Title: A new method of measuring pulmonary diffusing capacity for oxygen in patients with diffuse lung disease.
Abstract: Pulmonary diffusion was studied using both oxygen and carbon monoxide in 10 patients with diffuse lung disease and a decreased diffusing capacity for carbon monoxide, as measured by the single-breath method. A new method for measuring diffusing capacity for oxygen during short-term hypoxia on exercise was used in 6 patients in whom the alveolar-arterial oxygen gradient due to mismatching of ventilation with perfusion and right-left shunt was minimal during short-term hypoxia at rest. In 4 patients with alveolar-arterial oxygen gradients of 10 mm Hg or more in similar circumstances, a diffusing capacity for oxygen was not measured. The values for diffusing capacities for oxygen and carbon dioxide agreed well in the 6 patients in whom comparisons were made. The low values of diffusing capacity for carbon monoxide in the other 4 patients were considered to be due to abnormal distribution of ventilation. The new method for measuring diffusing capacity for oxygen makes it possible to identify patients with a l...
Publication Year: 1973
Publication Date: 1973-09-01
Language: en
Type: article
Indexed In: ['pubmed']
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