Publication Information

{'id': 'https://openalex.org/W1832937582', 'doi': 'https://doi.org/10.18632/oncotarget.1942', 'title': 'Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice', 'display_name': 'Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice', 'publication_year': 2014, 'publication_date': '2014-05-02', 'ids': {'openalex': 'https://openalex.org/W1832937582', 'doi': 'https://doi.org/10.18632/oncotarget.1942', 'mag': '1832937582', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24811731', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4058043'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1942', 'pdf_url': 'https://www.oncotarget.com/article/1942/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/1942/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077375717', 'display_name': 'Vijayendra Agrawal', 'orcid': 'https://orcid.org/0000-0002-3405-8425'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Vijayendra Agrawal', 'raw_affiliation_strings': ['Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea.', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044157135', 'display_name': 'Sony Maharjan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sony Maharjan', 'raw_affiliation_strings': ['Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081563912', 'display_name': 'Kyeojin Kim', 'orcid': 'https://orcid.org/0000-0002-2507-9427'}, 'institutions': [{'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kyeojin Kim', 'raw_affiliation_strings': ['College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea,', 'institution_ids': ['https://openalex.org/I139264467']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000442225', 'display_name': 'Nam‐Jung Kim', 'orcid': 'https://orcid.org/0000-0003-3991-5470'}, 'institutions': [{'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Nam-Jung Kim', 'raw_affiliation_strings': ['Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea,', 'institution_ids': ['https://openalex.org/I35928602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052985957', 'display_name': 'Jimin Son', 'orcid': 'https://orcid.org/0000-0001-7503-7252'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jimin Son', 'raw_affiliation_strings': ['Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002846905', 'display_name': 'Keunho Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Keunho Lee', 'raw_affiliation_strings': ['Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022451008', 'display_name': 'Hyun-Jung Choi', 'orcid': 'https://orcid.org/0000-0003-3695-3420'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyun-Jung Choi', 'raw_affiliation_strings': ['Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109389076', 'display_name': 'Seung-Sik Rho', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Seung-Sik Rho', 'raw_affiliation_strings': ['Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027714559', 'display_name': 'Sunjoo Ahn', 'orcid': 'https://orcid.org/0000-0002-6519-6492'}, 'institutions': [{'id': 'https://openalex.org/I4210151417', 'display_name': 'Korea Research Institute of Chemical Technology', 'ror': 'https://ror.org/043k4kk20', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151417']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sunjoo Ahn', 'raw_affiliation_strings': ['Korea Research Institute of Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon 305-343, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'Korea Research Institute of Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon 305-343, Republic of Korea,', 'institution_ids': ['https://openalex.org/I4210151417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110468327', 'display_name': 'Moo‐Ho Won', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Moo-Ho Won', 'raw_affiliation_strings': ['Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200-701, Republic of Korea,', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003546968', 'display_name': 'Sang‐Jun Ha', 'orcid': 'https://orcid.org/0000-0002-1192-6031'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sang-Jun Ha', 'raw_affiliation_strings': ['Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061682089', 'display_name': 'Gou Young Koh', 'orcid': 'https://orcid.org/0000-0002-1231-1485'}, 'institutions': [{'id': 'https://openalex.org/I157485424', 'display_name': 'Korea Advanced Institute of Science and Technology', 'ror': 'https://ror.org/05apxxy63', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I157485424']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Gou Young Koh', 'raw_affiliation_strings': ['National Research Laboratory of Vascular Biology and Stem Cells, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'National Research Laboratory of Vascular Biology and Stem Cells, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea,', 'institution_ids': ['https://openalex.org/I157485424']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054964892', 'display_name': 'Young‐Myeong Kim', 'orcid': 'https://orcid.org/0000-0002-8326-7768'}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Young-Myeong Kim', 'raw_affiliation_strings': ['Vascular System Research Center, Kangwon National University, Kangwon-Do, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Vascular System Research Center, Kangwon National University, Kangwon-Do, Republic of Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075143500', 'display_name': 'Young‐Ger Suh', 'orcid': 'https://orcid.org/0000-0003-1799-8607'}, 'institutions': [{'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Young-Ger Suh', 'raw_affiliation_strings': ['College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea,', 'institution_ids': ['https://openalex.org/I139264467']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076882757', 'display_name': 'Young‐Guen Kwon', 'orcid': 'https://orcid.org/0000-0002-1534-2455'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Young-Guen Kwon', 'raw_affiliation_strings': ['Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea,', 'institution_ids': ['https://openalex.org/I193775966']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.293, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.999894, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '5', 'issue': '9', 'first_page': '2761', 'last_page': '2777'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10422', 'display_name': 'Angiogenesis and VEGF in Cancer', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12065', 'display_name': 'Hippo pathway signaling and YAP/TAZ', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.58775616}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.5187676}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.34390464}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32923502}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.114634335}], 'mesh': [{'descriptor_ui': 'D015703', 'descriptor_name': 'Antigens, CD', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018827', 'descriptor_name': 'Carcinoma, Lewis Lung', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D012503', 'descriptor_name': 'Saponins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015703', 'descriptor_name': 'Antigens, CD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015703', 'descriptor_name': 'Antigens, CD', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018827', 'descriptor_name': 'Carcinoma, Lewis Lung', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': False}, {'descriptor_ui': 'D018827', 'descriptor_name': 'Carcinoma, Lewis Lung', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018827', 'descriptor_name': 'Carcinoma, Lewis Lung', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018827', 'descriptor_name': 'Carcinoma, Lewis Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003930', 'descriptor_name': 'Diabetic Retinopathy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003930', 'descriptor_name': 'Diabetic Retinopathy', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003930', 'descriptor_name': 'Diabetic Retinopathy', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003930', 'descriptor_name': 'Diabetic Retinopathy', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007124', 'descriptor_name': 'Immunoenzyme Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D008207', 'descriptor_name': 'Lymphatic Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012503', 'descriptor_name': 'Saponins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1942', 'pdf_url': 'https://www.oncotarget.com/article/1942/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4058043', 'pdf_url': 'https://europepmc.org/articles/pmc4058043?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058043', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24811731', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1942', 'pdf_url': 'https://www.oncotarget.com/article/1942/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1960606964', 'https://openalex.org/W1964128680', 'https://openalex.org/W1969339220', 'https://openalex.org/W1971945408', 'https://openalex.org/W1974218755', 'https://openalex.org/W1975447544', 'https://openalex.org/W1975815647', 'https://openalex.org/W1977439064', 'https://openalex.org/W1978139448', 'https://openalex.org/W1980079044', 'https://openalex.org/W1980363723', 'https://openalex.org/W1980714860', 'https://openalex.org/W1988135764', 'https://openalex.org/W1992649924', 'https://openalex.org/W1995168398', 'https://openalex.org/W2000334040', 'https://openalex.org/W2004262765', 'https://openalex.org/W2005666472', 'https://openalex.org/W2006202974', 'https://openalex.org/W2020423449', 'https://openalex.org/W2028437938', 'https://openalex.org/W2031941215', 'https://openalex.org/W2032995169', 'https://openalex.org/W2036835130', 'https://openalex.org/W2042411798', 'https://openalex.org/W2043463860', 'https://openalex.org/W2066834504', 'https://openalex.org/W2070636596', 'https://openalex.org/W2071020938', 'https://openalex.org/W2075966373', 'https://openalex.org/W2080997194', 'https://openalex.org/W2083162868', 'https://openalex.org/W2089258206', 'https://openalex.org/W2089880104', 'https://openalex.org/W2100891986', 'https://openalex.org/W2104300873', 'https://openalex.org/W2105653042', 'https://openalex.org/W2108623236', 'https://openalex.org/W2114125544', 'https://openalex.org/W2119629056', 'https://openalex.org/W2121946088', 'https://openalex.org/W2123629654', 'https://openalex.org/W2131507207', 'https://openalex.org/W2135627690', 'https://openalex.org/W2136023563', 'https://openalex.org/W2151062607', 'https://openalex.org/W2152393981', 'https://openalex.org/W2164230402', 'https://openalex.org/W2169265493', 'https://openalex.org/W4233232262'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2586801360', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'//': [0, 178], 'Vijayendra': [1], 'Agrawal': [2], '1': [3, 7, 19, 23, 27, 31, 43, 60, 61], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 49, 53], 'Sony': [5], 'Maharjan': [6], 'Kyeojin': [9], 'Kim': [10, 14, 51], '2': [11, 56, 78], 'Nam-Jung': [13], '3': [15, 93], 'Jimin': [17], 'Son': [18], 'Keunho': [21], 'Lee': [22], 'Hyun-Jung': [25], 'Choi': [26], 'Seung-Sik': [29], 'Rho': [30], 'Sunjoo': [33], 'Ahn': [34], '4': [35, 108], 'Moo-Ho': [37], 'Won': [38], '5': [39, 124], 'Sang-Jun': [41], 'Ha': [42], 'Gou': [45], 'Young': [46], 'Koh': [47], '6': [48, 139], 'Young-Myeong': [50], '7': [52, 162], 'Young-Ger': [54], 'Suh': [55], 'and': [57, 69, 146, 154, 209, 223, 259, 264, 295, 316, 322, 383], 'Young-Guen': [58, 175], 'Kwon': [59], 'Department': [62, 94, 125], 'of': [63, 66, 76, 80, 91, 95, 98, 106, 112, 122, 126, 129, 137, 143, 152, 160, 172, 234, 280, 285, 336, 344, 368, 379], 'Biochemistry,': [64], 'College': [65, 79, 97], 'Life': [67], 'Science': [68, 153], 'Biotechnology,': [70], 'Yonsei': [71], 'University,': [72, 84, 102, 133, 169], 'Seoul': [73, 82, 88, 103], '120-749,': [74], 'Republic': [75, 90, 105, 121, 136, 159, 171], 'Korea,': [77, 92, 107, 123, 138, 161], 'Pharmacy,': [81, 96, 99], 'National': [83, 132, 140, 168], '599': [85], 'Gwanak-ro,': [86], 'Gwanak-gu,': [87], '151-742,': [89], 'Kyung': [100], 'Hee': [101], '130-701,': [104], 'Korea': [109, 149], 'Research': [110, 141, 165], 'Institute': [111, 151], 'Chemical': [113], 'Technology': [114, 155], '(KRICT),': [115], '141': [116], 'Gajeong-ro,': [117], 'Yuseong-gu,': [118], 'Daejeon': [119, 157], '305-343,': [120], 'Neurobiology,': [127], 'School': [128], 'Medicine,': [130], 'Kangwon': [131, 167], 'Chuncheon': [134], '200-701,': [135], 'Laboratory': [142], 'Vascular': [144, 163, 181], 'Biology': [145], 'Stem': [147], 'Cells,': [148], 'Advanced': [150], '(KAIST),': [156], '305-701,': [158], 'System': [164], 'Center,': [166], 'Kangwon-Do,': [170], 'Korea.': [173], 'Correspondence:': [174], 'Kwon,': [176], 'email:': [177], 'Keywords': [179], ':': [180, 189, 194, 199], 'permeability,': [182], 'Hypoxia,': [183], 'Normalization,': [184], 'Epithelial-to-mesenchymal': [185], 'transition,': [186], 'Sac-1004': [187, 250, 271, 309, 356], 'Received': [188], 'April': [190, 195], '18,': [191], '2014': [192, 197, 202], 'Accepted': [193], '30,': [196], 'Published': [198], 'May': [200], '2,': [201], 'Abstract': [203], 'Tumor': [204], 'blood': [205, 214, 287, 381], 'vessels': [206, 258, 288, 382], 'are': [207], 'leaky': [208], 'immature,': [210], 'which': [211, 243], 'causes': [212], 'inadequate': [213], 'supply': [215], 'to': [216, 272, 313, 376], 'tumor': [217, 230, 257, 281, 324, 337, 358, 380], 'tissues': [218], 'resulting': [219], 'in': [220, 240, 256, 303, 320, 328, 333, 342, 355], 'hypoxic': [221], 'microenvironment': [222], 'promotes': [224], 'metastasis.': [225, 385], 'Here': [226], 'we': [227], 'have': [228, 273], 'explored': [229], 'vessel': [231], 'modulating': [232], 'activity': [233], 'Sac-1004,': [235], 'a': [236, 331, 373], 'recently': [237], 'developed': [238], 'molecule': [239], 'our': [241, 362], 'lab,': [242], 'directly': [244], 'potentiates': [245], 'VE-cadherin-mediated': [246], 'endothelial': [247], 'cell': [248, 351], 'junction.': [249], 'could': [251, 371], 'enhance': [252, 265], 'vascular': [253, 262, 266, 369], 'junction': [254, 370], 'integrity': [255], 'thereby': [260], 'inhibit': [261, 314], 'leakage': [263], 'perfusion.': [267], 'Improved': [268], 'perfusion': [269], 'enabled': [270], 'synergistic': [274], 'anti-tumor': [275], 'effect': [276], 'on': [277], 'cisplatin-mediated': [278], 'apoptosis': [279], 'cells.': [282], 'Interestingly,': [283], 'characteristics': [284], 'normalized': [286], 'namely': [289], 'reduced': [290], 'hypoxia,': [291], 'improved': [292], 'pericyte': [293], 'coverage': [294], 'decreased': [296], 'basement': [297], 'membrane': [298], 'thickness': [299], 'were': [300], 'readily': [301], 'observed': [302], 'tumors': [304], 'treated': [305, 357], 'with': [306, 330, 339], 'Sac-1004.': [307], 'Remarkably,': [308], 'was': [310, 327], 'also': [311], 'able': [312], 'lung': [315], 'lymph': [317], 'node': [318], 'metastasis': [319], 'MMTV': [321], 'B16BL6': [323], 'models.': [325], 'This': [326], 'correlation': [329], 'reduction': [332], 'epithelial-to-mesenchymal': [334], 'transition': [335], 'cells': [338], 'considerable': [340], 'diminution': [341], 'expression': [343], 'related': [345], 'transcription': [346], 'factors.': [347], 'Moreover,': [348], 'cancer': [349], 'stem': [350], 'population': [352], 'dropped': [353], 'substantially': [354], 'tissues.': [359], 'Taken': [360], 'together,': [361], 'results': [363], 'showed': [364], 'that': [365], 'direct': [366], 'restoration': [367], 'be': [372], 'significant': [374], 'strategy': [375], 'induce': [377], 'normalization': [378], 'reduce': [384]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1832937582', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-12-08T10:52:07.956876', 'created_date': '2016-06-24'}