Publication Information

{'id': 'https://openalex.org/W1897809568', 'doi': None, 'title': 'Study on how underlying uncertainty in the flux values affects metabolic control analysis of optimally grown E. coli', 'display_name': 'Study on how underlying uncertainty in the flux values affects metabolic control analysis of optimally grown E. coli', 'publication_year': 2015, 'publication_date': '2015-01-01', 'ids': {'openalex': 'https://openalex.org/W1897809568', 'mag': '1897809568'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://infoscience.epfl.ch/record/212969', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083840456', 'display_name': 'Hameri Tuure', 'orcid': 'https://orcid.org/0000-0003-3177-4087'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Tuure Eelis Hameri', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076299421', 'display_name': 'Georgios Fengos', 'orcid': 'https://orcid.org/0000-0001-8110-8424'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Georgios Fengos', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040395962', 'display_name': 'Meriç Ataman', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Meriç Ataman', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037008443', 'display_name': 'Ljubiša Mišković', 'orcid': 'https://orcid.org/0000-0001-7333-8211'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ljubisa Miskovic', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10932', 'display_name': 'Metabolic Engineering and Synthetic Biology', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10932', 'display_name': 'Metabolic Engineering and Synthetic Biology', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10621', 'display_name': 'Stochasticity in Gene Regulatory Networks', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13539', 'display_name': 'Applications of Calorimetry in Scientific Research', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/1606', 'display_name': 'Physical and Theoretical Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/robustness', 'display_name': 'Robustness (evolution)', 'score': 0.60294276}, {'id': 'https://openalex.org/keywords/flux-balance-analysis', 'display_name': 'Flux Balance Analysis', 'score': 0.553188}], 'concepts': [{'id': 'https://openalex.org/C63479239', 'wikidata': 'https://www.wikidata.org/wiki/Q7353546', 'display_name': 'Robustness (evolution)', 'level': 3, 'score': 0.60294276}, {'id': 'https://openalex.org/C117251300', 'wikidata': 'https://www.wikidata.org/wiki/Q1849855', 'display_name': 'Parametric statistics', 'level': 2, 'score': 0.5715141}, {'id': 'https://openalex.org/C2780598303', 'wikidata': 'https://www.wikidata.org/wiki/Q65921492', 'display_name': 'Flexibility (engineering)', 'level': 2, 'score': 0.5454463}, {'id': 'https://openalex.org/C167091322', 'wikidata': 'https://www.wikidata.org/wiki/Q5463029', 'display_name': 'Flux balance analysis', 'level': 2, 'score': 0.5452829}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.5428368}, {'id': 'https://openalex.org/C186060115', 'wikidata': 'https://www.wikidata.org/wiki/Q30336093', 'display_name': 'Biological system', 'level': 1, 'score': 0.4266113}, {'id': 'https://openalex.org/C68709404', 'wikidata': 'https://www.wikidata.org/wiki/Q1134475', 'display_name': 'Flux (metallurgy)', 'level': 2, 'score': 0.41490048}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.3947741}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.23514271}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.21625727}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.18672103}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.17920658}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.17773631}, {'id': 'https://openalex.org/C105795698', 'wikidata': 'https://www.wikidata.org/wiki/Q12483', 'display_name': 'Statistics', 'level': 1, 'score': 0.12897742}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://infoscience.epfl.ch/record/212969', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.64, 'id': 'https://metadata.un.org/sdg/16', 'display_name': 'Peace, justice, and strong institutions'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W89125745', 'https://openalex.org/W79364934', 'https://openalex.org/W64473206', 'https://openalex.org/W412505528', 'https://openalex.org/W3135981712', 'https://openalex.org/W2948744685', 'https://openalex.org/W2883468939', 'https://openalex.org/W2796870706', 'https://openalex.org/W2767970996', 'https://openalex.org/W2735233379', 'https://openalex.org/W2567211879', 'https://openalex.org/W2563657197', 'https://openalex.org/W2262980303', 'https://openalex.org/W2233183256', 'https://openalex.org/W2226658599', 'https://openalex.org/W2086196945', 'https://openalex.org/W2076599644', 'https://openalex.org/W2076262841', 'https://openalex.org/W2041174099', 'https://openalex.org/W18034897'], 'abstract_inverted_index': {'Large-scale': [0], 'kinetic': [1, 35, 142, 217, 294], 'models': [2, 36, 50, 218, 295], 'of': [3, 13, 55, 77, 91, 127, 159, 163, 193, 208, 216, 239, 250, 254, 266, 282, 293, 305, 326, 344], 'metabolism': [4], 'are': [5, 31, 64, 167, 220], 'essential': [6], 'for': [7, 153, 179, 296], 'understanding': [8], 'and': [9, 39, 70, 113, 131, 144, 147, 205, 230], 'predicting': [10], 'the': [11, 21, 27, 45, 89, 96, 117, 121, 125, 128, 151, 160, 164, 173, 180, 184, 202, 223, 228, 240, 243, 248, 251, 255, 259, 267, 279, 283, 303, 312, 315, 321, 324, 327, 333, 342, 345], 'behavior': [12], 'cellular': [14], 'systems': [15], 'when': [16, 272], 'subject': [17], 'to': [18, 33, 58, 66, 196, 213, 290, 332, 340], 'perturbations.': [19], 'Despite': [20], 'advances': [22], 'in': [23, 68, 81, 88, 120], 'experimental': [24, 48], 'measurement': [25], 'technologies,': [26], 'numerous': [28], 'parameters': [29], 'that': [30, 79, 219, 242], 'required': [32], 'build': [34, 214], 'remain': [37], 'scarce': [38], 'involve': [40], 'uncertainty.': [41], 'Even': [42], 'after': [43], 'incorporating': [44], 'partially': [46], 'available': [47], 'data,': [49], 'still': [51], 'have': [52, 246], 'many': [53], 'degrees': [54], 'freedom.': [56], 'Due': [57], 'this': [59, 105, 136], 'parametric': [60], 'uncertainty,': [61], 'some': [62], 'reactions': [63, 78], 'able': [65, 339], 'operate': [67, 80], 'forward': [69], 'reverse': [71], 'directions.': [72], 'An': [73], 'operational': [74, 93, 111, 175, 186, 351], 'configuration': [75, 112], 'consists': [76], 'a': [82, 140, 190, 236, 349], 'unique': [83], 'direction.': [84], 'This': [85], 'flexibility': [86], 'results': [87], 'existence': [90], 'alternative': [92], 'configurations': [94], 'representing': [95], 'same': [97], 'physiology,': [98, 225], 'with': [99, 222, 314], 'very': [100], 'distinct': [101], 'regulatory': [102, 132, 252, 346], 'properties.': [103], 'In': [104], 'study,': [106], 'we': [107, 114, 138, 188, 301, 337], 'focus': [108], 'on': [109, 247], 'one': [110], 'investigate': [115], 'how': [116], 'underlying': [118], 'uncertainty': [119], 'flux': [122, 170, 181, 244, 268, 274, 298, 307, 335], 'values': [123], 'affects': [124], 'robustness': [126, 249, 343], 'model': [129, 143], 'predictions': [130, 347], 'capabilities.': [133], 'To': [134, 177], 'study': [135], 'question,': [137], 'used': [139, 201, 258, 288], 'large-scale': [141], 'integrated': [145], 'fluxomics': [146], 'metabolomics': [148], 'data': [149], 'describing': [150], 'physiology': [152], 'aerobically': [154], 'grown': [155], 'E.': [156], 'coli.': [157], 'Because': [158], 'under-determined': [161], 'nature': [162], 'system,': [165], 'there': [166], 'infinite': [168], 'existing': [169], 'solutions': [171], 'within': [172, 183, 348], 'selected': [174, 189], 'configuration.': [176, 352], 'account': [178], 'variability': [182], 'designated': [185], 'configuration,': [187], 'reference': [191, 271, 334], 'vector': [192], 'concentrations': [194], 'close': [195], 'their': [197, 306], 'nominal': [198], 'value.': [199], 'We': [200, 233, 257, 287], 'ORACLE': [203, 289], '(optimization': [204], 'risk': [206], 'analysis': [207, 238], 'complex': [209], 'living': [210], 'entities)': [211], 'framework': [212], 'populations': [215, 292], 'consistent': [221], 'given': [224], 'while': [226], 'satisfying': [227], 'stoichiometric': [229], 'thermodynamic': [231], 'constraints.': [232], 'next': [234], 'performed': [235], 'systematic': [237], 'effect': [241], 'profiles': [245, 277], 'properties': [253], 'system.': [256], 'mean': [260], 'PCA': [261, 284], '(principle': [262], 'component': [263], 'analysis)': [264], 'value': [265], 'samples': [269], 'as': [270], 'selecting': [273], 'profiles.': [275, 299], 'Flux': [276], 'across': [278], 'main': [280], 'components': [281], 'were': [285, 338], 'studied.': [286], 'generate': [291], 'these': [297], 'Then,': [300], 'computed': [302], 'distributions': [304, 325], 'control': [308], 'coefficients': [309], '(FCCs)': [310], 'along': [311], 'dimensions': [313], 'highest': [316], 'variance.': [317], 'Finally,': [318], 'by': [319], 'comparing': [320], 'changes': [322], 'among': [323], 'FCCs': [328], 'versus': [329], 'those': [330], 'corresponding': [331], 'profile,': [336], 'quantify': [341], 'specific': [350]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1897809568', 'counts_by_year': [], 'updated_date': '2024-09-15T02:43:36.357700', 'created_date': '2016-06-24'}