Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1859226939', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-3990', 'title': 'Abstract 3990: Chemerin and chemerin receptors in neuroblastoma tumor microenvironment', 'display_name': 'Abstract 3990: Chemerin and chemerin receptors in neuroblastoma tumor microenvironment', 'publication_year': 2014, 'publication_date': '2014-10-01', 'ids': {'openalex': 'https://openalex.org/W1859226939', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-3990', 'mag': '1859226939'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-3990', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109985416', 'display_name': 'Conny Tuemmler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78037679', 'display_name': 'UiT The Arctic University of Norway', 'ror': 'https://ror.org/00wge5k78', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I78037679']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Conny Tuemmler', 'raw_affiliation_strings': ['University of Tromso, Tromso, Norway.'], 'affiliations': [{'raw_affiliation_string': 'University of Tromso, Tromso, Norway.', 'institution_ids': ['https://openalex.org/I78037679']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031331381', 'display_name': 'Igor Snapkov', 'orcid': 'https://orcid.org/0000-0001-5341-685X'}, 'institutions': [{'id': 'https://openalex.org/I78037679', 'display_name': 'UiT The Arctic University of Norway', 'ror': 'https://ror.org/00wge5k78', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I78037679']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Igor Snapkov', 'raw_affiliation_strings': ['University of Tromso, Tromso, Norway.'], 'affiliations': [{'raw_affiliation_string': 'University of Tromso, Tromso, Norway.', 'institution_ids': ['https://openalex.org/I78037679']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076669745', 'display_name': 'Ugo Moens', 'orcid': 'https://orcid.org/0000-0002-1931-5462'}, 'institutions': [{'id': 'https://openalex.org/I78037679', 'display_name': 'UiT The Arctic University of Norway', 'ror': 'https://ror.org/00wge5k78', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I78037679']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Ugo L. Moens', 'raw_affiliation_strings': ['University of Tromso, Tromso, Norway.'], 'affiliations': [{'raw_affiliation_string': 'University of Tromso, Tromso, Norway.', 'institution_ids': ['https://openalex.org/I78037679']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068603373', 'display_name': 'Baldur Sveinbjørnsson', 'orcid': 'https://orcid.org/0000-0002-5499-9345'}, 'institutions': [{'id': 'https://openalex.org/I78037679', 'display_name': 'UiT The Arctic University of Norway', 'ror': 'https://ror.org/00wge5k78', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I78037679']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Baldur Sveinbjørnsson', 'raw_affiliation_strings': ['University of Tromso, Tromso, Norway.'], 'affiliations': [{'raw_affiliation_string': 'University of Tromso, Tromso, Norway.', 'institution_ids': ['https://openalex.org/I78037679']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '74', 'issue': '19_Supplement', 'first_page': '3990', 'last_page': '3990'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 0.9673, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 0.9673, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13374', 'display_name': 'Hematological disorders and diagnostics', 'score': 0.9253, 'subfield': {'id': 'https://openalex.org/subfields/2711', 'display_name': 'Emergency Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chemerin', 'display_name': 'Chemerin', 'score': 0.99909925}], 'concepts': [{'id': 'https://openalex.org/C199901988', 'wikidata': 'https://www.wikidata.org/wiki/Q18031045', 'display_name': 'Chemerin', 'level': 5, 'score': 0.99909925}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.514674}, {'id': 'https://openalex.org/C194832188', 'wikidata': 'https://www.wikidata.org/wiki/Q2638593', 'display_name': 'Adipokine', 'level': 4, 'score': 0.50614923}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4523682}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.45198146}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.43906516}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.43304208}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.41859594}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39323506}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3209651}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2672154}, {'id': 'https://openalex.org/C2780613262', 'wikidata': 'https://www.wikidata.org/wiki/Q223739', 'display_name': 'Leptin', 'level': 3, 'score': 0.09218675}, {'id': 'https://openalex.org/C511355011', 'wikidata': 'https://www.wikidata.org/wiki/Q12174', 'display_name': 'Obesity', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C3020616263', 'wikidata': 'https://www.wikidata.org/wiki/Q1216998', 'display_name': 'Tumor cells', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-3990', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.72, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4390109760', 'https://openalex.org/W3164953822', 'https://openalex.org/W3154639592', 'https://openalex.org/W3152905034', 'https://openalex.org/W3091857335', 'https://openalex.org/W2769499568', 'https://openalex.org/W2542863144', 'https://openalex.org/W2393680254', 'https://openalex.org/W2383761989', 'https://openalex.org/W2197999755'], 'abstract_inverted_index': {'Abstract': [0], 'Tumor': [1], 'promoting': [2], 'inflammatory': [3, 8], 'cells': [4], 'as': [5, 7, 11, 20, 32, 57, 67], 'well': [6], 'mediators': [9], 'such': [10], 'chemokines': [12], 'are': [13], 'important': [14], 'contributors': [15], 'to': [16, 148], 'the': [17, 77, 101, 118, 134, 150, 233, 269, 274], 'tumor': [18, 24, 135, 263], 'microenvironment': [19, 136], 'they': [21], 'can': [22, 73], 'support': [23], 'progression,': [25], 'angiogenesis': [26], 'and': [27, 44, 46, 54, 65, 92, 99, 125, 131, 154, 173, 175, 183, 196, 205, 208, 212, 217, 258], 'metastasis.': [28], 'Chemerin': [29, 112, 257], '(also': [30], 'known': [31, 48], 'TIG-2': [33], 'or': [34, 109], 'RARRES2)': [35], 'is': [36, 62, 113, 147], 'a': [37, 47, 58, 80, 114, 166, 176], 'chemoattractant': [38], 'factor': [39], 'for': [40, 117, 243, 277], 'macrophages,': [41], 'immature': [42], 'DCs': [43], 'NK-cells': [45], 'adipokine': [49], 'involved': [50], 'in': [51, 86, 133, 157, 179, 188, 203, 227, 261], 'inflammation,': [52], 'metabolism': [53], 'adipogenesis.': [55], 'Synthesized': [56], '163aa': [59], 'preproprotein,': [60], 'chemerin': [61, 72, 103, 130, 153, 201, 216, 259], 'N-terminally': [63], 'cleaved': [64, 75], 'secreted': [66], 'inactive': [68], 'prochemerin.': [69], 'Following': [70], 'secretion,': [71], 'be': [74, 230], 'at': [76], 'C-terminus': [78], 'by': [79, 193, 232], 'variety': [81], 'of': [82, 129, 144, 152, 161, 171, 224, 235, 268, 273], 'extracellular': [83], 'proteases': [84], 'resulting': [85], 'several': [87], 'isoforms': [88, 104], 'with': [89, 200], 'varying': [90], 'length': [91], 'biological': [93], 'activity.': [94], 'During': [95], 'inflammation': [96], 'initiation,': [97], 'maintenance': [98], 'resolution': [100], 'different': [102, 189], 'may': [105], 'function': [106, 151], 'pro-': [107], 'and/': [108], 'anti-': [110], 'inflammatory.': [111], 'natural': [115], 'ligand': [116], 'G': [119], 'protein-': [120], 'coupled': [121], 'receptors': [122, 156, 260], 'CMKLR1': [123, 132, 172, 182, 218, 226], '(Chem23)': [124], 'GPR1.': [126], 'The': [127, 142, 221], 'role': [128], 'has': [137], 'not': [138], 'been': [139], 'extensively': [140], 'studied.': [141], 'aim': [143], 'this': [145], 'work': [146], 'study': [149], 'its': [155], 'neuroblastoma': [158, 190, 262], '(NB).': [159], 'Screening': [160], 'mRNA': [162], 'expression': [163, 170, 185], 'arrays': [164], 'showed': [165], 'correlation': [167], 'between': [168], 'high': [169], 'GPR1': [174, 184], 'worsened': [177], 'prognosis': [178], 'NB.': [180], 'Chemerin,': [181], 'was': [186], 'detected': [187], 'cell': [191, 240], 'lines': [192], 'RT-PCR,': [194], 'immunocytochemistry': [195], 'Western': [197], 'Blot.': [198], 'Stimulation': [199], 'resulted': [202], 'rapid': [204], 'transient': [206], 'ERK1/2': [207], 'Akt': [209], 'phosphorylation.': [210], 'TNF-α': [211], 'IL-1β': [213], 'treatment': [214], 'increased': [215], 'protein': [219], 'levels.': [220], 'functional': [222], 'significance': [223], 'chemerin/': [225, 244], 'NB': [228, 236], 'will': [229], 'assessed': [231], 'use': [234], 'animal': [237], 'models': [238], 'using': [239], 'clones': [241], 'silenced': [242], 'CMKLR1.': [245], 'Citation': [246], 'Format:': [247], 'Conny': [248], 'Tuemmler,': [249], 'Igor': [250], 'Snapkov,': [251], 'Ugo': [252], 'L.': [253], 'Moens,': [254], 'Baldur': [255], 'Sveinbjørnsson.': [256], 'microenvironment.': [264], '[abstract].': [265], 'In:': [266], 'Proceedings': [267], '105th': [270], 'Annual': [271], 'Meeting': [272], 'American': [275], 'Association': [276], 'Cancer': [278, 289], 'Research;': [279], '2014': [280], 'Apr': [281], '5-9;': [282], 'San': [283], 'Diego,': [284], 'CA.': [285], 'Philadelphia': [286], '(PA):': [287], 'AACR;': [288], 'Res': [290], '2014;74(19': [291], 'Suppl):Abstract': [292], 'nr': [293], '3990.': [294], 'doi:10.1158/1538-7445.AM2014-3990': [295]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1859226939', 'counts_by_year': [], 'updated_date': '2024-12-08T15:20:27.606695', 'created_date': '2016-06-24'}