Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1901072364', 'doi': 'https://doi.org/10.1152/ajpcell.1997.272.5.c1726', 'title': 'Different interactions of cardiac and skeletal muscle ryanodine receptors with FK-506 binding protein isoforms', 'display_name': 'Different interactions of cardiac and skeletal muscle ryanodine receptors with FK-506 binding protein isoforms', 'publication_year': 1997, 'publication_date': '1997-05-01', 'ids': {'openalex': 'https://openalex.org/W1901072364', 'doi': 'https://doi.org/10.1152/ajpcell.1997.272.5.c1726', 'mag': '1901072364', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9176165'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpcell.1997.272.5.c1726', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62704344', 'display_name': 'AJP Cell Physiology', 'issn_l': '0363-6143', 'issn': ['0363-6143', '1522-1563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001448846', 'display_name': 'Sebastian Barg', 'orcid': 'https://orcid.org/0000-0003-4661-5724'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S. Barg', 'raw_affiliation_strings': ['Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070339203', 'display_name': 'Julio A. Copello', 'orcid': 'https://orcid.org/0000-0002-2388-7164'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. A. Copello', 'raw_affiliation_strings': ['Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016750178', 'display_name': 'Sidney Fleischer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S. Fleischer', 'raw_affiliation_strings': ['Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA', 'institution_ids': ['https://openalex.org/I200719446']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.388, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 114, 'citation_normalized_percentile': {'value': 0.937336, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '272', 'issue': '5', 'first_page': 'C1726', 'last_page': 'C1733'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9779, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9767, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fkbp', 'display_name': 'FKBP', 'score': 0.9206697}, {'id': 'https://openalex.org/keywords/cardiac-muscle', 'display_name': 'Cardiac muscle', 'score': 0.5394614}], 'concepts': [{'id': 'https://openalex.org/C113217602', 'wikidata': 'https://www.wikidata.org/wiki/Q416781', 'display_name': 'Ryanodine receptor', 'level': 3, 'score': 0.9523649}, {'id': 'https://openalex.org/C133956753', 'wikidata': 'https://www.wikidata.org/wiki/Q583864', 'display_name': 'FKBP', 'level': 2, 'score': 0.9206697}, {'id': 'https://openalex.org/C2776333580', 'wikidata': 'https://www.wikidata.org/wiki/Q18031340', 'display_name': 'RYR1', 'level': 4, 'score': 0.86143935}, {'id': 'https://openalex.org/C190712762', 'wikidata': 'https://www.wikidata.org/wiki/Q18031341', 'display_name': 'Ryanodine receptor 2', 'level': 4, 'score': 0.8369792}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.5806149}, {'id': 'https://openalex.org/C2779959927', 'wikidata': 'https://www.wikidata.org/wiki/Q1048687', 'display_name': 'Skeletal muscle', 'level': 2, 'score': 0.5584345}, {'id': 'https://openalex.org/C2778996579', 'wikidata': 'https://www.wikidata.org/wiki/Q10334846', 'display_name': 'Cardiac muscle', 'level': 2, 'score': 0.5394614}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.51733035}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5038449}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49756935}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.41131338}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39135256}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3649842}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35481176}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.33840567}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15485379}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015220', 'descriptor_name': 'Calcium Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002110', 'descriptor_name': 'Caffeine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002110', 'descriptor_name': 'Caffeine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015220', 'descriptor_name': 'Calcium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015220', 'descriptor_name': 'Calcium Channels', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007473', 'descriptor_name': 'Ion Channels', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007473', 'descriptor_name': 'Ion Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007473', 'descriptor_name': 'Ion Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007536', 'descriptor_name': 'Isomerism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019837', 'descriptor_name': 'Ryanodine Receptor Calcium Release Channel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012519', 'descriptor_name': 'Sarcoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012519', 'descriptor_name': 'Sarcoplasmic Reticulum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012519', 'descriptor_name': 'Sarcoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D022021', 'descriptor_name': 'Tacrolimus Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpcell.1997.272.5.c1726', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62704344', 'display_name': 'AJP Cell Physiology', 'issn_l': '0363-6143', 'issn': ['0363-6143', '1522-1563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9176165', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1156084614', 'https://openalex.org/W1891886782', 'https://openalex.org/W1964709412', 'https://openalex.org/W1970734629', 'https://openalex.org/W1982594839', 'https://openalex.org/W1984754431', 'https://openalex.org/W1990092264', 'https://openalex.org/W2001479401', 'https://openalex.org/W2024929666', 'https://openalex.org/W2032188253', 'https://openalex.org/W2033059279', 'https://openalex.org/W2034598316', 'https://openalex.org/W2042224433', 'https://openalex.org/W2045326768', 'https://openalex.org/W2046406478', 'https://openalex.org/W2059647854', 'https://openalex.org/W2063564131', 'https://openalex.org/W2107272556', 'https://openalex.org/W2123090800', 'https://openalex.org/W2128113643', 'https://openalex.org/W2129220177', 'https://openalex.org/W2141385342', 'https://openalex.org/W2154198415', 'https://openalex.org/W4235579029'], 'related_works': ['https://openalex.org/W2585167927', 'https://openalex.org/W2091224260', 'https://openalex.org/W2056880825', 'https://openalex.org/W2054586347', 'https://openalex.org/W2052222838', 'https://openalex.org/W2021176048', 'https://openalex.org/W2007320632', 'https://openalex.org/W1989056964', 'https://openalex.org/W1972170845', 'https://openalex.org/W156392546'], 'abstract_inverted_index': {'In': [0], 'the': [1, 76, 91, 97, 100, 103, 133], 'present': [2], 'study,': [3], 'we': [4], 'compare': [5], 'functional': [6, 142], 'consequences': [7], 'of': [8, 12, 37, 75, 88, 99, 106, 120], 'dissociation': [9], 'and': [10, 16, 24, 47, 53, 72, 80, 146], 'reconstitution': [11], 'binding': [13, 79], 'proteins': [14], 'FKBP12': [15, 46, 111, 145], 'FKBP12.6': [17, 48, 89, 113, 125], 'with': [18, 42, 138, 144], 'ryanodine': [19, 135], 'receptors': [20], 'from': [21, 90], 'cardiac': [22, 92, 122], '(RyR2)': [23], 'skeletal': [25, 29], 'muscle': [26, 30], '(RyR1).': [27], 'The': [28], 'RyR1': [31, 52], 'channel': [32, 57, 101, 118], 'became': [33], 'activated': [34], 'on': [35, 117], 'removal': [36, 87], 'endogenously': [38], 'bound': [39], 'FKBP12,': [40], 'consistent': [41], 'previous': [43], 'reports.': [44], 'Both': [45], 'rebind': [49], 'to': [50, 140], 'FKBP-depleted': [51], 'restore': [54], 'its': [55], 'quiescent': [56], 'behavior': [58, 74], 'by': [59, 65], 'altering': [60], 'ligand': [61], 'sensitivity,': [62], 'as': [63, 108], 'studied': [64], 'single-channel': [66], 'recordings': [67], 'in': [68], 'planar': [69], 'lipid': [70], 'bilayers,': [71], 'macroscopic': [73], 'channels': [77], '(ryanodine': [78], 'net': [81], 'energized': [82], 'Ca2-': [83], 'uptake).': [84], 'By': [85], 'contrast,': [86], 'RyR2': [93], 'did': [94], 'not': [95], 'modulate': [96], 'function': [98], 'using': [102], 'same': [104], 'types': [105], 'assays': [107], 'for': [109], 'RyR1.': [110], 'or': [112], 'had': [114], 'no': [115], 'effect': [116], 'activity': [119], 'FKBP12.6-depleted': [121], 'RyR2,': [123], 'although': [124], 'rebinds.': [126], 'Our': [127], 'studies': [128], 'reveal': [129], 'important': [130], 'differences': [131], 'between': [132], 'two': [134], 'receptor': [136], 'isoforms': [137], 'respect': [139], 'their': [141], 'interaction': [143], 'FKBP12.6.': [147]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1901072364', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-12T23:22:02.153871', 'created_date': '2016-06-24'}