; Jochen Meyer; Claus‐Dieter Langhans; Christine‐Maria Hartog; Roman Pfeifer; Hubert Serve; Anthony D. Ho; Jürgen G. Okun; Alwin Krämer; Andreas von Deimling
{'id': 'https://openalex.org/W1907671556', 'doi': 'https://doi.org/10.1111/j.1600-0609.2010.01505.x', 'title': 'Increased levels of 2‐hydroxyglutarate in AML patients with IDH1‐R132H and IDH2‐R140Q mutations', 'display_name': 'Increased levels of 2‐hydroxyglutarate in AML patients with IDH1‐R132H and IDH2‐R140Q mutations', 'publication_year': 2010, 'publication_date': '2010-07-26', 'ids': {'openalex': 'https://openalex.org/W1907671556', 'doi': 'https://doi.org/10.1111/j.1600-0609.2010.01505.x', 'mag': '1907671556', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20659156'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0609.2010.01505.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159715054', 'display_name': 'European Journal Of Haematology', 'issn_l': '0902-4441', 'issn': ['0902-4441', '1600-0609'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078894628', 'display_name': 'Leopold Sellner', 'orcid': 'https://orcid.org/0000-0002-7893-401X'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Leopold Sellner', 'raw_affiliation_strings': ['Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center and Department of Internal Medicine V, University of Heidelberg, Heidelberg', 'Department of Internal Medicine V, University of Heidelberg, Heidelberg', 'These authors contributed equally to this work.'], 'affiliations': [{'raw_affiliation_string': 'These authors contributed equally to this work.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Internal Medicine V, University of Heidelberg, Heidelberg', 'institution_ids': ['https://openalex.org/I223822909']}, {'raw_affiliation_string': 'Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center and Department of Internal Medicine V, University of Heidelberg, Heidelberg', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039647180', 'display_name': 'David Capper', 'orcid': 'https://orcid.org/0000-0003-1945-497X'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'David Capper', 'raw_affiliation_strings': ['Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg', 'These authors contributed equally to this work.'], 'affiliations': [{'raw_affiliation_string': 'These authors contributed equally to this work.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102764244', 'display_name': 'Jochen Meyer', 'orcid': 'https://orcid.org/0009-0000-8610-0077'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jochen Meyer', 'raw_affiliation_strings': ['Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112142956', 'display_name': 'Claus‐Dieter Langhans', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}, {'id': 'https://openalex.org/I4210090147', 'display_name': 'Uniwersytecki Szpital Dziecięcy', 'ror': 'https://ror.org/009x1kj44', 'country_code': 'PL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210090147']}, {'id': 'https://openalex.org/I4210115958', 'display_name': "Children's Clinical University Hospital", 'ror': 'https://ror.org/01js8h045', 'country_code': 'LV', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115958']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE', 'LV', 'PL'], 'is_corresponding': False, 'raw_author_name': 'Claus‐Dieter Langhans', 'raw_affiliation_strings': ["Department of General Pediatrics, University Children's Hospital, Heidelberg"], 'affiliations': [{'raw_affiliation_string': "Department of General Pediatrics, University Children's Hospital, Heidelberg", 'institution_ids': ['https://openalex.org/I2802164966', 'https://openalex.org/I4210090147', 'https://openalex.org/I4210115958', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105734865', 'display_name': 'Christine‐Maria Hartog', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christine‐Maria Hartog', 'raw_affiliation_strings': ['Department of Internal Medicine II, University of Frankfurt, Frankfurt'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine II, University of Frankfurt, Frankfurt', 'institution_ids': ['https://openalex.org/I114090438']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101553405', 'display_name': 'Roman Pfeifer', 'orcid': 'https://orcid.org/0000-0003-1543-3995'}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Heike Pfeifer', 'raw_affiliation_strings': ['Department of Internal Medicine II, University of Frankfurt, Frankfurt'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine II, University of Frankfurt, Frankfurt', 'institution_ids': ['https://openalex.org/I114090438']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086016311', 'display_name': 'Hubert Serve', 'orcid': 'https://orcid.org/0000-0001-8472-5516'}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hubert Serve', 'raw_affiliation_strings': ['Department of Internal Medicine II, University of Frankfurt, Frankfurt'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine II, University of Frankfurt, Frankfurt', 'institution_ids': ['https://openalex.org/I114090438']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067574718', 'display_name': 'Anthony D. Ho', 'orcid': 'https://orcid.org/0000-0002-1656-0833'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Anthony D. Ho', 'raw_affiliation_strings': ['Department of Internal Medicine V, University of Heidelberg, Heidelberg'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine V, University of Heidelberg, Heidelberg', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110880219', 'display_name': 'Jürgen G. Okun', 'orcid': 'https://orcid.org/0000-0003-2975-1054'}, 'institutions': [{'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}, {'id': 'https://openalex.org/I4210090147', 'display_name': 'Uniwersytecki Szpital Dziecięcy', 'ror': 'https://ror.org/009x1kj44', 'country_code': 'PL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210090147']}, {'id': 'https://openalex.org/I4210115958', 'display_name': "Children's Clinical University Hospital", 'ror': 'https://ror.org/01js8h045', 'country_code': 'LV', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115958']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}], 'countries': ['DE', 'LV', 'PL'], 'is_corresponding': False, 'raw_author_name': 'Jürgen G. Okun', 'raw_affiliation_strings': ['Clinical Cooperation Unit Neuropathology, German Cancer Research Center and Institute of Pathology, University of Heidelberg, Heidelberg, Germany', "Department of General Pediatrics, University Children's Hospital, Heidelberg"], 'affiliations': [{'raw_affiliation_string': "Department of General Pediatrics, University Children's Hospital, Heidelberg", 'institution_ids': ['https://openalex.org/I2802164966', 'https://openalex.org/I4210090147', 'https://openalex.org/I4210115958', 'https://openalex.org/I223822909']}, {'raw_affiliation_string': 'Clinical Cooperation Unit Neuropathology, German Cancer Research Center and Institute of Pathology, University of Heidelberg, Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113606061', 'display_name': 'Alwin Krämer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Alwin Krämer', 'raw_affiliation_strings': ['Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center and Department of Internal Medicine V, University of Heidelberg, Heidelberg'], 'affiliations': [{'raw_affiliation_string': 'Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center and Department of Internal Medicine V, University of Heidelberg, Heidelberg', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052657395', 'display_name': 'Andreas von Deimling', 'orcid': 'https://orcid.org/0000-0002-5863-540X'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Andreas Von Deimling', 'raw_affiliation_strings': ['Clinical Cooperation Unit Neuropathology, German Cancer Research Center and Institute of Pathology, University of Heidelberg, Heidelberg, Germany', 'Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg', 'institution_ids': ['https://openalex.org/I223822909']}, {'raw_affiliation_string': 'Clinical Cooperation Unit Neuropathology, German Cancer Research Center and Institute of Pathology, University of Heidelberg, Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4220, 'currency': 'USD', 'value_usd': 4220, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.943478, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '85', 'issue': '5', 'first_page': '457', 'last_page': '459'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10129', 'display_name': 'Glioma Diagnosis and Treatment', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10345', 'display_name': 'Hematopoietic Stem Cell Transplantation', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neuropathology', 'display_name': 'Neuropathology', 'score': 0.5679476}], 'concepts': [{'id': 'https://openalex.org/C2780130745', 'wikidata': 'https://www.wikidata.org/wiki/Q1650750', 'display_name': 'Neuropathology', 'level': 3, 'score': 0.5679476}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.52485585}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.3523757}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26814547}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.13759941}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005977', 'descriptor_name': 'Glutarates', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D007521', 'descriptor_name': 'Isocitrate Dehydrogenase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015470', 'descriptor_name': 'Leukemia, Myeloid, Acute', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005977', 'descriptor_name': 'Glutarates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007521', 'descriptor_name': 'Isocitrate Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015470', 'descriptor_name': 'Leukemia, Myeloid, Acute', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0609.2010.01505.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159715054', 'display_name': 'European Journal Of Haematology', 'issn_l': '0902-4441', 'issn': ['0902-4441', '1600-0609'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20659156', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 11, 'referenced_works': ['https://openalex.org/W1991775451', 'https://openalex.org/W1995675594', 'https://openalex.org/W1998548151', 'https://openalex.org/W2043216151', 'https://openalex.org/W2079901663', 'https://openalex.org/W2080452140', 'https://openalex.org/W2115400483', 'https://openalex.org/W2120963683', 'https://openalex.org/W2127738065', 'https://openalex.org/W2134061682', 'https://openalex.org/W2159731673'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2586801360', 'https://openalex.org/W2409174684', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166'], 'abstract_inverted_index': {'European': [0], 'Journal': [1], 'of': [2, 11, 36, 41, 45, 50, 70, 73, 76, 96, 99, 102, 115, 132, 137, 150, 155, 168, 173, 188, 193, 208, 225, 228, 252, 257, 272, 275, 278, 291, 294, 319, 324, 328, 333, 353, 356, 359, 379, 382, 385, 398, 415, 420, 433, 438, 451, 456, 471, 476, 491, 508, 511, 535, 540, 555, 558, 561, 574, 577, 607, 612, 641, 644, 677, 687, 700, 711], 'HaematologyVolume': [3], '85,': [4], 'Issue': [5], '5': [6], 'p.': [7], '457-459': [8, 732], 'Increased': [9], 'levels': [10], '2-hydroxyglutarate': [12], 'in': [13], 'AML': [14], 'patients': [15], 'with': [16, 714], 'IDH1-R132H': [17], 'and': [18, 34, 223, 250, 289, 317, 506, 533, 572, 605, 646, 675, 679, 691, 698, 717], 'IDH2-R140Q': [19], 'mutations': [20], 'Leopold': [21, 23, 304, 306], 'Sellner,': [22, 305], 'Sellner': [24, 307], 'Clinical': [25, 215, 241, 281, 308, 498, 524, 564, 596], 'Cooperation': [26, 216, 242, 282, 309, 499, 525, 565, 597], 'Unit': [27, 217, 243, 283, 310, 500, 526, 566, 598], 'Molecular': [28, 244, 311, 527, 599], 'Hematology/Oncology,': [29, 245, 312, 528], 'German': [30, 219, 246, 285, 313, 502, 529, 568, 601], 'Cancer': [31, 220, 247, 286, 314, 503, 530, 569, 602], 'Research': [32, 221, 248, 287, 315, 504, 531, 570, 603], 'Center': [33, 222, 249, 288, 316, 505, 532, 571, 604], 'Department': [35, 44, 69, 95, 114, 131, 149, 167, 187, 207, 251, 271, 318, 327, 352, 378, 397, 414, 432, 450, 470, 490, 534, 554, 606], 'Internal': [37, 46, 133, 151, 169, 189, 253, 320, 329, 416, 434, 452, 472, 536, 608], 'Medicine': [38, 47, 134, 152, 170, 190, 254, 321, 330, 417, 435, 453, 473, 537, 609], 'V,': [39, 48, 191, 255, 322, 331, 474, 538, 610], 'University': [40, 49, 75, 101, 118, 136, 154, 172, 192, 211, 227, 256, 277, 293, 323, 332, 358, 384, 401, 419, 437, 455, 475, 494, 510, 539, 560, 576, 611, 643], 'Heidelberg,': [42, 51, 77, 103, 194, 229, 230, 258, 279, 295, 296, 325, 334, 360, 386, 477, 512, 513, 541, 562, 578, 579, 613, 619, 645], 'Heidelberg': [43, 52, 78, 214, 280, 326, 335, 361, 497, 563], 'These': [53, 79, 336, 362], 'authors': [54, 80, 337, 363], 'contributed': [55, 81, 338, 364], 'equally': [56, 82, 339, 365], 'to': [57, 83, 340, 366, 661, 683, 706], 'this': [58, 64, 84, 90, 109, 126, 144, 162, 180, 200, 236, 264, 302, 341, 347, 367, 373, 392, 409, 427, 445, 463, 483, 519, 547, 585, 712], 'work.Search': [59, 85, 342, 368], 'for': [60, 86, 105, 122, 140, 158, 176, 196, 232, 260, 298, 343, 369, 388, 405, 423, 441, 459, 479, 515, 543, 581], 'more': [61, 87, 106, 123, 141, 159, 177, 197, 233, 261, 299, 344, 370, 389, 406, 424, 442, 460, 480, 516, 544, 582], 'papers': [62, 88, 107, 124, 142, 160, 178, 198, 234, 262, 300, 345, 371, 390, 407, 425, 443, 461, 481, 517, 545, 583], 'by': [63, 89, 108, 125, 143, 161, 179, 199, 235, 263, 301, 346, 372, 391, 408, 426, 444, 462, 482, 518, 546, 584, 636], 'authorDavid': [65, 348], 'Capper,': [66, 349], 'David': [67, 350], 'Capper': [68, 351], 'Neuropathology,': [71, 97, 218, 273, 284, 354, 380, 501, 556, 567], 'Institute': [72, 98, 224, 274, 290, 355, 381, 507, 557, 573], 'Pathology,': [74, 100, 226, 276, 292, 357, 383, 509, 559, 575], 'authorJochen': [91, 374], 'Meyer,': [92, 375], 'Jochen': [93, 376], 'Meyer': [94, 377], 'HeidelbergSearch': [104, 121, 195, 259, 387, 404, 478, 542], 'authorClaus-Dieter': [110, 393], 'Langhans,': [111, 394], 'Claus-Dieter': [112, 395], 'Langhans': [113, 396], 'General': [116, 209, 399, 492], 'Pediatrics,': [117, 210, 400, 493], "Children's": [119, 212, 402, 495], 'Hospital,': [120, 213, 403, 496], 'authorChristine-Maria': [127, 410], 'Hartog,': [128, 411], 'Christine-Maria': [129, 412], 'Hartog': [130, 413], 'II,': [135, 153, 171, 418, 436, 454], 'Frankfurt,': [138, 156, 174, 421, 439, 457], 'FrankfurtSearch': [139, 157, 175, 422, 440, 458], 'authorHeike': [145, 428], 'Pfeifer,': [146, 429], 'Heike': [147, 430], 'Pfeifer': [148, 431], 'authorHubert': [163, 446], 'Serve,': [164, 447], 'Hubert': [165, 448], 'Serve': [166, 449], 'authorAnthony': [181, 464], 'D.': [182, 185, 465, 468], 'Ho,': [183, 466], 'Anthony': [184, 467], 'Ho': [186, 469], 'authorJürgen': [201, 484], 'G.': [202, 205, 485, 488], 'Okun,': [203, 486], 'Jürgen': [204, 487], 'Okun': [206, 489], 'GermanySearch': [231, 297, 514, 580], 'authorAlwin': [237, 520], 'Krämer,': [238, 521, 595], 'Alwin': [239, 522, 594], 'Krämer': [240, 523], 'authorAndreas': [265, 548], 'Von': [266, 269, 549, 552], 'Deimling,': [267, 550], 'Andreas': [268, 551], 'Deimling': [270, 553], 'author': [303, 586], 'First': [587], 'published:': [588], '26': [589], 'July': [590], '2010': [591], 'https://doi.org/10.1111/j.1600-0609.2010.01505.xCitations:': [592], '35': [593], 'Hematology/Oncology': [600], 'Im': [614], 'Neuenheimer': [615], 'Feld': [616], '581,': [617], '69120': [618], 'Germany.Tel:': [620], '+49': [621, 626], '6221': [622, 627], '42': [623, 628], '1440;': [624], 'Fax:': [625], '1444;': [629], 'e-mail:': [630], '[email protected]': [631], 'The': [632], 'study': [633], 'was': [634, 649], 'approved': [635], 'the': [637, 642, 655, 693, 703], 'ethical': [638], 'review': [639, 672], 'board': [640], 'informed': [647], 'consent': [648], 'obtained': [650], 'from': [651], 'all': [652], 'patients.': [653], 'Read': [654], 'full': [656, 667], 'textAboutPDF': [657], 'ToolsRequest': [658], 'permissionExport': [659], 'citationAdd': [660], 'favoritesTrack': [662], 'citation': [663], 'ShareShare': [664], 'Give': [665], 'accessShare': [666, 669], 'text': [668], 'full-text': [670, 685, 709], 'accessPlease': [671], 'our': [673], 'Terms': [674, 697], 'Conditions': [676, 699], 'Use': [678], 'check': [680], 'box': [681], 'below': [682, 705], 'share': [684, 707], 'version': [686, 710], 'article.I': [688], 'have': [689], 'read': [690], 'accept': [692], 'Wiley': [694], 'Online': [695], 'Library': [696], 'UseShareable': [701], 'LinkUse': [702], 'link': [704], 'a': [708, 723], 'article': [713], 'your': [715], 'friends': [716], 'colleagues.': [718], 'Learn': [719], 'more.Copy': [720], 'URL': [721], 'Share': [722], 'linkShare': [724], 'onFacebookTwitterLinked': [725], 'InRedditWechat': [726], 'Citing': [727], 'Literature': [728], 'Volume85,': [729], 'Issue5November': [730], '2010Pages': [731], 'RelatedInformation': [733]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1907671556', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-14T08:10:49.859533', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
