Title: A BACTERIAL PHOSPHOTRANSFERASE SYSTEM AND ITS ROLE IN SUGAR TRANSPORT
Abstract: A bacterial phosphotransferase system catalyzes the transfer of phosphate from phosphoenolpyruvate to a number of sugars. This system has recently been shown to be involved in a variety of important physiological processes in the bacterial cell, the best defined function being in the transport of various carbohydrates across the cell membrane by the process of group translocation. Less well defined functions of the system are in the regulation of inducible enzyme synthesis, the regulation of intracellular levels of cyclic AMP, motility, etc. Permeases which transport sugars not phosphorylated by the phosphotransferase system also appear to be regulated by this system. Studies with one such sugar, melibiose, indicate that this sugar is co-transported with sodium ion and the kinetics of the melibiose permease in Gram-negative organisms indicates that it functions in the same manner as the amino acid and sugar transport systems of animal cells.
Publication Year: 1972
Publication Date: 1972-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 21
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