Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1893278446', 'doi': 'https://doi.org/10.18632/oncotarget.5385', 'title': 'PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms', 'display_name': 'PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms', 'publication_year': 2015, 'publication_date': '2015-10-01', 'ids': {'openalex': 'https://openalex.org/W1893278446', 'doi': 'https://doi.org/10.18632/oncotarget.5385', 'mag': '1893278446', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26452133', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4742204'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5385', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5385&path%5B%5D=15233', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5385&path%5B%5D=15233', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101992958', 'display_name': 'Xiaolan Li', 'orcid': 'https://orcid.org/0000-0003-3656-2569'}, 'institutions': [{'id': 'https://openalex.org/I4210116071', 'display_name': 'Suzhou Municipal Hospital', 'ror': 'https://ror.org/02cdyrc89', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116071']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['CN', 'SG'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Lan Li', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Republic of Singapore.', 'Department of Gastroenterology, Suzhou Municipal Hospital (Eastern), Suzhou City, Jiangsu Province, 215001, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Suzhou Municipal Hospital (Eastern), Suzhou City, Jiangsu Province, 215001, P.R. China', 'institution_ids': ['https://openalex.org/I4210116071']}, {'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Republic of Singapore.', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045967361', 'display_name': 'Jianbiao Zhou', 'orcid': 'https://orcid.org/0000-0002-5679-671X'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Jianbiao Zhou', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Republic of Singapore.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Republic of Singapore.', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064895815', 'display_name': 'Zit-Liang Chan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Zit-Liang Chan', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Republic of Singapore.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Republic of Singapore.', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057555967', 'display_name': 'Jing-Yuan Chooi', 'orcid': 'https://orcid.org/0009-0004-6438-7555'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Jing-Yuan Chooi', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Republic of Singapore.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Republic of Singapore.', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101914034', 'display_name': 'Zhirong Chen', 'orcid': 'https://orcid.org/0009-0001-7039-7707'}, 'institutions': [{'id': 'https://openalex.org/I4210116071', 'display_name': 'Suzhou Municipal Hospital', 'ror': 'https://ror.org/02cdyrc89', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116071']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi-Rong Chen', 'raw_affiliation_strings': ['Department of Gastroenterology, Suzhou Municipal Hospital (Eastern), Suzhou City, Jiangsu Province, 215001, P.R. China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Suzhou Municipal Hospital (Eastern), Suzhou City, Jiangsu Province, 215001, P.R. China.', 'institution_ids': ['https://openalex.org/I4210116071']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066282840', 'display_name': 'Wee Joo Chng', 'orcid': 'https://orcid.org/0000-0003-2578-8335'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}, {'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I4210146690', 'display_name': 'National University Hospital', 'ror': 'https://ror.org/04fp9fm22', 'country_code': 'SG', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146690']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Wee-Joo Chng', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Republic of Singapore', 'Department of Hematology-Oncology, National University Hospital, Singapore 119228, Republic of Singapore', 'Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Republic of Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Republic of Singapore', 'institution_ids': ['https://openalex.org/I165932596']}, {'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Republic of Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}, {'raw_affiliation_string': 'Department of Hematology-Oncology, National University Hospital, Singapore 119228, Republic of Singapore', 'institution_ids': ['https://openalex.org/I4210146690']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.517, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.856575, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '6', 'issue': '34', 'first_page': '36689', 'last_page': '36699'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.57697266}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5431731}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.54037815}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.48586363}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42973223}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4183439}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.36221015}, {'id': 'https://openalex.org/C74909509', 'wikidata': 'https://www.wikidata.org/wiki/Q10387', 'display_name': 'Gerontology', 'level': 1, 'score': 0.32549}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20932207}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.10629839}], 'mesh': [{'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011812', 'descriptor_name': 'Quinuclidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018938', 'descriptor_name': 'Caco-2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019073', 'descriptor_name': 'HT29 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016688', 'descriptor_name': 'Mice, Inbred NOD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011812', 'descriptor_name': 'Quinuclidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5385', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5385&path%5B%5D=15233', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4742204', 'pdf_url': 'https://europepmc.org/articles/pmc4742204?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742204', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26452133', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5385', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5385&path%5B%5D=15233', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.78}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1536968302', 'https://openalex.org/W1966841369', 'https://openalex.org/W1978782811', 'https://openalex.org/W1980250100', 'https://openalex.org/W1999403469', 'https://openalex.org/W2019759811', 'https://openalex.org/W2020587750', 'https://openalex.org/W2022167872', 'https://openalex.org/W2025441055', 'https://openalex.org/W2030526282', 'https://openalex.org/W2038444562', 'https://openalex.org/W2039269113', 'https://openalex.org/W2048221004', 'https://openalex.org/W2051357113', 'https://openalex.org/W2058624670', 'https://openalex.org/W2064508063', 'https://openalex.org/W2069931679', 'https://openalex.org/W2078363421', 'https://openalex.org/W2085653208', 'https://openalex.org/W2092902276', 'https://openalex.org/W2099459640', 'https://openalex.org/W2104398672', 'https://openalex.org/W2120775866', 'https://openalex.org/W2131474316', 'https://openalex.org/W2137553864', 'https://openalex.org/W2137623277', 'https://openalex.org/W2141285914', 'https://openalex.org/W2142765738', 'https://openalex.org/W2144044603', 'https://openalex.org/W2147186597', 'https://openalex.org/W2150625137', 'https://openalex.org/W2157547728', 'https://openalex.org/W2161274278'], 'related_works': ['https://openalex.org/W3152233030', 'https://openalex.org/W3150682115', 'https://openalex.org/W3148810057', 'https://openalex.org/W2755853517', 'https://openalex.org/W2471519923', 'https://openalex.org/W2380755462', 'https://openalex.org/W2376402795', 'https://openalex.org/W2374019147', 'https://openalex.org/W2014198377', 'https://openalex.org/W1565061379'], 'abstract_inverted_index': {'//': [0], 'Xiao-Lan': [1], 'Li': [2], '1,': [3, 9, 26], '2,': [4], '*': [5, 10, 94], ',': [6, 11, 15, 19, 23, 124], 'Jianbiao': [7], 'Zhou': [8], 'Zit-Liang': [12], 'Chan': [13], '1': [14, 18, 29], 'Jing-Yuan': [16], 'Chooi': [17], 'Zhi-Rong': [20, 109], 'Chen': [21], '2': [22, 48], 'Wee-Joo': [24, 105], 'Chng': [25], '3,': [27], '4': [28, 82], 'Cancer': [30], 'Science': [31], 'Institute': [32], 'of': [33, 37, 46, 50, 65, 71, 75, 80, 84, 92, 150, 156, 174, 190, 194, 211, 227, 241, 260], 'Singapore,': [34, 38, 76], 'National': [35, 73, 86], 'University': [36, 74, 87], 'Centre': [39], 'for': [40, 218], 'Translational': [41], 'Medicine,': [42, 66, 72], 'Singapore': [43, 47, 77, 81, 89, 93], '117599,': [44], 'Republic': [45, 79, 91], 'Department': [49, 64, 83], 'Gastroenterology,': [51], 'Suzhou': [52, 56], 'Municipal': [53], 'Hospital': [54], '(Eastern),': [55], 'City,': [57], 'Jiangsu': [58], 'Province,': [59], '215001,': [60], 'P.R.': [61], 'China': [62], '3': [63], 'Yong': [67], 'Loo': [68], 'Lin': [69], 'School': [70], '119074,': [78], 'Hematology-Oncology,': [85], 'Hospital,': [88], '119228,': [90], 'These': [95], 'authors': [96], 'have': [97], 'contributed': [98], 'equally': [99], 'to': [100, 164, 255], 'this': [101], 'work': [102], 'Correspondence': [103], 'to:': [104], 'Chng,': [106], 'e-mail:': [107, 111], '[email protected]': [108], 'Chen,': [110], '[email protected]': [112], 'Keywords:': [113], 'colorectal': [114], 'cancer': [115], '(CRC),': [116], 'p53,': [117], 'tumor': [118, 234], 'suppressor': [119], 'gene': [120], '(TSG),': [121], 'PRIMA-1': [122, 140, 151, 159, 181, 198, 219, 229, 242, 261], 'met': [123, 141, 160, 182, 199, 220, 230, 243, 262], 'targeted': [125], 'therapy': [126], 'Received:': [127], 'July': [128], '14,': [129], '2015': [130, 134, 138], 'Accepted:': [131], 'September': [132], '17,': [133], 'Published:': [135], 'October': [136], '01,': [137], 'ABSTRACT': [139], '(APR-246)': [142], 'is': [143, 183, 216], 'a': [144, 213, 252], 'methylated': [145], 'derivative': [146], 'and': [147, 154, 172], 'structural': [148], 'analog': [149], '(p53': [152], 're-activation': [153], 'induction': [155], 'massive': [157], 'apoptosis).': [158], 'has': [161], 'been': [162], 'reported': [163], 'restore': [165], 'both': [166], 'the': [167, 188, 257], 'wild': [168], 'type': [169], '(wt)': [170], 'structure': [171], 'function': [173], 'mutant': [175, 208], 'p53.': [176, 209], 'Here,': [177], 'we': [178], 'show': [179], 'that': [180], 'highly': [184], 'effective': [185], 'at': [186], 'limiting': [187], 'growth': [189], 'CRC': [191, 205, 233, 245, 264], 'cells': [192, 206], 'regardless': [193], 'p53': [195, 248, 268], 'status.': [196, 269], 'However,': [197], 'induces': [200], 'robust': [201], 'apoptosis': [202], 'only': [203], 'in': [204, 244, 263], 'with': [207, 246, 266], 'Upregulation': [210], 'Noxa,': [212], 'proapoptotic': [214], 'molecule,': [215], 'crucial': [217], 'mediated': [221], 'activity.': [222], 'In': [223], 'human': [224], 'xenograft': [225], 'model': [226], 'disease,': [228], 'effectively': [231], 'suppresses': [232], 'growth.': [235], 'Our': [236], 'results': [237], 'uncover': [238], 'distinct': [239], 'mechanisms': [240], 'different': [247, 267], 'status,': [249], 'thus': [250], 'providing': [251], 'mechanistic': [253], 'rationale': [254], 'evaluate': [256], 'clinical': [258], 'efficacy': [259], 'patients': [265]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1893278446', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-12-08T14:21:01.585123', 'created_date': '2016-06-24'}