Abstract: Cognitive impairment is a far too common medical problem. Moreover, there is no effective therapy for increasing memory and learning in individuals with such an impairment. Recent studies implicate that mTOR pathway may be involved in learning and behavior. Thus, we tested the hypothesis that mTOR inhibition can increase the learning and memory in mice. We examined spatial learning ability in mTOR heterozygous and control mice by Morris Water Maze. In the control group of mice, we also inhibited mTOR pathway by rapamycin administration and examined its effect on learning and memory.Our results demonstrate that mTOR heterozygous mice had significantly higher ability for spatial learning. Also, inhibition of mTOR in control mice increased the spatial learning ability. We conclude that mTOR inhibition can lead to increased learning ability. However, further investigations are needed to examine the role of mTOR in Alzheimer and disorders in which memory impairment is the major pathology.
Publication Year: 2014
Publication Date: 2014-04-01
Language: en
Type: article
Indexed In: ['crossref']
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