Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1840911629', 'doi': 'https://doi.org/10.18632/oncotarget.4926', 'title': 'Genetic interaction of<i>P2X7</i>receptor and<i>VEGFR-2</i>polymorphisms identifies a favorable prognostic profile in prostate cancer patients', 'display_name': 'Genetic interaction of<i>P2X7</i>receptor and<i>VEGFR-2</i>polymorphisms identifies a favorable prognostic profile in prostate cancer patients', 'publication_year': 2015, 'publication_date': '2015-08-21', 'ids': {'openalex': 'https://openalex.org/W1840911629', 'doi': 'https://doi.org/10.18632/oncotarget.4926', 'mag': '1840911629', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26337470', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4745689'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4926', 'pdf_url': 'https://www.oncotarget.com/article/4926/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/4926/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045879499', 'display_name': 'Anna Solini', 'orcid': 'https://orcid.org/0000-0002-7855-8253'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Anna Solini', 'raw_affiliation_strings': ['Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047513866', 'display_name': 'Vittorio Simeon', 'orcid': 'https://orcid.org/0000-0003-2387-4125'}, 'institutions': [{'id': 'https://openalex.org/I4210094078', 'display_name': 'Centro di Riferimento Oncologico della Basilicata', 'ror': 'https://ror.org/00n6jcj93', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094078', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Vittorio Simeon', 'raw_affiliation_strings': ['Laboratory of Pre-Clinical and Translational Research, IRCCS - CROB Referral Cancer Center of Basilicata, Rionero in Vulture, Potenza, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Pre-Clinical and Translational Research, IRCCS - CROB Referral Cancer Center of Basilicata, Rionero in Vulture, Potenza, Italy.', 'institution_ids': ['https://openalex.org/I4210094078', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054491406', 'display_name': 'Lisa Derosa', 'orcid': 'https://orcid.org/0000-0003-0527-2964'}, 'institutions': [{'id': 'https://openalex.org/I4210165410', 'display_name': 'Azienda Ospedaliera Universitaria Pisana', 'ror': 'https://ror.org/05xrcj819', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165410']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Lisa Derosa', 'raw_affiliation_strings': ['Oncology Unit 2, University Hospital of Pisa, Pisa, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Oncology Unit 2, University Hospital of Pisa, Pisa, Italy.', 'institution_ids': ['https://openalex.org/I4210165410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064835475', 'display_name': 'Paola Orlandi', 'orcid': 'https://orcid.org/0000-0002-5697-5769'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paola Orlandi', 'raw_affiliation_strings': ['Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039595222', 'display_name': 'Chiara Rossi', 'orcid': 'https://orcid.org/0000-0002-5724-268X'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Chiara Rossi', 'raw_affiliation_strings': ['Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101821292', 'display_name': 'Andrea Fontana', 'orcid': 'https://orcid.org/0000-0003-2496-2506'}, 'institutions': [{'id': 'https://openalex.org/I4210165410', 'display_name': 'Azienda Ospedaliera Universitaria Pisana', 'ror': 'https://ror.org/05xrcj819', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165410']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Andrea Fontana', 'raw_affiliation_strings': ['Oncology Unit 2, University Hospital of Pisa, Pisa, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Oncology Unit 2, University Hospital of Pisa, Pisa, Italy.', 'institution_ids': ['https://openalex.org/I4210165410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029935476', 'display_name': 'Luca Galli', 'orcid': 'https://orcid.org/0000-0001-6008-0266'}, 'institutions': [{'id': 'https://openalex.org/I4210165410', 'display_name': 'Azienda Ospedaliera Universitaria Pisana', 'ror': 'https://ror.org/05xrcj819', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165410']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luca Galli', 'raw_affiliation_strings': ['Oncology Unit 2, University Hospital of Pisa, Pisa, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Oncology Unit 2, University Hospital of Pisa, Pisa, Italy.', 'institution_ids': ['https://openalex.org/I4210165410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033055161', 'display_name': 'Teresa Di Desidero', 'orcid': 'https://orcid.org/0000-0002-5487-071X'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Teresa Di Desidero', 'raw_affiliation_strings': ['Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103498721', 'display_name': 'Anna Fioravanti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Anna Fioravanti', 'raw_affiliation_strings': ['Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089467403', 'display_name': 'Sara Lucchesi', 'orcid': None}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Sara Lucchesi', 'raw_affiliation_strings': ['Division of Medical Oncology, Pontedera Hospital, Azienda USL of Pisa, Pontedera, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Division of Medical Oncology, Pontedera Hospital, Azienda USL of Pisa, Pontedera, Italy.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089760716', 'display_name': 'Luigi Coltelli', 'orcid': 'https://orcid.org/0000-0002-5268-5107'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luigi Coltelli', 'raw_affiliation_strings': ['Division of Medical Oncology, Pontedera Hospital, Azienda USL of Pisa, Pontedera, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Division of Medical Oncology, Pontedera Hospital, Azienda USL of Pisa, Pontedera, Italy.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063379322', 'display_name': 'Laura Ginocchi', 'orcid': 'https://orcid.org/0000-0002-2278-7372'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Laura Ginocchi', 'raw_affiliation_strings': ['Division of Medical Oncology, Pontedera Hospital, Azienda USL of Pisa, Pontedera, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Division of Medical Oncology, Pontedera Hospital, Azienda USL of Pisa, Pontedera, Italy.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083540572', 'display_name': 'Giacomo Allegrini', 'orcid': None}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giacomo Allegrini', 'raw_affiliation_strings': ['Division of Medical Oncology, Pontedera Hospital, Azienda USL of Pisa, Pontedera, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Division of Medical Oncology, Pontedera Hospital, Azienda USL of Pisa, Pontedera, Italy.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083693387', 'display_name': 'Romano Danesi', 'orcid': 'https://orcid.org/0000-0002-4414-8934'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Romano Danesi', 'raw_affiliation_strings': ['Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012034272', 'display_name': 'Alfredo Falcone', 'orcid': 'https://orcid.org/0000-0001-5840-2529'}, 'institutions': [{'id': 'https://openalex.org/I4210165410', 'display_name': 'Azienda Ospedaliera Universitaria Pisana', 'ror': 'https://ror.org/05xrcj819', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165410']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alfredo Falcone', 'raw_affiliation_strings': ['Oncology Unit 2, University Hospital of Pisa, Pisa, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Oncology Unit 2, University Hospital of Pisa, Pisa, Italy.', 'institution_ids': ['https://openalex.org/I4210165410']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025020524', 'display_name': 'Guido Bocci', 'orcid': 'https://orcid.org/0000-0001-7120-9141'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Guido Bocci', 'raw_affiliation_strings': ['Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.758, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.856575, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '6', 'issue': '30', 'first_page': '28743', 'last_page': '28754'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11193', 'display_name': 'Adenosine and Purinergic Signaling', 'score': 0.9838, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.7114477}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.55773735}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.533003}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.48193192}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.44380522}, {'id': 'https://openalex.org/C153209595', 'wikidata': 'https://www.wikidata.org/wiki/Q501128', 'display_name': 'Single-nucleotide polymorphism', 'level': 4, 'score': 0.41538697}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.41451922}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30793554}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.27435136}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.23273325}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.21173164}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D058486', 'descriptor_name': 'Receptors, Purinergic P2X7', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D040301', 'descriptor_name': 'Vascular Endothelial Growth Factor Receptor-2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056726', 'descriptor_name': 'Genetic Association Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007558', 'descriptor_name': 'Italy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016016', 'descriptor_name': 'Proportional Hazards Models', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058486', 'descriptor_name': 'Receptors, Purinergic P2X7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040301', 'descriptor_name': 'Vascular Endothelial Growth Factor Receptor-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4926', 'pdf_url': 'https://www.oncotarget.com/article/4926/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4745689', 'pdf_url': 'https://europepmc.org/articles/pmc4745689?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745689', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11568/755864', 'pdf_url': 'https://arpi.unipi.it/bitstream/11568/755864.6/7/Oncotarget%202015.pdf', 'source': {'id': 'https://openalex.org/S4377196265', 'display_name': 'CINECA IRIS Institutial research information system (University of Pisa)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I108290504', 'host_organization_name': 'University of Pisa', 'host_organization_lineage': ['https://openalex.org/I108290504'], 'host_organization_lineage_names': ['University of Pisa'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26337470', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4926', 'pdf_url': 'https://www.oncotarget.com/article/4926/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.78, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1481135965', 'https://openalex.org/W1544539327', 'https://openalex.org/W1603504301', 'https://openalex.org/W1783597341', 'https://openalex.org/W1964525882', 'https://openalex.org/W1964675300', 'https://openalex.org/W1964755615', 'https://openalex.org/W1965088318', 'https://openalex.org/W1965143125', 'https://openalex.org/W1965168184', 'https://openalex.org/W1966360257', 'https://openalex.org/W1990474202', 'https://openalex.org/W1992112921', 'https://openalex.org/W1993059138', 'https://openalex.org/W1996799865', 'https://openalex.org/W2000735821', 'https://openalex.org/W2005707803', 'https://openalex.org/W2007669896', 'https://openalex.org/W2010796941', 'https://openalex.org/W2019124577', 'https://openalex.org/W2020373718', 'https://openalex.org/W2020721601', 'https://openalex.org/W2025052745', 'https://openalex.org/W2027572371', 'https://openalex.org/W2028896157', 'https://openalex.org/W2031082289', 'https://openalex.org/W2040599999', 'https://openalex.org/W2058064767', 'https://openalex.org/W2074196937', 'https://openalex.org/W2076220518', 'https://openalex.org/W2080002312', 'https://openalex.org/W2082119653', 'https://openalex.org/W2092616666', 'https://openalex.org/W2116636936', 'https://openalex.org/W2117318706', 'https://openalex.org/W2123502959', 'https://openalex.org/W2128153851', 'https://openalex.org/W2130501081', 'https://openalex.org/W2136008196', 'https://openalex.org/W2147386725', 'https://openalex.org/W2151516998', 'https://openalex.org/W2151959508', 'https://openalex.org/W2159945718', 'https://openalex.org/W2160998301', 'https://openalex.org/W2162530578', 'https://openalex.org/W2329619353', 'https://openalex.org/W257500189', 'https://openalex.org/W4249963938', 'https://openalex.org/W71725349', 'https://openalex.org/W8586986'], 'related_works': ['https://openalex.org/W4281885123', 'https://openalex.org/W3171449477', 'https://openalex.org/W299695548', 'https://openalex.org/W2407337938', 'https://openalex.org/W2391388634', 'https://openalex.org/W2384122898', 'https://openalex.org/W2345040638', 'https://openalex.org/W2335257745', 'https://openalex.org/W2070581548', 'https://openalex.org/W151774199'], 'abstract_inverted_index': {'//': [0], 'Anna': [1, 34], 'Solini': [2], '1': [3, 15, 19, 32, 36, 56, 64, 65], ',': [4, 8, 12, 16, 20, 24, 28, 33, 37, 41, 45, 49, 53, 57, 61], 'Vittorio': [5], 'Simeon': [6], '2': [7, 77], 'Lisa': [9], 'Derosa': [10], '3': [11, 23, 27, 60, 97], 'Paola': [13], 'Orlandi': [14], 'Chiara': [17], 'Rossi': [18], 'Andrea': [21], 'Fontana': [22], 'Luca': [25], 'Galli': [26], 'Teresa': [29], 'Di': [30], 'Desidero': [31], 'Fioravanti': [35], 'Sara': [38], 'Lucchesi': [39], '4': [40, 44, 48, 52, 107], 'Luigi': [42], 'Coltelli': [43], 'Laura': [46], 'Ginocchi': [47], 'Giacomo': [50], 'Allegrini': [51], 'Romano': [54], 'Danesi': [55], 'Alfredo': [58], 'Falcone': [59], 'Guido': [62, 122], 'Bocci': [63], 'Department': [66], 'of': [67, 73, 79, 90, 103, 109, 116, 168, 199, 251, 313], 'Clinical': [68], 'and': [69, 81, 151, 165, 184, 189, 214, 259, 275, 284, 302], 'Experimental': [70], 'Medicine,': [71], 'University': [72, 101], 'Pisa,': [74, 75, 104, 105, 117], 'Italy': [76, 96, 106, 119], 'Laboratory': [78], 'Pre-clinical': [80], 'Translational': [82], 'Research,': [83], 'IRCCS': [84], '-': [85], 'CROB': [86], 'Referral': [87], 'Cancer': [88], 'Center': [89], 'Basilicata,': [91], 'Rionero': [92], 'in': [93, 196], 'Vulture,': [94], 'Potenza,': [95], 'Oncology': [98], 'Unit': [99], '2,': [100], 'Hospital': [102], 'Division': [108], 'Medical': [110], 'Oncology,': [111], 'Pontedera': [112], 'Hospital,': [113], 'Azienda': [114], 'USL': [115], 'Pontedera,': [118], 'Correspondence': [120], 'to:': [121], 'Bocci,': [123], 'e-mail:': [124], '[email protected]': [125], 'Keywords:': [126], 'survival': [127, 194, 223], 'dimensionality': [128, 224], 'reduction': [129, 225], 'analysis,': [130], 'P2X7': [131], 'receptor,': [132], 'VEGFR-2,': [133], 'polymorphisms,': [134], 'prostate': [135, 169, 201, 314], 'cancer': [136, 202, 315], 'Received:': [137], 'April': [138], '07,': [139], '2015': [140, 144, 148], 'Accepted:': [141], 'August': [142, 146], '10,': [143], 'Published:': [145], '21,': [147], 'ABSTRACT': [149], 'VEGFR-2': [150, 183, 256, 299], 'P2X': [152, 185, 260, 303], '7': [153, 156, 186, 261, 304], 'receptor': [154], '(P2X': [155], 'R)': [157], 'have': [158], 'been': [159, 175], 'described': [160], 'to': [161, 177, 230], 'stimulate': [162], 'the': [163, 179, 232, 252, 282, 285], 'angiogenesis': [164], 'inflammatory': [166], 'processes': [167], 'cancer.': [170], 'The': [171, 222, 242, 266, 294], 'present': [172], 'study': [173], 'has': [174], 'performed': [176, 206], 'investigate': [178, 231], 'genetic': [180, 233, 247, 287, 295], 'interactions': [181], 'among': [182], 'R': [187, 262, 305], 'SNPs': [188, 215], 'their': [190], 'correlation': [191], 'with': [192, 317], 'overall': [193], '(OS)': [195], 'a': [197, 311, 318], 'population': [198, 312], 'metastatic': [200], 'patients.': [203], 'Analyses': [204], 'were': [205, 216, 240], 'on': [207], 'germline': [208], 'DNA': [209], 'obtained': [210], 'from': [211], 'blood': [212], 'samples': [213], 'investigated': [217], 'by': [218], 'real-time': [219], 'PCR': [220], 'technique.': [221], '(SDR)': [226], 'methodology': [227], 'was': [228, 269], 'applied': [229], 'interaction': [234, 248, 297], 'between': [235, 254, 298], 'SNPs.': [236], 'One': [237], 'hundred': [238], 'patients': [239, 316], 'enrolled.': [241], 'SDR': [243], 'software': [244], 'provided': [245], 'two': [246], 'profiles': [249], 'consisting': [250], 'combination': [253], 'specific': [255], '(rs2071559,': [257, 300], 'rs11133360)': [258, 301], '(rs3751143,': [263, 306], 'rs208294)': [264, 307], 'genotypes.': [265], 'median': [267], 'OS': [268], '126': [270], 'months': [271, 277], '(95%': [272, 278], 'CI,': [273, 279], '115.94–152.96)': [274], '65.65': [276], '52.95–76.53)': [280], 'for': [281], 'favorable': [283], 'unfavorable': [286], 'profile,': [288], 'respectively': [289], '(': [290], 'p': [291], '<': [292], '0.0001).': [293], 'statistical': [296], 'genotypes': [308], 'may': [309], 'identify': [310], 'better': [319], 'prognosis.': [320]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1840911629', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-12-08T11:10:46.158734', 'created_date': '2016-06-24'}