Publication Information

{'id': 'https://openalex.org/W1890882717', 'doi': 'https://doi.org/10.3109/09537104.2015.1069809', 'title': 'Cangrelor inhibits the binding of the active metabolites of clopidogrel and prasugrel to P2Y<sub>12</sub>receptors<i>in vitro</i>', 'display_name': 'Cangrelor inhibits the binding of the active metabolites of clopidogrel and prasugrel to P2Y<sub>12</sub>receptors<i>in vitro</i>', 'publication_year': 2015, 'publication_date': '2015-08-13', 'ids': {'openalex': 'https://openalex.org/W1890882717', 'doi': 'https://doi.org/10.3109/09537104.2015.1069809', 'mag': '1890882717', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26270719'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/09537104.2015.1069809', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103305516', 'display_name': 'Platelets', 'issn_l': '0953-7104', 'issn': ['0953-7104', '1369-1635'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320449', 'host_organization_name': 'Informa', 'host_organization_lineage': ['https://openalex.org/P4310320449'], 'host_organization_lineage_names': ['Informa'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'http://eprints.whiterose.ac.uk/102492/7/Cangrelor_interaction_paper__lib.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051638272', 'display_name': 'Heather M. Judge', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I91136226', 'display_name': 'University of Sheffield', 'ror': 'https://ror.org/05krs5044', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I91136226']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Heather M. Judge', 'raw_affiliation_strings': ['Department of Cardiovascular Science, University of Sheffield , Sheffield , UK and.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Science, University of Sheffield , Sheffield , UK and.', 'institution_ids': ['https://openalex.org/I91136226']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077202666', 'display_name': 'Robert Buckland', 'orcid': 'https://orcid.org/0000-0001-9749-5422'}, 'institutions': [{'id': 'https://openalex.org/I91136226', 'display_name': 'University of Sheffield', 'ror': 'https://ror.org/05krs5044', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I91136226']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Robert J. Buckland', 'raw_affiliation_strings': ['Department of Cardiovascular Science, University of Sheffield , Sheffield , UK and.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Science, University of Sheffield , Sheffield , UK and.', 'institution_ids': ['https://openalex.org/I91136226']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111519360', 'display_name': 'Joseph A. Jakubowski', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I168537998', 'display_name': 'Eli Lilly (United States)', 'ror': 'https://ror.org/01qat3289', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I168537998']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph A. Jakubowski', 'raw_affiliation_strings': ['Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.'], 'affiliations': [{'raw_affiliation_string': 'Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.', 'institution_ids': ['https://openalex.org/I168537998']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039450208', 'display_name': 'Robert F. Storey', 'orcid': 'https://orcid.org/0000-0002-6677-6229'}, 'institutions': [{'id': 'https://openalex.org/I91136226', 'display_name': 'University of Sheffield', 'ror': 'https://ror.org/05krs5044', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I91136226']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Robert F. Storey', 'raw_affiliation_strings': ['Department of Cardiovascular Science, University of Sheffield , Sheffield , UK and.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Science, University of Sheffield , Sheffield , UK and.', 'institution_ids': ['https://openalex.org/I91136226']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4055, 'currency': 'AUD', 'value_usd': 2970, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.269, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.999958, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '27', 'issue': '3', 'first_page': '191', 'last_page': '195'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy and Cardiovascular Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy and Cardiovascular Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13489', 'display_name': 'Synthesis of β-Lactam Compounds', 'score': 0.9852, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cangrelor', 'display_name': 'Cangrelor', 'score': 0.9804089}, {'id': 'https://openalex.org/keywords/thienopyridine', 'display_name': 'Thienopyridine', 'score': 0.86487937}], 'concepts': [{'id': 'https://openalex.org/C2776708134', 'wikidata': 'https://www.wikidata.org/wiki/Q3655338', 'display_name': 'Cangrelor', 'level': 5, 'score': 0.9804089}, {'id': 'https://openalex.org/C2777028646', 'wikidata': 'https://www.wikidata.org/wiki/Q416232', 'display_name': 'Prasugrel', 'level': 4, 'score': 0.97790676}, {'id': 'https://openalex.org/C2779837110', 'wikidata': 'https://www.wikidata.org/wiki/Q3074941', 'display_name': 'Thienopyridine', 'level': 4, 'score': 0.86487937}, {'id': 'https://openalex.org/C49059817', 'wikidata': 'https://www.wikidata.org/wiki/Q14916330', 'display_name': 'P2Y12', 'level': 4, 'score': 0.8302623}, {'id': 'https://openalex.org/C2777849778', 'wikidata': 'https://www.wikidata.org/wiki/Q410237', 'display_name': 'Clopidogrel', 'level': 3, 'score': 0.7691778}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.6021363}, {'id': 'https://openalex.org/C2780890252', 'wikidata': 'https://www.wikidata.org/wiki/Q420542', 'display_name': 'Ticagrelor', 'level': 4, 'score': 0.44371387}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.35084414}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.32180125}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.22089803}, {'id': 'https://openalex.org/C2777628954', 'wikidata': 'https://www.wikidata.org/wiki/Q18216', 'display_name': 'Aspirin', 'level': 2, 'score': 0.09341332}], 'mesh': [{'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000068799', 'descriptor_name': 'Prasugrel Hydrochloride', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D058921', 'descriptor_name': 'Purinergic P2Y Receptor Antagonists', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D058925', 'descriptor_name': 'Receptors, Purinergic P2Y12', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013988', 'descriptor_name': 'Ticlopidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077144', 'descriptor_name': 'Clopidogrel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010979', 'descriptor_name': 'Platelet Function Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068799', 'descriptor_name': 'Prasugrel Hydrochloride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000068799', 'descriptor_name': 'Prasugrel Hydrochloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058921', 'descriptor_name': 'Purinergic P2Y Receptor Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D058921', 'descriptor_name': 'Purinergic P2Y Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058925', 'descriptor_name': 'Receptors, Purinergic P2Y12', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013988', 'descriptor_name': 'Ticlopidine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013988', 'descriptor_name': 'Ticlopidine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013988', 'descriptor_name': 'Ticlopidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/09537104.2015.1069809', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103305516', 'display_name': 'Platelets', 'issn_l': '0953-7104', 'issn': ['0953-7104', '1369-1635'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320449', 'host_organization_name': 'Informa', 'host_organization_lineage': ['https://openalex.org/P4310320449'], 'host_organization_lineage_names': ['Informa'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://eprints.whiterose.ac.uk/102492/7/Cangrelor_interaction_paper__lib.pdf', 'pdf_url': 'http://eprints.whiterose.ac.uk/102492/7/Cangrelor_interaction_paper__lib.pdf', 'source': {'id': 'https://openalex.org/S4377196101', 'display_name': 'White Rose Research Online (University of Leeds)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130828816', 'host_organization_name': 'University of Leeds', 'host_organization_lineage': ['https://openalex.org/I130828816'], 'host_organization_lineage_names': ['University of Leeds'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26270719', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://eprints.whiterose.ac.uk/102492/7/Cangrelor_interaction_paper__lib.pdf', 'pdf_url': 'http://eprints.whiterose.ac.uk/102492/7/Cangrelor_interaction_paper__lib.pdf', 'source': {'id': 'https://openalex.org/S4377196101', 'display_name': 'White Rose Research Online (University of Leeds)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130828816', 'host_organization_name': 'University of Leeds', 'host_organization_lineage': ['https://openalex.org/I130828816'], 'host_organization_lineage_names': ['University of Leeds'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1939515787', 'https://openalex.org/W1966433445', 'https://openalex.org/W1978591428', 'https://openalex.org/W1984368932', 'https://openalex.org/W1986455514', 'https://openalex.org/W1991498809', 'https://openalex.org/W1994303428', 'https://openalex.org/W2002249287', 'https://openalex.org/W2065390746', 'https://openalex.org/W2068295374', 'https://openalex.org/W2078644068', 'https://openalex.org/W2079311486', 'https://openalex.org/W2111109999', 'https://openalex.org/W2124078235', 'https://openalex.org/W2147746835', 'https://openalex.org/W2150655309', 'https://openalex.org/W2153447053', 'https://openalex.org/W2161055506', 'https://openalex.org/W2168795101', 'https://openalex.org/W2170029016'], 'related_works': ['https://openalex.org/W4245656066', 'https://openalex.org/W4234507240', 'https://openalex.org/W2987399071', 'https://openalex.org/W2954511599', 'https://openalex.org/W2592653943', 'https://openalex.org/W2412129801', 'https://openalex.org/W2232821929', 'https://openalex.org/W2099206832', 'https://openalex.org/W1890882717', 'https://openalex.org/W1594417447'], 'abstract_inverted_index': {'Cangrelor': [0], 'is': [1, 33, 37], 'a': [2, 63, 97, 120, 202], 'rapid-acting,': [3], 'direct-binding,': [4], 'and': [5, 53, 69, 81, 189, 219], 'reversible': [6], 'P2Y12': [7, 29, 44, 93, 102, 108, 130, 155, 157, 194], 'antagonist': [8, 45], 'which': [9], 'has': [10], 'been': [11], 'studied': [12, 104], 'for': [13, 152, 167, 173], 'use': [14], 'during': [15], 'percutaneous': [16], 'coronary': [17], 'intervention': [18], '(PCI)': [19], 'in': [20, 72, 106, 123, 180, 221], 'patients': [21], 'with': [22, 26, 150, 162, 197], 'or': [23, 55, 88], 'without': [24], 'pretreatment': [25], 'an': [27, 42], 'oral': [28, 43], 'antagonist.': [30], 'As': [31], 'cangrelor': [32, 68, 80, 127, 151, 163, 182, 220], 'administered': [34], 'intravenously,': [35], 'it': [36], 'necessary': [38], 'to': [39, 41, 148, 154, 192, 209, 212, 216, 223], 'switch': [40], 'following': [46, 230], 'PCI,': [47], 'such': [48], 'as': [49], 'the': [50, 56, 76, 82, 124, 134, 185, 193, 198, 225], 'thienopyridines': [51], 'clopidogrel,': [52], 'prasugrel': [54, 89, 116, 139, 174, 190], 'non-pyridine': [57], 'ticagrelor.': [58], 'Previous': [59], 'studies': [60], 'have': [61], 'suggested': [62], 'negative': [64, 203], 'pharmacodynamic': [65, 204], 'interaction': [66, 78], 'between': [67, 79], 'thienopyridines.': [70], 'This': [71], 'vitro': [73, 181], 'study': [74], 'evaluated': [75], 'receptor-level': [77], 'active': [83], 'metabolite': [84], '(AM)': [85], 'of': [86, 126, 187, 201, 227], 'clopidogrel': [87, 113, 168, 188], 'by': [90, 133], 'assessing': [91], 'functional': [92], 'receptor': [94, 109, 131, 158], 'number': [95], 'using': [96], '33P-2MeSADP': [98], 'binding': [99, 153, 186], 'assay.': [100], 'All': [101], 'antagonists': [103], 'resulted': [105], 'strong': [107], 'blockade': [110, 132, 159], '(cangrelor:': [111], '93.6%;': [112], 'AM:': [114, 117, 137, 140], '93.0%;': [115], '97.9%).': [118], 'Adding': [119], 'thienopyridine': [121, 143, 217], 'AM': [122, 135, 169, 175], 'presence': [125], 'strongly': [128, 183], 'reduces': [129], '(clopidogrel': [136], '7%,': [138], '3.2%).': [141], 'The': [142], 'AMs': [144, 191, 218], 'had': [145], 'limited': [146], 'ability': [147], 'compete': [149], '(%': [156], 'after': [160], 'co-incubation': [161], '1000': [164], 'nmol/L:': [165], '11.7%': [166], '3': [170, 176], 'µmol/L;': [171], '34.1%': [172], 'µmol/L).': [177], 'In': [178], 'conclusion,': [179], 'inhibits': [184], 'receptor,': [195], 'consistent': [196], 'previous': [199], 'observation': [200], 'interaction.': [205], 'Care': [206], 'may': [207], 'need': [208], 'be': [210], 'taken': [211], 'not': [213], 'overlap': [214], 'exposure': [215], 'order': [222], 'reduce': [224], 'risk': [226], 'thrombotic': [228], 'complications': [229], 'PCI.': [231]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1890882717', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-09T07:40:57.300144', 'created_date': '2016-06-24'}