Title: Response to exercise in patients with obstructive sleep apnea
Abstract: Aim of this study was to assess cardio-pulmonary response to exercise (CPET) and the effect of continuous positive airway pressure (CPAP) on response to exercise. Methods The study group consisted of 140 patients (138 M, age 49±10 yrs, BMI 30±4 kg/m 2 ). Baseline testing included polysomnography, CPET and lung function testing. The first post-CPAP testing (I) was performed in 73 patients after 4±1 weeks, second (II, n=24) after 15±3 weeks, distant tests (III) in 64 patients after 47±18 months. Results Mean AHI was 43.6±23. In 23% of patients CPET was terminated due to increase in systolic blood pressure (BP) > 220 mmHg. Peak O 2 consumption VO 2peak was 29.1±6 ml/kg/min, but in 49% of patients it was 40 had lower VO 2peak (27.6±6 vs 30.8±6 ml/kg/min; p=0.001). During study I no changes in VO 2peak were noticed, however peak sys. and dias. BP decreased 15.9±19.7 mmHg (p During study II increase in VO 2peak of 4.2±5.6 ml/kg/min (p 2peak increased 2.7±3.3 ml/kg/min (p 2peak decreased 4.1±3.1 ml/kg/min (p Conlusions In 50% of untreated OSAS patients a decrease in VO 2peak can be expected. Increase in arterial BP pressure is a frequent reason of exercise termination. CPAP treatment attenuates BP pressure response to CPET and accelerates recovery of BP and heart rate. A failure to start the treatment of OSAS leads to a decrease in exercise tolerance.
Publication Year: 2014
Publication Date: 2014-09-01
Language: en
Type: article
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