Targeting the <scp>LOX</scp> / <scp>hypoxia</scp> axis reverses many of the features that make pancreatic cancer deadly: inhibition of <scp>LOX</scp> abrogates metastasis and enhances drug efficacy

Name: Work Video:
Duration: 3 min 30 s
Bryan W. Miller; Jennifer P. Morton; Mark Pinese; Grazia Saturno; Nigel B. Jamieson; Ewan J. McGhee; Paul Timpson; Joshua D.G. Leach; Lynn McGarry; Emma Shanks; Peter J. Bailey; David K. Chang; Karin A. Oien; Saadia A. Karim; Amy Au; Colin W. Steele; Christopher Ross Carter; Colin J. McKay; Kurt I. Anderson; T.R. Jeffry Evans; Richard Marais; Caroline J. Springer; Andrew V. Biankin; Janine T. Erler; Owen J. Sansom
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246, 249, 268, 271, 290, 293, 313, 333, 353, 376, 397, 417, 441, 449, 452, 507, 510, 561, 583, 605, 667, 687, 727, 747, 767, 786, 789, 808, 811, 830, 833, 853, 873, 893, 916, 937, 957, 981, 989, 992, 1047, 1050, 1101, 1180, 1207, 1215, 1218], 'Search': [45, 67, 87, 106, 129, 149, 169, 189, 209, 229, 251, 273, 295, 315, 335, 355, 378, 399, 419, 454, 473, 490, 512, 539, 563, 585, 607, 627, 646, 669, 689, 709, 729, 749, 769, 791, 813, 835, 855, 875, 895, 918, 939, 959, 994, 1013, 1030, 1052, 1079, 1103], 'for': [46, 68, 88, 107, 130, 150, 170, 190, 210, 230, 252, 274, 296, 316, 336, 356, 379, 400, 420, 455, 474, 491, 513, 540, 564, 586, 608, 628, 647, 670, 690, 710, 730, 750, 770, 792, 814, 836, 856, 876, 896, 919, 940, 960, 995, 1014, 1031, 1053, 1080, 1104, 1575, 1682, 1756, 2760, 2776, 2800, 2864, 3066, 3070, 3736, 3800, 3856, 3867, 4049, 4054, 4065, 4076, 4089, 4127, 4211], 'more': [47, 69, 89, 108, 131, 151, 171, 191, 211, 231, 253, 275, 297, 317, 337, 357, 380, 401, 421, 456, 475, 492, 514, 541, 565, 587, 609, 629, 648, 671, 691, 711, 731, 751, 771, 793, 815, 837, 857, 877, 897, 920, 941, 961, 996, 1015, 1032, 1054, 1081, 1105, 1787], 'papers': [48, 70, 90, 109, 132, 152, 172, 192, 212, 232, 254, 276, 298, 318, 338, 358, 381, 402, 422, 457, 476, 493, 515, 542, 566, 588, 610, 630, 649, 672, 692, 712, 732, 752, 772, 794, 816, 838, 858, 878, 898, 921, 942, 962, 997, 1016, 1033, 1055, 1082, 1106], 'by': [49, 71, 91, 110, 133, 153, 173, 193, 213, 233, 255, 277, 299, 319, 339, 359, 382, 403, 423, 458, 477, 494, 516, 543, 567, 589, 611, 631, 650, 673, 693, 713, 733, 753, 773, 795, 817, 839, 859, 879, 899, 922, 943, 963, 998, 1017, 1034, 1056, 1083, 1107, 1789, 1900, 1956, 2070, 2614, 3310, 3319, 3343, 3578, 3604, 3617, 3681, 3845, 3935, 3966, 3974, 4163, 4236], 'this': [50, 72, 92, 111, 134, 154, 174, 194, 214, 234, 256, 278, 300, 320, 340, 360, 383, 404, 424, 459, 478, 495, 517, 544, 568, 590, 612, 632, 651, 674, 694, 714, 734, 754, 774, 796, 818, 840, 860, 880, 900, 923, 944, 964, 999, 1018, 1035, 1057, 1084, 1108, 1243, 1344, 1875, 2251, 2501, 2608, 2678, 2858, 2943, 3655, 4050, 4159, 4221, 4346], 'author': [51, 73, 93, 112, 135, 155, 175, 195, 215, 235, 257, 279, 301, 321, 341, 361, 384, 405, 425, 460, 479, 496, 518, 545, 569, 591, 613, 633, 652, 675, 695, 715, 735, 755, 775, 797, 819, 841, 861, 881, 901, 924, 945, 965, 1000, 1019, 1036, 1058, 1085, 1109, 1301], 'Jennifer': [52, 55, 592, 595, 1115], 'P': [53, 56, 593, 596, 1116, 3146, 3199, 3273, 3296, 3500, 3963], 'Morton': [54, 57, 594, 597, 2385], 'Mark': [74, 76, 614, 616, 1118], 'Pinese': [75, 77, 615, 617], 'The': [78, 160, 618, 700, 1670, 3149], 'Garvan': [79, 161, 619, 701, 1183], 'Institute': [80, 162, 240, 262, 284, 443, 484, 501, 620, 702, 780, 802, 824, 983, 1024, 1041, 1184], 'Medical': [82, 164, 622, 704, 1186], 'Research,': [83, 165, 487, 623, 705, 1027, 1187, 1223], 'Sydney,': [84, 166, 624, 706, 1188], 'NSW,': [85, 167, 625, 707, 1189], 'Australia': [86, 168, 626, 708, 1190], 'Grazia': [94, 96, 634, 636, 1120], 'Saturno': [95, 97, 635, 637], 'Manchester': [101, 468, 641, 1008, 1194], 'Withington,': [103, 470, 643, 1010, 1196], 'Manchester,': [104, 471, 644, 1011, 1197], 'Nigel': [113, 116, 653, 656, 1122], 'B': [114, 117, 654, 657, 1123], 'Jamieson': [115, 118, 655, 658, 2238], 'West': [119, 368, 389, 659, 908, 929], 'Scotland': [121, 370, 391, 661, 910, 931, 1201], 'Pancreatic': [122, 371, 392, 662, 911, 932, 1202, 1314, 1608, 1634], 'Unit,': [123, 372, 393, 663, 912, 933, 1203], 'Glasgow': [124, 373, 394, 664, 913, 934, 1204, 2956, 2993, 3047, 3247], 'Royal': [125, 374, 395, 665, 914, 935, 1205], 'Infirmary,': [126, 375, 396, 666, 915, 936, 1206], 'Ewan': [136, 138, 676, 678, 1125], 'McGhee': [137, 139, 677, 679], 'Paul': [156, 158, 696, 698, 1127], 'Timpson': [157, 159, 697, 699], 'Joshua': [176, 178, 716, 718, 1129], 'Leach': [177, 179, 717, 719], 'Lynn': [196, 198, 736, 738, 1131], 'McGarry': [197, 199, 737, 739], 'Emma': [216, 218, 756, 758, 1133], 'Shanks': [217, 219, 757, 759], 'Peter': [236, 238, 776, 778, 1135], 'Bailey': [237, 239, 777, 779], 'Sciences,': [243, 265, 287, 446, 504, 783, 805, 827, 986, 1044, 1212], 'University': [244, 266, 288, 447, 505, 533, 784, 806, 828, 987, 1045, 1073, 1213, 1232], 'David': [258, 260, 798, 800, 1137], 'Chang': [259, 261, 799, 801], 'Karin': [280, 282, 820, 822, 1139], 'Oien': [281, 283, 821, 823], 'Saadia': [302, 304, 842, 844, 1141], 'Karim': [303, 305, 843, 845], 'Amy': [322, 324, 862, 864, 1143], 'Au': [323, 325, 863, 865], 'Colin': [342, 344, 385, 387, 882, 884, 925, 927, 1145, 1150], 'Steele': [343, 345, 883, 885], 'Christopher': [362, 365, 902, 905, 1147], 'Ross': [363, 366, 903, 906, 1148], 'Carter': [364, 367, 904, 907], 'McKay': [386, 388, 926, 928], 'Kurt': [406, 408, 946, 948, 1152], 'Anderson': [407, 409, 947, 949], 'Thomas': [426, 430, 966, 970, 1154], 'R': [427, 431, 967, 971, 1155], 'Jeffry': [428, 432, 968, 972, 1156], 'Evans': [429, 433, 969, 973], 'Richard': [461, 463, 1001, 1003, 1158], 'Marais': [462, 464, 1002, 1004], 'Caroline': [480, 482, 1020, 1022, 1160], 'Springer': [481, 483, 1021, 1023], 'London,': [488, 1028, 1224], 'Andrew': [497, 499, 1037, 1039, 1162], 'Biankin': [498, 500, 1038, 1040], 'Janine': [519, 524, 1059, 1064, 1164], 'T': [520, 525, 1060, 1065, 1165], 'Erler': [521, 526, 1061, 1066, 1166, 2088], 'Corresponding': [522, 549, 1062, 1089], 'Author': [523, 550, 1063, 1090, 1110], 'Biotech': [527, 1067], '&': [529, 1069, 1228, 1311, 2041, 2122], 'Innovation': [530, 1070, 1229], 'Centre': [531, 1071, 1230], '(BRIC),': [532, 1072, 1231], 'Copenhagen,': [535, 1075, 1234], 'Copenhagen': [536, 1076, 1235], '(UCPH),': [537, 1077, 1236], 'Denmark': [538, 1078, 1237], 'Owen': [546, 551, 1086, 1091, 1169], 'J': [547, 552, 1087, 1092, 1170], 'Sansom': [548, 553, 1088, 1093, 1171], 'Information': [1111], 'Miller1,‡,': [1114], 'Morton1,‡,': [1117], 'Pinese2,‡,': [1119], 'Saturno3,‡,': [1121], 'Jamieson4,': [1124], 'McGhee1,': [1126], 'Timpson2,': [1128], 'Leach1,': [1130], 'McGarry1,': [1132], 'Shanks1,': [1134], 'Bailey5,': [1136], 'Chang5,': [1138], 'Oien5,': [1140], 'Karim1,': [1142], 'Au1,': [1144], 'Steele1,': [1146], 'Carter4,': [1149], 'McKay4,': [1151], 'Anderson1,': [1153], 'Evans1,5,': [1157], 'Marais3,': [1159], 'Springer6,‡,': [1161], 'Biankin5,‡,': [1163], '7,‡': [1167], '1,‡': [1172], '1Cancer': [1173], '2The': [1182], '3Cancer': [1191], '4West': [1199], '5Institute': [1209], '6Institute': [1220], '7Biotech': [1226], '‡These': [1238], 'authors': [1239], 'contributed': [1240], 'equally': [1241], 'to': [1242, 1303, 1306, 1436, 1477, 1488, 1564, 1677, 1699, 1758, 1766, 1800, 1866, 1911, 1913, 1932, 1943, 1968, 2054, 2067, 2107, 2147, 2179, 2249, 2268, 2328, 2444, 2451, 2551, 2560, 2579, 2603, 2656, 2661, 2702, 2833, 2870, 3039, 3229, 3459, 3548, 3561, 3582, 3663, 3722, 3732, 3837, 3862, 4015, 4085, 4120, 4132, 4174, 4271, 4283, 4377], 'work': [1244, 2461], '*Corresponding': [1245, 1258], 'author.': [1246, 1259], 'Tel:': [1247, 1260], '+45': [1248, 1252], '3532': [1249, 1253], '5666;': [1250], 'Fax:': [1251, 1265], '5669;': [1254], 'E-mail:': [1255, 1270], '[email': [1256, 1271], 'protected]': [1257, 1272], '+44': [1261, 1266], '141': [1262, 1267], '330': [1263], '3656;': [1264], '942': [1268], '6521;': [1269], 'EMBO': [1273], 'Mol': [1274], 'Med': [1275], '(2015)7:1063-1076https://doi.org/10.15252/emmm.201404827': [1276], 'PDFDownload': [1277], 'PDF': [1278], 'article': [1280], 'text': [1281], 'main': [1283], 'figures.': [1284], 'Peer': [1285], 'ReviewDownload': [1286], 'a': [1287, 1352, 1382, 1508, 1754, 1840, 1858, 1957, 1977, 2046, 2165, 2219, 2403, 2496, 2547, 2681, 2709, 2727, 2754, 2770, 2848, 2974, 3067, 3074, 3109, 3122, 3173, 3350, 3369, 3388, 3438, 3627, 3803, 3998, 4019, 4025, 4040, 4074, 4143, 4175, 4196, 4209, 4302, 4396, 4430, 4453], 'summary': [1288], 'editorial': [1291, 1295], 'decision': [1292, 1296], 'process': [1293], 'including': [1294, 1456, 1547, 2227, 4471], 'letters,': [1297], 'reviewer': [1298], 'comments': [1299], 'responses': [1302], 'feedback.': [1304], 'ToolsAdd': [1305], 'favoritesDownload': [1307], 'CitationsTrack': [1308], 'CitationsPermissions': [1309], 'Figures': [1310], 'Info': [1312], 'Abstract': [1313], 'ductal': [1315, 1513, 1635], 'adenocarcinoma': [1316, 1514, 1636, 2448, 3625], '(PDAC)': [1317, 1637], 'is': [1318, 1398, 1475, 1505, 1610, 1638, 1753, 1883, 1953, 2045, 2164, 2171, 2202, 2215, 2254, 3282, 3317, 3408, 3614, 3798, 3811, 4037, 4063], 'one': [1319, 1611, 3687], 'leading': [1322, 1614], 'causes': [1323, 1615, 2628], 'cancer-related': [1325, 1617], 'mortality.': [1326], 'Despite': [1327], 'significant': [1328, 1373, 2604, 2821, 3068], 'advances': [1329], 'made': [1330, 1785, 1954], 'in': [1331, 1343, 1367, 1390, 1400, 1414, 1444, 1497, 1511, 1520, 1529, 1538, 1567, 1582, 1619, 1874, 1995, 2011, 2020, 2023, 2131, 2174, 2222, 2284, 2307, 2326, 2345, 2500, 2522, 2622, 2631, 2690, 2705, 2740, 2893, 2895, 2912, 2954, 3010, 3045, 3079, 3088, 3162, 3168, 3189, 3207, 3245, 3288, 3422, 3437, 3463, 3537, 3654, 3701, 3707, 3788, 3802, 3816, 4001, 4018, 4027, 4031, 4078, 4098, 4170, 4177, 4195, 4213, 4234, 4244, 4273, 4285, 4297, 4305, 4314, 4339, 4363, 4387, 4391, 4416], 'treatment': [1333, 1826], 'other': [1335], 'cancers,': [1336], 'current': [1337], 'chemotherapies': [1338], 'offer': [1339], 'little': [1340], 'survival': [1341, 1389, 1443, 1732, 2521, 2739, 2789, 2911, 2937, 3078, 3185, 3227, 3261, 3287, 3494], 'benefit': [1342], 'disease.': [1345, 1362, 1500, 2297], 'Pancreaticoduodenectomy': [1346], 'offers': [1347], 'patients': [1348, 1369, 1656, 1673, 1737, 1761, 1832, 1843, 1996, 2691, 2706, 2926, 2959, 2962, 3135, 3704], 'possibility': [1350], 'cure,': [1353], 'but': [1354, 3648, 4319], 'most': [1355, 1736, 2460, 2672], 'will': [1356, 2103, 2556], 'die': [1357, 1834], 'recurrent': [1359, 1689, 1836], 'or': [1360, 1690, 1741, 1850, 2515, 2598, 3619, 3691], 'metastatic': [1361, 1365, 1401, 1568, 1691, 1837, 2313, 3671, 3760, 3776, 3789, 3814, 4081, 4441], 'Hence,': [1363, 1751], 'preventing': [1364], 'disease': [1366, 1569, 1660, 1692, 1838, 1914, 2190, 2314, 3539, 3761, 3790, 3815], 'these': [1368, 1415, 1720, 1829, 2285, 2320, 2588, 2674, 3063, 4281, 4298, 4371, 4388, 4464], 'would': [1370, 2262], 'be': [1371, 1565, 1777, 1801, 1857, 1872, 2068, 2495, 2552, 2557, 2585, 2680, 2748, 3040, 3535, 3556, 4016, 4161, 4230], 'benefit.': [1374], 'Using': [1375, 1555, 3425], 'principal': [1376], 'component': [1377], 'analysis': [1378, 2712, 2866, 2947, 3092, 3158, 3203, 3241, 3277, 3677], '(PCA),': [1379], 'we': [1380, 2392, 2610, 2791, 2861, 2868, 2941, 3415, 3428, 3484, 3506, 3565, 3641, 3673, 3711, 4083, 4104, 4129, 4184, 4332, 4393, 4427, 4444], 'identified': [1381, 1506, 2731], 'signature': [1384, 1532, 2711, 2729, 2850, 3175, 3721, 3810, 3825, 3853, 4009], 'associated': [1385, 1452, 1550, 1778, 2217, 2765, 3041, 3284, 3409, 3491, 3513], 'with': [1386, 1434, 1447, 1453, 1551, 1590, 1622, 1735, 1779, 1975, 1997, 2126, 2218, 2390, 2412, 2595, 2633, 2692, 2707, 2766, 2823, 2852, 2884, 2935, 2973, 3042, 3117, 3133, 3136, 3154, 3187, 3214, 3231, 3249, 3263, 3265, 3285, 3330, 3358, 3410, 3492, 3514, 3626, 3875, 3898, 4012, 4277, 4324], 'poor': [1387, 1552, 1780, 1959, 2641, 2688, 2703, 2767, 2853, 2975, 3008, 3043, 3077, 3086], 'patient': [1388, 1553, 1876, 2936, 3061], 'resectable': [1391, 1499, 1831, 2645, 3089], 'patients.': [1392, 3447], 'We': [1393, 2812, 2842, 2908, 2951, 4239, 4256], 'found': [1394, 1563, 1798, 2397, 3038, 3485, 3644, 4014, 4345, 4445], 'expression': [1397, 1543, 1572, 2763, 2779, 2846, 2916, 2971, 3026, 3072, 3107, 3120, 3139, 3217, 3233, 3252, 3267, 3667, 3772, 3797, 3971, 4097, 4124, 4135, 4152, 4292, 4307, 4386], 'upregulated': [1399], 'tumors': [1402, 1438, 1942, 1969, 2116, 2214, 2292, 3348, 3361, 3367, 3379, 3398, 3679, 3749], 'from': [1403, 3095, 3716, 3827, 3850, 3880, 4113, 4436], 'Pdx1-Cre': [1404, 3588, 3599, 4114, 4437], 'KrasG12D/+': [1405, 3600, 4115], 'Trp53R172H/+': [1406], '(KPC)': [1407, 3891, 4440], 'mice': [1408, 1416, 1446, 1584, 2289, 2300, 2399, 2411, 2431, 3601, 3621, 3745, 3757], 'suppressed': [1417, 1422], 'metastasis.': [1418, 1530, 2353], 'Mechanistically,': [1419], 'both': [1423, 4106], 'migration': [1424, 2471, 3475, 4091, 4138, 4252], 'invasion': [1426, 1643, 2351, 2473, 3386, 3523, 3801, 3871, 3931, 3960, 4068, 4216, 4349, 4369], 'KPC': [1428, 1445, 3756, 3881, 3926, 4107, 4140, 4155, 4171, 4214, 4340, 4407], 'cells.': [1429], 'also': [1432, 1928, 1964, 2203, 2590, 4428], 'synergized': [1433], 'gemcitabine': [1435, 1594], 'kill': [1437], 'significantly': [1440, 3123, 3183, 3225, 3259, 3283, 3490, 3512, 3893, 3929, 3958, 4153, 4347], 'prolonged': [1441], 'tumor-free': [1442], 'early-stage': [1448], 'tumors.': [1449, 1471, 4118, 4442], 'This': [1450, 1782, 1889, 1951, 3526, 3729], 'was': [1451, 1540, 1549, 1562, 1573, 2713, 2730, 2764, 2780, 2831, 2981, 3489, 3511, 3972, 4125], 'stromal': [1454, 1525, 1596, 1887, 1985], 'alterations,': [1455, 1597], 'increased': [1457, 1464, 1521, 2180, 2762, 2778, 3515], 'vasculature': [1458, 1961], 'decreased': [1460, 2520, 3184, 3226, 3260], 'fibrillar': [1461, 3280, 3420, 3487, 3509, 3532], 'collagen,': [1462], 'infiltration': [1465, 1600], 'macrophages': [1467], 'neutrophils': [1469, 2212], 'into': [1470, 2750, 3925, 3954], 'Therefore,': [1472, 2319], 'able': [1476], 'reverse': [1478, 2671], 'PDAC': [1485, 1539, 1576, 1799, 1882, 1999, 2308, 2658, 2694, 3090, 3290, 3538, 3603, 3808, 3876, 4099], 'inherently': [1486, 2659], 'refractory': [1487, 2660], 'conventional': [1489, 2662], 'therapies': [1490, 2283, 2330], 'targeting': [1492, 2333, 2491, 3579, 3923], 'could': [1494, 2600, 2737, 2747, 2874, 3651, 4160, 4229], 'improve': [1495, 1712], 'outcome': [1496, 1713], 'surgically': [1498, 1658, 1830, 2644], 'Synopsis': [1501], 'Lysyl': [1502], 'oxidase': [1503, 2018], '(LOX)': [1504, 2019], 'as': [1507, 1988, 2027, 2211, 2323, 2546, 2617, 3073, 3912, 3942, 3997, 4039], 'therapeutic': [1509, 1860, 2498, 2620, 2683, 3999], 'target': [1510, 2621, 4000], '(PDAC).': [1515], 'Inhibition': [1516, 1579, 4167], 'resulted': [1519, 4194, 4415], 'changes': [1526, 3668, 3699, 3773], 'reduction': [1528, 4026, 4176], 'A': [1531, 1878, 4461], 'hazardous': [1534, 2755, 2794, 2816, 3112, 4007], 'protective': [1536, 2771, 2796, 2829], 'genes': [1537, 4013], 'defined.': [1541], 'High': [1542], 'hypoxia-associated': [1545], 'genes,': [1546, 3113], 'LOX,': [1548, 2612, 4472], 'prognosis.': [1554, 1781], 'transgenic': [1556, 1583], 'mouse': [1557, 2136, 2523, 3571, 3709, 3724, 3739, 3817, 3828], 'models': [1558, 2137, 2325, 2524, 3572, 3818, 4390], 'PDAC,': [1560, 2183, 2708, 3574, 4082], 'overexpressed': [1566, 3787, 4017], 'its': [1571, 2881, 2891], 'required': [1574, 3799, 4064, 4126], 'cell': [1577, 1599, 2133, 2469, 3474, 3878, 3886, 4029, 4090, 4100, 4108, 4156, 4215, 4299, 4315, 4389, 4450], 'invasion.': [1578], 'inhibited': [1585], 'metastasis,': [1586], 'while': [1587, 2184, 4412], 'combination': [1588, 2632], 'therapy': [1589], 'induced': [1595, 2069], 'immune': [1598, 1893], 'tumor': [1602, 1918, 1933, 1960, 2172, 2270, 2278, 2543, 2605, 2629, 3516, 3720, 3829, 3877, 3896, 3927, 3956, 4366], 'necrosis': [1603, 2630], 'improved': [1605], 'survival.': [1606], 'Introduction': [1607, 3920, 3950], 'death': [1618], 'around': [1623], '7,000': [1624], 'cases': [1625, 3094, 3161, 3206, 3244], 'being': [1626, 3015], 'diagnosed': [1627], 'every': [1628], 'year': [1629], '(Mukherjee': [1630], 'et': [1631, 1667, 1694, 1723, 1727, 1748, 1906, 1948, 1971, 2001, 2033, 2037, 2059, 2085, 2089, 2093, 2118, 2139, 2160, 2193, 2197, 2231, 2235, 2239, 2316, 2374, 2378, 2382, 2386, 2418, 2422, 2455, 2526, 2530, 2534, 2722, 2809, 2901, 2905, 2928, 2995, 3003, 3477, 3608, 3637, 3658, 4218], 'al,': [1632, 1668, 1695, 1724, 1728, 1749, 1907, 1949, 1972, 2002, 2034, 2038, 2060, 2086, 2090, 2094, 2119, 2140, 2161, 2194, 2198, 2232, 2236, 2240, 2317, 2375, 2379, 2383, 2387, 2419, 2423, 2456, 2527, 2531, 2535, 2723, 2810, 2902, 2906, 2929, 2996, 3004, 3478, 3609, 3638, 3659, 4219], '2008).': [1633], 'almost': [1639, 1686], 'universally': [1640], 'lethal.': [1641], 'Aggressive': [1642], 'early': [1645, 1767, 2571], 'metastases': [1646], 'are': [1647, 1675, 1864, 2245, 2879, 3341, 3576, 3910, 3940, 4010, 4046], 'characteristic': [1648, 1879], 'disease,': [1651, 2502, 3672], 'such': [1652, 1987, 2026, 2210], '80–90%': [1654], 'have': [1657, 1797, 1981, 1992, 2104, 2148, 2359, 2395, 2505, 2963, 3182, 3224, 3258, 3349, 3368, 3387, 3642, 4257], 'unresectable': [1659], 'at': [1661, 1705, 2332, 4232], 'time': [1663], 'diagnosis': [1665], '(Giovinazzo': [1666, 1747], '2012).': [1669, 1750, 2061, 2199, 2241, 2724], 'majority': [1671, 2485, 3743], 'who': [1674, 1833], 'selected': [1676, 2862], 'undergo': [1678], 'potentially': [1679, 1772], 'curative': [1680], 'resection': [1681], 'small,': [1683], 'localized': [1684], 'lesions': [1685], 'inevitably': [1687], 'develop': [1688, 2291, 2447, 3602, 3623], '(Yeo': [1693], '2002),': [1696], 'presumably': [1697], 'due': [1698], 'presence': [1701, 2207], 'undetected': [1703], 'micro-metastases': [1704], 'initial': [1706], 'diagnosis.': [1707], 'Adjuvant': [1708], '(post-operative)': [1709], 'chemotherapy': [1710, 1945], 'can': [1711, 2076, 2321, 2648, 2670], 'despite': [1714], 'modest': [1716], 'anti-tumor': [1717], 'agents': [1721, 1946], '(Neoptolemos': [1722], '2004;': [1725, 2376], 'Stocken': [1726], '2005).': [1729, 2811], 'Nevertheless,': [1730], 'overall': [1731, 2910], 'remains': [1733], 'disappointing': [1734], 'developing': [1738], 'local': [1739], 'recurrence': [1740, 1768], 'extra-pancreatic': [1742], 'within': [1744, 2213], '2': [1745, 4056], 'years': [1746], 'there': [1752, 2006, 2244], 'requirement': [1755, 4210], 'biomarkers': [1757], 'predict/prognosticate': [1759], 'those': [1760, 3134, 3153, 3188, 3230, 3264], 'do': [1763], 'not': [1764, 2476, 3649, 4268, 4320], 'succumb': [1765], 'post-resection': [1769], 'identify': [1771, 2611, 2783, 3460], 'targetable': [1773], 'pathways': [1774], 'may': [1776, 1856, 1871, 1963, 2494, 2679, 3467, 3534, 3555], 'has': [1783, 2007, 2063, 2144, 2367, 2427, 2462, 2475, 2518, 3455], 'been': [1784, 2008, 2065, 2145, 2428, 2964, 3456], 'even': [1786], 'important': [1788, 2559, 2619, 3536, 3557], 'recent': [1790, 1922, 2503], 'sequencing': [1791], 'studies': [1792, 1923, 1980, 2098, 2358, 2487, 2504, 2537, 2589], 'cancer,': [1795, 2575, 2624], 'which': [1796, 1962, 2049, 2327, 2562, 2577, 2627, 2761, 2777, 3466, 3575], 'very': [1802, 1958, 2558], 'complex': [1803, 2274], 'contain': [1805], 'multiple': [1806, 3060, 3780], 'low-frequency': [1807], 'mutations': [1808, 1818, 2304, 2342, 2372], 'unknown': [1810], 'functional': [1811, 4034, 4431], 'significance.': [1812], 'Moreover,': [1813, 2979], 'none': [1814], 'major': [1817], '(KRAS,': [1819], 'TP53,': [1820], 'SMAD4': [1821], 'INK4A)': [1823], 'currently': [1824], 'confer': [1825], 'opportunities.': [1827], 'Importantly,': [1828, 2635], 'represent': [1839], 'set': [1841, 2756, 2772, 2806, 3049, 3110], 'where': [1844, 2960], 'suppression': [1845, 1851], '(either': [1848], 'prevention': [1849], 'growth': [1853, 1919, 4405, 4418], 'micro-metastasis)': [1855], 'realistic': [1859], 'option': [1861, 2499], 'trials': [1863], 'underway': [1865], 'test': [1867, 2329], 'whether': [1868, 2478, 3697, 4122], 'SRC': [1869, 2129, 4178, 4191, 4212, 4237], 'inhibitors': [1870, 2130], 'beneficial': [1873], 'set.': [1877], 'feature': [1880], 'highly': [1885], 'desmoplastic': [1886, 2259], 'microenvironment.': [1888], 'stroma': [1890, 1927, 2261, 2335, 2493, 2544, 2566, 2877], 'consists': [1891], 'cells,': [1894, 1934], 'collagen': [1895, 2051, 3281, 3352, 3371, 3390, 3413, 3421, 3436, 3454, 3461, 3488, 3510, 3533, 3550], 'fibronectin': [1897], 'laid': [1898], 'down': [1899], 'fibroblasts': [1901], 'stellate': [1903], 'cells': [1904, 2153, 3897, 3928, 3957, 4111, 4141, 4172, 4247, 4266, 4282, 4341, 4353, 4367, 4372, 4408, 4421, 4435], '(Chu': [1905], '2007).': [1908], 'In': [1909, 2607, 3481, 3559, 3661, 4375, 4425], 'addition': [1910, 3592], 'contributing': [1912], 'progression,': [1915], 'promoting': [1917, 2173], 'invasion,': [1921, 4093, 4128], 'suggest': [1924, 2099, 2538, 4073], 'limits': [1929], 'delivery': [1931], 'partly': [1935], 'explaining': [1936], 'profound': [1938], 'resistance': [1939], 'systemic': [1944], '(Olive': [1947, 1970, 2373], '2009).': [1950, 1973, 3480], 'situation': [1952], 'worse': [1955], 'limit': [1965], 'access': [1967], 'Consistent': [1974, 2389], 'this,': [1976, 2391, 2726, 3564, 4103], 'number': [1978, 4030, 4462], 'shown': [1982, 2066, 2360, 2506, 3911, 3941, 4038, 4259], 'potential': [1984, 2106, 2784], 'markers': [1986], 'S100A2': [1989], 'A4': [1991], 'prognostic': [1993], 'value': [1994], 'resected': [1998, 2693], '(Jamieson': [2000, 2994], '2011).': [2003, 2907], 'More': [2004], 'recently,': [2005], 'great': [2009], 'interest': [2010], 'role': [2013, 3069, 4075], 'enzyme': [2016, 2048], 'lysyl': [2017], 'driving': [2021], 'epithelial': [2024], 'cancers': [2025, 2646], 'breast': [2028, 2896], 'colorectal': [2030], '(Payne': [2032, 2084, 2900], '2005;': [2035, 2087, 2380, 2903], 'Baker': [2036, 2092, 2904], '2011;': [2039], 'Cox': [2040, 2121], 'Erler,': [2042, 2123], '2013).': [2043, 2096, 2162, 2930], 'copper-dependent': [2047], 'cross-links': [2050], 'elastins': [2053], 'drive': [2055, 2567, 3652], 'tissue': [2056, 3441], 'stiffness': [2057], '(Barker': [2058], 'It': [2062, 2583], 'previously': [2064, 2396, 3458, 3643, 4258], 'hypoxia-inducible': [2071], 'factor': [2072], '1α': [2073], '(HIF1α)': [2074], 'function': [2077, 2416, 2435], 'upstream': [2078], 'SRC/FAK': [2081], 'tyrosine': [2082], 'kinases': [2083], '2006;': [2091], '2011,': [2095], 'These': [2097, 3840], 'suppress': [2108], 'rather': [2110], 'than': [2111, 2410, 3395, 3895], 'causing': [2112], 'regression': [2113], 'established': [2115], '(Cox': [2117], '2013;': [2120], '2014),': [2124], 'consistent': [2125, 4323], 'observations': [2127], 'using': [2128, 2919, 2945, 3586, 4342, 4452], 'lines': [2134, 3879, 3887, 4109, 4300, 4316], '(Morton': [2138, 2315, 2417, 3657, 4217], '2010a).': [2141], 'Additionally,': [2142, 3024], 'reported': [2146, 2429, 2519], 'direct': [2149], 'effects': [2150, 4226, 4250, 4380], 'on': [2151, 2464, 2715, 3103, 3469, 4251, 4433], 'themselves': [2154], 'through': [2155, 4142], 'regulation': [2156, 3411], 'senescence': [2158], '(Wiel': [2159], 'There': [2163], 'plethora': [2166], 'evidence': [2168], 'inflammation': [2170], 'cancer.': [2176, 3081, 3821, 4003], 'Pancreatitis': [2177], 'leads': [2178], 'risk': [2181, 3734, 3752, 3764, 3865], 'cerulein': [2185], 'promotes': [2186, 3959], 'acinar-to-ductal': [2187], 'metaplasia': [2188], 'progression': [2191, 2572, 3540], '(Guerra': [2192], '2007;': [2195], 'Rhim': [2196, 2533], 'However,': [2200, 2425, 3611], 'it': [2201, 2255, 2426, 2479, 2555], 'clear': [2204, 4303], 'leukocytes': [2209, 2267], 'often': [2216], 'good': [2220], 'prognosis': [2221, 2642, 2689, 2704, 2854, 2976, 3009, 3044, 3087, 3125], 'different': [2224, 2508], 'types': [2226], '(Caruso': [2230], '2002;': [2233], 'Schaider': [2234], '2003;': [2237], 'Thus': [2242], 'far,': [2243], 'no': [2246], 'mechanistic': [2247], 'data': [2248, 3048, 3329, 3338, 3726, 3993, 4045, 4072, 4207], 'explain': [2250, 2649], 'phenomenon,': [2252], 'nor': [2253], 'known': [2256], 'how': [2257, 2465], '"stiff"': [2260], 'affect': [2263], 'ability': [2265, 3471, 4262, 4279], 'penetrate': [2269], 'tissue.': [2271], 'Given': [2272, 4069, 4204], 'interplay': [2275], 'between': [2276, 2991, 3631, 3775], 'stroma,': [2281, 2350], 'modeling': [2282], 'systems': [2286], 'require': [2287], 'immunocompetent': [2288], 'closely': [2294], 'recapitulate': [2295], 'human': [2296, 3289, 3311, 3423, 3439, 3719, 4245], 'Genetically': [2298], 'engineered': [2299, 3570], 'carrying': [2301, 2432, 4317], 'common': [2303], 'occur': [2306, 2344], 'rapidly': [2309, 3622], 'generate': [2310, 3549], 'invasive': [2311, 3397, 3624], '2010b).': [2318, 2388, 3660], 'serve': [2322], 'excellent': [2324], 'aimed': [2331], 'assess': [2337, 4121], 'impact': [2339, 3468], 'upon': [2348], 'Our': [2354], "others'": [2356], 'previous': [2357, 2882, 4206], 'accumulating': [2363], 'mutant': [2364, 2466, 2615, 3804, 3889, 4066, 4079, 4264, 4318, 4351], 'p53': [2365, 2415, 2437, 2467, 3613, 3646, 3690, 3904, 4265, 4352, 4364], '(p53R172H)': [2366], 'gain-of-function': [2368], 'properties': [2369], 'over': [2370], 'loss-of-function': [2371, 4321, 4365], 'Jackson': [2377], 'Adorno': [2381], '2009;': [2384], 'others': [2394, 3014], 'expressing': [2400], 'p53R172H': [2401, 3890, 4439], 'display': [2402], 'far': [2404], 'higher': [2405, 3351, 3370, 3389], 'frequency': [2406], 'liver': [2408, 2453], 'loss': [2413, 2433, 2440], '2010b;': [2420], 'Weissmueller': [2421], '2014).': [2424], 'INK4': [2439], 'alongside': [2441], 'KrasG12D': [2442, 4438], 'targeted': [2443, 2511, 3616], 'pancreas': [2446, 3585], 'metastasizes': [2450], '(Bardeesy': [2454], '2006).': [2457], 'As': [2458, 3406], 'yet,': [2459], 'focused': [2463], 'facilitates': [2468], 'autonomous': [2470], 'examined': [2477, 2909], 'affects': [2480], 'tumor–stromal': [2481], 'interactions.': [2482], 'While': [2483, 3741], 'had': [2488, 3121, 3747, 3750, 3762, 4248], 'suggested': [2489, 3527], 'promising': [2497, 2682], 'dramatically': [2507], 'results.': [2509], 'Here,': [2510], 'sonic': [2512], 'hedgehog': [2513], 'depletion': [2514], 'myofibroblast': [2516], 'disruption': [2517], '(Lee': [2525], '2014;': [2528, 2532], 'Ozdemir': [2529], '2014).These': [2536], 'thinking': [2540], 'simply': [2545], 'tumor-promoting': [2548], 'entity': [2549], 'needs': [2550], 're-evaluated': [2553], 'understand': [2561], 'elements': [2563], 'chemoresistance': [2569], 'act': [2578], 'constrain': [2580], 'tumor.': [2582], 'should': [2584], 'noted': [2586], 'showed': [2591, 2820, 3507, 4301], 'subsequent': [2593], 'co-targeting': [2594], 'either': [2596], 'anti-angiogenesis': [2597], 'immunotherapy': [2599], 'then': [2601, 3843], 'lead': [2602], 'regression.': [2606], 'study,': [2609, 3483], 'driven': [2613, 3680], 'p53,': [2616, 4322], 'an': [2618, 2920, 4032], 'gemcitabine.': [2634], 'LOX–hypoxia': [2637], 'defines': [2639], 'contribute': [2655, 2701], 'making': [2657], 'cytotoxic': [2663], 'chemotherapy.': [2664], 'Most': [2665], 'importantly,': [2666], 'features,': [2675], 'suggesting': [2676], 'approach.': [2684], 'Results': [2685], 'marks': [2687, 3085], 'To': [2695, 2782, 3695], 'elucidate': [2696], 'key': [2698], 'components': [2699], 'gene': [2710, 2752, 2805, 3666, 3771], 'performed': [2714, 3874, 4429], 'transcriptome': [2717], '73': [2719], 'PDACs': [2720], '(Biankin': [2721], 'From': [2725, 2857], 'single': [2728], '(called': [2732], 'PC-1)': [2733], 'following': [2735], 'cross-validation': [2736], 'predict': [2738], 'discovery': [2742], 'cohort': [2743, 2923, 2957, 2998, 3098, 3165, 3210, 3248], '(Fig': [2744, 2855, 2938, 2977, 3503, 3524, 3766, 3791, 4287, 4354, 4373], '1A).': [2745], 'PC-1': [2746, 2799, 2819, 3718, 3809, 3852, 4008], 'split': [2749], 'two': [2751], 'sets:': [2753], '321': [2758], 'transcripts,': [2759, 2775], 'prognosis,': [2768], '238': [2774], 'beneficial.': [2781], 'biological': [2785], 'processes': [2786], 'underlying': [2787], 'signature,': [2790, 2860], 'tested': [2792], 'sets': [2797, 2988, 3727, 3994], 'overlap': [2801, 2822], 'against': [2802], 'MSigDB': [2804], 'database': [2807], '(Subramanian': [2808], 'observed': [2813, 3700, 3774], 'subset': [2817, 2830], 'numerous': [2824], 'hypoxia': [2825, 2849, 2859, 3174], 'signatures,': [2826], 'linked': [2832], 'lymphocyte': [2834], 'antigen': [2836], 'presentation': [2837], 'signatures': [2838, 3006], '(Supplementary': [2839, 2948, 3021, 3050, 4146, 4180, 4201, 4253, 4328, 4409, 4422, 4458], 'Table': [2840, 2949, 4459], 'S1).': [2841, 3023], 'confirmed': [2843, 2942, 4185, 4240], 'high': [2845, 2969, 3025, 3215, 3250], 'correlated': [2851, 2934, 2972], '1B).': [2856], 'further': [2865, 3028, 3562, 3894], 'given': [2867, 3056], 'wished': [2869], 'investigate': [2871, 3563], 'factors': [2872], 'modulate': [2875], 'targetable,': [2880], 'association': [2883], 'mesenchymal': [2886], 'subtype': [2887], 'reports': [2889], 'involvement': [2892], 'colon': [2898], 'terms': [2913], 'expanded': [2921], 'APGI': [2922, 3209], '266': [2925], '(Chou': [2927], 'Expression': [2931], '1C),': [2939], 'correlation': [2944], 'multivariate': [2946], 'S2).': [2950], 'next': [2952], 'looked': [2953], 'our': [2955, 3482, 3708, 3723, 4071, 4205, 4325], '47': [2961], 'profiled': [2965], 'once': [2967], 'again': [2968], '1D).': [2978], '1': [2982, 3901], 'out': [2983, 3675, 4334, 4395], 'only': [2985, 3596], '5': [2986], 'probe': [2987], 'overlapped': [2990], '2011)': [2997, 3005], 'Collisson': [3001], '(Collisson': [3002], '(the': [3013], 'S100A2,': [3016], 'TWIST,': [3017], 'NT5E': [3018], 'PAPPA)': [3020], 'Fig': [3022, 3051, 4147, 4181, 4202, 4254, 4329, 4357, 4410, 4423], 'family': [3030, 3785, 4295, 4312], 'members': [3031, 3781, 4296, 4313], '(LOXL1,': [3032], '2,': [3033], '3': [3034], '4)': [3036], 'were': [3037, 3705, 3786, 3831, 3842, 3873, 4467], 'S1B–E).': [3052], 'Taken': [3053], 'together,': [3054], 'reproducibility': [3058], 'across': [3059, 3833, 3859], 'cohorts,': [3062], 'findings': [3064], 'argued': [3065], 'determinant': [3075], 'Figure': [3082, 3794, 4055], '1.': [3083], 'Kaplan–Meier': [3091, 3157, 3202, 3240, 3276], 'showing': [3093, 3159, 3204, 3242, 3278, 3321, 3384, 4208], 'Australian': [3097, 3164], '(n': [3099, 3211], '=': [3100, 3147, 3200, 3212, 3256, 3271, 3274, 3297, 3363, 3381, 3400, 3501], '73)': [3101], 'delineated': [3102], 'basis': [3105], 'termed': [3114], 'PC-1.': [3115], 'Patients': [3116], 'highest': [3119, 3170], 'poorer': [3124], '(red': [3126, 3176, 3222, 3253], 'line,': [3127, 3141, 3177, 3194, 3254, 3269], 'median': [3128, 3142, 3178, 3195, 3628], 'survival:': [3129, 3143, 3179, 3196], '11.6': [3130], 'months)': [3131, 3181], 'compared': [3132, 3186, 3228, 3262, 3357], 'lowest': [3138, 3191], '(blue': [3140, 3193, 3238, 3268], '34.4': [3144], 'months,': [3145, 3295, 3499], '0.01).': [3148, 3908], 'black': [3150], 'line': [3151], 'shows': [3152], 'medium': [3155], 'expression.': [3156], 'fell': [3167], 'quartile': [3171, 3192, 3326], '11.4': [3180], '25.2': [3197], 'months;': [3198], '0.03).': [3201], '266)': [3213], 'above': [3218], '3rd': [3220], 'quantile': [3221, 3237], 'line)': [3223], 'low': [3232, 3266, 4187], 'below': [3234], '1st': [3236], 'line).': [3239], 'n': [3255, 3270], '24)': [3257], '23;': [3272], '0.005).': [3275], 'reduced': [3286, 3493, 4348, 4449], '(20': [3291, 3495], 'months': [3292, 3496], 'vs.': [3293, 3376, 3497], '28.3': [3294, 3498], '0.033).': [3298], 'Mean': [3299, 3314], 'decay': [3300, 3315, 3354, 3373, 3392], 'distance': [3301, 3316, 3355, 3374, 3393], 'second': [3304, 3323, 3431], 'harmonic': [3305, 3432, 3449], 'generation': [3306, 3450, 3530], '(SHG)': [3307, 3451], 'signal': [3308, 3434], 'emitted': [3309], 'PDAC-associated': [3312], 'collagen.': [3313], 'represented': [3318], 'boxplots': [3320], 'third': [3325], 'whiskers': [3332], 'indicating': [3333], 'maximum': [3335], 'minimum': [3337], 'points.': [3339], 'Outliers': [3340], 'indicated': [3342], 'individual': [3344, 3738], 'markers.': [3345], 'Stage': [3346, 3359], 'T3': [3347], 'mean': [3353, 3372, 3391, 3981], 'score': [3356, 3375, 3394, 3866], 'T2': [3360], '(P': [3362, 3380, 3399, 3906, 3932], '0.02).': [3364], 'Lymph': [3365], 'node-positive': [3366], 'lymph': [3377, 3518], 'node-negative': [3378], '0.047).': [3382], 'Tumors': [3383], 'vascular': [3385, 3522], 'non-vascular': [3396], '0.037).': [3401], 'Download': [3402, 3404, 4058, 4060], 'figure': [3403, 4059], 'PowerPoint': [3405, 4061], 'cross-linking,': [3414], 'assessed': [3416, 3973], 'status': [3418], 'PDAC.': [3424], 'multiphoton': [3426], 'microscopy,': [3427], 'analyzed': [3429], 'resonance': [3433], 'microarray': [3442, 3676, 3725, 4020, 4326], '(TMA)': [3443], 'consisting': [3444], '80': [3446], 'Second': [3448], 'imaging': [3452], 'used': [3457, 3566, 4105, 4130], '"signatures"': [3462], 'mammary': [3464], 'tumors,': [3465, 3779], '(Provenzano': [3476], '2006,': [3479], '0.033)': [3502], '1E).': [3504], 'Further,': [3505], 'stage,': [3517], 'node': [3519], 'spread': [3520], '1F).': [3525], 'cross-linking': [3546], 'needed': [3547], 'fibers': [3551], 'via': [3552], 'therapeutically.': [3558], 'order': [3560, 3662, 4376], 'immunocompetent,': [3567], 'autochthonous': [3568], 'genetically': [3569], 'initiated': [3577], 'Kras': [3580, 3682], 'mutation': [3581, 3683, 3685], 'murine': [3584], 'transgene.': [3589], 'Without': [3590], 'cooperating': [3594], 'mutations,': [3595], 'one-third': [3597], '500': [3605], 'days': [3606, 3635], '(Hingorani': [3607, 3636], '2003).': [3610], 'when': [3612], 'additionally': [3615], 'deletion': [3618, 3692, 3899], 'mutation,': [3620, 3647], 'latency': [3629], '120': [3632], '180': [3634], '2005)': [3639], 'loss,': [3650], 'model': [3656, 3806], 'characterize': [3664], 'underlie': [3670], 'carried': [3674, 4333, 4394], 'copy': [3688, 3902], 'p53.': [3694], 'address': [3696, 4086], 'transcriptional': [3698], 'reflected': [3706], 'models,': [3710], 'applied': [3712], 'loading': [3713, 3848], 'values': [3714, 3841, 3849], 'obtained': [3715], '(http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE67358).': [3728], 'allowed': [3730], 'us': [3731], 'derive': [3733], 'scores': [3735, 3765], 'each': [3737, 3857], 'transcriptome.': [3740], 'non-metastatic': [3748, 3778], 'negative': [3751], 'scores,': [3753], '100%': [3754], 'developed': [3759], 'positive': [3763], '2A,': [3767, 3792], 'top).': [3768], 'Of': [3769], 'bottom).': [3793], '2.': [3795], 'p53-driven': [3805, 4067, 4080], 'predictive': [3812], 'Log-transformed': [3822], 'expressions': [3823], 'transcripts': [3826, 3861], 'microarrays': [3830], 'mean-centered': [3832], 'samples': [3834], 'scaled': [3836], 'unit': [3838], 'variance.': [3839], 'multiplied': [3844], 'matching': [3847], 'summarized': [3855], 'sample': [3858], 'all': [3860], 'yield': [3863], 'sample.': [3869], 'Inverted': [3870], 'assays': [3872], 'KPflC': [3883, 3955, 4420], 'mice.': [3884], 'Tumor': [3885], 'bearing': [3888], 'invade': [3892, 4272], '(KPflC)': [3905, 4117], '≤': [3907, 3933, 3964], 'average': [3914, 3944], 'four': [3916, 3946, 3983], 'wells': [3917, 3947], '+': [3918, 3948], 'SEM.': [3919, 3949, 3989], 'shRNA': [3922, 4343], 'Lox': [3924], 'inhibits': [3930], '0.01': [3934, 3965], 'unpaired': [3936, 3967], "Student's": [3937, 3968], 't-test).': [3938, 3969], 'exogenous': [3952], '(left': [3961], 'panel,': [3962], 'immunoblotting': [3975], '(right': [3976], 'panel).': [3977], 'Columns': [3978], 'indicate': [3979, 3988], 'well': [3984, 4276], 'error': [3986], 'bars': [3987], 'Integration': [3990], 'heterogeneous': [3992], 'identifies': [3995], 'Components': [4004], 'overlaid': [4011], 'hits': [4022, 4466], 'cause': [4024], 'viable': [4028], 'RNAi': [4033], 'screen.': [4035], 'Overlap': [4036], 'proportional': [4041], 'Venn': [4042], 'diagram.': [4043], 'available': [4047], 'online': [4048], 'figure.': [4051], '[emmm201404827-sup-0012-SDataFig2.pdf]': [4057], 'decided': [4084], 'consequences': [4088], 'manipulating': [4095], 'models.': [4101], 'For': [4102], 'derived': [4112], 'p53flox/+': [4116], 'Initially,': [4119], 'siRNA': [4131], 'knockdown': [4133, 4243, 4336, 4402], 'measured': [4137], 'Matrigel': [4144], 'matrix': [4145, 4469], 'S2A).': [4148], 'Loss': [4149], 'impaired': [4154], 'migration,': [4157], 'rescued': [4162], 'recombinant': [4164], 'protein.': [4166], 'led': [4173], 'phosphorylation': [4179], 'S2B),': [4182], 'doses': [4188], 'inhibitor': [4192], 'dasatinib': [4193], 'slowing': [4197], 'wound': [4199], 'healing': [4200], 'S2C).': [4203], '2010a),': [4220], 'suggests': [4222], 'pro-migratory': [4225], 'mediated': [4231], 'least': [4233], 'part': [4235], 'activation.': [4238], 'Panc-1': [4246], 'similar': [4249], 'S2D).': [4255], '(and': [4267], 'p53-deleted': [4269], 'cells)': [4270], 'vitro': [4274], 'correlates': [4275], 'metastasize': [4284], 'vivo': [4286], '2B).': [4288], 'Analysis': [4289], 'increase': [4304], 'analyses': [4327], 'S2E).': [4330], 'Thus,': [4331], 'stable': [4335], '2C;': [4355], 'Supplementary': [4356], 'S2F).': [4358], 'Conversely,': [4359], 'overexpression': [4360, 4414], 'promoted': [4368], '2D).': [4374], 'determine': [4378], 'modulation': [4383], 'vivo,': [4392], 'series': [4397], 'allograft': [4399, 4404], 'experiments.': [4400], 'slowed': [4403], 'S2G),': [4411], 'faster': [4417], 'S2H).': [4424], 'parallel,': [4426], 'screen': [4432, 4465], 'primary': [4434], 'Overall,': [4443], '920': [4447], 'siRNAs': [4448], 'viability': [4451], 'Z-score': [4454], 'threshold': [4455], '-3': [4457], 'S3).': [4460], 'extracellular': [4468], 'components,': [4470], 'fi': [4473]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1844836761', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 26}, {'year': 2022, 'cited_by_count': 26}, {'year': 2021, 'cited_by_count': 39}, {'year': 2020, 'cited_by_count': 30}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 33}, {'year': 2017, 'cited_by_count': 23}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 4}], 'updated_date': '2025-01-11T00:48:56.969045', 'created_date': '2016-06-24'}
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