Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1889312632', 'doi': 'https://doi.org/10.18632/oncotarget.4352', 'title': 'Role and regulation of coordinately expressed<i>de novo</i>purine biosynthetic enzymes<i>PPAT</i>and<i>PAICS</i>in lung cancer', 'display_name': 'Role and regulation of coordinately expressed<i>de novo</i>purine biosynthetic enzymes<i>PPAT</i>and<i>PAICS</i>in lung cancer', 'publication_year': 2015, 'publication_date': '2015-06-23', 'ids': {'openalex': 'https://openalex.org/W1889312632', 'doi': 'https://doi.org/10.18632/oncotarget.4352', 'mag': '1889312632', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26140362', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4695129'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4352', 'pdf_url': 'https://www.oncotarget.com/article/4352/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/4352/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087336616', 'display_name': 'Moloy T. Goswami', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Moloy T. Goswami', 'raw_affiliation_strings': ['Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001276721', 'display_name': 'Guoan Chen', 'orcid': 'https://orcid.org/0000-0001-5608-6761'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Guoan Chen', 'raw_affiliation_strings': ['Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051133829', 'display_name': 'Balabhadrapatruni V. S. K. Chakravarthi', 'orcid': 'https://orcid.org/0000-0003-2761-9690'}, 'institutions': [{'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}, {'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Balabhadrapatruni V.S.K. Chakravarthi', 'raw_affiliation_strings': ['Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA', 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA', 'institution_ids': ['https://openalex.org/I32389192']}, {'raw_affiliation_string': 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070221783', 'display_name': 'Satya S. Pathi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}, {'id': 'https://openalex.org/I30558944', 'display_name': 'Oklahoma Medical Research Foundation', 'ror': 'https://ror.org/035z6xf33', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I30558944']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Satya S. Pathi', 'raw_affiliation_strings': ['Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA', 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA'], 'affiliations': [{'raw_affiliation_string': 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA', 'institution_ids': ['https://openalex.org/I30558944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086144340', 'display_name': 'Sharath Kumar Anand', 'orcid': 'https://orcid.org/0000-0001-7282-4293'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sharath K. Anand', 'raw_affiliation_strings': ['Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103415933', 'display_name': 'Shannon L. Carskadon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}, {'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shannon L. Carskadon', 'raw_affiliation_strings': ['Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I4210117557']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077701232', 'display_name': 'Thomas J. Giordano', 'orcid': 'https://orcid.org/0000-0003-0641-8873'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas J. Giordano', 'raw_affiliation_strings': ['Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003311852', 'display_name': 'Arul M. Chinnaiyan', 'orcid': 'https://orcid.org/0000-0001-9282-3415'}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}, {'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arul M. Chinnaiyan', 'raw_affiliation_strings': ['Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA', 'Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030234836', 'display_name': 'Dafydd G. Thomas', 'orcid': 'https://orcid.org/0000-0002-0379-7460'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dafydd G. Thomas', 'raw_affiliation_strings': ['Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042167871', 'display_name': 'Nallasivam Palanisamy', 'orcid': 'https://orcid.org/0000-0002-0633-9772'}, 'institutions': [{'id': 'https://openalex.org/I154057602', 'display_name': 'Henry Ford Health System', 'ror': 'https://ror.org/02kwnkm68', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I154057602']}, {'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nallasivam Palanisamy', 'raw_affiliation_strings': ['Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'Department of Urology, Henry Ford Health System, Detroit, MI 48202, USA', 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Henry Ford Health System, Detroit, MI 48202, USA', 'institution_ids': ['https://openalex.org/I154057602']}, {'raw_affiliation_string': 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057943415', 'display_name': 'David G. Beer', 'orcid': 'https://orcid.org/0000-0002-2662-9507'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David G. Beer', 'raw_affiliation_strings': ['Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5079699559', 'display_name': 'Sooryanarayana Varambally', 'orcid': 'https://orcid.org/0000-0002-2277-1127'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}, {'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}, {'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sooryanarayana Varambally', 'raw_affiliation_strings': ['Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA', 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA', 'institution_ids': ['https://openalex.org/I32389192']}, {'raw_affiliation_string': 'Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.275, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 86, 'citation_normalized_percentile': {'value': 0.856575, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '6', 'issue': '27', 'first_page': '23445', 'last_page': '23461'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.63483036}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.5164671}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.39636773}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.34070045}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.299352}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1643143}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000582', 'descriptor_name': 'Amidophosphoribosyltransferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002262', 'descriptor_name': 'Carboxy-Lyases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010453', 'descriptor_name': 'Peptide Synthases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000582', 'descriptor_name': 'Amidophosphoribosyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000782', 'descriptor_name': 'Aneuploidy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002262', 'descriptor_name': 'Carboxy-Lyases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003980', 'descriptor_name': 'Diazooxonorleucine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D003980', 'descriptor_name': 'Diazooxonorleucine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005973', 'descriptor_name': 'Glutamine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005973', 'descriptor_name': 'Glutamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005973', 'descriptor_name': 'Glutamine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009368', 'descriptor_name': 'Neoplasm Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010453', 'descriptor_name': 'Peptide Synthases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011687', 'descriptor_name': 'Purines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011687', 'descriptor_name': 'Purines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4352', 'pdf_url': 'https://www.oncotarget.com/article/4352/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4695129', 'pdf_url': 'https://europepmc.org/articles/pmc4695129?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695129', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26140362', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4352', 'pdf_url': 'https://www.oncotarget.com/article/4352/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.79, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 77, 'referenced_works': ['https://openalex.org/W1540415768', 'https://openalex.org/W1605420823', 'https://openalex.org/W1663117206', 'https://openalex.org/W1667881669', 'https://openalex.org/W1745549119', 'https://openalex.org/W1775259416', 'https://openalex.org/W1892496998', 'https://openalex.org/W1967362499', 'https://openalex.org/W1968065996', 'https://openalex.org/W1968315432', 'https://openalex.org/W1968510406', 'https://openalex.org/W1973304708', 'https://openalex.org/W1974720903', 'https://openalex.org/W1979843175', 'https://openalex.org/W1980121152', 'https://openalex.org/W1988078905', 'https://openalex.org/W1996646041', 'https://openalex.org/W2000492963', 'https://openalex.org/W2000630389', 'https://openalex.org/W2000771269', 'https://openalex.org/W2002575472', 'https://openalex.org/W2002765383', 'https://openalex.org/W2008699255', 'https://openalex.org/W2022323055', 'https://openalex.org/W2023103376', 'https://openalex.org/W2029195626', 'https://openalex.org/W2034530633', 'https://openalex.org/W2038623184', 'https://openalex.org/W2044545697', 'https://openalex.org/W2046759180', 'https://openalex.org/W2049923433', 'https://openalex.org/W2050079849', 'https://openalex.org/W2051886524', 'https://openalex.org/W2056174640', 'https://openalex.org/W2058451329', 'https://openalex.org/W2065746026', 'https://openalex.org/W2069269337', 'https://openalex.org/W2070544303', 'https://openalex.org/W2071373243', 'https://openalex.org/W2071480068', 'https://openalex.org/W2076562742', 'https://openalex.org/W2080903186', 'https://openalex.org/W2082668371', 'https://openalex.org/W2086816631', 'https://openalex.org/W2090029719', 'https://openalex.org/W2090406819', 'https://openalex.org/W2091607700', 'https://openalex.org/W2092527265', 'https://openalex.org/W2093775484', 'https://openalex.org/W2094576137', 'https://openalex.org/W2094957481', 'https://openalex.org/W2095987251', 'https://openalex.org/W2097259163', 'https://openalex.org/W2099755355', 'https://openalex.org/W2104830962', 'https://openalex.org/W2114843025', 'https://openalex.org/W2116201681', 'https://openalex.org/W2117692326', 'https://openalex.org/W2121691257', 'https://openalex.org/W2132165198', 'https://openalex.org/W2134847995', 'https://openalex.org/W2141082830', 'https://openalex.org/W2142748510', 'https://openalex.org/W2149441684', 'https://openalex.org/W2151499633', 'https://openalex.org/W2154678665', 'https://openalex.org/W2155354546', 'https://openalex.org/W2155680682', 'https://openalex.org/W2155888371', 'https://openalex.org/W2157760261', 'https://openalex.org/W2162102103', 'https://openalex.org/W2165831518', 'https://openalex.org/W2167972473', 'https://openalex.org/W2170552969', 'https://openalex.org/W4233769980', 'https://openalex.org/W4243903519', 'https://openalex.org/W4248892322'], 'related_works': ['https://openalex.org/W3204273758', 'https://openalex.org/W3103789129', 'https://openalex.org/W2788277189', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2082860237', 'https://openalex.org/W2013243191', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418', 'https://openalex.org/W1564105650'], 'abstract_inverted_index': {'//': [0], 'Moloy': [1], 'T.': [2], 'Goswami': [3], '1,': [4, 16, 24, 36, 48, 62, 75], '2,': [5, 17, 25, 42, 49, 57, 63, 76], '*': [6, 11, 19, 197], ',': [7, 12, 20, 27, 32, 38, 44, 53, 59, 66, 72], 'Guoan': [8], 'Chen': [9], '4,': [10, 70], 'Balabhadrapatruni': [13], 'V.S.K.': [14], 'Chakravarthi': [15], '8,': [18], 'Satya': [21], 'S.': [22], 'Pathi': [23], '9': [26, 182], 'Sharath': [28], 'K.': [29], 'Anand': [30], '2': [31, 37, 90], 'Shannon': [33], 'L.': [34], 'Carskadon': [35], 'Thomas': [39, 56], 'J.': [40], 'Giordano': [41], '5': [43, 58, 71, 128], 'Arul': [45], 'M.': [46], 'Chinnaiyan': [47], '3,': [50], '5,': [51, 64, 77], '6': [52, 142], 'Dafydd': [54], 'G.': [55, 68, 213], 'Nallasivam': [60], 'Palanisamy': [61], '7': [65, 157], 'David': [67, 212], 'Beer': [69], 'Sooryanarayana': [73, 208], 'Varambally': [74], '8': [78, 169], '1': [79], 'Michigan': [80, 134, 149], 'Center': [81], 'for': [82, 303, 374, 389, 448], 'Translational': [83], 'Pathology,': [84, 93, 172], 'Ann': [85, 97, 109, 123, 137, 152], 'Arbor,': [86, 98, 110, 124, 138, 153], 'MI': [87, 99, 111, 125, 139, 154, 166], '48109,': [88, 100, 112, 126, 140, 155], 'USA': [89, 101, 113, 127, 141, 156, 168, 181, 196], 'Department': [91, 103, 117, 158, 170], 'of': [92, 95, 104, 107, 118, 121, 133, 148, 159, 171, 174, 261, 273, 309, 357, 367, 376, 400], 'University': [94, 106, 120, 132, 147, 173], 'Michigan,': [96, 108, 122], '3': [102], 'Urology,': [105, 160], '4': [114], 'Thoracic': [115], 'Surgery,': [116, 119], 'Comprehensive': [129], 'Cancer': [130, 185, 238], 'Center,': [131], 'Medical': [135, 145, 150, 189], 'School,': [136, 151], 'Howard': [143], 'Hughes': [144], 'Institute,': [146], 'Henry': [161], 'Ford': [162], 'Health': [163], 'System,': [164], 'Detroit,': [165], '48202,': [167], 'Alabama': [175], 'at': [176], 'Birmingham,': [177, 178], 'AL': [179], '35233,': [180], 'Immunobiology': [183], 'and': [184, 265, 288, 296, 321, 331, 339, 348, 355, 379, 381, 402, 426, 428, 434], 'Research': [186, 190], 'Program,': [187], 'Oklahoma': [188, 192], 'Foundation,': [191], 'City,': [193], 'OK': [194], '73104,': [195], 'These': [198], 'authors': [199], 'have': [200], 'contributed': [201], 'equally': [202], 'to': [203], 'this': [204, 413], 'work': [205], 'Correspondence': [206], 'to:': [207], 'Varambally,': [209], 'e-mail:': [210, 215], '[email protected]': [211], 'Beer,': [214], '[email protected]': [216], 'Keywords:': [217], 'lung': [218, 280, 305, 368, 441], 'adenocarcinoma,': [219], 'amplification,': [220], 'purine': [221, 254, 276, 421], 'biosynthesis,': [222], 'glutamine,': [223], 'xenograft': [224], 'Received:': [225], 'May': [226], '04,': [227], '2015': [228, 232, 236], 'Accepted:': [229], 'June': [230, 234], '12,': [231], 'Published:': [233], '23,': [235], 'ABSTRACT': [237], 'cells': [239, 443], 'exhibit': [240], 'altered': [241], 'metabolism': [242], 'including': [243], 'aerobic': [244], 'glycolysis': [245], 'that': [246, 294, 336, 444], 'channels': [247], 'several': [248], 'glycolytic': [249], 'intermediates': [250], 'into': [251], 'de': [252, 274], 'novo': [253, 275], 'biosynthetic': [255, 277, 422], 'pathway.': [256], 'We': [257, 370], 'discovered': [258], 'increased': [259, 316, 433], 'expression': [260, 290, 317, 341], 'phosphoribosyl': [262], 'amidotransferase': [263], '(PPAT)': [264], 'phosphoribosylaminoimidazole': [266, 268], 'carboxylase,': [267], 'succinocarboxamide': [269], 'synthetase': [270], '(PAICS)': [271], 'enzymes': [272, 424], 'pathway': [278, 423], 'in': [279, 364, 440], 'adenocarcinomas.': [281], 'Transcript': [282], 'analyses': [283], 'from': [284], 'next-generation': [285], 'RNA': [286], 'sequencing': [287], 'gene': [289, 329], 'profiling': [291], 'studies': [292, 333], 'suggested': [293], 'PPAT': [295, 338, 378, 401, 425], 'PAICS': [297, 310, 340, 380, 403], 'can': [298, 445], 'serve': [299], 'as': [300, 404, 406], 'prognostic': [301], 'biomarkers': [302], 'aggressive': [304], 'adenocarcinoma.': [306], 'Immunohistochemical': [307], 'analysis': [308], 'performed': [311], 'on': [312], 'tissue': [313], 'microarrays': [314], 'showed': [315], 'with': [318, 325], 'disease': [319], 'progression': [320], 'was': [322], 'significantly': [323], 'associated': [324], 'poor': [326], 'prognosis.': [327], 'Through': [328], 'knockdown': [330], 'over-expression': [332], 'we': [334, 351], 'demonstrate': [335], 'altering': [337], 'modulates': [342], 'pyruvate': [343, 382, 408, 429], 'kinase': [344, 383, 409, 430], 'activity,': [345], 'cell': [346], 'proliferation': [347], 'invasion.': [349], 'Furthermore': [350], 'identified': [352], 'genomic': [353, 362], 'amplification': [354], 'aneuploidy': [356], 'the': [358, 416], 'divergently': [359], 'transcribed': [360], 'PPAT-PAICS': [361], 'region': [363], 'a': [365, 387], 'subset': [366], 'cancers.': [369], 'also': [371], 'present': [372], 'evidence': [373], 'regulation': [375], 'both': [377], 'activity': [384, 431], 'by': [385, 419], 'L-glutamine,': [386], 'co-substrate': [388], 'PPAT.': [390], 'A': [391], 'glutamine': [392, 397], 'antagonist,': [393], '6-Diazo-5-oxo-L-norleucine': [394], '(DON)': [395], 'blocked': [396], 'mediated': [398], 'induction': [399], 'well': [405], 'reduced': [407], 'activity.': [410], 'In': [411], 'summary,': [412], 'study': [414], 'reveals': [415], 'regulatory': [417], 'mechanisms': [418], 'which': [420], 'PAICS,': [427], 'is': [432], 'exposes': [435], 'an': [436], 'existing': [437], 'metabolic': [438], 'vulnerability': [439], 'cancer': [442], 'be': [446], 'explored': [447], 'pharmacological': [449], 'intervention.': [450]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1889312632', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 4}], 'updated_date': '2024-12-14T08:57:55.761881', 'created_date': '2016-06-24'}