Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1888700889', 'doi': 'https://doi.org/10.18632/oncotarget.6176', 'title': 'Cancer stem cell targeted therapy: progress amid controversies', 'display_name': 'Cancer stem cell targeted therapy: progress amid controversies', 'publication_year': 2015, 'publication_date': '2015-10-19', 'ids': {'openalex': 'https://openalex.org/W1888700889', 'doi': 'https://doi.org/10.18632/oncotarget.6176', 'mag': '1888700889', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26496035', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4792551'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6176', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6176&path%5B%5D=15440', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6176&path%5B%5D=15440', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100453627', 'display_name': 'Tao Wang', 'orcid': 'https://orcid.org/0000-0002-9623-8800'}, 'institutions': [{'id': 'https://openalex.org/I149704539', 'display_name': 'Deakin University', 'ror': 'https://ror.org/02czsnj07', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I149704539']}, {'id': 'https://openalex.org/I38877650', 'display_name': 'Zhengzhou University', 'ror': 'https://ror.org/04ypx8c21', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I38877650']}], 'countries': ['AU', 'CN'], 'is_corresponding': False, 'raw_author_name': 'Tao Wang', 'raw_affiliation_strings': ['School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia.', 'School of Nursing, Zhengzhou University, Zhengzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia.', 'institution_ids': ['https://openalex.org/I149704539']}, {'raw_affiliation_string': 'School of Nursing, Zhengzhou University, Zhengzhou, China.', 'institution_ids': ['https://openalex.org/I38877650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091767535', 'display_name': 'Sarah Shigdar', 'orcid': 'https://orcid.org/0000-0001-8084-8447'}, 'institutions': [{'id': 'https://openalex.org/I149704539', 'display_name': 'Deakin University', 'ror': 'https://ror.org/02czsnj07', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I149704539']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Sarah Shigdar', 'raw_affiliation_strings': ['School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia', 'institution_ids': ['https://openalex.org/I149704539']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028263566', 'display_name': 'Michael P. Gantier', 'orcid': 'https://orcid.org/0000-0003-3740-698X'}, 'institutions': [{'id': 'https://openalex.org/I2802600346', 'display_name': 'Hudson Institute of Medical Research', 'ror': 'https://ror.org/0083mf965', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802600346']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Michael P. Gantier', 'raw_affiliation_strings': ['Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia', 'Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia.'], 'affiliations': [{'raw_affiliation_string': 'Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia', 'institution_ids': ['https://openalex.org/I2802600346']}, {'raw_affiliation_string': 'Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia.', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062388610', 'display_name': 'Yingchun Hou', 'orcid': 'https://orcid.org/0000-0002-0636-7458'}, 'institutions': [{'id': 'https://openalex.org/I88830068', 'display_name': 'Shaanxi Normal University', 'ror': 'https://ror.org/0170z8493', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I88830068']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yingchun Hou', 'raw_affiliation_strings': ["Co-Innovation Center for Qinba Region's Sustainable Development, Shaanxi Normal University, Xi'an, China."], 'affiliations': [{'raw_affiliation_string': "Co-Innovation Center for Qinba Region's Sustainable Development, Shaanxi Normal University, Xi'an, China.", 'institution_ids': ['https://openalex.org/I88830068']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100336281', 'display_name': 'Li Wang', 'orcid': 'https://orcid.org/0009-0005-5697-4183'}, 'institutions': [{'id': 'https://openalex.org/I38877650', 'display_name': 'Zhengzhou University', 'ror': 'https://ror.org/04ypx8c21', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I38877650']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li Wang', 'raw_affiliation_strings': ['Department of Gynecologic Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Gynecologic Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.', 'institution_ids': ['https://openalex.org/I38877650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029768249', 'display_name': 'Yong Li', 'orcid': 'https://orcid.org/0000-0002-8910-9787'}, 'institutions': [{'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Yong Li', 'raw_affiliation_strings': ['Cancer Care Centre, St George Hospital and St George Clinical School, University of New South Wales (UNSW), Kensington, Australia.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Care Centre, St George Hospital and St George Clinical School, University of New South Wales (UNSW), Kensington, Australia.', 'institution_ids': ['https://openalex.org/I31746571']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014833060', 'display_name': 'Hadi Al Shamaileh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149704539', 'display_name': 'Deakin University', 'ror': 'https://ror.org/02czsnj07', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I149704539']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Hadi Al Shamaileh', 'raw_affiliation_strings': ['School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia', 'institution_ids': ['https://openalex.org/I149704539']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101764017', 'display_name': 'Wang Yin', 'orcid': 'https://orcid.org/0000-0002-5665-3559'}, 'institutions': [{'id': 'https://openalex.org/I149704539', 'display_name': 'Deakin University', 'ror': 'https://ror.org/02czsnj07', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I149704539']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Wang Yin', 'raw_affiliation_strings': ['School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia', 'institution_ids': ['https://openalex.org/I149704539']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007122446', 'display_name': 'Shu‐Feng Zhou', 'orcid': 'https://orcid.org/0000-0002-7215-707X'}, 'institutions': [{'id': 'https://openalex.org/I2613432', 'display_name': 'University of South Florida', 'ror': 'https://ror.org/032db5x82', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2613432']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shu-Feng Zhou', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA', 'institution_ids': ['https://openalex.org/I2613432']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101882271', 'display_name': 'Xinhan Zhao', 'orcid': 'https://orcid.org/0000-0002-8525-4178'}, 'institutions': [{'id': 'https://openalex.org/I87445476', 'display_name': "Xi'an Jiaotong University", 'ror': 'https://ror.org/017zhmm22', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87445476']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xinhan Zhao', 'raw_affiliation_strings': ["Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an, China."], 'affiliations': [{'raw_affiliation_string': "Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an, China.", 'institution_ids': ['https://openalex.org/I87445476']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088285841', 'display_name': 'Wei Duan', 'orcid': 'https://orcid.org/0000-0001-5782-9184'}, 'institutions': [{'id': 'https://openalex.org/I149704539', 'display_name': 'Deakin University', 'ror': 'https://ror.org/02czsnj07', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I149704539']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Wei Duan', 'raw_affiliation_strings': ['School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia', 'institution_ids': ['https://openalex.org/I149704539']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.865, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 136, 'citation_normalized_percentile': {'value': 0.630154, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '42', 'first_page': '44191', 'last_page': '44206'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12835', 'display_name': 'FOXO transcription factor regulation', 'score': 0.9883, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/targeted-therapy', 'display_name': 'Targeted Therapy', 'score': 0.7259671}, {'id': 'https://openalex.org/keywords/cancer-therapy', 'display_name': 'Cancer Therapy', 'score': 0.5072348}, {'id': 'https://openalex.org/keywords/stem-cell-therapy', 'display_name': 'Stem Cell Therapy', 'score': 0.46701652}], 'concepts': [{'id': 'https://openalex.org/C2781230642', 'wikidata': 'https://www.wikidata.org/wiki/Q492646', 'display_name': 'Targeted therapy', 'level': 3, 'score': 0.7259671}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.67352057}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.52322835}, {'id': 'https://openalex.org/C2983331546', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer therapy', 'level': 3, 'score': 0.5072348}, {'id': 'https://openalex.org/C2779389132', 'wikidata': 'https://www.wikidata.org/wiki/Q1533033', 'display_name': 'Stem-cell therapy', 'level': 3, 'score': 0.46701652}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.45356154}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4175558}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.40994588}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.35584378}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2950549}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.17060757}, {'id': 'https://openalex.org/C2911091166', 'wikidata': 'https://www.wikidata.org/wiki/Q106419912', 'display_name': 'Transplantation', 'level': 2, 'score': 0.1161035}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09939301}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D055808', 'descriptor_name': 'Drug Discovery', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055808', 'descriptor_name': 'Drug Discovery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013269', 'descriptor_name': 'Stochastic Processes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059016', 'descriptor_name': 'Tumor Microenvironment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6176', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6176&path%5B%5D=15440', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4792551', 'pdf_url': 'https://europepmc.org/articles/pmc4792551?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Cancer_stem_cell_targeted_therapy_progress_amid_controversies/20897017', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Cancer_stem_cell_targeted_therapy_progress_amid_controversies/20897017/3/files/37168945.pdf', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10536/DRO/DU:30080436', 'pdf_url': 'https://dro.deakin.edu.au/articles/journal_contribution/Cancer_stem_cell_targeted_therapy_progress_amid_controversies/20897017/2/files/37168945.pdf', 'source': {'id': 'https://openalex.org/S4306402457', 'display_name': 'Deakin Research Online (Deakin University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I149704539', 'host_organization_name': 'Deakin University', 'host_organization_lineage': ['https://openalex.org/I149704539'], 'host_organization_lineage_names': ['Deakin University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792551', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://research.monash.edu/en/publications/44aa1145-d34b-403d-b570-456c73e15e1e', 'pdf_url': 'https://research.monash.edu/files/235497421/3577229_oa.pdf', 'source': {'id': 'https://openalex.org/S4306402625', 'display_name': 'Monash University Research Portal (Monash University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I56590836', 'host_organization_name': 'Monash University', 'host_organization_lineage': ['https://openalex.org/I56590836'], 'host_organization_lineage_names': ['Monash University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26496035', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6176', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6176&path%5B%5D=15440', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 148, 'referenced_works': ['https://openalex.org/W1500946936', 'https://openalex.org/W1534849470', 'https://openalex.org/W1876073362', 'https://openalex.org/W1911233385', 'https://openalex.org/W191900123', 'https://openalex.org/W1966110667', 'https://openalex.org/W1966427351', 'https://openalex.org/W1969465530', 'https://openalex.org/W1970910239', 'https://openalex.org/W1978139448', 'https://openalex.org/W1979345147', 'https://openalex.org/W1979421565', 'https://openalex.org/W1979830686', 'https://openalex.org/W1980000654', 'https://openalex.org/W1980325735', 'https://openalex.org/W1981550751', 'https://openalex.org/W1984229970', 'https://openalex.org/W1988397531', 'https://openalex.org/W1989414412', 'https://openalex.org/W1989506825', 'https://openalex.org/W1990757263', 'https://openalex.org/W1992676863', 'https://openalex.org/W1992819841', 'https://openalex.org/W1994599132', 'https://openalex.org/W1995596330', 'https://openalex.org/W1997338647', 'https://openalex.org/W1998196049', 'https://openalex.org/W1998718877', 'https://openalex.org/W2002013266', 'https://openalex.org/W2002579647', 'https://openalex.org/W2002736769', 'https://openalex.org/W2004331554', 'https://openalex.org/W2004878973', 'https://openalex.org/W2007126419', 'https://openalex.org/W2009886857', 'https://openalex.org/W2009949136', 'https://openalex.org/W2011895269', 'https://openalex.org/W2012224968', 'https://openalex.org/W2013497246', 'https://openalex.org/W2017322644', 'https://openalex.org/W2018671779', 'https://openalex.org/W2020131167', 'https://openalex.org/W2021401668', 'https://openalex.org/W2022286638', 'https://openalex.org/W2023427658', 'https://openalex.org/W2023457181', 'https://openalex.org/W2023560061', 'https://openalex.org/W2024495487', 'https://openalex.org/W2025092145', 'https://openalex.org/W2025690227', 'https://openalex.org/W2026721712', 'https://openalex.org/W2027364921', 'https://openalex.org/W2027950772', 'https://openalex.org/W2028025998', 'https://openalex.org/W2029231546', 'https://openalex.org/W2029520352', 'https://openalex.org/W2033364737', 'https://openalex.org/W2034145807', 'https://openalex.org/W2034226010', 'https://openalex.org/W2034230062', 'https://openalex.org/W2034916462', 'https://openalex.org/W2035023838', 'https://openalex.org/W2035252444', 'https://openalex.org/W2044183760', 'https://openalex.org/W2044905529', 'https://openalex.org/W2047580721', 'https://openalex.org/W2050093720', 'https://openalex.org/W2051055358', 'https://openalex.org/W2051588629', 'https://openalex.org/W2052467200', 'https://openalex.org/W2053924952', 'https://openalex.org/W2054449135', 'https://openalex.org/W2055970002', 'https://openalex.org/W2056772956', 'https://openalex.org/W2057624501', 'https://openalex.org/W2058569154', 'https://openalex.org/W2060586075', 'https://openalex.org/W2063380435', 'https://openalex.org/W2066858578', 'https://openalex.org/W2067114333', 'https://openalex.org/W2069387683', 'https://openalex.org/W2070478388', 'https://openalex.org/W2071123870', 'https://openalex.org/W2073917039', 'https://openalex.org/W2077036771', 'https://openalex.org/W2079356804', 'https://openalex.org/W2079400283', 'https://openalex.org/W2082259335', 'https://openalex.org/W2086535578', 'https://openalex.org/W2087500600', 'https://openalex.org/W2090982381', 'https://openalex.org/W2092946257', 'https://openalex.org/W2093048604', 'https://openalex.org/W2094735859', 'https://openalex.org/W2098076875', 'https://openalex.org/W2098432933', 'https://openalex.org/W2099023875', 'https://openalex.org/W2101885447', 'https://openalex.org/W2102394111', 'https://openalex.org/W2103300371', 'https://openalex.org/W2104666893', 'https://openalex.org/W2107823533', 'https://openalex.org/W2109336877', 'https://openalex.org/W2110034822', 'https://openalex.org/W2110690713', 'https://openalex.org/W2110845079', 'https://openalex.org/W2112296880', 'https://openalex.org/W2117199255', 'https://openalex.org/W2117692326', 'https://openalex.org/W2118577068', 'https://openalex.org/W2123956915', 'https://openalex.org/W2125455141', 'https://openalex.org/W2125987139', 'https://openalex.org/W2129305290', 'https://openalex.org/W2129375080', 'https://openalex.org/W2131436977', 'https://openalex.org/W2135330733', 'https://openalex.org/W2135943905', 'https://openalex.org/W2140254135', 'https://openalex.org/W2140350596', 'https://openalex.org/W2141815918', 'https://openalex.org/W2142159058', 'https://openalex.org/W2143425711', 'https://openalex.org/W2145178473', 'https://openalex.org/W2152387543', 'https://openalex.org/W2153824299', 'https://openalex.org/W2155507705', 'https://openalex.org/W2155667408', 'https://openalex.org/W2156365913', 'https://openalex.org/W2159607376', 'https://openalex.org/W2162012621', 'https://openalex.org/W2164244124', 'https://openalex.org/W2166741387', 'https://openalex.org/W2167017433', 'https://openalex.org/W2167414381', 'https://openalex.org/W2170107010', 'https://openalex.org/W2170731941', 'https://openalex.org/W2301074049', 'https://openalex.org/W2324080174', 'https://openalex.org/W2331141044', 'https://openalex.org/W2335220233', 'https://openalex.org/W2413868450', 'https://openalex.org/W2475911225', 'https://openalex.org/W2604396587', 'https://openalex.org/W2787082951', 'https://openalex.org/W2971274129', 'https://openalex.org/W4240746805', 'https://openalex.org/W4300820761'], 'related_works': ['https://openalex.org/W3212040808', 'https://openalex.org/W3048262645', 'https://openalex.org/W3016741759', 'https://openalex.org/W2980880396', 'https://openalex.org/W2807627867', 'https://openalex.org/W2625131095', 'https://openalex.org/W2554267979', 'https://openalex.org/W2386241483', 'https://openalex.org/W2129260485', 'https://openalex.org/W1978711798'], 'abstract_inverted_index': {'//': [0, 177, 181], 'Tao': [1], 'Wang': [2, 19, 31], '1,2': [3], ',': [4, 8, 13, 17, 21, 25, 30, 34, 38], 'Sarah': [5], 'Shigdar': [6], '2': [7, 29, 33, 45, 54], 'Michael': [9], 'P.': [10], 'Gantier': [11], '3,4': [12], 'Yingchun': [14], 'Hou': [15], '5': [16, 89], 'Li': [18, 23], '6': [20, 102], 'Yong': [22], '7': [24, 119], 'Hadi': [26], 'Al': [27], 'Shamaileh': [28], 'Yin': [32], 'Shu-Feng': [35], 'Zhou': [36], '8': [37, 139], 'Xinhan': [39, 174], 'Zhao': [40], '9': [41, 154], 'and': [42, 81, 126, 255, 264, 279, 288], 'Wei': [43, 178], 'Duan': [44], '1': [46], 'School': [47, 55, 167], 'of': [48, 56, 71, 79, 104, 114, 132, 141, 145, 148, 156, 163, 168, 228, 231, 281, 294, 305], 'Nursing,': [49], 'Zhengzhou': [50, 115], 'University,': [51, 59, 85, 99, 116], 'Zhengzhou,': [52, 117], 'China': [53, 101, 118, 171], 'Medicine,': [57, 169], 'Deakin': [58], 'Waurn': [60], 'Ponds,': [61], 'Victoria,': [62, 75, 87], 'Australia': [63, 76, 88, 138], '3': [64], 'Centre': [65], 'for': [66, 92], 'Cancer': [67, 108, 112, 120], 'Research,': [68, 73], 'Hudson': [69], 'Institute': [70], 'Medical': [72, 157], 'Clayton,': [74, 86], '4': [77], 'Department': [78, 103, 140, 155], 'Molecular': [80], 'Translational': [82], 'Science,': [83], 'Monash': [84], 'Co-Innovation': [90], 'Center': [91], 'Qinba': [93], "Region's": [94], 'Sustainable': [95], 'Development,': [96], 'Shaanxi': [97], 'Normal': [98], "Xi'an,": [100, 170], 'Gynecologic': [105], 'Oncology,': [106, 158], 'Henan': [107], 'Hospital,': [109], 'The': [110, 159], 'Affiliated': [111, 161], 'Hospital': [113, 125, 162], 'Care': [121], 'Centre,': [122], 'St': [123, 127], 'George': [124, 128], 'Clinical': [129], 'School,': [130], 'University': [131, 147, 166], 'New': [133], 'South': [134, 149], 'Wales': [135], '(UNSW),': [136], 'Kensington,': [137], 'Pharmaceutical': [142], 'Sciences,': [143], 'College': [144], 'Pharmacy,': [146], 'Florida,': [150], 'Tampa,': [151], 'FL,': [152], 'USA': [153], 'First': [160], "Xi'an": [164], 'Jiaotong': [165], 'Correspondence': [172], 'to:': [173], 'Zhao,': [175], 'email:': [176, 180], 'Duan,': [179], 'Keywords': [182], ':': [183, 199, 204, 209], 'cancer,': [184], 'cancer': [185, 190, 194, 215, 241, 252, 266, 282, 295, 306], 'stem': [186, 191, 195, 216, 242, 253, 257, 267, 283, 307], 'cell,': [187], 'anti-cancer': [188, 310], 'treatment,': [189], 'cell': [192, 196], 'marker,': [193], 'model': [197], 'Received': [198], 'August': [200], '12,': [201], '2015': [202, 207, 212], 'Accepted': [203], 'October': [205, 210], '06,': [206], 'Published': [208], '19,': [211], 'Abstract': [213], 'Although': [214], 'cells': [217, 243, 254, 258, 268, 284, 308], 'have': [218, 234], 'been': [219, 235], 'well': [220], 'characterized': [221], 'in': [222], 'numerous': [223], 'malignancies,': [224], 'the': [225, 265, 276, 299, 303], 'fundamental': [226], 'characteristics': [227], 'this': [229], 'group': [230], 'cells,': [232], 'however,': [233], 'challenged': [236], 'by': [237], 'some': [238], 'recent': [239, 300], 'observations:': [240], 'may': [244, 259], 'not': [245], 'necessary': [246], 'to': [247], 'be': [248], 'rare': [249], 'within': [250], 'tumors;': [251], 'non-cancer': [256], 'undergo': [260], 'reversible': [261], 'phenotypic': [262], 'changes;': [263], 'phenotype': [269], 'can': [270], 'vary': [271], 'substantially': [272], 'between': [273], 'patients.': [274], 'Here': [275], 'current': [277], 'status': [278], 'progresses': [280], 'theory': [285], 'is': [286], 'illustrated': [287], 'via': [289], 'providing': [290], 'a': [291], 'panoramic': [292], 'view': [293], 'therapy,': [296], 'we': [297], 'addressed': [298], 'controversies': [301], 'regarding': [302], 'feasibility': [304], 'targeted': [309], 'therapy.': [311]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1888700889', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 27}, {'year': 2019, 'cited_by_count': 25}, {'year': 2018, 'cited_by_count': 18}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 9}], 'updated_date': '2025-01-07T18:11:10.521215', 'created_date': '2016-06-24'}