Publication Information

{'id': 'https://openalex.org/W1898172578', 'doi': 'https://doi.org/10.1111/j.1742-4658.2010.07566.x', 'title': 'Upregulation of the α‐secretase ADAM10 – risk or reason for hope?', 'display_name': 'Upregulation of the α‐secretase ADAM10 – risk or reason for hope?', 'publication_year': 2010, 'publication_date': '2010-02-03', 'ids': {'openalex': 'https://openalex.org/W1898172578', 'doi': 'https://doi.org/10.1111/j.1742-4658.2010.07566.x', 'mag': '1898172578', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20136654'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1742-4658.2010.07566.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-4658.2010.07566.x', 'source': {'id': 'https://openalex.org/S37672443', 'display_name': 'FEBS Journal', 'issn_l': '1742-464X', 'issn': ['1742-464X', '1742-4658'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-4658.2010.07566.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073529348', 'display_name': 'Kristina Endres', 'orcid': 'https://orcid.org/0000-0002-1099-8287'}, 'institutions': [{'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Kristina Endres', 'raw_affiliation_strings': ['Department of Psychiatry and Psychotherapy, Clinical Research Group, Johannes Gutenberg-University, Mainz, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry and Psychotherapy, Clinical Research Group, Johannes Gutenberg-University, Mainz, Germany.', 'institution_ids': ['https://openalex.org/I197323543']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5011484618', 'display_name': 'Falk Fahrenholz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Falk Fahrenholz', 'raw_affiliation_strings': ['Department of Psychiatry and Psychotherapy, Clinical Research Group, Johannes Gutenberg-University, Mainz, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry and Psychotherapy, Clinical Research Group, Johannes Gutenberg-University, Mainz, Germany.', 'institution_ids': ['https://openalex.org/I197323543']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4580, 'currency': 'USD', 'value_usd': 4580, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.215, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 69, 'citation_normalized_percentile': {'value': 0.725216, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '277', 'issue': '7', 'first_page': '1585', 'last_page': '1596'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12030', 'display_name': 'S100 Proteins: Structure, Function, and Pathology', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase Inhibitors in Neurodegenerative Diseases', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adam10', 'display_name': 'ADAM10', 'score': 0.9849022}, {'id': 'https://openalex.org/keywords/alpha-secretase', 'display_name': 'Alpha secretase', 'score': 0.60457855}, {'id': 'https://openalex.org/keywords/protein-precursor', 'display_name': 'Protein precursor', 'score': 0.5556175}, {'id': 'https://openalex.org/keywords/protein-misfolding', 'display_name': 'Protein Misfolding', 'score': 0.509176}], 'concepts': [{'id': 'https://openalex.org/C2778715156', 'wikidata': 'https://www.wikidata.org/wiki/Q17709536', 'display_name': 'ADAM10', 'level': 5, 'score': 0.9849022}, {'id': 'https://openalex.org/C2778259572', 'wikidata': 'https://www.wikidata.org/wiki/Q407908', 'display_name': 'Disintegrin', 'level': 4, 'score': 0.8239069}, {'id': 'https://openalex.org/C55728118', 'wikidata': 'https://www.wikidata.org/wiki/Q425402', 'display_name': 'Metalloproteinase', 'level': 3, 'score': 0.6621563}, {'id': 'https://openalex.org/C31705614', 'wikidata': 'https://www.wikidata.org/wiki/Q423510', 'display_name': 'Amyloid precursor protein', 'level': 4, 'score': 0.63844067}, {'id': 'https://openalex.org/C36103677', 'wikidata': 'https://www.wikidata.org/wiki/Q4749551', 'display_name': 'Amyloid precursor protein secretase', 'level': 5, 'score': 0.61842245}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.6078714}, {'id': 'https://openalex.org/C41007966', 'wikidata': 'https://www.wikidata.org/wiki/Q908080', 'display_name': 'Alpha secretase', 'level': 5, 'score': 0.60457855}, {'id': 'https://openalex.org/C7860815', 'wikidata': 'https://www.wikidata.org/wiki/Q258658', 'display_name': 'Protein precursor', 'level': 3, 'score': 0.5556175}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.454728}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41670045}, {'id': 'https://openalex.org/C109523444', 'wikidata': 'https://www.wikidata.org/wiki/Q424216', 'display_name': 'Matrix metalloproteinase', 'level': 2, 'score': 0.41494864}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.38395754}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3771228}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3709697}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.34824523}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32537946}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.282242}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2624119}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2560539}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.19881535}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09661585}], 'mesh': [{'descriptor_ui': 'D051722', 'descriptor_name': 'ADAM Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D053829', 'descriptor_name': 'Amyloid Precursor Protein Secretases', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D051722', 'descriptor_name': 'ADAM Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072197', 'descriptor_name': 'ADAM10 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053829', 'descriptor_name': 'Amyloid Precursor Protein Secretases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053829', 'descriptor_name': 'Amyloid Precursor Protein Secretases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024141', 'descriptor_name': 'Collagen Type IV', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024141', 'descriptor_name': 'Collagen Type IV', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1742-4658.2010.07566.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-4658.2010.07566.x', 'source': {'id': 'https://openalex.org/S37672443', 'display_name': 'FEBS Journal', 'issn_l': '1742-464X', 'issn': ['1742-464X', '1742-4658'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20136654', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1742-4658.2010.07566.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-4658.2010.07566.x', 'source': {'id': 'https://openalex.org/S37672443', 'display_name': 'FEBS Journal', 'issn_l': '1742-464X', 'issn': ['1742-464X', '1742-4658'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.52, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 124, 'referenced_works': ['https://openalex.org/W120263029', 'https://openalex.org/W1483984181', 'https://openalex.org/W1486033467', 'https://openalex.org/W1549817168', 'https://openalex.org/W1551782890', 'https://openalex.org/W1555938246', 'https://openalex.org/W1572211058', 'https://openalex.org/W1580230845', 'https://openalex.org/W1592121394', 'https://openalex.org/W1596272559', 'https://openalex.org/W1660631781', 'https://openalex.org/W1675105744', 'https://openalex.org/W1736480315', 'https://openalex.org/W1775873926', 'https://openalex.org/W1831764476', 'https://openalex.org/W1965630120', 'https://openalex.org/W1966822531', 'https://openalex.org/W1969287946', 'https://openalex.org/W1969916240', 'https://openalex.org/W1970988215', 'https://openalex.org/W1974024894', 'https://openalex.org/W1975877815', 'https://openalex.org/W1982004402', 'https://openalex.org/W1982037687', 'https://openalex.org/W1982092344', 'https://openalex.org/W1983202100', 'https://openalex.org/W1984933995', 'https://openalex.org/W1990295421', 'https://openalex.org/W1992265794', 'https://openalex.org/W1997642891', 'https://openalex.org/W1998098913', 'https://openalex.org/W1998664054', 'https://openalex.org/W2002081155', 'https://openalex.org/W2004472806', 'https://openalex.org/W2007969407', 'https://openalex.org/W2009111659', 'https://openalex.org/W2012289375', 'https://openalex.org/W2014378878', 'https://openalex.org/W2015338082', 'https://openalex.org/W2015979748', 'https://openalex.org/W2017831981', 'https://openalex.org/W2018524295', 'https://openalex.org/W2019500453', 'https://openalex.org/W2019771217', 'https://openalex.org/W2020677206', 'https://openalex.org/W2021456178', 'https://openalex.org/W2021937623', 'https://openalex.org/W2022745640', 'https://openalex.org/W2023876261', 'https://openalex.org/W2026084202', 'https://openalex.org/W2028337591', 'https://openalex.org/W2029017865', 'https://openalex.org/W2029391653', 'https://openalex.org/W2031740592', 'https://openalex.org/W2033206948', 'https://openalex.org/W2033771299', 'https://openalex.org/W2034301871', 'https://openalex.org/W2034597519', 'https://openalex.org/W2040373875', 'https://openalex.org/W2041717330', 'https://openalex.org/W2042449171', 'https://openalex.org/W2044863101', 'https://openalex.org/W2046207936', 'https://openalex.org/W2046353810', 'https://openalex.org/W2047070640', 'https://openalex.org/W2047613132', 'https://openalex.org/W2049346195', 'https://openalex.org/W2049959146', 'https://openalex.org/W2056181922', 'https://openalex.org/W2061459919', 'https://openalex.org/W2063661531', 'https://openalex.org/W2065053969', 'https://openalex.org/W2065314790', 'https://openalex.org/W2066431245', 'https://openalex.org/W2070469106', 'https://openalex.org/W2070854099', 'https://openalex.org/W2070941753', 'https://openalex.org/W2074442731', 'https://openalex.org/W2074881372', 'https://openalex.org/W2076233716', 'https://openalex.org/W2077693249', 'https://openalex.org/W2078250335', 'https://openalex.org/W2078368771', 'https://openalex.org/W2078401587', 'https://openalex.org/W2080062007', 'https://openalex.org/W2081080245', 'https://openalex.org/W2081656219', 'https://openalex.org/W2081934244', 'https://openalex.org/W2087197243', 'https://openalex.org/W2089027583', 'https://openalex.org/W2091499641', 'https://openalex.org/W2092863938', 'https://openalex.org/W2093498736', 'https://openalex.org/W2097520077', 'https://openalex.org/W2098878950', 'https://openalex.org/W2106253300', 'https://openalex.org/W2106782671', 'https://openalex.org/W2114579860', 'https://openalex.org/W2116347075', 'https://openalex.org/W2118876004', 'https://openalex.org/W2121266814', 'https://openalex.org/W2122215582', 'https://openalex.org/W2129033989', 'https://openalex.org/W2129270491', 'https://openalex.org/W2130038947', 'https://openalex.org/W2132810311', 'https://openalex.org/W2143561528', 'https://openalex.org/W2143815948', 'https://openalex.org/W2145123193', 'https://openalex.org/W2146649884', 'https://openalex.org/W2147110025', 'https://openalex.org/W2147114673', 'https://openalex.org/W2147177629', 'https://openalex.org/W2147782235', 'https://openalex.org/W2148372535', 'https://openalex.org/W2152101209', 'https://openalex.org/W2153266189', 'https://openalex.org/W2156246185', 'https://openalex.org/W2160264227', 'https://openalex.org/W2160994404', 'https://openalex.org/W2162512841', 'https://openalex.org/W2166083817', 'https://openalex.org/W2166611044', 'https://openalex.org/W4240866326'], 'related_works': ['https://openalex.org/W4377564460', 'https://openalex.org/W4223480264', 'https://openalex.org/W2748625268', 'https://openalex.org/W2622383255', 'https://openalex.org/W2137592631', 'https://openalex.org/W2098549339', 'https://openalex.org/W2049959146', 'https://openalex.org/W2011690803', 'https://openalex.org/W1996511362', 'https://openalex.org/W1898172578'], 'abstract_inverted_index': {'A': [0], 'decade': [1], 'ago,': [2], 'a': [3, 16, 47, 66, 75, 103, 110, 114, 181], 'disintegrin': [4], 'and': [5, 14, 57, 61, 132, 163, 167], 'metalloproteinase': [6, 52], '10': [7], '(ADAM10)': [8], 'was': [9, 37, 84], 'identified': [10, 131], 'as': [11, 15, 79, 180], 'an': [12, 42, 88], 'α‐secretase': [13, 148, 179], 'key': [17], 'proteinase': [18], 'in': [19, 34], 'the': [20, 23, 28, 51, 72, 91, 126, 133, 143, 161, 169, 173, 178], 'processing': [21], 'of': [22, 44, 50, 74, 96, 117, 146, 165, 177], 'amyloid': [24, 121], 'precursor': [25, 122], 'protein.': [26], 'Accordingly,': [27], 'important': [29], 'role': [30], 'that': [31], 'it': [32], 'plays': [33], 'Alzheimer’s': [35], 'disease': [36, 77], 'manifested.': [38], 'Animal': [39], 'models': [40], 'with': [41, 53, 69], 'overexpression': [43], 'ADAM10': [45, 64, 83, 147, 166], 'revealed': [46], 'beneficial': [48], 'profile': [49], 'respect': [54, 70], 'to': [55, 71, 86, 101, 151], 'learning': [56], 'memory,': [58], 'plaque': [59], 'load': [60], 'synaptogenesis.': [62], 'Therefore,': [63], 'presents': [65], 'worthwhile': [67], 'target': [68], 'treatment': [73], 'neurodegenerative': [76], 'such': [78], 'Morbus': [80], 'Alzheimer.': [81], 'Initially,': [82], 'suggested': [85], 'be': [87, 102, 152], 'enzyme,': [89], 'shaping': [90], 'extracellular': [92], 'matrix': [93], 'by': [94], 'cleavage': [95], 'collagen': [97], 'type': [98], 'IV,': [99], 'or': [100], 'tumour': [104], 'necrosis': [105], 'factor': [106], 'α': [107], 'convertase.': [108], 'In': [109], 'relatively': [111], 'short': [112], 'time,': [113], 'wide': [115], 'variety': [116], 'additional': [118], 'substrates': [119], '(with': [120], 'protein': [123], 'probably': [124], 'being': [125], 'most': [127], 'prominent)': [128], 'has': [129], 'been': [130], 'search': [134], 'is': [135], 'still': [136], 'ongoing.': [137], 'Hence,': [138], 'any': [139], 'side': [140], 'effects': [141], 'concerning': [142], 'therapeutic': [144, 182], 'enhancement': [145], 'activity': [149, 176], 'have': [150], 'considered.': [153], 'The': [154], 'present': [155], 'review': [156], 'summarizes': [157], 'our': [158], 'knowledge': [159], 'about': [160], 'structure': [162], 'function': [164], 'highlights': [168], 'opportunities': [170], 'for': [171], 'enhancing': [172], 'expression': [174], 'and/or': [175], 'target.': [183]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1898172578', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-09-26T18:00:50.112466', 'created_date': '2016-06-24'}