Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1856564249', 'doi': 'https://doi.org/10.18632/oncotarget.622', 'title': 'Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma', 'display_name': 'Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma', 'publication_year': 2012, 'publication_date': '2012-08-31', 'ids': {'openalex': 'https://openalex.org/W1856564249', 'doi': 'https://doi.org/10.18632/oncotarget.622', 'mag': '1856564249', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22948084', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3663613'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.622', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=622&path%5B%5D=961', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=622&path%5B%5D=961', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089377084', 'display_name': 'Irfan A. Asangani', 'orcid': 'https://orcid.org/0000-0001-5381-1702'}, 'institutions': [{'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Irfan A. Asangani', 'raw_affiliation_strings': ['Department of Pathology, University of Michigan', 'Michigan Center for Translational Pathology'], 'affiliations': [{'raw_affiliation_string': 'Michigan Center for Translational Pathology', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044405915', 'display_name': 'Paul W. Harms', 'orcid': 'https://orcid.org/0000-0002-0802-2883'}, 'institutions': [{'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul W. Harms', 'raw_affiliation_strings': ['Department of Dermatology, University of Michigan', 'Department of Pathology, University of Michigan', 'Michigan Center for Translational Pathology'], 'affiliations': [{'raw_affiliation_string': 'Michigan Center for Translational Pathology', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Department of Dermatology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067699443', 'display_name': 'Lois Dodson', 'orcid': 'https://orcid.org/0000-0002-3126-8873'}, 'institutions': [{'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lois Dodson', 'raw_affiliation_strings': ['Michigan Center for Translational Pathology'], 'affiliations': [{'raw_affiliation_string': 'Michigan Center for Translational Pathology', 'institution_ids': ['https://openalex.org/I4210117557']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011482137', 'display_name': 'Mithil Pandhi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mithil Pandhi', 'raw_affiliation_strings': ['Michigan Center for Translational Pathology'], 'affiliations': [{'raw_affiliation_string': 'Michigan Center for Translational Pathology', 'institution_ids': ['https://openalex.org/I4210117557']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110320430', 'display_name': 'Lakshmi P. Kunju', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lakshmi P. Kunju', 'raw_affiliation_strings': ['Department of Pathology, University of Michigan', 'Michigan Center for Translational Pathology'], 'affiliations': [{'raw_affiliation_string': 'Michigan Center for Translational Pathology', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028616783', 'display_name': 'Christopher A. Maher', 'orcid': 'https://orcid.org/0000-0002-9035-603X'}, 'institutions': [{'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}, {'id': 'https://openalex.org/I4210148697', 'display_name': 'Institute of Bioinformatics', 'ror': 'https://ror.org/04hqfvm50', 'country_code': 'IN', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210148697']}], 'countries': ['IN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Christopher A. Maher', 'raw_affiliation_strings': ['Bone Marrow Transp', 'Center for Computational Medicine and Bioinformatics', 'Department of Pathology, University of Michigan', 'Michigan Center for Translational Pathology'], 'affiliations': [{'raw_affiliation_string': 'Michigan Center for Translational Pathology', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Center for Computational Medicine and Bioinformatics', 'institution_ids': ['https://openalex.org/I4210148697']}, {'raw_affiliation_string': 'Bone Marrow Transp', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016216331', 'display_name': 'Douglas R. Fullen', 'orcid': 'https://orcid.org/0000-0002-2524-4509'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Douglas R. Fullen', 'raw_affiliation_strings': ['Department of Dermatology, University of Michigan', 'Department of Pathology, University of Michigan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Department of Dermatology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103112079', 'display_name': 'Timothy M. Johnson', 'orcid': 'https://orcid.org/0000-0003-3466-3040'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Timothy M. Johnson', 'raw_affiliation_strings': ['Department of Dermatology, University of Michigan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077701232', 'display_name': 'Thomas J. Giordano', 'orcid': 'https://orcid.org/0000-0003-0641-8873'}, 'institutions': [{'id': 'https://openalex.org/I2799803081', 'display_name': 'Diabetes Australia', 'ror': 'https://ror.org/008aaf926', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799803081']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Thomas J. Giordano', 'raw_affiliation_strings': ['Department of Pathology, University of Michigan', 'Internal Medicine - Metabolism, Endocrinology, and Diabetes'], 'affiliations': [{'raw_affiliation_string': 'Internal Medicine - Metabolism, Endocrinology, and Diabetes', 'institution_ids': ['https://openalex.org/I2799803081']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042167871', 'display_name': 'Nallasivam Palanisamy', 'orcid': 'https://orcid.org/0000-0002-0633-9772'}, 'institutions': [{'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}, {'id': 'https://openalex.org/I4210148693', 'display_name': 'Metropolitan University', 'ror': 'https://ror.org/04hdrrs71', 'country_code': 'BD', 'type': 'education', 'lineage': ['https://openalex.org/I4210148693']}], 'countries': ['BD', 'US'], 'is_corresponding': False, 'raw_author_name': 'Nallasivam Palanisamy', 'raw_affiliation_strings': ['Comprehensive Cancer Center, University of Michigan Medical School', 'Department of Pathology, University of Michigan', 'Michigan Center for Translational Pathology', 'Shared senior authors'], 'affiliations': [{'raw_affiliation_string': 'Michigan Center for Translational Pathology', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Department of Pathology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Comprehensive Cancer Center, University of Michigan Medical School', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Shared senior authors', 'institution_ids': ['https://openalex.org/I4210148693']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5003311852', 'display_name': 'Arul M. Chinnaiyan', 'orcid': 'https://orcid.org/0000-0001-9282-3415'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}, {'id': 'https://openalex.org/I4210117557', 'display_name': 'Michigan Center for Translational Pathology', 'ror': 'https://ror.org/027t4kk23', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114445', 'https://openalex.org/I4210117557']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arul M. Chinnaiyan', 'raw_affiliation_strings': ['Comprehensive Cancer Center, University of Michigan Medical School', 'Department of Pathology, University of Michigan', 'Department of Urology, University of Michigan', 'Howard Hughes Medical Institute, University of Michigan Medical School', 'Michigan Center for Translational Pathology'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Comprehensive Cancer Center, University of Michigan Medical School', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Michigan Center for Translational Pathology', 'institution_ids': ['https://openalex.org/I4210117557']}, {'raw_affiliation_string': 'Howard Hughes Medical Institute, University of Michigan Medical School', 'institution_ids': ['https://openalex.org/I1344073410']}, {'raw_affiliation_string': 'Department of Urology, University of Michigan', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.593, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 133, 'citation_normalized_percentile': {'value': 0.999888, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '3', 'issue': '9', 'first_page': '1011', 'last_page': '1025'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.73756224}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.67847174}, {'id': 'https://openalex.org/C50171091', 'wikidata': 'https://www.wikidata.org/wiki/Q17917770', 'display_name': 'EZH2', 'level': 4, 'score': 0.5943583}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.58276725}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.505564}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.49888134}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.49853706}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.38419282}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3680412}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.3318924}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.2425147}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.23121682}], 'mesh': [{'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D063151', 'descriptor_name': 'Polycomb Repressive Complex 2', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D048708', 'descriptor_name': 'Cell Growth Processes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048708', 'descriptor_name': 'Cell Growth Processes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071221', 'descriptor_name': 'Enhancer of Zeste Homolog 2 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D063151', 'descriptor_name': 'Polycomb Repressive Complex 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063151', 'descriptor_name': 'Polycomb Repressive Complex 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D063151', 'descriptor_name': 'Polycomb Repressive Complex 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.622', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=622&path%5B%5D=961', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3663613', 'pdf_url': 'https://europepmc.org/articles/pmc3663613?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663613', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22948084', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.622', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=622&path%5B%5D=961', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.44, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1565276921', 'https://openalex.org/W1589065184', 'https://openalex.org/W1665488395', 'https://openalex.org/W1909795006', 'https://openalex.org/W1968667083', 'https://openalex.org/W1971874692', 'https://openalex.org/W1971969564', 'https://openalex.org/W1974631544', 'https://openalex.org/W1978944350', 'https://openalex.org/W1996487270', 'https://openalex.org/W1998449659', 'https://openalex.org/W2000183036', 'https://openalex.org/W2006535551', 'https://openalex.org/W2008033547', 'https://openalex.org/W2009489886', 'https://openalex.org/W2009708494', 'https://openalex.org/W2020170641', 'https://openalex.org/W2022683869', 'https://openalex.org/W2028197291', 'https://openalex.org/W2036015321', 'https://openalex.org/W2039606711', 'https://openalex.org/W2040182688', 'https://openalex.org/W2050079849', 'https://openalex.org/W2051121956', 'https://openalex.org/W2057065967', 'https://openalex.org/W2060608189', 'https://openalex.org/W2067155951', 'https://openalex.org/W2073009647', 'https://openalex.org/W2084487847', 'https://openalex.org/W2089041551', 'https://openalex.org/W2098844933', 'https://openalex.org/W2100365251', 'https://openalex.org/W2102326716', 'https://openalex.org/W2106789761', 'https://openalex.org/W2111863560', 'https://openalex.org/W2112581947', 'https://openalex.org/W2113634596', 'https://openalex.org/W2125496315', 'https://openalex.org/W2130634531', 'https://openalex.org/W2134471382', 'https://openalex.org/W2135007926', 'https://openalex.org/W2161016452', 'https://openalex.org/W2163188200', 'https://openalex.org/W2167444471', 'https://openalex.org/W2169491358'], 'related_works': ['https://openalex.org/W4366603091', 'https://openalex.org/W4284991400', 'https://openalex.org/W3112098854', 'https://openalex.org/W3029316033', 'https://openalex.org/W2372977766', 'https://openalex.org/W2293624935', 'https://openalex.org/W2130686293', 'https://openalex.org/W1991879524', 'https://openalex.org/W1976749758', 'https://openalex.org/W1971791563'], 'abstract_inverted_index': {'//': [0, 121], 'Irfan': [1], 'A.': [2, 24], 'Asangani': [3], '1,2,*': [4], ',Paul': [5], 'W.': [6], 'Harms': [7], '1,2,3,*': [8], ',': [9, 13, 17, 22, 27, 32, 37, 42, 46], 'Lois': [10], 'Dodson': [11], '1': [12, 16, 51], 'Mithil': [14], 'Pandhi': [15], 'Lakshmi': [18], 'P.': [19], 'Kunju': [20], '2': [21, 41, 57], 'Christopher': [23], 'Maher': [25], '1,2,4': [26], 'Douglas': [28], 'R.': [29], 'Fullen': [30], '2,3': [31], 'Timothy': [33], 'M.': [34, 48, 118], 'Johnson': [35], '3': [36, 64], 'Thomas': [38], 'J.': [39], 'Giordano': [40], 'Nallasivam': [43], 'Palanisamy': [44], '1,2,5,8': [45], 'Arul': [47, 117], 'Chinnaiyan': [49], '1,2,5,6,7,8': [50], 'Michigan': [52, 63, 70, 84, 94, 103], 'Center': [53, 72], 'for': [54, 73, 335], 'Translational': [55], 'Pathology': [56], 'Department': [58, 65, 98], 'of': [59, 62, 66, 69, 83, 93, 99, 102, 192, 211, 223, 244, 247, 255, 268, 303, 308, 315], 'Pathology,': [60], 'University': [61, 68, 82, 92, 101], 'Dermatology,': [67], '4': [71], 'Computational': [74], 'Medicine': [75], 'and': [76, 167, 189, 207, 216, 232, 235, 261, 278, 291, 305, 322, 339], 'Bioinformatics': [77], '5': [78], 'Comprehensive': [79], 'Cancer': [80], 'Center,': [81], 'Medical': [85, 90, 95], 'School': [86, 96], '6': [87], 'Howard': [88], 'Hughes': [89], 'Institute,': [91], '7': [97], 'Urology,': [100], '8': [104], 'Shared': [105], 'senior': [106], 'authors': [107, 110], '*': [108], 'These': [109], 'contributed': [111], 'equally': [112], 'to': [113], 'this': [114], 'work': [115], 'Correspondence:': [116], 'Chinnaiyan,': [119], 'email:': [120], 'Keywords': [122], ':': [123, 124, 132, 137, 142], 'microRNA-31,': [125], 'melanoma,': [126], 'tumor': [127, 332], 'suppressor,': [128], 'EZH2,': [129], 'DZNep': [130], 'Received': [131], 'August': [133, 138, 143], '15,': [134], '2012,': [135, 140], 'Accepted': [136], '28,': [139], 'Published': [141], '31,': [144], '2012': [145], 'Abstract': [146], 'MicroRNAs': [147], '(miRs)': [148], 'play': [149], 'a': [150, 226, 242, 253, 306, 331], 'key': [151], 'role': [152, 191, 334], 'in': [153, 163, 172, 181, 199, 213, 229, 241, 270, 301, 337], 'cancer': [154], 'etiology': [155], 'by': [156, 258], 'coordinately': [157], 'repressing': [158], 'numerous': [159], 'target': [160, 310], 'genes': [161], 'involved': [162], 'cell': [164, 217, 233, 273, 276], 'proliferation,': [165], 'migration': [166, 277], 'invasion.': [168, 279], 'The': [169], 'genomic': [170, 239], 'region': [171], 'chromosome': [173], '9p21': [174], 'that': [175, 221], 'encompasses': [176], 'miR-31': [177, 193, 212, 224, 248, 269, 280, 298, 336], 'is': [178], 'frequently': [179], 'deleted': [180], 'solid': [182], 'cancers': [183], 'including': [184], 'melanoma;': [185], 'however': [186], 'the': [187, 204, 292], 'expression': [188, 205, 250, 314], 'functional': [190, 209], 'has': [194], 'not': [195], 'been': [196], 'previously': [197], 'studied': [198], 'melanoma.': [200], 'Here,': [201], 'we': [202], 'queried': [203], 'status': [206], 'performed': [208], 'characterization': [210], 'melanoma': [214, 230, 272, 293, 320, 338], 'tissues': [215], 'lines.': [218], 'We': [219], 'found': [220], 'down-regulation': [222, 302], 'was': [225, 236, 251, 317], 'common': [227], 'event': [228], 'tumors': [231], 'lines': [234, 274], 'associated': [237, 318], 'with': [238, 319], 'loss': [240], 'subset': [243], 'samples.': [245], 'Down-regulation': [246], 'gene': [249, 311], 'also': [252], 'result': [254], 'epigenetic': [256], 'silencing': [257], 'DNA': [259], 'methylation,': [260], 'via': [262], 'EZH2-mediated': [263], 'histone': [264], 'methylation.': [265], 'Ectopic': [266], 'overexpression': [267, 299], 'various': [271], 'inhibited': [275], 'targets': [281], 'include': [282], 'oncogenic': [283], 'kinases': [284], 'such': [285], 'as': [286], 'SRC,': [287], 'MET,': [288], 'NIK': [289], '(MAP3K14)': [290], 'specific': [294], 'oncogene': [295], 'RAB27a.': [296], 'Furthermore,': [297], 'resulted': [300], 'EZH2': [304, 316], 'de-repression': [307], 'its': [309], 'rap1GAP;': [312], 'increased': [313], 'progression': [321], 'overall': [323], 'patient': [324], 'survival.': [325], 'Taken': [326], 'together,': [327], 'our': [328], 'study': [329], 'supports': [330], 'suppressor': [333], 'identifies': [340], 'novel': [341], 'therapeutic': [342], 'targets.': [343]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1856564249', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 28}, {'year': 2014, 'cited_by_count': 22}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-09T00:20:37.902489', 'created_date': '2016-06-24'}