Title: 6.5 C–C Bond Formation: Aldol Reaction with Non-Proline Derivatives
Abstract: The aldol reaction is one of the most important carbon–carbon bond-forming reactions in organic synthesis. Since the discovery of intra- and intermolecular aldol reactions catalyzed by proline, organocatalyst-mediated aldol reactions have been developed extensively. Currently, asymmetric organocatalytic aldol reactions can be classified into four major categories, differentiated by their reaction mechanisms: (1) enamine mechanisms; (2) ion-pair mechanisms; (3) chiral enolate mechanisms; and (4) electron acceptor activation by Brønsted acids. In this chapter, the authors describe these four types of aldol reactions; herein, the authors limit their discussion to reactions catalyzed by nonproline derivatives, whereas in the previous chapter, aldol reactions catalyzed by proline and proline derivatives are reviewed.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 1
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