Publication Information

{'id': 'https://openalex.org/W1904823828', 'doi': None, 'title': 'Selective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen.', 'display_name': 'Selective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen.', 'publication_year': 1990, 'publication_date': '1990-11-01', 'ids': {'openalex': 'https://openalex.org/W1904823828', 'mag': '1904823828', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2208170'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2208170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012440042', 'display_name': 'Baldew Gs', 'orcid': None}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Baldew Gs', 'raw_affiliation_strings': ['Department of Radiochemistry, Interfaculty Reactor Institute, Delft, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiochemistry, Interfaculty Reactor Institute, Delft, The Netherlands.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042726299', 'display_name': 'McVie Jg', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'McVie Jg', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090374893', 'display_name': 'van der Valk', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'van der Valk Ma', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073006898', 'display_name': 'Los G', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Los G', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070692246', 'display_name': 'de Goeij Jj', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'de Goeij Jj', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5027199677', 'display_name': 'Nico Vermeulen', 'orcid': 'https://orcid.org/0000-0003-4194-6401'}, 'institutions': [{'id': 'https://openalex.org/I4210142535', 'display_name': 'Society of Environmental Toxicology and Chemistry', 'ror': 'https://ror.org/049dnw004', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210142535']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vermeulen Np', 'raw_affiliation_strings': ['Molecular and Computational Toxicology'], 'affiliations': [{'raw_affiliation_string': 'Molecular and Computational Toxicology', 'institution_ids': ['https://openalex.org/I4210142535']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.872, 'has_fulltext': False, 'cited_by_count': 54, 'citation_normalized_percentile': {'value': 0.951819, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '50', 'issue': '21', 'first_page': '7031', 'last_page': '6'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11931', 'display_name': 'Organoselenium and organotellurium chemistry', 'score': 0.9784, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11931', 'display_name': 'Organoselenium and organotellurium chemistry', 'score': 0.9784, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11979', 'display_name': 'Garlic and Onion Studies', 'score': 0.9661, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ebselen', 'display_name': 'Ebselen', 'score': 0.9937157}, {'id': 'https://openalex.org/keywords/nephrotoxicity', 'display_name': 'Nephrotoxicity', 'score': 0.8434677}, {'id': 'https://openalex.org/keywords/blood-urea-nitrogen', 'display_name': 'Blood urea nitrogen', 'score': 0.5850389}], 'concepts': [{'id': 'https://openalex.org/C2779138974', 'wikidata': 'https://www.wikidata.org/wiki/Q5332073', 'display_name': 'Ebselen', 'level': 5, 'score': 0.9937157}, {'id': 'https://openalex.org/C126189478', 'wikidata': 'https://www.wikidata.org/wiki/Q1468324', 'display_name': 'Nephrotoxicity', 'level': 3, 'score': 0.8434677}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.68306035}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.62304366}, {'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.5979548}, {'id': 'https://openalex.org/C2778176769', 'wikidata': 'https://www.wikidata.org/wiki/Q764079', 'display_name': 'Blood urea nitrogen', 'level': 3, 'score': 0.5850389}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.5175325}, {'id': 'https://openalex.org/C2780306776', 'wikidata': 'https://www.wikidata.org/wiki/Q426660', 'display_name': 'Creatinine', 'level': 2, 'score': 0.513409}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.29128987}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.23420683}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.2083036}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20464304}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.13449958}, {'id': 'https://openalex.org/C2778760513', 'wikidata': 'https://www.wikidata.org/wiki/Q24773045', 'display_name': 'Glutathione peroxidase', 'level': 4, 'score': 0.12157369}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.12046465}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001393', 'descriptor_name': 'Azoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D016566', 'descriptor_name': 'Organoselenium Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012643', 'descriptor_name': 'Selenium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D001393', 'descriptor_name': 'Azoles', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D001393', 'descriptor_name': 'Azoles', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001393', 'descriptor_name': 'Azoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004334', 'descriptor_name': 'Drug Administration Schedule', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054833', 'descriptor_name': 'Isoindoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008325', 'descriptor_name': 'Mammary Neoplasms, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008325', 'descriptor_name': 'Mammary Neoplasms, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010954', 'descriptor_name': 'Plasmacytoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010954', 'descriptor_name': 'Plasmacytoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D012643', 'descriptor_name': 'Selenium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012643', 'descriptor_name': 'Selenium', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D012643', 'descriptor_name': 'Selenium', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2208170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.65, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2998462003', 'https://openalex.org/W2794586347', 'https://openalex.org/W2767770044', 'https://openalex.org/W2318589452', 'https://openalex.org/W2313648664', 'https://openalex.org/W2137827655', 'https://openalex.org/W2114054808', 'https://openalex.org/W2085185859', 'https://openalex.org/W1994716500', 'https://openalex.org/W1967900456'], 'abstract_inverted_index': {'2-Phenyl-1,2-benzisoselenazol-3(2H)-one': [0], '(ebselen)': [1], 'is': [2, 25, 207, 232], 'classified': [3], 'as': [4, 21, 214], 'a': [5, 89, 100], 'relatively': [6], 'nontoxic': [7], 'selenium': [8, 15], 'compound,': [9], 'probably': [10], 'because': [11], 'of': [12, 45, 58, 65, 83, 92, 103, 106, 115, 137, 153, 158, 169, 204], 'its': [13], 'bound': [14], 'moiety.': [16], 'In': [17], 'thiol-rich': [18], 'tissues,': [19], 'such': [20], 'the': [22, 134, 192, 200], 'kidneys,': [23], 'ebselen': [24, 46, 84, 130, 223], 'converted': [26], 'into': [27], 'selenol': [28], 'intermediates.': [29], 'Selenols': [30], 'are': [31, 196], 'nucleophilic': [32], 'agents': [33], 'which': [34, 206], 'might': [35, 239], 'be': [36, 157], 'able': [37], 'to': [38], 'react': [39], 'with': [40, 129, 199], 'platinum': [41], 'compounds.': [42, 60], 'The': [43, 218], 'influence': [44], 'on': [47], 'cis-diamminedichloroplatinum(II)': [48], '(cisplatin)-induced': [49], 'nephrotoxicity': [50, 155], 'in': [51, 77, 147, 191, 197, 209, 243], 'mice': [52], 'was': [53, 85, 97, 108, 164], 'assessed,': [54], 'using': [55], 'single': [56, 101], 'doses': [57, 168], 'both': [59], 'Ebselen': [61], 'prevented': [62], 'cisplatin-induced': [63, 154, 228], 'elevations': [64, 190], 'blood': [66, 177], 'urea': [67, 178], 'nitrogen': [68], 'and': [69, 73], 'serum': [70, 180, 182, 187], 'creatinine': [71], 'levels': [72], 'morphological': [74], 'kidney': [75], 'damage': [76], 'BALB/c': [78, 148], 'mice.': [79, 149, 193], 'This': [80, 238], 'protective': [81], 'effect': [82], 'dose': [86, 91, 102], 'dependent:': [87], 'at': [88, 166], 'cisplatin': [90, 122, 138], '14.5': [93], 'mg/kg,': [94, 118, 173], 'maximal': [95], 'protection': [96, 226], 'achieved': [98, 165], 'when': [99, 230], '10': [104, 117, 172], 'mg': [105], 'ebselen/kg': [107], 'administered': [109], '1': [110, 119], 'h': [111, 120], 'before': [112, 234], 'cisplatin.': [113, 237], 'Administration': [114], 'ebselen,': [116, 205], 'after': [121, 236], 'also': [123], 'protected': [124], 'against': [125, 139, 227], 'severe': [126], 'nephrotoxicity.': [127], 'Treatment': [128], 'did': [131, 174], 'not': [132, 175], 'reduce': [133], 'antitumor': [135], 'activity': [136], 'MPC': [140], '11': [141], 'plasmacytoma': [142], 'or': [143, 186, 235], 'Prima': [144], 'breast': [145], 'tumor': [146], 'However,': [150], 'this': [151], 'reduction': [152], 'would': [156], 'little': [159], 'clinical': [160, 212], 'value': [161], 'if': [162], 'it': [163, 231], 'toxic': [167], 'ebselen.': [170], 'Ebselen,': [171], 'induce': [176], 'nitrogen,': [179], 'creatinine,': [181], 'glutamic': [183, 188], 'pyruvate': [184], 'transaminase,': [185], 'oxalate': [189], 'These': [194], 'results': [195, 220], 'agreement': [198], 'reported': [201], 'low': [202], 'toxicity': [203], 'now': [208], 'Phase': [210], 'I': [211], 'trials': [213], 'an': [215], 'antiinflammatory': [216], 'drug.': [217], 'present': [219], 'indicate': [221], 'that': [222], 'may': [224], 'provide': [225], 'nephrotoxicity,': [229], 'given': [233], 'open': [240], 'new': [241], 'perspectives': [242], 'cancer': [244], 'chemotherapy.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1904823828', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-16T07:38:07.921826', 'created_date': '2016-06-24'}