Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells

Name: Work Video:
Duration: 3 min 30 s
Takumi Shiraishi; James E. Verdone; Jessie Huang; Ulf D. Kahlert; James R. Hernandez; Gonzalo Torga; Jelani C. Zarif; Tamir Epstein; Robert A. Gatenby; Annemarie M. McCartney; Jennifer H. Elisseeff; Steven M. Mooney; Steven S. An; Kenneth J. Pienta
{'id': 'https://openalex.org/W1860424934', 'doi': 'https://doi.org/10.18632/oncotarget.2766', 'title': 'Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells', 'display_name': 'Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells', 'publication_year': 2014, 'publication_date': '2014-11-16', 'ids': {'openalex': 'https://openalex.org/W1860424934', 'doi': 'https://doi.org/10.18632/oncotarget.2766', 'mag': '1860424934', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25426557', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4381583'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2766', 'pdf_url': 'https://www.oncotarget.com/article/2766/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/2766/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101121273', 'display_name': 'Takumi Shiraishi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Takumi Shiraishi', 'raw_affiliation_strings': ['Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029063787', 'display_name': 'James E. Verdone', 'orcid': 'https://orcid.org/0009-0007-5896-1778'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James E. Verdone', 'raw_affiliation_strings': ['Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061861612', 'display_name': 'Jessie Huang', 'orcid': 'https://orcid.org/0000-0002-5297-3563'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jessie Huang', 'raw_affiliation_strings': ['Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008627959', 'display_name': 'Ulf D. Kahlert', 'orcid': 'https://orcid.org/0000-0002-6021-1841'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ulf D. Kahlert', 'raw_affiliation_strings': ['Department of Pathology, Division of Neuropathology, The Johns Hopkins Hospital, Baltimore, MD, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Division of Neuropathology, The Johns Hopkins Hospital, Baltimore, MD, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103544562', 'display_name': 'James R. Hernandez', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James R. Hernandez', 'raw_affiliation_strings': ['Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052344224', 'display_name': 'Gonzalo Torga', 'orcid': 'https://orcid.org/0000-0002-6401-5127'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gonzalo Torga', 'raw_affiliation_strings': ['Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025386954', 'display_name': 'Jelani C. Zarif', 'orcid': 'https://orcid.org/0000-0003-3880-2124'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jelani C. Zarif', 'raw_affiliation_strings': ['Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112614619', 'display_name': 'Tamir Epstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3019308854', 'display_name': 'Moffitt Cancer Center', 'ror': 'https://ror.org/01xf75524', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019308854']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tamir Epstein', 'raw_affiliation_strings': ['Department of Integrative Mathematical Oncology and Department of Diagnostic Imaging, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Integrative Mathematical Oncology and Department of Diagnostic Imaging, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.', 'institution_ids': ['https://openalex.org/I3019308854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032533490', 'display_name': 'Robert A. Gatenby', 'orcid': 'https://orcid.org/0000-0002-1621-1510'}, 'institutions': [{'id': 'https://openalex.org/I3019308854', 'display_name': 'Moffitt Cancer Center', 'ror': 'https://ror.org/01xf75524', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019308854']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Gatenby', 'raw_affiliation_strings': ['Department of Integrative Mathematical Oncology and Department of Diagnostic Imaging, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Integrative Mathematical Oncology and Department of Diagnostic Imaging, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.', 'institution_ids': ['https://openalex.org/I3019308854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013837322', 'display_name': 'Annemarie M. McCartney', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Annemarie McCartney', 'raw_affiliation_strings': ['The Wilmer Eye Institute and Department of Biomedical Engineering, Baltimore, MD, USA.'], 'affiliations': [{'raw_affiliation_string': 'The Wilmer Eye Institute and Department of Biomedical Engineering, Baltimore, MD, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017494930', 'display_name': 'Jennifer H. Elisseeff', 'orcid': 'https://orcid.org/0000-0002-5066-1996'}, 'institutions': [{'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer H. Elisseeff', 'raw_affiliation_strings': ['The Wilmer Eye Institute and Department of Biomedical Engineering, Baltimore, MD, USA.'], 'affiliations': [{'raw_affiliation_string': 'The Wilmer Eye Institute and Department of Biomedical Engineering, Baltimore, MD, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060055762', 'display_name': 'Steven M. Mooney', 'orcid': 'https://orcid.org/0000-0002-0548-7001'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven M. Mooney', 'raw_affiliation_strings': ['Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013362793', 'display_name': 'Steven S. An', 'orcid': 'https://orcid.org/0000-0003-4723-1888'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}, {'id': 'https://openalex.org/I4210166946', 'display_name': 'Imaging Center', 'ror': 'https://ror.org/05hsqsk33', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven S. An', 'raw_affiliation_strings': ['Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA', 'Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA', 'In Vivo Cellular and Molecular Imaging Center, The Johns Hopkins School of Medicine, Baltimore, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'In Vivo Cellular and Molecular Imaging Center, The Johns Hopkins School of Medicine, Baltimore, MD, USA', 'institution_ids': ['https://openalex.org/I4210166946', 'https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5087520734', 'display_name': 'Kenneth J. Pienta', 'orcid': 'https://orcid.org/0000-0002-4138-2186'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenneth J. Pienta', 'raw_affiliation_strings': ['Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA', 'Department of Oncology, Johns Hopkins University, Baltimore, MD, USA', 'Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, USA', 'Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of Oncology, Johns Hopkins University, Baltimore, MD, USA', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, USA', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA', 'institution_ids': ['https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.241, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 173, 'citation_normalized_percentile': {'value': 0.999894, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '1', 'first_page': '130', 'last_page': '143'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/anaerobic-glycolysis', 'display_name': 'Anaerobic glycolysis', 'score': 0.637365}, {'id': 'https://openalex.org/keywords/bioenergetics', 'display_name': 'Bioenergetics', 'score': 0.4479034}], 'concepts': [{'id': 'https://openalex.org/C58207958', 'wikidata': 'https://www.wikidata.org/wiki/Q33596', 'display_name': 'Motility', 'level': 2, 'score': 0.79215336}, {'id': 'https://openalex.org/C20251656', 'wikidata': 'https://www.wikidata.org/wiki/Q162643', 'display_name': 'Glycolysis', 'level': 3, 'score': 0.75398445}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.68943447}, {'id': 'https://openalex.org/C55885012', 'wikidata': 'https://www.wikidata.org/wiki/Q4750801', 'display_name': 'Anaerobic glycolysis', 'level': 4, 'score': 0.637365}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6005185}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53259295}, {'id': 'https://openalex.org/C57600042', 'wikidata': 'https://www.wikidata.org/wiki/Q227564', 'display_name': 'Oxidative phosphorylation', 'level': 2, 'score': 0.49696758}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.48919988}, {'id': 'https://openalex.org/C137738243', 'wikidata': 'https://www.wikidata.org/wiki/Q189092', 'display_name': 'Cell migration', 'level': 3, 'score': 0.4648214}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.4625143}, {'id': 'https://openalex.org/C100206155', 'wikidata': 'https://www.wikidata.org/wiki/Q570714', 'display_name': 'Bioenergetics', 'level': 3, 'score': 0.4479034}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.415041}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3363123}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.32309973}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2732582}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.17366639}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006019', 'descriptor_name': 'Glycolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000332', 'descriptor_name': 'Aerobiosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059630', 'descriptor_name': 'Mesenchymal Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059630', 'descriptor_name': 'Mesenchymal Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008858', 'descriptor_name': 'Microscopy, Phase-Contrast', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D010085', 'descriptor_name': 'Oxidative Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2766', 'pdf_url': 'https://www.oncotarget.com/article/2766/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4381583', 'pdf_url': 'https://europepmc.org/articles/pmc4381583?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381583', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25426557', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2766', 'pdf_url': 'https://www.oncotarget.com/article/2766/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1484020898', 'https://openalex.org/W1541248931', 'https://openalex.org/W1543399622', 'https://openalex.org/W1605420823', 'https://openalex.org/W1874303456', 'https://openalex.org/W1960948712', 'https://openalex.org/W1964332003', 'https://openalex.org/W1965653791', 'https://openalex.org/W1967532587', 'https://openalex.org/W1975215468', 'https://openalex.org/W1978880986', 'https://openalex.org/W1980026529', 'https://openalex.org/W1990253071', 'https://openalex.org/W2004130591', 'https://openalex.org/W2010069724', 'https://openalex.org/W2010110230', 'https://openalex.org/W2014694740', 'https://openalex.org/W2019787798', 'https://openalex.org/W2020118391', 'https://openalex.org/W2030869361', 'https://openalex.org/W2044614457', 'https://openalex.org/W2052400143', 'https://openalex.org/W2053424420', 'https://openalex.org/W2054017633', 'https://openalex.org/W2055394225', 'https://openalex.org/W2062172186', 'https://openalex.org/W2072451938', 'https://openalex.org/W2083988824', 'https://openalex.org/W2090692979', 'https://openalex.org/W2093921289', 'https://openalex.org/W2093985232', 'https://openalex.org/W2097259163', 'https://openalex.org/W2098229250', 'https://openalex.org/W2099616702', 'https://openalex.org/W2105599008', 'https://openalex.org/W2110239146', 'https://openalex.org/W2110834542', 'https://openalex.org/W2112451226', 'https://openalex.org/W2126496496', 'https://openalex.org/W2130503287', 'https://openalex.org/W2135394915', 'https://openalex.org/W2146885685', 'https://openalex.org/W2154154147', 'https://openalex.org/W2166153671', 'https://openalex.org/W2171218391'], 'related_works': ['https://openalex.org/W4206078893', 'https://openalex.org/W2891404117', 'https://openalex.org/W2472294291', 'https://openalex.org/W2417959622', 'https://openalex.org/W2410947740', 'https://openalex.org/W2371884692', 'https://openalex.org/W2115256268', 'https://openalex.org/W2079598623', 'https://openalex.org/W2056444349', 'https://openalex.org/W2008713788'], 'abstract_inverted_index': {'//': [0, 203, 208], 'Takumi': [1], 'Shiraishi': [2], '1': [3, 8, 22, 26, 31, 53, 64], ',': [4, 9, 13, 18, 23, 27, 32, 36, 40, 44, 49, 54], 'James': [5, 19, 69], 'E.': [6], 'Verdone': [7], 'Jessie': [10], 'Huang': [11], '5': [12, 116], 'Ulf': [14], 'D.': [15], 'Kahlert': [16], '6': [17, 132], 'R.': [20], 'Hernandez': [21], 'Gonzalo': [24], 'Torga': [25], 'Jelani': [28], 'C.': [29], 'Zarif': [30], 'Tamir': [33], 'Epstein': [34], '7': [35, 39, 146], 'Robert': [37], 'Gatenby': [38], 'Annemarie': [41], 'McCartney': [42], '8': [43, 48, 168], 'Jennifer': [45], 'H.': [46, 157], 'Elisseeff': [47], 'Steven': [50, 55, 204], 'M.': [51], 'Mooney': [52], 'S.': [56, 205], 'An': [57], '4,5,9': [58], 'and': [59, 94, 107, 152, 173, 185, 245, 321, 350, 359, 381], 'Kenneth': [60, 199], 'J.': [61, 200], 'Pienta': [62], '1,2,3,4': [63], 'Department': [65, 81, 91, 104, 117, 133, 147, 153, 174], 'of': [66, 82, 92, 105, 118, 126, 134, 137, 148, 154, 175, 193, 235, 280, 314, 326, 332, 338, 372, 387, 395, 416], 'Urology,': [67], 'The': [68, 139, 169, 189, 233], 'Buchanan': [70], 'Brady': [71], 'Urological': [72], 'Institute,': [73, 164], 'Johns': [74, 84, 97, 110, 122, 140, 190], 'Hopkins': [75, 85, 98, 111, 123, 141, 191], 'University,': [76, 86, 99, 112], 'Baltimore,': [77, 87, 100, 113, 129, 143, 178, 195], 'MD,': [78, 88, 101, 114, 130, 144, 179, 196], 'USA': [79, 89, 102, 115, 131, 145, 167, 180, 197], '2': [80], 'Oncology,': [83], '3': [90], 'Pharmacology': [93], 'Molecular': [95, 186], 'Sciences,': [96, 121], '4': [103], 'Chemical': [106], 'Biomolecular': [108], 'Engineering,': [109, 177], 'Environmental': [119], 'Health': [120], 'Bloomberg': [124], 'School': [125, 192], 'Public': [127], 'Health,': [128], 'Pathology,': [135], 'Division': [136], 'Neuropathology,': [138], 'Hospital,': [142], 'Integrative': [149], 'Mathematical': [150], 'Oncology': [151], 'Diagnostic': [155], 'Imaging,': [156], 'Lee': [158], 'Moffitt': [159], 'Cancer': [160], 'Center': [161], '&amp;': [162], 'Research': [163], 'Tampa,': [165], 'FL,': [166], 'Wilmer': [170], 'Eye': [171], 'Institute': [172], 'Biomedical': [176], '9': [181], 'In': [182], 'Vivo': [183], 'Cellular': [184], 'Imaging': [187], 'Center,': [188], 'Medicine,': [194], 'Correspondence:': [198], 'Pienta,': [201], 'email:': [202, 207], 'An,': [206], 'Keywords': [209], ':': [210, 218, 223, 228], 'cytoskeleton,': [211], 'motility,': [212], 'cancer': [213, 237, 255, 274, 285, 294, 347, 417], 'metabolism,': [214, 419], 'glycolysis,': [215, 333], 'metastasis': [216], 'Received': [217], 'September': [219], '23,': [220], '2014': [221, 226, 231], 'Accepted': [222], 'November': [224, 229], '15,': [225], 'Published': [227], '16,': [230], 'Abstract': [232], 'ability': [234], 'a': [236, 253, 422], 'cell': [238, 275, 318, 323, 348, 403, 418], 'to': [239, 247, 252, 292, 368, 378], 'detach': [240], 'from': [241, 390], 'the': [242, 281, 373], 'primary': [243], 'tumor': [244, 268], 'move': [246], 'distant': [248], 'sites': [249, 394], 'is': [250, 353, 366, 399], 'fundamental': [251], 'lethal': [254], 'phenotype.': [256], 'Metabolic': [257], 'transformations': [258], 'are': [259], 'associated': [260, 310, 426], 'with': [261, 311, 376, 427], 'highly': [262], 'motile': [263], 'aggressive': [264, 428], 'cellular': [265, 379, 407], 'phenotypes': [266], 'in': [267, 302], 'progression.': [269], 'Here,': [270], 'we': [271], 'report': [272], 'that': [273, 346, 385], 'motility': [276, 349, 380, 404], 'requires': [277], 'increased': [278, 312], 'utilization': [279], 'glycolytic': [282, 374, 391], 'pathway.': [283], 'Mesenchymal': [284], 'cells': [286, 295], 'exhibited': [287], 'higher': [288], 'aerobic': [289, 357], 'glycolysis': [290, 308, 358], 'compared': [291], 'epithelial': [293], 'while': [296], 'no': [297], 'significant': [298], 'change': [299], 'was': [300, 309], 'observed': [301], 'mitochondrial': [303, 339], 'ATP': [304, 340, 365, 388, 408], 'production': [305, 409], 'rate.': [306, 410], 'Higher': [307], 'rates': [313], 'cytoskeletal': [315], 'remodeling,': [316], 'greater': [317], 'traction': [319], 'forces': [320], 'faster': [322], 'migration,': [324], 'all': [325], 'which': [327], 'were': [328], 'blocked': [329], 'by': [330, 336], 'inhibition': [331, 337, 371], 'but': [334], 'not': [335, 360], 'synthesis.': [341], 'Thus,': [342], 'our': [343, 414], 'results': [344, 412], 'demonstrate': [345], 'cytoskeleton': [351], 'rearrangement': [352, 398], 'energetically': [354], 'dependent': [355], 'on': [356], 'oxidative': [361], 'phosphorylation.': [362], 'Mitochondrial': [363], 'derived': [364, 389], 'insufficient': [367], 'compensate': [369], 'for': [370, 402], 'pathway': [375, 425], 'regard': [377], 'CSK': [382, 397], 'rearrangement,': [383], 'implying': [384], 'localization': [386], 'enzymes': [392], 'near': [393], 'active': [396], 'more': [400], 'important': [401], 'than': [405], 'total': [406], 'These': [411], 'extend': [413], 'understanding': [415], 'potentially': [420], 'providing': [421], 'target': [423], 'metabolic': [424], 'disease.': [429]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1860424934', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 26}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-12-13T13:07:53.166890', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
