Publication Information

{'id': 'https://openalex.org/W1855226956', 'doi': None, 'title': 'DSCR2, a Down syndrome critical region protein, is localized to the endoplasmic reticulum of mammalian cells.', 'display_name': 'DSCR2, a Down syndrome critical region protein, is localized to the endoplasmic reticulum of mammalian cells.', 'publication_year': 2004, 'publication_date': '2004-12-14', 'ids': {'openalex': 'https://openalex.org/W1855226956', 'mag': '1855226956', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15590417'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/1ba4078e3b12455b9c0c524496ebdf19', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['doaj', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067165337', 'display_name': 'Patrícia A. Possik', 'orcid': 'https://orcid.org/0000-0003-2899-0969'}, 'institutions': [{'id': 'https://openalex.org/I177909021', 'display_name': 'Universidade Federal de São Carlos', 'ror': 'https://ror.org/00qdc6m37', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I177909021']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'P A Possik', 'raw_affiliation_strings': ['Department of Genetics and Evolution, Federal University of São Carlos, São Carlos, SP, Brazil.'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics and Evolution, Federal University of São Carlos, São Carlos, SP, Brazil.', 'institution_ids': ['https://openalex.org/I177909021']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103423906', 'display_name': 'CA. Sommer', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C A Sommer', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006903282', 'display_name': 'Juliana I. Hori', 'orcid': 'https://orcid.org/0000-0002-5421-3728'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Issa Hori', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036619623', 'display_name': 'Gláucia Maria Machado‐Santelli', 'orcid': 'https://orcid.org/0000-0003-2046-9693'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'G M Machado-Santelli', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109901463', 'display_name': 'M C Jamur', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M C Jamur', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005899813', 'display_name': 'Flávio Henrique‐Silva', 'orcid': 'https://orcid.org/0000-0003-3329-4597'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'F Henrique-Silva', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 950, 'currency': 'EUR', 'value_usd': 1024, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.339, 'has_fulltext': False, 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.672642, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 77}, 'biblio': {'volume': '48', 'issue': '3', 'first_page': '267', 'last_page': '72'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11015', 'display_name': 'Down syndrome and intellectual disability research', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11015', 'display_name': 'Down syndrome and intellectual disability research', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.9625, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11725', 'display_name': 'Immunodeficiency and Autoimmune Disorders', 'score': 0.9501, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/membrane-contact-site', 'display_name': 'Membrane contact site', 'score': 0.49708155}], 'concepts': [{'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.96703374}, {'id': 'https://openalex.org/C162740809', 'wikidata': 'https://www.wikidata.org/wiki/Q15334560', 'display_name': 'STIM1', 'level': 3, 'score': 0.80446625}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.67056257}, {'id': 'https://openalex.org/C2776879804', 'wikidata': 'https://www.wikidata.org/wiki/Q7630919', 'display_name': 'Subcellular localization', 'level': 3, 'score': 0.5908152}, {'id': 'https://openalex.org/C161200384', 'wikidata': 'https://www.wikidata.org/wiki/Q1757382', 'display_name': 'Integral membrane protein', 'level': 4, 'score': 0.57211334}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.56797683}, {'id': 'https://openalex.org/C144647389', 'wikidata': 'https://www.wikidata.org/wiki/Q423042', 'display_name': 'Membrane protein', 'level': 3, 'score': 0.5111459}, {'id': 'https://openalex.org/C88020867', 'wikidata': 'https://www.wikidata.org/wiki/Q6815123', 'display_name': 'Membrane contact site', 'level': 5, 'score': 0.49708155}, {'id': 'https://openalex.org/C24530287', 'wikidata': 'https://www.wikidata.org/wiki/Q424204', 'display_name': 'Transmembrane protein', 'level': 3, 'score': 0.48963815}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.48055652}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39746648}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39628923}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.3521733}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.23070356}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22729477}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004314', 'descriptor_name': 'Down Syndrome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019556', 'descriptor_name': 'COS Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002522', 'descriptor_name': 'Chlorocebus aethiops', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004314', 'descriptor_name': 'Down Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017384', 'descriptor_name': 'Sequence Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doaj.org/article/1ba4078e3b12455b9c0c524496ebdf19', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15590417', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W1486716192', 'https://openalex.org/W1860217789', 'https://openalex.org/W2003815042', 'https://openalex.org/W2012342847', 'https://openalex.org/W2013238087', 'https://openalex.org/W2025782007', 'https://openalex.org/W2027036934', 'https://openalex.org/W2037762546', 'https://openalex.org/W2045568306', 'https://openalex.org/W2072881240', 'https://openalex.org/W2078144829', 'https://openalex.org/W2083736779', 'https://openalex.org/W2085702771', 'https://openalex.org/W2107886504', 'https://openalex.org/W2116056093', 'https://openalex.org/W2167988140', 'https://openalex.org/W2466748360'], 'related_works': ['https://openalex.org/W643852130', 'https://openalex.org/W3182472765', 'https://openalex.org/W2221005623', 'https://openalex.org/W2154990586', 'https://openalex.org/W2150351373', 'https://openalex.org/W2068122493', 'https://openalex.org/W2019831795', 'https://openalex.org/W1855226956', 'https://openalex.org/W1764799499', 'https://openalex.org/W1489842037'], 'abstract_inverted_index': {'We': [0, 55], 'used': [1], 'immunocytochemical': [2], 'and': [3, 117], 'fluorescence': [4], 'assays': [5], 'to': [6], 'investigate': [7], 'the': [8, 12, 35, 49, 59, 78, 81, 85, 88, 96, 107, 122, 126, 132], 'subcellular': [9, 66], 'location': [10], 'of': [11, 53, 62, 80, 125], 'protein': [13, 47, 116], 'encoded': [14], 'by': [15, 128], 'Down': [16], 'syndrome': [17], 'critical': [18], 'region': [19], 'gene': [20], '2': [21], '(DSCR2)': [22], 'in': [23, 34, 48], 'transfected': [24], 'cells.': [25, 54], 'It': [26], 'was': [27], 'previously': [28], 'suggested': [29], 'that': [30, 71], 'DSCR2': [31, 63, 72, 103], 'is': [32, 74, 104, 111, 119], 'located': [33], 'plasma': [36], 'membrane': [37, 41, 79, 115, 134], 'as': [38], 'an': [39, 113], 'integral': [40, 114], 'protein.': [42, 138], 'Interestingly,': [43], 'we': [44], 'observed': [45], 'this': [46], 'endoplasmic': [50, 82, 108], 'reticulum': [51, 83], '(ER)': [52], 'also': [56], 'studied': [57], 'whether': [58], 'truncated': [60], 'forms': [61], 'showed': [64], 'different': [65], 'distributions.': [67], 'Our': [68, 98], 'observations': [69], 'indicate': [70], 'probably': [73], 'not': [75, 112], 'inserted': [76], 'into': [77], 'since': [84], 'fragments': [86], 'lacking': [87], 'predicted': [89], 'transmembrane': [90], '(TM)': [91], 'helices': [92], 'remained': [93], 'associated': [94, 105], 'with': [95, 106, 131, 136], 'ER.': [97], 'analyses': [99], 'suggest': [100], 'that,': [101], 'although': [102], 'reticulum,': [109], 'it': [110, 118], 'maintained': [120], 'on': [121], 'cytoplasmic': [123], 'side': [124], 'ER': [127, 133], 'indirect': [129], 'interaction': [130], 'or': [135], 'another': [137]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1855226956', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-17T14:46:19.959961', 'created_date': '2016-06-24'}