Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1851949377', 'doi': 'https://doi.org/10.18632/oncotarget.4857', 'title': 'Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics', 'display_name': 'Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics', 'publication_year': 2015, 'publication_date': '2015-07-10', 'ids': {'openalex': 'https://openalex.org/W1851949377', 'doi': 'https://doi.org/10.18632/oncotarget.4857', 'mag': '1851949377', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26219338', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4627281'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4857', 'pdf_url': 'https://www.oncotarget.com/article/4857/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/4857/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011273565', 'display_name': 'Gaurav S. Choudhary', 'orcid': 'https://orcid.org/0000-0001-5365-6706'}, 'institutions': [{'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}, {'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}, {'id': 'https://openalex.org/I4210153792', 'display_name': 'University School', 'ror': 'https://ror.org/05ap66461', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210153792']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gaurav S. Choudhary', 'raw_affiliation_strings': ['Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA', 'Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA', 'institution_ids': ['https://openalex.org/I36373038']}, {'raw_affiliation_string': 'Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA', 'institution_ids': ['https://openalex.org/I58956616', 'https://openalex.org/I4210153792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059052286', 'display_name': 'Trinh Tat', 'orcid': 'https://orcid.org/0000-0002-6419-8007'}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}, {'id': 'https://openalex.org/I4210153792', 'display_name': 'University School', 'ror': 'https://ror.org/05ap66461', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210153792']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Trinh T. Tat', 'raw_affiliation_strings': ['Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, USA', 'institution_ids': ['https://openalex.org/I58956616', 'https://openalex.org/I4210153792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001496532', 'display_name': 'Saurav Misra', 'orcid': 'https://orcid.org/0000-0002-1385-8554'}, 'institutions': [{'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Saurav Misra', 'raw_affiliation_strings': ['Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA', 'institution_ids': ['https://openalex.org/I36373038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006235077', 'display_name': 'Brian T. Hill', 'orcid': 'https://orcid.org/0000-0001-8781-3327'}, 'institutions': [{'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brian T. Hill', 'raw_affiliation_strings': ['Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA', 'institution_ids': ['https://openalex.org/I1316902750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089854184', 'display_name': 'Mitchell R. Smith', 'orcid': 'https://orcid.org/0000-0003-1428-8765'}, 'institutions': [{'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mitchell R. Smith', 'raw_affiliation_strings': ['Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA', 'institution_ids': ['https://openalex.org/I1316902750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090436641', 'display_name': 'Alexandru Almasan', 'orcid': 'https://orcid.org/0000-0002-8916-6650'}, 'institutions': [{'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}, {'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexandru Almasan', 'raw_affiliation_strings': ['Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.', 'Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.', 'institution_ids': ['https://openalex.org/I36373038']}, {'raw_affiliation_string': 'Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.', 'institution_ids': ['https://openalex.org/I36373038', 'https://openalex.org/I58956616']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030544023', 'display_name': 'Suparna Mazumder', 'orcid': 'https://orcid.org/0000-0002-9738-0040'}, 'institutions': [{'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}, {'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Suparna Mazumder', 'raw_affiliation_strings': ['Department of Immunology, Lerner Research Institute, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.', 'Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Lerner Research Institute, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.', 'institution_ids': ['https://openalex.org/I36373038']}, {'raw_affiliation_string': 'Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.', 'institution_ids': ['https://openalex.org/I36373038', 'https://openalex.org/I58956616']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.015, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 57, 'citation_normalized_percentile': {'value': 0.999878, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '6', 'issue': '19', 'first_page': '16912', 'last_page': '16925'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9884, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9884, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9881, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9875, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyclin-e', 'display_name': 'Cyclin E', 'score': 0.51411134}, {'id': 'https://openalex.org/keywords/cyclin-a', 'display_name': 'Cyclin A', 'score': 0.4697319}, {'id': 'https://openalex.org/keywords/hematology', 'display_name': 'Hematology', 'score': 0.41524014}], 'concepts': [{'id': 'https://openalex.org/C94561458', 'wikidata': 'https://www.wikidata.org/wiki/Q24724860', 'display_name': 'Cyclin E', 'level': 5, 'score': 0.51411134}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5105337}, {'id': 'https://openalex.org/C16438837', 'wikidata': 'https://www.wikidata.org/wiki/Q5198260', 'display_name': 'Cyclin A', 'level': 5, 'score': 0.4697319}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.43219984}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.42731458}, {'id': 'https://openalex.org/C194409129', 'wikidata': 'https://www.wikidata.org/wiki/Q103824', 'display_name': 'Hematology', 'level': 2, 'score': 0.41524014}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.41357893}, {'id': 'https://openalex.org/C124320809', 'wikidata': 'https://www.wikidata.org/wiki/Q46292', 'display_name': 'Cyclin-dependent kinase', 'level': 4, 'score': 0.3883088}, {'id': 'https://openalex.org/C82495950', 'wikidata': 'https://www.wikidata.org/wiki/Q14911732', 'display_name': 'Cyclin-dependent kinase 2', 'level': 4, 'score': 0.37637016}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.34604025}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3432493}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.34048432}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28199112}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10770765}], 'mesh': [{'descriptor_ui': 'D019927', 'descriptor_name': 'Cyclin E', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051357', 'descriptor_name': 'Cyclin-Dependent Kinase 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D064549', 'descriptor_name': 'Myeloid Cell Leukemia Sequence 1 Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001713', 'descriptor_name': 'Biphenyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001713', 'descriptor_name': 'Biphenyl Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019086', 'descriptor_name': 'Bridged Bicyclo Compounds, Heterocyclic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019086', 'descriptor_name': 'Bridged Bicyclo Compounds, Heterocyclic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019927', 'descriptor_name': 'Cyclin E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051357', 'descriptor_name': 'Cyclin-Dependent Kinase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015151', 'descriptor_name': 'Immunoblotting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047468', 'descriptor_name': 'Immunoprecipitation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064549', 'descriptor_name': 'Myeloid Cell Leukemia Sequence 1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009596', 'descriptor_name': 'Nitrophenols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009596', 'descriptor_name': 'Nitrophenols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D055550', 'descriptor_name': 'Protein Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4857', 'pdf_url': 'https://www.oncotarget.com/article/4857/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4627281', 'pdf_url': 'https://europepmc.org/articles/pmc4627281?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627281', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26219338', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4857', 'pdf_url': 'https://www.oncotarget.com/article/4857/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.69}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1966383348', 'https://openalex.org/W1966937303', 'https://openalex.org/W1979248048', 'https://openalex.org/W1980622220', 'https://openalex.org/W1982030535', 'https://openalex.org/W1982254984', 'https://openalex.org/W1982820305', 'https://openalex.org/W1984931879', 'https://openalex.org/W1987821813', 'https://openalex.org/W1990624451', 'https://openalex.org/W1990983360', 'https://openalex.org/W1998359020', 'https://openalex.org/W2025332440', 'https://openalex.org/W2027395744', 'https://openalex.org/W2040907359', 'https://openalex.org/W2041345719', 'https://openalex.org/W2041797768', 'https://openalex.org/W2046279786', 'https://openalex.org/W2046416127', 'https://openalex.org/W2054799428', 'https://openalex.org/W2060508679', 'https://openalex.org/W2065480137', 'https://openalex.org/W2066404900', 'https://openalex.org/W2067776092', 'https://openalex.org/W2068720118', 'https://openalex.org/W2088418102', 'https://openalex.org/W2090970397', 'https://openalex.org/W2091327303', 'https://openalex.org/W2103580937', 'https://openalex.org/W2112767263', 'https://openalex.org/W2123122199', 'https://openalex.org/W2129476862', 'https://openalex.org/W2136910701', 'https://openalex.org/W2137240394', 'https://openalex.org/W2140642045', 'https://openalex.org/W2142183096', 'https://openalex.org/W2150838826', 'https://openalex.org/W2152876030', 'https://openalex.org/W2153571329', 'https://openalex.org/W2155789124', 'https://openalex.org/W2165804364', 'https://openalex.org/W2172242534', 'https://openalex.org/W2979875117'], 'related_works': ['https://openalex.org/W2156541342', 'https://openalex.org/W2143162998', 'https://openalex.org/W2089218510', 'https://openalex.org/W2077716326', 'https://openalex.org/W2044365359', 'https://openalex.org/W2044312503', 'https://openalex.org/W2003865982', 'https://openalex.org/W1996237823', 'https://openalex.org/W1506524128', 'https://openalex.org/W1482407871'], 'abstract_inverted_index': {'//': [0, 139, 143], 'Gaurav': [1], 'S.': [2], 'Choudhary': [3], '1,6': [4], ',': [5, 10, 14, 19, 24], 'Trinh': [6], 'T.': [7, 16], 'Tat': [8], '7': [9, 120], 'Saurav': [11], 'Misra': [12], '2': [13, 45], 'Brian': [15], 'Hill': [17], '4': [18, 23, 73], 'Mitchell': [20], 'R.': [21], 'Smith': [22], 'Alexandru': [25, 140], 'Almasan': [26], '1,5': [27], 'and': [28, 77, 191, 213, 228, 252, 310, 312, 324, 348, 359, 388], 'Suparna': [29, 136], 'Mazumder': [30], '3,5': [31], '1': [32], 'Department': [33, 46, 59, 74, 88, 107, 121], 'of': [34, 47, 60, 75, 89, 96, 98, 108, 115, 122, 129, 216, 233, 262, 275, 297, 373, 385], 'Cancer': [35, 66, 80], 'Biology,': [36], 'Lerner': [37, 50, 62, 94], 'Research': [38, 51, 63], 'Institute,': [39, 52, 64, 67, 81], 'Cleveland': [40, 53, 68, 82, 92], 'Clinic,': [41, 54, 69, 83], 'Cleveland,': [42, 55, 70, 84, 103, 117, 131], 'OH,': [43, 56, 71, 85, 104, 118, 132], 'USA': [44, 57, 72, 86, 105, 119, 133], 'Molecular': [48, 90], 'Cardiology,': [49], '3': [58, 221], 'Immunology,': [61], 'Taussig': [65, 79], 'Hematology': [76], 'Oncology,': [78], '5': [87], 'Medicine,': [91, 116, 130], 'Clinic': [93], 'College': [95], 'Medicine': [97], 'Case': [99, 110, 124], 'Western': [100, 111, 125], 'Reserve': [101, 112, 126], 'University,': [102], '6': [106], 'Pathology,': [109], 'University': [113, 127], 'School': [114, 128], 'Biochemistry,': [123], 'Correspondence': [134], 'to:': [135], 'Mazumder,': [137], 'email:': [138, 142], 'Almasan,': [141], 'Keywords': [144], ':': [145, 155, 160, 165], 'Mcl-1,': [146, 198], 'cyclin': [147, 188, 234, 253, 276, 294, 374], 'E,': [148, 277], 'Cdk2,': [149], 'dinaciclib': [150, 333], 'ABT-737,': [151, 214], 'ABT-199,': [152], 'CLL': [153], 'Received': [154], 'February': [156], '26,': [157], '2015': [158, 163, 168], 'Accepted': [159], 'July': [161, 166], '01,': [162], 'Published': [164], '15,': [167], 'Abstract': [169], 'Cyclin': [170, 223, 244, 316], 'E/Cdk2': [171, 189, 235], 'kinase': [172], 'activity': [173], 'is': [174], 'frequently': [175], 'deregulated': [176], 'in': [177, 181, 238, 247, 268, 305, 335, 340, 344, 351, 356], 'human': [178, 249], 'cancers,': [179], 'resulting': [180], 'impaired': [182], 'apoptosis.': [183], 'Here,': [184], 'we': [185], 'show': [186, 292], 'that': [187, 293, 378], 'phosphorylates': [190], 'stabilizes': [192], 'the': [193, 206, 217, 273], 'pro-survival': [194], 'Bcl-2': [195, 209, 218, 386], 'family': [196, 210, 387], 'protein': [197, 285], 'a': [199, 370, 380], 'key': [200], 'cell': [201, 354], 'death': [202, 355], 'resistance': [203], 'determinant': [204], 'to': [205, 241, 283, 322], 'small': [207], 'molecule': [208], 'inhibitors': [211, 390], 'ABT-199': [212, 349], 'mimetics': [215], 'homology': [219], 'domain': [220, 303], '(BH3).': [222], 'E': [224, 245, 254, 317], 'levels': [225, 261], 'were': [226], 'elevated': [227], 'there': [229], 'was': [230, 280], 'increased': [231, 306], 'association': [232], 'with': [236, 265, 288, 346], 'Mcl-1': [237, 263, 269, 278, 289, 298, 307, 339, 376], 'ABT-737-resistant': [239, 341], 'compared': [240], 'parental': [242], 'cells.': [243, 329, 342], 'depletion': [246], 'various': [248], 'tumor': [250, 328], 'cell-lines': [251], '-/-': [255], 'mouse': [256], 'embryo': [257], 'fibroblasts': [258], 'showed': [259], 'decreased': [260, 284], 'protein,': [264], 'no': [266], 'change': [267], 'mRNA': [270], 'levels.': [271], 'In': [272], 'absence': [274], 'ubiquitination': [279], 'enhanced,': [281], 'leading': [282], 'stability.': [286], 'Studies': [287], 'phosphorylation': [290, 296], 'mutants': [291], 'E/Cdk2-dependent': [295], 'residues': [299], 'on': [300], 'its': [301], 'PEST': [302], 'resulted': [304, 334, 350], 'stability': [308], '(Thr92,': [309], 'Thr163)': [311], 'Bim': [313, 336], 'binding': [314], '(Ser64).': [315], 'knock-down': [318], 'restored': [319], 'ABT-737': [320, 347], 'sensitivity': [321], 'acquired': [323], 'inherently': [325], 'resistant': [326], 'Mcl-1-dependent': [327, 392], 'CDK': [330], 'inhibition': [331], 'by': [332], 'release': [337], 'from': [338], 'Dinaciclib': [343], 'combination': [345], 'robust': [352], 'synergistic': [353], 'leukemic': [357], 'cells': [358], 'primary': [360], 'chronic': [361], 'lymphocytic': [362], 'leukemia': [363], 'patient': [364], 'samples.': [365], 'Collectively,': [366], 'our': [367], 'findings': [368], 'identify': [369], 'novel': [371], 'mechanism': [372], 'E-mediated': [375], 'regulation': [377], 'provides': [379], 'rationale': [381], 'for': [382, 391], 'clinical': [383], 'use': [384], 'Cdk': [389], 'tumors.': [393]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1851949377', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2025-01-07T16:18:38.097322', 'created_date': '2016-06-24'}