Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1838829111', 'doi': 'https://doi.org/10.18632/oncotarget.3377', 'title': 'Multiple mechanisms of MYCN dysregulation in Wilms tumour', 'display_name': 'Multiple mechanisms of MYCN dysregulation in Wilms tumour', 'publication_year': 2015, 'publication_date': '2015-01-31', 'ids': {'openalex': 'https://openalex.org/W1838829111', 'doi': 'https://doi.org/10.18632/oncotarget.3377', 'mag': '1838829111', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25749049', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4466681'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3377', 'pdf_url': 'https://www.oncotarget.com/article/3377/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/3377/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003107599', 'display_name': 'Richard D. Williams', 'orcid': 'https://orcid.org/0000-0002-7710-2975'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Richard D. Williams', 'raw_affiliation_strings': ['UCL Institute of Child Health, London, UK'], 'affiliations': [{'raw_affiliation_string': 'UCL Institute of Child Health, London, UK', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043094453', 'display_name': 'Tasnim Chagtai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Tasnim Chagtai', 'raw_affiliation_strings': ['UCL Institute of Child Health, London, UK'], 'affiliations': [{'raw_affiliation_string': 'UCL Institute of Child Health, London, UK', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010741060', 'display_name': 'Marisa Alcaide-German', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Marisa Alcaide-German', 'raw_affiliation_strings': ['UCL Institute of Child Health, London, UK'], 'affiliations': [{'raw_affiliation_string': 'UCL Institute of Child Health, London, UK', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017969996', 'display_name': 'John Apps', 'orcid': 'https://orcid.org/0000-0001-7902-482X'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'John Apps', 'raw_affiliation_strings': ['UCL Institute of Child Health, London, UK'], 'affiliations': [{'raw_affiliation_string': 'UCL Institute of Child Health, London, UK', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044647886', 'display_name': 'Jenny Wegert', 'orcid': 'https://orcid.org/0009-0009-4505-5519'}, 'institutions': [{'id': 'https://openalex.org/I4210100919', 'display_name': 'Comprehensive Cancer Center Mainfranken', 'ror': 'https://ror.org/013tmk464', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I25974101', 'https://openalex.org/I4210100919', 'https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jenny Wegert', 'raw_affiliation_strings': ['Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry and Comprehensive Cancer Center Mainfranken, Wuerzburg University, Wuerzburg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry and Comprehensive Cancer Center Mainfranken, Wuerzburg University, Wuerzburg, Germany.', 'institution_ids': ['https://openalex.org/I4210100919']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101512344', 'display_name': 'Sergey Popov', 'orcid': 'https://orcid.org/0000-0003-1172-3557'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sergey Popov', 'raw_affiliation_strings': ['Institute of Cancer Research, Sutton, Surrey, UK.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Research, Sutton, Surrey, UK.', 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069561562', 'display_name': 'Gordan Vujanić', 'orcid': 'https://orcid.org/0000-0003-0726-6939'}, 'institutions': [{'id': 'https://openalex.org/I79510175', 'display_name': 'Cardiff University', 'ror': 'https://ror.org/03kk7td41', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79510175']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gordan Vujanic', 'raw_affiliation_strings': ['Cardiff University, School of Medicine, Heath Park, Cardiff, UK.'], 'affiliations': [{'raw_affiliation_string': 'Cardiff University, School of Medicine, Heath Park, Cardiff, UK.', 'institution_ids': ['https://openalex.org/I79510175']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031176507', 'display_name': 'Harm van Tinteren', 'orcid': 'https://orcid.org/0000-0002-4626-8702'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Harm van Tinteren', 'raw_affiliation_strings': ['Biometrics Department, Netherlands Cancer Institute, Antonie van Leeuwenhoek Ziekenhuis, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Biometrics Department, Netherlands Cancer Institute, Antonie van Leeuwenhoek Ziekenhuis, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I2898336195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035945818', 'display_name': 'Marry M. van den Heuvel‐Eibrink', 'orcid': 'https://orcid.org/0000-0002-7760-879X'}, 'institutions': [{'id': 'https://openalex.org/I4210142620', 'display_name': 'Erasmus MC - Sophia Children’s Hospital', 'ror': 'https://ror.org/047afsm11', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686', 'https://openalex.org/I4210142620']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Marry M. van den Heuvel-Eibrink', 'raw_affiliation_strings': ["Department of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatric Oncology/Hematology, Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands", 'institution_ids': ['https://openalex.org/I4210142620']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073211182', 'display_name': 'Marcel Kool', 'orcid': 'https://orcid.org/0000-0002-6557-5468'}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Marcel Kool', 'raw_affiliation_strings': ['German Cancer Research Centre, Heidelberg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'German Cancer Research Centre, Heidelberg, Germany.', 'institution_ids': ['https://openalex.org/I17937529']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109211632', 'display_name': 'Jan de Kraker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802928900', 'display_name': 'Academic Medical Center', 'ror': 'https://ror.org/03t4gr691', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802928900', 'https://openalex.org/I4210151833']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jan de Kraker', 'raw_affiliation_strings': ['Academic Medical Center, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Academic Medical Center, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I2802928900']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021648287', 'display_name': 'David Gisselsson', 'orcid': 'https://orcid.org/0000-0002-0301-426X'}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'David Gisselsson', 'raw_affiliation_strings': ['Department of Clinical Genetics, Lund University, Sweden.'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Genetics, Lund University, Sweden.', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029830172', 'display_name': 'Norbert Graf', 'orcid': 'https://orcid.org/0000-0002-2248-323X'}, 'institutions': [{'id': 'https://openalex.org/I91712215', 'display_name': 'Saarland University', 'ror': 'https://ror.org/01jdpyv68', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I91712215']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Norbert Graf', 'raw_affiliation_strings': ['Department of Paediatric Oncology and Haematology, Saarland University Hospital, Homburg/Saar, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Paediatric Oncology and Haematology, Saarland University Hospital, Homburg/Saar, Germany.', 'institution_ids': ['https://openalex.org/I91712215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079767149', 'display_name': 'Manfred Gessler', 'orcid': 'https://orcid.org/0000-0002-7915-6045'}, 'institutions': [{'id': 'https://openalex.org/I4210100919', 'display_name': 'Comprehensive Cancer Center Mainfranken', 'ror': 'https://ror.org/013tmk464', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I25974101', 'https://openalex.org/I4210100919', 'https://openalex.org/I4210126310']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Manfred Gessler', 'raw_affiliation_strings': ['Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry and Comprehensive Cancer Center Mainfranken, Wuerzburg University, Wuerzburg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry and Comprehensive Cancer Center Mainfranken, Wuerzburg University, Wuerzburg, Germany.', 'institution_ids': ['https://openalex.org/I4210100919']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035410237', 'display_name': 'Kathy Pritchard‐Jones', 'orcid': 'https://orcid.org/0000-0002-2384-9475'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Kathy Pritchard-Jones', 'raw_affiliation_strings': ['UCL Institute of Child Health, London, UK'], 'affiliations': [{'raw_affiliation_string': 'UCL Institute of Child Health, London, UK', 'institution_ids': ['https://openalex.org/I45129253']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 10, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.551, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 89, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '9', 'first_page': '7232', 'last_page': '7243'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12140', 'display_name': 'Renal and related cancers', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12140', 'display_name': 'Renal and related cancers', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T14437', 'display_name': 'Ethics and Legal Issues in Pediatric Healthcare', 'score': 0.9873, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11141', 'display_name': "Childhood Cancer Survivors' Quality of Life", 'score': 0.9369, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/anaplasia', 'display_name': 'Anaplasia', 'score': 0.81072295}, {'id': 'https://openalex.org/keywords/exome', 'display_name': 'Exome', 'score': 0.42708868}, {'id': 'https://openalex.org/keywords/gene-dosage', 'display_name': 'Gene dosage', 'score': 0.42208585}, {'id': 'https://openalex.org/keywords/targeted-therapy', 'display_name': 'Targeted Therapy', 'score': 0.41563433}], 'concepts': [{'id': 'https://openalex.org/C2780263296', 'wikidata': 'https://www.wikidata.org/wiki/Q486082', 'display_name': 'Anaplasia', 'level': 2, 'score': 0.81072295}, {'id': 'https://openalex.org/C2775999222', 'wikidata': 'https://www.wikidata.org/wiki/Q756289', 'display_name': "Wilms' tumor", 'level': 2, 'score': 0.6751939}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5926261}, {'id': 'https://openalex.org/C134305767', 'wikidata': 'https://www.wikidata.org/wiki/Q725508', 'display_name': 'Somatic cell', 'level': 3, 'score': 0.5594365}, {'id': 'https://openalex.org/C13514818', 'wikidata': 'https://www.wikidata.org/wiki/Q5552256', 'display_name': 'Germline mutation', 'level': 4, 'score': 0.54362005}, {'id': 'https://openalex.org/C16671776', 'wikidata': 'https://www.wikidata.org/wiki/Q5420592', 'display_name': 'Exome sequencing', 'level': 4, 'score': 0.5076152}, {'id': 'https://openalex.org/C109825262', 'wikidata': 'https://www.wikidata.org/wiki/Q1139164', 'display_name': 'Germline', 'level': 3, 'score': 0.49760917}, {'id': 'https://openalex.org/C120821319', 'wikidata': 'https://www.wikidata.org/wiki/Q1501491', 'display_name': 'Copy-number variation', 'level': 4, 'score': 0.49474213}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.463048}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45364213}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4486742}, {'id': 'https://openalex.org/C10590036', 'wikidata': 'https://www.wikidata.org/wiki/Q417664', 'display_name': 'Exome', 'level': 5, 'score': 0.42708868}, {'id': 'https://openalex.org/C55548728', 'wikidata': 'https://www.wikidata.org/wiki/Q1465102', 'display_name': 'Gene dosage', 'level': 4, 'score': 0.42208585}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.42183998}, {'id': 'https://openalex.org/C2781230642', 'wikidata': 'https://www.wikidata.org/wiki/Q492646', 'display_name': 'Targeted therapy', 'level': 3, 'score': 0.41563433}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.4102241}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.32182688}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.29935217}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.20228234}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.1634239}], 'mesh': [{'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059472', 'descriptor_name': 'Exome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018628', 'descriptor_name': 'Gene Dosage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016259', 'descriptor_name': 'Genes, myc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016158', 'descriptor_name': 'Genes, p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009364', 'descriptor_name': 'Neoplasm Recurrence, Local', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017354', 'descriptor_name': 'Point Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000090063', 'descriptor_name': 'Proto-Oncogene Mas', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009396', 'descriptor_name': 'Wilms Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3377', 'pdf_url': 'https://www.oncotarget.com/article/3377/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4466681', 'pdf_url': 'https://europepmc.org/articles/pmc4466681?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466681', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-143471', 'pdf_url': 'https://opus.bibliothek.uni-wuerzburg.de/files/14347/029_Williams_ONCOTARGET.pdf', 'source': {'id': 'https://openalex.org/S4306401635', 'display_name': 'Online Publication Service of Würzburg University (Würzburg University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I25974101', 'host_organization_name': 'University of Würzburg', 'host_organization_lineage': ['https://openalex.org/I25974101'], 'host_organization_lineage_names': ['University of Würzburg'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://lup.lub.lu.se/record/5265054', 'pdf_url': 'https://lup.lub.lu.se/search/files/3206935/8055119.pdf', 'source': {'id': 'https://openalex.org/S4306400536', 'display_name': 'Lund University Publications (Lund University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I187531555', 'host_organization_name': 'Lund University', 'host_organization_lineage': ['https://openalex.org/I187531555'], 'host_organization_lineage_names': ['Lund University'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://portal.research.lu.se/files/3206935/8055119.pdf', 'pdf_url': 'https://portal.research.lu.se/files/3206935/8055119.pdf', 'source': {'id': 'https://openalex.org/S4306400536', 'display_name': 'Lund University Publications (Lund University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I187531555', 'host_organization_name': 'Lund University', 'host_organization_lineage': ['https://openalex.org/I187531555'], 'host_organization_lineage_names': ['Lund University'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25749049', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3377', 'pdf_url': 'https://www.oncotarget.com/article/3377/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.77, 'id': 'https://metadata.un.org/sdg/1', 'display_name': 'No poverty'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W112404563', 'https://openalex.org/W1546952499', 'https://openalex.org/W1563940013', 'https://openalex.org/W1653566857', 'https://openalex.org/W1976133851', 'https://openalex.org/W1980740976', 'https://openalex.org/W1984068087', 'https://openalex.org/W1984086686', 'https://openalex.org/W1993951035', 'https://openalex.org/W1995541594', 'https://openalex.org/W1997051770', 'https://openalex.org/W1999149586', 'https://openalex.org/W2007439143', 'https://openalex.org/W2021341670', 'https://openalex.org/W2024187144', 'https://openalex.org/W2024733621', 'https://openalex.org/W2025183726', 'https://openalex.org/W2026715510', 'https://openalex.org/W2031760182', 'https://openalex.org/W2042644193', 'https://openalex.org/W2045981557', 'https://openalex.org/W2048838478', 'https://openalex.org/W2056881795', 'https://openalex.org/W2062696188', 'https://openalex.org/W2064068907', 'https://openalex.org/W2065517576', 'https://openalex.org/W2081924229', 'https://openalex.org/W2082904471', 'https://openalex.org/W2084214818', 'https://openalex.org/W2092741708', 'https://openalex.org/W2095579742', 'https://openalex.org/W2096791516', 'https://openalex.org/W2101870168', 'https://openalex.org/W2103441770', 'https://openalex.org/W2103648100', 'https://openalex.org/W2106133720', 'https://openalex.org/W2106608030', 'https://openalex.org/W2115919763', 'https://openalex.org/W2117131162', 'https://openalex.org/W2119180969', 'https://openalex.org/W2120258802', 'https://openalex.org/W2124601182', 'https://openalex.org/W2126880094', 'https://openalex.org/W2132546867', 'https://openalex.org/W2138601221', 'https://openalex.org/W2139320672', 'https://openalex.org/W2147526198', 'https://openalex.org/W2148069086', 'https://openalex.org/W2149497955', 'https://openalex.org/W2154097321', 'https://openalex.org/W2158435278', 'https://openalex.org/W2160697532', 'https://openalex.org/W2163743218', 'https://openalex.org/W2167532631', 'https://openalex.org/W2171862017', 'https://openalex.org/W4242743062'], 'related_works': ['https://openalex.org/W4394757508', 'https://openalex.org/W4392513024', 'https://openalex.org/W3028606754', 'https://openalex.org/W2762217692', 'https://openalex.org/W2371815150', 'https://openalex.org/W2351007721', 'https://openalex.org/W2261357522', 'https://openalex.org/W2184337485', 'https://openalex.org/W2131096798', 'https://openalex.org/W2063583146'], 'abstract_inverted_index': {'//': [0, 171], 'Richard': [1, 167], 'D.': [2, 168], 'Williams': [3], '1': [4, 8, 12, 16, 65, 66], ',': [5, 9, 13, 17, 21, 25, 29, 34, 41, 45, 50, 54, 58], 'Tasnim': [6], 'Chagtai': [7], 'Marisa': [10], 'Alcaide-German': [11], 'John': [14], 'Apps': [15], 'Jenny': [18], 'Wegert': [19], '2': [20, 61, 74], 'Sergey': [22], 'Popov': [23], '3': [24, 87], 'Gordan': [26], 'Vujanic': [27], '4': [28, 95], 'Harm': [30], 'van': [31, 37, 112], 'Tinteren': [32], '5': [33, 105], 'Marry': [35], 'M.': [36], 'den': [38], 'Heuvel-Eibrink': [39], '6': [40, 118], 'Marcel': [42], 'Kool': [43], '7': [44, 131], 'Jan': [46], 'de': [47], 'Kraker': [48], '8': [49, 138], 'David': [51], 'Gisselsson': [52], '9': [53, 145], 'Norbert': [55], 'Graf': [56], '10': [57, 153], 'Manfred': [59], 'Gessler': [60], 'and': [62, 78, 158, 241, 245, 254, 260, 278, 302, 365], 'Kathy': [63], 'Pritchard-Jones': [64], 'UCL': [67], 'Institute': [68, 88], 'of': [69, 89, 99, 120, 147, 155, 201, 225, 234, 249, 297, 305, 311, 321, 354], 'Child': [70], 'Health,': [71], 'London,': [72], 'UK': [73, 94, 104], 'Theodor-Boveri-Institute/Biocenter,': [75], 'Developmental': [76], 'Biochemistry': [77], 'Comprehensive': [79], 'Cancer': [80, 90, 109, 133], 'Center': [81], 'Mainfranken,': [82], 'Wuerzburg': [83], 'University,': [84, 151], 'Wuerzburg,': [85], 'Germany': [86, 137, 164], 'Research,': [91], 'Sutton,': [92], 'Surrey,': [93], 'Cardiff': [96], 'University': [97, 161], 'School': [98], 'Medicine,': [100], 'Heath': [101], 'Park,': [102], 'Cardiff,': [103], 'Biometrics': [106], 'Department,': [107], 'Netherlands': [108, 117, 130, 144], 'Institute,': [110], 'Antonie': [111], 'Leeuwenhoek': [113], 'Ziekenhuis,': [114], 'Amsterdam,': [115, 142], 'The': [116, 129, 143], 'Department': [119, 146, 154], 'Pediatric': [121], 'Oncology/Hematology,': [122], 'Erasmus': [123], 'MC,': [124], 'Sophia': [125], "Children's": [126], 'Hospital,': [127, 162], 'Rotterdam,': [128], 'German': [132], 'Research': [134], 'Centre,': [135], 'Heidelberg,': [136], 'Academic': [139], 'Medical': [140], 'Center,': [141], 'Clinical': [148], 'Genetics,': [149], 'Lund': [150], 'Sweden': [152], 'Paediatric': [156], 'Oncology': [157], 'Haematology,': [159], 'Saarland': [160], 'Homburg/Saar,': [163], 'Correspondence': [165], 'to:': [166], 'Williams,': [169], 'email:': [170], 'Keywords': [172], ':': [173, 184, 189, 194], 'Wilms': [174, 228, 355], 'tumour,': [175], 'MYCN,': [176], 'copy': [177, 222, 299], 'number,': [178], 'DNA': [179, 280], 'methylation,': [180], 'prognostic': [181], 'marker': [182], 'Received': [183], 'August': [185], '08,': [186], '2014': [187], 'Accepted': [188], 'January': [190, 195], '14,': [191], '2015': [192, 197], 'Published': [193], '31,': [196], 'Abstract': [198], 'Genomic': [199], 'gain': [200, 233, 301, 336, 361], 'the': [202, 308, 351, 368], 'proto-oncogene': [203], 'transcription': [204], 'factor': [205], 'gene': [206, 236], 'MYCN': [207, 226, 266, 285, 306, 335, 348, 360], 'is': [208, 237, 267, 337, 362, 373], 'associated': [209, 238, 283], 'with': [210, 239, 242, 258, 284, 289], 'poor': [211], 'prognosis': [212], 'in': [213, 227, 287, 307, 316, 333, 350], 'several': [214], 'childhood': [215], 'cancers.': [216], 'Here': [217], 'we': [218, 263], 'present': [219], 'a': [220, 273, 312, 329, 338, 344], 'comprehensive': [221], 'number': [223, 300], 'analysis': [224], 'tumour': [229], '(WT),': [230], 'demonstrating': [231], 'that': [232, 265, 359, 367], 'this': [235], 'anaplasia': [240], 'poorer': [243], 'relapse-free': [244], 'overall': [246], 'survival,': [247], 'independent': [248, 318], 'histology.': [250], 'Using': [251], 'whole': [252], 'exome': [253], 'gene-specific': [255], 'sequencing,': [256], 'together': [257], 'methylation': [259], 'expression': [261], 'profiling,': [262], 'show': [264], 'targeted': [268], 'by': [269], 'other': [270], 'mechanisms,': [271], 'including': [272], 'recurrent': [274], 'somatic': [275, 371], 'mutation,': [276], 'P44L,': [277], 'specific': [279], 'hypomethylation': [281], 'events': [282], 'overexpression': [286], 'tumours': [288, 310], 'high': [290], 'risk': [291], 'histologies.': [292], 'We': [293, 327, 357], 'describe': [294], 'parallel': [295], 'evolution': [296], 'genomic': [298], 'point': [303], 'mutation': [304], 'contralateral': [309, 319], 'remarkable': [313], 'bilateral': [314, 331], 'case': [315, 332], 'which': [317, 334], 'mutations': [320], 'TP53': [322], 'also': [323], 'evolve': [324], 'over': [325], 'time.': [326], 'report': [328], 'second': [330], 'germline': [339], 'aberration.': [340], 'Our': [341], 'results': [342], 'suggest': [343, 366], 'significant': [345], 'role': [346], 'for': [347], 'dysregulation': [349], 'molecular': [352], 'biology': [353], 'tumour.': [356], 'conclude': [358], 'prognostically': [363], 'significant,': [364], 'novel': [369], 'P44L': [370], 'variant': [372], 'likely': [374], 'to': [375], 'be': [376], 'an': [377], 'activating': [378], 'mutation.': [379]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1838829111', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 6}], 'updated_date': '2024-12-14T09:10:22.044866', 'created_date': '2016-06-24'}