Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1875744479', 'doi': 'https://doi.org/10.18632/oncotarget.1911', 'title': 'Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells', 'display_name': 'Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells', 'publication_year': 2014, 'publication_date': '2014-04-18', 'ids': {'openalex': 'https://openalex.org/W1875744479', 'doi': 'https://doi.org/10.18632/oncotarget.1911', 'mag': '1875744479', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24810717', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4039164'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1911', 'pdf_url': 'https://www.oncotarget.com/article/1911/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/1911/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075209661', 'display_name': 'Verena Licht', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210127789', 'display_name': 'Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)', 'ror': 'https://ror.org/039a53269', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210127789']}, {'id': 'https://openalex.org/I76198965', 'display_name': 'Friedrich Schiller University Jena', 'ror': 'https://ror.org/05qpz1x62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I76198965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Verena Licht', 'raw_affiliation_strings': ['Friedrich-Schiller-Universität Jena, Centre for Molecular Biomedicine (CMB), Institute for Biochemistry and Biophysics, Hans-Knöll-Str. 2, 07745 Jena, Germany', 'Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany'], 'affiliations': [{'raw_affiliation_string': 'Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany', 'institution_ids': ['https://openalex.org/I4210127789']}, {'raw_affiliation_string': 'Friedrich-Schiller-Universität Jena, Centre for Molecular Biomedicine (CMB), Institute for Biochemistry and Biophysics, Hans-Knöll-Str. 2, 07745 Jena, Germany', 'institution_ids': ['https://openalex.org/I76198965']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036504996', 'display_name': 'Katrin Noack', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I76198965', 'display_name': 'Friedrich Schiller University Jena', 'ror': 'https://ror.org/05qpz1x62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I76198965']}, {'id': 'https://openalex.org/I4210134900', 'display_name': 'Jena University Hospital', 'ror': 'https://ror.org/035rzkx15', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210134900']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Katrin Noack', 'raw_affiliation_strings': ['Friedrich-Schiller-Universität Jena, Centre for Molecular Biomedicine (CMB), Institute for Biochemistry and Biophysics, Hans-Knöll-Str. 2, 07745 Jena, Germany', 'Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, , Erlanger Allee 101, 07747 Jena, Germany'], 'affiliations': [{'raw_affiliation_string': 'Friedrich-Schiller-Universität Jena, Centre for Molecular Biomedicine (CMB), Institute for Biochemistry and Biophysics, Hans-Knöll-Str. 2, 07745 Jena, Germany', 'institution_ids': ['https://openalex.org/I76198965']}, {'raw_affiliation_string': 'Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, , Erlanger Allee 101, 07747 Jena, Germany', 'institution_ids': ['https://openalex.org/I4210134900']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029992720', 'display_name': 'Bernhard Schlott', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210127789', 'display_name': 'Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)', 'ror': 'https://ror.org/039a53269', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210127789']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Bernhard Schlott', 'raw_affiliation_strings': ['Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany'], 'affiliations': [{'raw_affiliation_string': 'Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany', 'institution_ids': ['https://openalex.org/I4210127789']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101947656', 'display_name': 'Martin Förster', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210134900', 'display_name': 'Jena University Hospital', 'ror': 'https://ror.org/035rzkx15', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210134900']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Martin Förster', 'raw_affiliation_strings': ['Internal Medicine I, Pulmonary Medicine and Allergy/Immunology, University Clinics Jena, Erlanger Allee 101, 07747 Jena, Germany'], 'affiliations': [{'raw_affiliation_string': 'Internal Medicine I, Pulmonary Medicine and Allergy/Immunology, University Clinics Jena, Erlanger Allee 101, 07747 Jena, Germany', 'institution_ids': ['https://openalex.org/I4210134900']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038839771', 'display_name': 'Yvonne Schlenker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210134900', 'display_name': 'Jena University Hospital', 'ror': 'https://ror.org/035rzkx15', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210134900']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Yvonne Schlenker', 'raw_affiliation_strings': ['Internal Medicine I, Pulmonary Medicine and Allergy/Immunology, University Clinics Jena, Erlanger Allee 101, 07747 Jena, Germany'], 'affiliations': [{'raw_affiliation_string': 'Internal Medicine I, Pulmonary Medicine and Allergy/Immunology, University Clinics Jena, Erlanger Allee 101, 07747 Jena, Germany', 'institution_ids': ['https://openalex.org/I4210134900']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051327581', 'display_name': 'Andreas Licht', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118637', 'display_name': 'Jena Bioscience (Germany)', 'ror': 'https://ror.org/02f0gnt04', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I4210118637']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Andreas Licht', 'raw_affiliation_strings': ['Jena Bioscience GmbH, Loebstedter Strasse 80, 07749 Jena, Germany'], 'affiliations': [{'raw_affiliation_string': 'Jena Bioscience GmbH, Loebstedter Strasse 80, 07749 Jena, Germany', 'institution_ids': ['https://openalex.org/I4210118637']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049942833', 'display_name': 'Oliver H. Krämer', 'orcid': 'https://orcid.org/0000-0003-3973-045X'}, 'institutions': [{'id': 'https://openalex.org/I197323543', 'display_name': 'Johannes Gutenberg University Mainz', 'ror': 'https://ror.org/023b0x485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I197323543']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Oliver H. Krämer', 'raw_affiliation_strings': ['Institut für Toxikologie, Universitätsmedizin Mainz, Obere Zahlbacher Str. 67, 55131 Mainz, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Toxikologie, Universitätsmedizin Mainz, Obere Zahlbacher Str. 67, 55131 Mainz, Germany', 'institution_ids': ['https://openalex.org/I197323543']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5015940174', 'display_name': 'Thorsten Heinzel', 'orcid': 'https://orcid.org/0009-0003-8937-6089'}, 'institutions': [{'id': 'https://openalex.org/I76198965', 'display_name': 'Friedrich Schiller University Jena', 'ror': 'https://ror.org/05qpz1x62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I76198965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Thorsten Heinzel', 'raw_affiliation_strings': ['Friedrich-Schiller-Universität Jena, Centre for Molecular Biomedicine (CMB), Institute for Biochemistry and Biophysics, Hans-Knöll-Str. 2, 07745 Jena, Germany'], 'affiliations': [{'raw_affiliation_string': 'Friedrich-Schiller-Universität Jena, Centre for Molecular Biomedicine (CMB), Institute for Biochemistry and Biophysics, Hans-Knöll-Str. 2, 07745 Jena, Germany', 'institution_ids': ['https://openalex.org/I76198965']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.949, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.750822, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '5', 'issue': '8', 'first_page': '2305', 'last_page': '2317'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stat1', 'display_name': 'STAT1', 'score': 0.42998862}], 'concepts': [{'id': 'https://openalex.org/C2777003663', 'wikidata': 'https://www.wikidata.org/wiki/Q14912030', 'display_name': 'STAT1', 'level': 3, 'score': 0.42998862}, {'id': 'https://openalex.org/C171958077', 'wikidata': 'https://www.wikidata.org/wiki/Q419333', 'display_name': 'STAT protein', 'level': 4, 'score': 0.4290046}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.41572607}, {'id': 'https://openalex.org/C2778923194', 'wikidata': 'https://www.wikidata.org/wiki/Q14912019', 'display_name': 'STAT3', 'level': 3, 'score': 0.40286532}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.38299027}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.35923707}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.31508446}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.2811795}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27876788}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09361443}], 'mesh': [{'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053178', 'descriptor_name': 'Caspase 6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050794', 'descriptor_name': 'STAT1 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002087', 'descriptor_name': 'Butyrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002087', 'descriptor_name': 'Butyrates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053178', 'descriptor_name': 'Caspase 6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056572', 'descriptor_name': 'Histone Deacetylase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056572', 'descriptor_name': 'Histone Deacetylase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050794', 'descriptor_name': 'STAT1 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1911', 'pdf_url': 'https://www.oncotarget.com/article/1911/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4039164', 'pdf_url': 'https://europepmc.org/articles/pmc4039164?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039164', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24810717', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1911', 'pdf_url': 'https://www.oncotarget.com/article/1911/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.65, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W149655857', 'https://openalex.org/W1528483543', 'https://openalex.org/W1640134355', 'https://openalex.org/W1765001480', 'https://openalex.org/W1866128922', 'https://openalex.org/W1967912613', 'https://openalex.org/W1968527707', 'https://openalex.org/W1968890035', 'https://openalex.org/W1970489031', 'https://openalex.org/W1972789666', 'https://openalex.org/W1973454407', 'https://openalex.org/W1975766627', 'https://openalex.org/W1977149080', 'https://openalex.org/W1986625462', 'https://openalex.org/W1988969017', 'https://openalex.org/W1990492856', 'https://openalex.org/W1990575049', 'https://openalex.org/W1991366673', 'https://openalex.org/W1994941668', 'https://openalex.org/W1997383546', 'https://openalex.org/W2000407232', 'https://openalex.org/W2007666820', 'https://openalex.org/W2008342628', 'https://openalex.org/W2013036001', 'https://openalex.org/W2013588387', 'https://openalex.org/W2016949937', 'https://openalex.org/W2017059819', 'https://openalex.org/W2017214930', 'https://openalex.org/W2022186026', 'https://openalex.org/W2024282024', 'https://openalex.org/W2028517598', 'https://openalex.org/W2035261278', 'https://openalex.org/W2052788415', 'https://openalex.org/W2056155809', 'https://openalex.org/W2060449956', 'https://openalex.org/W2060796398', 'https://openalex.org/W2062505071', 'https://openalex.org/W2068294387', 'https://openalex.org/W2068337524', 'https://openalex.org/W2068751269', 'https://openalex.org/W2069699197', 'https://openalex.org/W2074651846', 'https://openalex.org/W2075362954', 'https://openalex.org/W2076104235', 'https://openalex.org/W2077187292', 'https://openalex.org/W2079357798', 'https://openalex.org/W2079870321', 'https://openalex.org/W2084897539', 'https://openalex.org/W2088788982', 'https://openalex.org/W2091095196', 'https://openalex.org/W2091619297', 'https://openalex.org/W2096655588', 'https://openalex.org/W2106095322', 'https://openalex.org/W2106775330', 'https://openalex.org/W2110807341', 'https://openalex.org/W2113890278', 'https://openalex.org/W2116512522', 'https://openalex.org/W2125333406', 'https://openalex.org/W2128511441', 'https://openalex.org/W2136575978', 'https://openalex.org/W2138049320', 'https://openalex.org/W2142451896', 'https://openalex.org/W2146784178', 'https://openalex.org/W2148448562', 'https://openalex.org/W2155530747', 'https://openalex.org/W2159232188', 'https://openalex.org/W2166512255', 'https://openalex.org/W2323827802'], 'related_works': ['https://openalex.org/W3159709528', 'https://openalex.org/W2967775152', 'https://openalex.org/W2917410143', 'https://openalex.org/W2886181943', 'https://openalex.org/W2365509284', 'https://openalex.org/W2079870321', 'https://openalex.org/W1993520606', 'https://openalex.org/W1980817114', 'https://openalex.org/W1980081171', 'https://openalex.org/W1964215388'], 'abstract_inverted_index': {'//': [0, 142, 146], 'Verena': [1], 'Licht': [2, 22], '1,2,*': [3], ',': [4, 8, 12, 16, 20, 24, 29, 82], 'Katrin': [5], 'Noack': [6], '2,3,*': [7], 'Bernhard': [9], 'Schlott': [10], '1': [11, 33], 'Martin': [13], 'Förster': [14], '4': [15, 19, 89], 'Yvonne': [17], 'Schlenker': [18], 'Andreas': [21], '5': [23, 106], 'Oliver': [25, 138], 'H.': [26, 139], 'Krämer': [27], '6': [28, 116], 'Thorsten': [30, 143], 'Heinzel': [31], '2': [32, 48], 'Leibniz': [34], 'Institute': [35, 56], 'for': [36, 52, 57, 73, 329], 'Age': [37], 'Research': [38, 68], '–': [39], 'Fritz': [40], 'Lipmann': [41], 'Institute,': [42], 'Beutenbergstrasse': [43], '11,': [44], '07745': [45, 63], 'Jena,': [46, 50, 64, 87, 99, 104, 114], 'Germany': [47, 65, 88, 105, 115, 128], 'Friedrich-Schiller-Universität': [49], 'Centre': [51], 'Molecular': [53], 'Biomedicine': [54], '(CMB),': [55], 'Biochemistry': [58], 'and': [59, 69, 76, 95, 173, 189, 210, 248, 262, 282, 307], 'Biophysics,': [60], 'Hans-Knöll-Str.': [61], '2,': [62], '3': [66], 'Integrated': [67], 'Treatment': [70], 'Center,': [71], 'Center': [72], 'Sepsis': [74], 'Control': [75], 'Care': [77], '(CSCC),': [78], 'Jena': [79, 107], 'University': [80, 97], 'Hospital,': [81], 'Erlanger': [83, 100], 'Allee': [84, 101], '101,': [85, 102], '07747': [86, 103], 'Internal': [90], 'Medicine': [91, 94], 'I,': [92], 'Pulmonary': [93], 'Allergy/Immunology,': [96], 'Clinics': [98], 'Bioscience': [108], 'GmbH,': [109], 'Loebstedter': [110], 'Strasse': [111], '80,': [112], '07749': [113], 'Institut': [117], 'für': [118], 'Toxikologie,': [119], 'Universitätsmedizin': [120], 'Mainz,': [121, 127], 'Obere': [122], 'Zahlbacher': [123], 'Str.': [124], '67,': [125], '55131': [126], '*': [129], 'These': [130, 294], 'authors': [131], 'corresponded': [132], 'equally': [133], 'to': [134, 229, 238], 'this': [135], 'work': [136], 'Correspondence:': [137], 'Krämer,': [140], 'email:': [141, 145], 'Heinzel,': [144], 'Keywords': [147], ':': [148, 156, 161, 166], 'Apoptosis,': [149], 'Caspase-3,': [150], 'Caspase-6,': [151], 'HDACi,': [152], 'Leukemia,': [153], 'STAT1': [154, 195, 242, 271, 281, 299, 313], 'Received': [155], 'February': [157], '18,': [158, 168], '2014': [159, 164, 169], 'Accepted': [160], 'April': [162, 167], '16,': [163], 'Published': [165], 'Abstract': [170], 'Signal': [171], 'Transducer': [172], 'Activator': [174], 'of': [175, 213, 221, 232, 241, 285, 333], 'Transcription-1': [176], '(STAT1)': [177], 'is': [178, 300, 314], 'phosphorylated': [179], 'upon': [180], 'interferon': [181], '(IFN)': [182], 'stimulation,': [183], 'which': [184], 'can': [185, 196], 'restrict': [186], 'cell': [187, 276], 'proliferation': [188], 'survival.': [190], 'Nevertheless,': [191], 'in': [192, 198, 255, 318], 'some': [193], 'cancers': [194], 'act': [197], 'an': [199, 327], 'anti-apoptotic': [200], 'manner.': [201], 'Moreover,': [202], 'certain': [203], 'malignancies': [204], 'are': [205], 'characterized': [206], 'by': [207, 246, 305, 316], 'the': [208, 219, 230, 239, 330], 'overexpression': [209], 'constitutive': [211], 'activation': [212], 'STAT1.': [214], 'Here,': [215], 'we': [216], 'demonstrate': [217], 'that': [218, 265, 297, 312], 'treatment': [220], 'transformed': [222], 'hematopoietic': [223, 260, 321], 'cells': [224, 264], 'with': [225, 279, 291], 'epigenetic': [226], 'drugs': [227], 'belonging': [228], 'class': [231], 'histone': [233], 'deacetylase': [234], 'inhibitors': [235], '(HDACi)': [236], 'leads': [237], 'cleavage': [240, 272], 'at': [243, 302], 'multiple': [244, 303], 'sites': [245, 304], 'caspase-3': [247, 306], 'caspase-6.': [249, 308], 'This': [250, 323], 'process': [251], 'does': [252], 'not': [253], 'occur': [254], 'solid': [256], 'tumor': [257], 'cells,': [258, 261], 'normal': [259], 'leukemic': [263, 338], 'underwent': [266], 'granulocytic': [267], 'or': [268], 'monocytic': [269], 'differentiation.': [270], 'was': [273], 'studied': [274], 'under': [275], 'free': [277], 'conditions': [278], 'purified': [280], 'a': [283], 'set': [284], 'candidate': [286], 'caspases': [287, 317], 'as': [288, 290], 'well': [289], 'mass': [292], 'spectrometry.': [293], 'assays': [295], 'indicate': [296], 'unmodified': [298], 'cleaved': [301], 'Our': [309], 'study': [310], 'shows': [311], 'targeted': [315], 'malignant': [319], 'undifferentiated': [320], 'cells.': [322, 339], 'observation': [324], 'may': [325], 'provide': [326], 'explanation': [328], 'selective': [331], 'toxicity': [332], 'HDACi': [334], 'against': [335], 'rapidly': [336], 'proliferating': [337]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1875744479', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-12T23:52:09.788390', 'created_date': '2016-06-24'}