Publication Information

{'id': 'https://openalex.org/W1868779397', 'doi': 'https://doi.org/10.1111/j.2042-7158.2011.01254.x', 'title': 'Amelioration of cerebral infarction and improvement of neurological deficit by a Korean herbal medicine, modified Bo-Yang-Hwan-O-Tang', 'display_name': 'Amelioration of cerebral infarction and improvement of neurological deficit by a Korean herbal medicine, modified Bo-Yang-Hwan-O-Tang', 'publication_year': 2011, 'publication_date': '2011-03-15', 'ids': {'openalex': 'https://openalex.org/W1868779397', 'doi': 'https://doi.org/10.1111/j.2042-7158.2011.01254.x', 'mag': '1868779397', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21492172'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.2011.01254.x', 'pdf_url': 'https://academic.oup.com/jpp/article-pdf/63/5/695/36354984/j.2042-7158.2011.01254.x.pdf', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://academic.oup.com/jpp/article-pdf/63/5/695/36354984/j.2042-7158.2011.01254.x.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077870640', 'display_name': 'Yookeum Choi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197347611', 'display_name': 'Korea University', 'ror': 'https://ror.org/047dqcg40', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I197347611']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yookeum Choi', 'raw_affiliation_strings': ['Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I197347611']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100733126', 'display_name': 'Seul-Ki Kim', 'orcid': 'https://orcid.org/0000-0001-9796-2764'}, 'institutions': [{'id': 'https://openalex.org/I197347611', 'display_name': 'Korea University', 'ror': 'https://ror.org/047dqcg40', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I197347611']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Seul-Ki Kim', 'raw_affiliation_strings': ['Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I197347611']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019382914', 'display_name': 'In Young Choi', 'orcid': 'https://orcid.org/0000-0002-2860-9411'}, 'institutions': [{'id': 'https://openalex.org/I197347611', 'display_name': 'Korea University', 'ror': 'https://ror.org/047dqcg40', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I197347611']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'In-Young Choi', 'raw_affiliation_strings': ['Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I197347611']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000551501', 'display_name': 'Chung Ju', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197347611', 'display_name': 'Korea University', 'ror': 'https://ror.org/047dqcg40', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I197347611']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Chung Ju', 'raw_affiliation_strings': ['Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I197347611']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111902165', 'display_name': 'Kung-Woo Nam', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197347611', 'display_name': 'Korea University', 'ror': 'https://ror.org/047dqcg40', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I197347611']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kung-Woo Nam', 'raw_affiliation_strings': ['Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I197347611']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018137685', 'display_name': 'Sun‐Young Hwang', 'orcid': 'https://orcid.org/0000-0002-0603-5381'}, 'institutions': [{'id': 'https://openalex.org/I197347611', 'display_name': 'Korea University', 'ror': 'https://ror.org/047dqcg40', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I197347611']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sunyoung Hwang', 'raw_affiliation_strings': ['Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I197347611']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067398781', 'display_name': 'Byung‐Woo Kim', 'orcid': 'https://orcid.org/0000-0003-4986-1162'}, 'institutions': [{'id': 'https://openalex.org/I197347611', 'display_name': 'Korea University', 'ror': 'https://ror.org/047dqcg40', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I197347611']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Byung-Woo Kim', 'raw_affiliation_strings': ['Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I197347611']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101546062', 'display_name': 'Min Ji Yoon', 'orcid': 'https://orcid.org/0000-0003-1292-3817'}, 'institutions': [{'id': 'https://openalex.org/I197347611', 'display_name': 'Korea University', 'ror': 'https://ror.org/047dqcg40', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I197347611']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Min Ji Yoon', 'raw_affiliation_strings': ['Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I197347611']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071539415', 'display_name': 'Moo‐Ho Won', 'orcid': 'https://orcid.org/0000-0002-7178-6501'}, 'institutions': [{'id': 'https://openalex.org/I146824383', 'display_name': 'Hallym University', 'ror': 'https://ror.org/03sbhge02', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I146824383']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Moo-Ho Won', 'raw_affiliation_strings': ['Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Gangwon-do, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I146824383']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110183963', 'display_name': 'Yong-Ki Park', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205490536', 'display_name': 'Dongguk University', 'ror': 'https://ror.org/057q6n778', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I205490536']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yong-Ki Park', 'raw_affiliation_strings': ['Oriental Medicine R&D Center, College of Oriental Medicine, Dongguk University, Gyeongju, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'Oriental Medicine R&D Center, College of Oriental Medicine, Dongguk University, Gyeongju, Republic of Korea.', 'institution_ids': ['https://openalex.org/I205490536']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002587541', 'display_name': 'Won-Ki Kim', 'orcid': 'https://orcid.org/0000-0001-6821-1742'}, 'institutions': [{'id': 'https://openalex.org/I197347611', 'display_name': 'Korea University', 'ror': 'https://ror.org/047dqcg40', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I197347611']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Won-Ki Kim', 'raw_affiliation_strings': ['Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, College of Medicine, Korea University, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I197347611']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2665, 'currency': 'GBP', 'value_usd': 3268, 'provenance': 'doaj'}, 'apc_paid': {'value': 2665, 'currency': 'GBP', 'value_usd': 3268, 'provenance': 'doaj'}, 'fwci': 5.054, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.890817, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '63', 'issue': '5', 'first_page': '695', 'last_page': '706'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11709', 'display_name': 'Traditional Chinese Medicine Analysis', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11709', 'display_name': 'Traditional Chinese Medicine Analysis', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Neuroinflammation and Neurodegeneration Mechanisms', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stroke', 'display_name': 'Stroke', 'score': 0.5154172}, {'id': 'https://openalex.org/keywords/neurological-deficit', 'display_name': 'Neurological deficit', 'score': 0.42981192}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.86870396}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.65737844}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.5391545}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.517041}, {'id': 'https://openalex.org/C2780645631', 'wikidata': 'https://www.wikidata.org/wiki/Q671554', 'display_name': 'Stroke (engine)', 'level': 2, 'score': 0.5154172}, {'id': 'https://openalex.org/C2775841333', 'wikidata': 'https://www.wikidata.org/wiki/Q498179', 'display_name': 'Middle cerebral artery', 'level': 3, 'score': 0.4978931}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4442059}, {'id': 'https://openalex.org/C2779450755', 'wikidata': 'https://www.wikidata.org/wiki/Q1209150', 'display_name': 'Cerebral infarction', 'level': 3, 'score': 0.44263864}, {'id': 'https://openalex.org/C2993523616', 'wikidata': 'https://www.wikidata.org/wiki/Q17146697', 'display_name': 'Neurological deficit', 'level': 2, 'score': 0.42981192}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.28131056}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002545', 'descriptor_name': 'Brain Ischemia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D007036', 'descriptor_name': 'Hypothermia, Induced', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008517', 'descriptor_name': 'Phytotherapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D015427', 'descriptor_name': 'Reperfusion Injury', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002545', 'descriptor_name': 'Brain Ischemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054022', 'descriptor_name': 'Cerebrum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054022', 'descriptor_name': 'Cerebrum', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D054022', 'descriptor_name': 'Cerebrum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054022', 'descriptor_name': 'Cerebrum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055670', 'descriptor_name': 'Medicine, Korean Traditional', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D015427', 'descriptor_name': 'Reperfusion Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015427', 'descriptor_name': 'Reperfusion Injury', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D015427', 'descriptor_name': 'Reperfusion Injury', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.2011.01254.x', 'pdf_url': 'https://academic.oup.com/jpp/article-pdf/63/5/695/36354984/j.2042-7158.2011.01254.x.pdf', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21492172', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.2011.01254.x', 'pdf_url': 'https://academic.oup.com/jpp/article-pdf/63/5/695/36354984/j.2042-7158.2011.01254.x.pdf', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 79, 'referenced_works': ['https://openalex.org/W1453284819', 'https://openalex.org/W1709664955', 'https://openalex.org/W1965455421', 'https://openalex.org/W1968081526', 'https://openalex.org/W1971257582', 'https://openalex.org/W1976709936', 'https://openalex.org/W1984965323', 'https://openalex.org/W1985148363', 'https://openalex.org/W1985221375', 'https://openalex.org/W1988054144', 'https://openalex.org/W1988870129', 'https://openalex.org/W1989700367', 'https://openalex.org/W1991207312', 'https://openalex.org/W1995102476', 'https://openalex.org/W2001677899', 'https://openalex.org/W2003389301', 'https://openalex.org/W2003912078', 'https://openalex.org/W2007037442', 'https://openalex.org/W2008186920', 'https://openalex.org/W2012189124', 'https://openalex.org/W2013661589', 'https://openalex.org/W2016773564', 'https://openalex.org/W2017722375', 'https://openalex.org/W2026793735', 'https://openalex.org/W2028517578', 'https://openalex.org/W2028596221', 'https://openalex.org/W2030358397', 'https://openalex.org/W2030674909', 'https://openalex.org/W2031941651', 'https://openalex.org/W2032569321', 'https://openalex.org/W2033413582', 'https://openalex.org/W2033900283', 'https://openalex.org/W2035729495', 'https://openalex.org/W2037410247', 'https://openalex.org/W2037595874', 'https://openalex.org/W2038418509', 'https://openalex.org/W2040671475', 'https://openalex.org/W2044401315', 'https://openalex.org/W2044495642', 'https://openalex.org/W2046297960', 'https://openalex.org/W2046953754', 'https://openalex.org/W2047548115', 'https://openalex.org/W2049934847', 'https://openalex.org/W2053977070', 'https://openalex.org/W2055988798', 'https://openalex.org/W2063794671', 'https://openalex.org/W2069066983', 'https://openalex.org/W2069239274', 'https://openalex.org/W2070680926', 'https://openalex.org/W2071054549', 'https://openalex.org/W2078602394', 'https://openalex.org/W2079287640', 'https://openalex.org/W2085226483', 'https://openalex.org/W2087560360', 'https://openalex.org/W2088859002', 'https://openalex.org/W2089889388', 'https://openalex.org/W2090169008', 'https://openalex.org/W2093903029', 'https://openalex.org/W2099983265', 'https://openalex.org/W2112763282', 'https://openalex.org/W2121609724', 'https://openalex.org/W2125683177', 'https://openalex.org/W2126171928', 'https://openalex.org/W2128212086', 'https://openalex.org/W2129648625', 'https://openalex.org/W2133438218', 'https://openalex.org/W2144918294', 'https://openalex.org/W2149709906', 'https://openalex.org/W2157474032', 'https://openalex.org/W2170166094', 'https://openalex.org/W2281438438', 'https://openalex.org/W2367802914', 'https://openalex.org/W2385558060', 'https://openalex.org/W2401205177', 'https://openalex.org/W2408339430', 'https://openalex.org/W2443370884', 'https://openalex.org/W2464931099', 'https://openalex.org/W3135571977', 'https://openalex.org/W318605956'], 'related_works': ['https://openalex.org/W3031460228', 'https://openalex.org/W2585153498', 'https://openalex.org/W2366274677', 'https://openalex.org/W2364153252', 'https://openalex.org/W2363025388', 'https://openalex.org/W2360566177', 'https://openalex.org/W2347214521', 'https://openalex.org/W2341358403', 'https://openalex.org/W2077655479', 'https://openalex.org/W2066020256'], 'abstract_inverted_index': {'Abstract': [0], 'Objectives': [1], 'Modified': [2], 'Bo-Yang-Hwan-O-Tang': [3], '(mBHT)': [4], 'is': [5], 'an': [6], 'improved': [7, 117], 'herbal': [8, 215], 'formula': [9], 'of': [10, 27, 88, 99, 127, 145, 175, 186, 220], 'BHT,': [11], 'which': [12], 'has': [13, 205], 'been': [14], 'widely': [15], 'used': [16], 'to': [17, 52], 'treat': [18], 'ischaemic': [19, 43, 123, 222], 'stroke': [20], 'in': [21, 45, 180], 'East': [22], 'Asia,': [23], 'by': [24, 111, 172], 'the': [25, 86, 103, 136, 218], 'addition': [26], 'five': [28], 'herbs': [29], 'having': [30], 'anti-ischaemic': [31, 143, 207], 'properties.': [32], 'In': [33, 158], 'this': [34], 'study,': [35], 'we': [36, 162], 'investigated': [37], 'whether': [38], 'mBHT': [39, 64, 100, 113, 128, 146, 166, 189, 204], 'would': [40, 210], 'reduce': [41], 'cerebral': [42, 56, 104, 122, 140, 221], 'injury': [44, 171], 'rats.': [46], 'Methods': [47], 'Sprague–Dawley': [48], 'rats': [49], 'were': [50], 'subjected': [51], 'a': [53, 212], '90-min': [54], 'middle': [55], 'artery': [57], 'occlusion': [58], '(MCAO)': [59], 'and': [60, 73, 107, 184, 209], 'subsequent': [61], '22-h': [62], 'reperfusion.': [63], 'was': [65, 147, 156], 'administered': [66], 'either': [67], 'intraperitoneally': [68], 'twice': [69], '15': [70, 74], 'min': [71, 75, 81, 84, 130], 'before': [72], 'after,': [76], 'or': [77, 82, 91], 'orally': [78], 'once': [79], '30': [80, 129], '120': [83], 'after': [85, 121, 131, 139], 'onset': [87], 'MCAO': [89], '(50': [90], '200': [92], 'mg/kg': [93], 'each).': [94], 'Key': [95], 'findings': [96], 'Intraperitoneal': [97], 'administration': [98, 126], 'markedly': [101, 134], 'reduced': [102, 135, 152], 'infarct': [105, 137], 'size': [106, 138], 'neurological': [108], 'deficit': [109], 'caused': [110], 'MCAO/reperfusion.': [112], 'treatment': [114, 219], 'also': [115, 133], 'significantly': [116], 'long-term': [118], 'survival': [119], 'rate': [120], 'injury.': [124], 'Oral': [125], 'ischaemia': [132], 'ischaemia.': [141], 'The': [142], 'effect': [144], 'significantly,': [148], 'but': [149], 'not': [150, 191], 'fully,': [151], 'when': [153], 'mBHT-induced': [154], 'hypothermia': [155], 'abolished.': [157], 'cultured': [159], 'cortical': [160], 'neurons,': [161], 'further': [163], 'found': [164], 'that': [165, 203], 'decreased': [167], 'oxygen-glucose': [168], 'deprivation/re-oxygenation-evoked': [169], 'neuronal': [170], 'inhibiting': [173], 'production': [174], 'reactive': [176], 'oxygen': [177], 'species,': [178], 'decrease': [179], 'mitochondrial': [181], 'transmembrane': [182], 'potential,': [183], 'activation': [185], 'caspase-3.': [187], 'However,': [188], 'did': [190], 'inhibit': [192], 'N-Methyl-D-aspartate': [193], '(NMDA)': [194], 'receptor-mediated': [195], 'excitotoxicity.': [196], 'Conclusions': [197], 'Taken': [198], 'together,': [199], 'our': [200], 'data': [201], 'suggest': [202], 'multiple': [206], 'properties': [208], 'be': [211], 'good': [213], 'therapeutic': [214], 'prescription': [216], 'for': [217], 'stroke.': [223]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1868779397', 'counts_by_year': [{'year': 2020, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-12T07:29:23.186571', 'created_date': '2016-06-24'}