Publication Information

{'id': 'https://openalex.org/W186774191', 'doi': None, 'title': 'Inhibition of intracellular pH control and relationship to cytotoxicity of chlorambucil and vinblastine.', 'display_name': 'Inhibition of intracellular pH control and relationship to cytotoxicity of chlorambucil and vinblastine.', 'publication_year': 1996, 'publication_date': '1996-07-01', 'ids': {'openalex': 'https://openalex.org/W186774191', 'mag': '186774191', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8763851', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2150010'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8763851', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111609606', 'display_name': 'C.S. Parkins', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801038905', 'display_name': 'Mount Vernon Hospital', 'ror': 'https://ror.org/04am5a125', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799786270', 'https://openalex.org/I2801038905']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'C S Parkins', 'raw_affiliation_strings': ['CRC Tumour Microcirculation Group, Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK.'], 'affiliations': [{'raw_affiliation_string': 'CRC Tumour Microcirculation Group, Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK.', 'institution_ids': ['https://openalex.org/I2801038905']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083910787', 'display_name': 'Jennifer A. Chadwick', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J A Chadwick', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111866561', 'display_name': 'David J. Chaplin', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'D J Chaplin', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.645, 'has_fulltext': False, 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.7102, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 78}, 'biblio': {'volume': '27', 'issue': None, 'first_page': 'S75', 'last_page': '7'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10522', 'display_name': 'Medical Imaging Techniques and Applications', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10522', 'display_name': 'Medical Imaging Techniques and Applications', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11395', 'display_name': 'Radiopharmaceutical Chemistry and Applications', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/intracellular-ph', 'display_name': 'Intracellular pH', 'score': 0.73209476}, {'id': 'https://openalex.org/keywords/nigericin', 'display_name': 'Nigericin', 'score': 0.6827892}, {'id': 'https://openalex.org/keywords/chlorambucil', 'display_name': 'Chlorambucil', 'score': 0.59251463}], 'concepts': [{'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.8942267}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.8426506}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.77175313}, {'id': 'https://openalex.org/C134897140', 'wikidata': 'https://www.wikidata.org/wiki/Q6058355', 'display_name': 'Intracellular pH', 'level': 3, 'score': 0.73209476}, {'id': 'https://openalex.org/C2777330628', 'wikidata': 'https://www.wikidata.org/wiki/Q7033077', 'display_name': 'Nigericin', 'level': 3, 'score': 0.6827892}, {'id': 'https://openalex.org/C2777866208', 'wikidata': 'https://www.wikidata.org/wiki/Q415939', 'display_name': 'Chlorambucil', 'level': 4, 'score': 0.59251463}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.52991724}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.51980555}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.4417118}, {'id': 'https://openalex.org/C2777132456', 'wikidata': 'https://www.wikidata.org/wiki/Q282629', 'display_name': 'Vinblastine', 'level': 3, 'score': 0.44029182}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.3330595}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30518144}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.2961769}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.15901059}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2776755627', 'wikidata': 'https://www.wikidata.org/wiki/Q408524', 'display_name': 'Cyclophosphamide', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018906', 'descriptor_name': 'Antineoplastic Agents, Alkylating', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002699', 'descriptor_name': 'Chlorambucil', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014747', 'descriptor_name': 'Vinblastine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000584', 'descriptor_name': 'Amiloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000584', 'descriptor_name': 'Amiloride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018906', 'descriptor_name': 'Antineoplastic Agents, Alkylating', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002699', 'descriptor_name': 'Chlorambucil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006863', 'descriptor_name': 'Hydrogen-Ion Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009550', 'descriptor_name': 'Nigericin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009550', 'descriptor_name': 'Nigericin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014747', 'descriptor_name': 'Vinblastine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8763851', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.42, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1954857248', 'https://openalex.org/W1956944003', 'https://openalex.org/W1978730527', 'https://openalex.org/W1983772024', 'https://openalex.org/W1987866292', 'https://openalex.org/W2038531245', 'https://openalex.org/W2047676254', 'https://openalex.org/W2067661419', 'https://openalex.org/W2074061850', 'https://openalex.org/W2152817797', 'https://openalex.org/W2165884308', 'https://openalex.org/W2412446999', 'https://openalex.org/W2416776186'], 'related_works': ['https://openalex.org/W2945384233', 'https://openalex.org/W2441727480', 'https://openalex.org/W2169203841', 'https://openalex.org/W2144332423', 'https://openalex.org/W2136435550', 'https://openalex.org/W2093091926', 'https://openalex.org/W2076783121', 'https://openalex.org/W2032314687', 'https://openalex.org/W1965547808', 'https://openalex.org/W186774191'], 'abstract_inverted_index': {'The': [0, 71], 'uptake': [1, 111, 144, 288], 'and': [2, 25, 138, 164, 199, 235, 258], 'cytotoxicity': [3, 53, 72, 82, 88, 119, 190, 208, 253, 273], 'of': [4, 54, 64, 73, 154, 157, 182, 222, 230, 254, 265, 279, 289], 'weakly': [5], 'acidic': [6, 39, 91, 96, 105, 122, 136, 294], 'or': [7, 282, 295], 'basic': [8, 127, 296], 'chemotherapeutic': [9, 290], 'agents': [10, 291], 'is': [11, 31, 37, 98, 129, 203, 225], 'determined': [12], 'in': [13, 48, 176, 180, 209, 271, 286], 'part': [14], 'by': [15, 238, 274, 284], 'passive': [16], 'diffusion': [17], 'along': [18], 'the': [19, 23, 52, 61, 65, 94, 113, 125, 146, 158, 165, 168, 183, 212, 228, 233, 240, 244, 252], 'pH': [20, 36, 63, 78, 106, 137, 215, 241, 267], 'gradient': [21, 242], 'between': [22, 232], 'intracellular': [24, 41, 116, 149, 169, 223, 236, 250], 'extracellular': [26, 35, 62, 214], 'compartments.': [27], 'In': [28, 247], 'vivo': [29, 210], 'it': [30], 'known': [32], 'that': [33, 201, 259], 'tumour': [34, 46, 207, 213], 'more': [38], 'than': [40], 'pH.': [42], 'Using': [43, 151], 'CaNT': [44], 'murine': [45], 'cells': [47, 184], 'vitro,': [49], 'we': [50], 'found': [51], 'chlorambucil': [55, 255], '(a': [56], 'weak': [57, 95, 126, 293], 'acid)': [58], 'increased': [59, 89], 'as': [60, 83], 'culture': [66], 'medium': [67], '(pHmed)': [68], 'was': [69, 85, 256, 262], 'acidified.': [70, 86, 173], 'vinblastine': [74, 261], 'shows': [75], 'a': [76, 101, 132, 152, 177], 'reverse': [77], 'relationship': [79], 'with': [80, 188, 292], 'reduced': [81, 257], 'pHmed': [84, 92, 123, 187, 196], 'Chlorambucil': [87], 'at': [90, 104, 121, 135], 'because': [93, 124], 'function': [97, 128], 'ionised': [99, 130], 'to': [100, 131, 185, 195, 226, 249, 277], 'lesser': [102], 'extent': [103, 134], 'and,': [107], 'therefore,': [108], 'favours': [109], 'drug': [110, 143], 'into': [112, 145], 'relatively': [114, 147], 'neutral': [115, 148], 'compartment.': [117, 150], 'Vinblastine': [118], 'decreased': [120], 'greater': [133], 'therefore': [139], 'does': [140], 'not': [141], 'favour': [142], 'combination': [153], 'an': [155], 'inhibitor': [156], 'cell': [159, 245], 'membrane': [160], 'proton': [161, 280], 'pump,': [162], 'amiloride,': [163], 'ionophore,': [166], 'nigericin,': [167], 'compartment': [170, 237], 'can': [171], 'be': [172], 'This': [174], 'results': [175], 'time-dependent': [178], 'increase': [179], 'sensitivity': [181], 'low': [186], 'significant': [189], 'after': [191], '6': [192], 'h': [193], 'exposure': [194], '=': [197], '6.2': [198], 'suggests': [200], 'there': [202], 'potential': [204], 'for': [205, 260], 'direct': [206, 272], 'if': [211], 'were': [216], 'equally': [217], 'acidic.': [218], 'An': [219], 'indirect': [220], 'effect': [221], 'acidification': [224, 275], 'alter': [227], 'distribution': [229], 'drugs': [231], 'extra-': [234], 'reducing': [239], 'across': [243], 'membrane.': [246], 'response': [248], 'acidification,': [251], 'increased.': [263], 'Inhibition': [264], 'cellular': [266], 'control': [268], 'may': [269], 'result': [270], 'due': [276], 'inhibition': [278], 'efflux': [281], 'indirectly': [283], 'resulting': [285], 'differential': [287], 'functions.': [297]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W186774191', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-14T17:25:08.104974', 'created_date': '2016-06-24'}