Publication Information

{'id': 'https://openalex.org/W1895278304', 'doi': 'https://doi.org/10.18632/oncotarget.2321', 'title': 'NOTCH1 signaling contributes to cell growth, anti-apoptosis and metastasis in salivary adenoid cystic carcinoma', 'display_name': 'NOTCH1 signaling contributes to cell growth, anti-apoptosis and metastasis in salivary adenoid cystic carcinoma', 'publication_year': 2014, 'publication_date': '2014-08-06', 'ids': {'openalex': 'https://openalex.org/W1895278304', 'doi': 'https://doi.org/10.18632/oncotarget.2321', 'mag': '1895278304', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25149541', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4196170'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2321', 'pdf_url': 'https://www.oncotarget.com/article/2321/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/2321/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111774122', 'display_name': 'Bo-Hua Su', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bo-Hua Su', 'raw_affiliation_strings': ['Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China. These authors contributed equally to this work.'], 'affiliations': [{'raw_affiliation_string': 'Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China. These authors contributed equally to this work.', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068627723', 'display_name': 'Jing Qu', 'orcid': 'https://orcid.org/0000-0003-2911-8777'}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Qu', 'raw_affiliation_strings': ['Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China. These authors contributed equally to this work.'], 'affiliations': [{'raw_affiliation_string': 'Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China. These authors contributed equally to this work.', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101727825', 'display_name': 'Min Song', 'orcid': 'https://orcid.org/0000-0002-4260-6268'}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Min Song', 'raw_affiliation_strings': ['Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China. These authors contributed equally to this work.'], 'affiliations': [{'raw_affiliation_string': 'Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China. These authors contributed equally to this work.', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091415658', 'display_name': 'Xiaoyu Huang', 'orcid': 'https://orcid.org/0000-0001-9467-3406'}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Yu Huang', 'raw_affiliation_strings': ['Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101927716', 'display_name': 'Xiaomeng Hu', 'orcid': 'https://orcid.org/0000-0003-3273-4335'}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Meng Hu', 'raw_affiliation_strings': ['Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100733499', 'display_name': 'Jian Xie', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian Xie', 'raw_affiliation_strings': ['Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103170818', 'display_name': 'Yong Zhao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yong Zhao', 'raw_affiliation_strings': ['Department of Pathology, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China.', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038156325', 'display_name': 'Lin-Can Ding', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lin-Can Ding', 'raw_affiliation_strings': ['Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113664441', 'display_name': 'Lin She', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lin She', 'raw_affiliation_strings': ['Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070688871', 'display_name': 'Jiang Chen', 'orcid': 'https://orcid.org/0000-0002-0010-0402'}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiang Chen', 'raw_affiliation_strings': ['Center of Dental Implant, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Center of Dental Implant, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China.', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079960883', 'display_name': 'Lisong Lin', 'orcid': 'https://orcid.org/0000-0003-2676-4351'}, 'institutions': [{'id': 'https://openalex.org/I4210121761', 'display_name': 'First Affiliated Hospital of Fujian Medical University', 'ror': 'https://ror.org/030e09f60', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210121761']}, {'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li-Song Lin', 'raw_affiliation_strings': ['Department of Oral and Maxillofacial Surgery, Affiliated First Hospital of Fujian Medical University, Fuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oral and Maxillofacial Surgery, Affiliated First Hospital of Fujian Medical University, Fuzhou, China', 'institution_ids': ['https://openalex.org/I4210121761', 'https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070879677', 'display_name': 'Xu Lin', 'orcid': 'https://orcid.org/0000-0002-5346-4605'}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xu Lin', 'raw_affiliation_strings': ['Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China', 'institution_ids': ['https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004769278', 'display_name': 'Dali Zheng', 'orcid': 'https://orcid.org/0000-0003-2345-4040'}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}, {'id': 'https://openalex.org/I3019308854', 'display_name': 'Moffitt Cancer Center', 'ror': 'https://ror.org/01xf75524', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019308854']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Da-Li Zheng', 'raw_affiliation_strings': ['Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China. Molecular Oncology, Moffitt Cancer Center, Tampa, FL, United States.', 'Molecular Oncology, Moffitt Cancer Center, Tampa, FL, United States'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China. Molecular Oncology, Moffitt Cancer Center, Tampa, FL, United States.', 'institution_ids': ['https://openalex.org/I129708740']}, {'raw_affiliation_string': 'Molecular Oncology, Moffitt Cancer Center, Tampa, FL, United States', 'institution_ids': ['https://openalex.org/I3019308854', 'https://openalex.org/I4210150208']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074030882', 'display_name': 'Youguang Lu', 'orcid': 'https://orcid.org/0000-0002-1325-3790'}, 'institutions': [{'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'You-Guang Lu', 'raw_affiliation_strings': ['Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China', 'institution_ids': ['https://openalex.org/I129708740']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.444, 'has_fulltext': False, 'cited_by_count': 56, 'citation_normalized_percentile': {'value': 0.999981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '5', 'issue': '16', 'first_page': '6885', 'last_page': '6895'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11035', 'display_name': 'Salivary Gland Tumors Diagnosis and Treatment', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11035', 'display_name': 'Salivary Gland Tumors Diagnosis and Treatment', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11787', 'display_name': 'Oral and Maxillofacial Pathology', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/3504', 'display_name': 'Oral Surgery'}, 'field': {'id': 'https://openalex.org/fields/35', 'display_name': 'Dentistry'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13383', 'display_name': 'Tumors and Oncological Cases', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adenoid-cystic-carcinoma', 'display_name': 'Adenoid Cystic Carcinoma', 'score': 0.47024575}], 'concepts': [{'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.7134721}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.71216357}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.67781234}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.6609364}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.62101156}, {'id': 'https://openalex.org/C161879069', 'wikidata': 'https://www.wikidata.org/wiki/Q904082', 'display_name': 'Notch signaling pathway', 'level': 3, 'score': 0.60422266}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5519721}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.54193115}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.506549}, {'id': 'https://openalex.org/C137738243', 'wikidata': 'https://www.wikidata.org/wiki/Q189092', 'display_name': 'Cell migration', 'level': 3, 'score': 0.48901758}, {'id': 'https://openalex.org/C2779231225', 'wikidata': 'https://www.wikidata.org/wiki/Q356005', 'display_name': 'Adenoid cystic carcinoma', 'level': 3, 'score': 0.47024575}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.38562748}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.33501807}, {'id': 'https://openalex.org/C2777546739', 'wikidata': 'https://www.wikidata.org/wiki/Q33525', 'display_name': 'Carcinoma', 'level': 2, 'score': 0.2970245}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.28637463}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.23563033}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.23413381}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08177942}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003528', 'descriptor_name': 'Carcinoma, Adenoid Cystic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D003528', 'descriptor_name': 'Carcinoma, Adenoid Cystic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051881', 'descriptor_name': 'Receptor, Notch1', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D012468', 'descriptor_name': 'Salivary Gland Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012468', 'descriptor_name': 'Salivary Gland Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003528', 'descriptor_name': 'Carcinoma, Adenoid Cystic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003528', 'descriptor_name': 'Carcinoma, Adenoid Cystic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064593', 'descriptor_name': 'Heterografts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051881', 'descriptor_name': 'Receptor, Notch1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051881', 'descriptor_name': 'Receptor, Notch1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051881', 'descriptor_name': 'Receptor, Notch1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012468', 'descriptor_name': 'Salivary Gland Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012468', 'descriptor_name': 'Salivary Gland Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2321', 'pdf_url': 'https://www.oncotarget.com/article/2321/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4196170', 'pdf_url': 'https://europepmc.org/articles/pmc4196170?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25149541', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2321', 'pdf_url': 'https://www.oncotarget.com/article/2321/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.5, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1722577819', 'https://openalex.org/W1964461246', 'https://openalex.org/W1966731849', 'https://openalex.org/W1967735960', 'https://openalex.org/W1978545732', 'https://openalex.org/W1984254504', 'https://openalex.org/W1987023842', 'https://openalex.org/W2004320731', 'https://openalex.org/W2005895632', 'https://openalex.org/W2007592701', 'https://openalex.org/W2011424762', 'https://openalex.org/W2012086408', 'https://openalex.org/W2041487183', 'https://openalex.org/W2046759180', 'https://openalex.org/W2060710804', 'https://openalex.org/W2083280774', 'https://openalex.org/W2085934079', 'https://openalex.org/W2088720735', 'https://openalex.org/W2088883749', 'https://openalex.org/W2089655089', 'https://openalex.org/W2095203455', 'https://openalex.org/W2099452211', 'https://openalex.org/W2104039084', 'https://openalex.org/W2105010725', 'https://openalex.org/W2107277218', 'https://openalex.org/W2126496132', 'https://openalex.org/W2127823872', 'https://openalex.org/W2132884452', 'https://openalex.org/W2143017330', 'https://openalex.org/W2145040878', 'https://openalex.org/W2147135997', 'https://openalex.org/W2151244476', 'https://openalex.org/W2151259727', 'https://openalex.org/W2322526574'], 'related_works': ['https://openalex.org/W4386799875', 'https://openalex.org/W4361818220', 'https://openalex.org/W4247833810', 'https://openalex.org/W4242240318', 'https://openalex.org/W4213065871', 'https://openalex.org/W3127487613', 'https://openalex.org/W3103789129', 'https://openalex.org/W3048105303', 'https://openalex.org/W2904239912', 'https://openalex.org/W1968932537'], 'abstract_inverted_index': {'//': [0, 152, 156], 'Bo-Hua': [1], 'Su': [2], '1,*': [3, 7, 11], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48], 'Jing': [5], 'Qu': [6], 'Min': [9], 'Song': [10], 'Xiao-Yu': [13], 'Huang': [14], '1': [15, 19, 23, 31, 35, 55, 56], 'Xiao-Meng': [17], 'Hu': [18], 'Jian': [21], 'Xie': [22], 'Yong': [25], 'Zhao': [26], '2': [27, 69], 'Lin-Can': [29], 'Ding': [30], 'Lin': [33, 42, 46], 'She': [34], 'Jiang': [37], 'Chen': [38], '3': [39, 81], 'Li-Song': [41], '4': [43, 94], 'Xu': [45], '5': [47, 110], 'Da-Li': [49, 149], 'Zheng': [50], '5,6': [51], 'and': [52, 98, 191, 227, 251, 264, 290, 301, 320, 322, 331, 356, 377], 'You-Guang': [53, 153], 'Lu': [54], 'Department': [57, 70, 95], 'of': [58, 71, 83, 96, 104, 113, 115, 121, 194, 212, 221, 229, 236, 249, 259, 311, 324, 341, 358], 'Preventive': [59], 'Dentistry,': [60], 'Affiliated': [61, 73, 86, 101], 'Stomatological': [62, 74, 87], 'Hospital,': [63, 75, 88], 'Fujian': [64, 76, 89, 105, 125], 'Medical': [65, 77, 90, 106, 123, 126], 'University,': [66, 78, 91, 107, 127], 'Fuzhou,': [67, 79, 92, 108, 128], 'China': [68, 80, 93, 109, 129], 'Pathology,': [72], 'Center': [82], 'Dental': [84], 'Implant,': [85], 'Oral': [97], 'Maxillofacial': [99], 'Surgery,': [100], 'First': [102], 'Hospital': [103], 'Key': [111], 'Laboratory': [112], 'Ministry': [114], 'Education': [116], 'for': [117], 'Gastrointestinal': [118], 'Cancer,': [119], 'School': [120], 'Basic': [122], 'Sciences,': [124], '6': [130], 'Molecular': [131], 'Oncology,': [132], 'Moffitt': [133], 'Cancer': [134], 'Center,': [135], 'Tampa,': [136], 'FL,': [137], 'United': [138], 'States': [139], '*': [140], 'These': [141], 'authors': [142], 'contributed': [143], 'equally': [144], 'to': [145, 217, 255], 'this': [146, 291, 342], 'work': [147], 'Correspondence:': [148], 'Zheng,': [150], 'email:': [151, 155], 'Lu,': [154], 'Keywords': [157], ':': [158, 168, 173, 178], 'NOTCH1,': [159], 'salivary': [160], 'adenoid': [161], 'cystic': [162], 'carcinoma,': [163], 'proliferation,': [164, 262], 'apoptosis,': [165], 'metastasis': [166, 228, 300, 357], 'Received': [167], 'July': [169], '07,': [170], '2014': [171, 176, 181], 'Accepted': [172], 'August': [174, 179], '05,': [175], 'Published': [177], '06,': [180], 'Abstract': [182], 'Background:': [183], 'Numerous': [184], 'studies': [185], 'have': [186, 364], 'reported': [187], 'both': [188], 'the': [189, 195, 213, 219, 224, 234, 247, 257, 352], 'tumor-suppressive': [190], 'oncogenic': [192], 'roles': [193], 'Notch': [196, 200], 'pathway,': [197], 'indicating': [198], 'that': [199, 278, 345], 'activity': [201], 'regulates': [202], 'tumor': [203], 'biology': [204], 'in': [205, 223, 238, 282, 296, 313, 329, 333, 351, 368], 'a': [206, 348], 'complex,': [207], 'context-dependent': [208], 'manner.': [209], 'The': [210], 'aim': [211], 'present': [214], 'study': [215, 343], 'was': [216, 280, 293], 'identify': [218], 'role': [220, 350], 'NOTCH1': [222, 237, 250, 254, 260, 266, 279, 312, 325, 346, 360], 'cell': [225, 317, 327, 337, 353, 375], 'growth': [226, 376], 'SACC.': [230, 359], 'Methods:': [231], 'We': [232, 245], 'analyzed': [233], 'expression': [235, 248], 'clinical': [239], 'SACC': [240, 283, 297, 306, 314, 370], 'samples': [241], 'using': [242], 'immunohistochemical': [243], 'staining.': [244], 'silenced': [246], 'overexpressed': [252], 'activated': [253], 'elucidate': [256], 'effects': [258], 'on': [261], 'migration': [263, 319], 'invasion.': [265], 'target': [267], 'genes': [268], 'were': [269], 'validated': [270], 'by': [271, 335, 372], 'real-time': [272], 'PCR.': [273], 'Results:': [274], 'Our': [275], 'results': [276, 340], 'showed': [277], 'upregulated': [281], 'tissues': [284, 298, 307], 'when': [285, 303], 'compared': [286, 304], 'with': [287, 299, 305], 'normal': [288], 'tissues,': [289], 'upregulation': [292], 'further': [294], 'enhanced': [295], 'recurrence': [302], 'without': [308], 'metastasis.': [309, 378], 'Overexpression': [310], 'cells': [315], 'promoted': [316], 'growth,': [318, 354], 'invasion,': [321], 'knockdown': [323], 'inhibited': [326], 'proliferation': [328], 'vitro': [330], 'tumorigenicity': [332], 'vivo': [334], 'inducing': [336], 'apoptosis.': [338], 'Conclusions:The': [339], 'suggest': [344], 'plays': [347], 'key': [349], 'anti-apoptosis,': [355], 'inhibitors': [361], 'might': [362], 'therefore': [363], 'potential': [365], 'therapeutic': [366], 'applications': [367], 'treating': [369], 'patients': [371], 'inhibiting': [373], 'cancer': [374]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1895278304', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-24T16:16:21.605073', 'created_date': '2016-06-24'}